24 completed. 24 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 24 | Completed 24 |
Follow Chromosome Disorders: new trials by email Literature Review of Chromosome Disorders trials Research Report on Chromosome Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fluoxetine Treatment of Depression in Down Syndrome Fluoxetine - Down Syndrome, Depression | Phase 4 | Completed | Massachusetts General Hospital | 4 | 2022-12-05 | 2025-03-30 |
| Metformin in Children With Fragile X Syndrome Metformin, Placebo - Fragile X Syndrome, Metformin | Phase 4 | Completed | Children's Hospital of Fudan University | 37 | 2021-12-29 | 2026-08-25 |
| Buspirone Treatment of Anxiety in Williams Syndrome Buspirone - Williams Syndrome, Anxiety | Phase 4 | Completed | Massachusetts General Hospital | 20 | 2021-08-01 | 2024-12-03 |
| Guanfacine Extended Release for the Reduction of Aggression and Self-injurious Behavior Associated With Prader-Willi Syndrome Guanfacine Extended Release, Placebo - Prader-Willi Syndrome, Aggression | Phase 4 | Completed | Maimonides Medical Center | 15 | 2020-12-17 | 2024-08-19 |
| Evaluating Treatment of ADHD in Children With Down Syndrome Quillivant XR, Placebo - Down Syndrome, ADHD | Phase 4 | Completed | Children's Hospital Medical Center, Cincinnati | 44 | 2020-10-02 | 2026-11-02 |
| TESTO: Testosterone Effects on Short-Term Outcomes in Infants With XXY Testosterone Cypionate 200 Milligram/Milliliter Injectable Solution, Placebo injectable saline - Klinefelter Syndrome | Phase 4 | Completed | University of Colorado, Denver | 72 | 2017-11-06 | 2022-05-06 |
| GH in Adults With PWS, Effect on Hypotonia Evaluated by Functional MRI, Relationship With Strength and Body Composition Growth hormone, Placebo - Prader-Willi Syndrome | Phase 4 | Completed | Corporacion Parc Tauli | 30 | 2017-06-19 | 2021-01-27 |
| Human Fibrinogen Concentrate in Pediatric Cardiac Surgery RiaStAP, Saline - Hypofibrinogenemia, Afibrinogenemia | Phase 4 | Completed | Nicklaus Children's Hospital f/k/a Miami Children's Hospital | 30 | 2017-06-01 | 2021-09-16 |
| Oxygen Versus Medical Air for Treatment of CSA in Prader Will Syndrome Medical Air vs Oxygen - Sleep Apnea, Central, Prader-Willi Syndrome | Phase 4 | Completed | The Hospital for Sick Children | 9 | 2016-09-01 | 2025-06-08 |
| Evaluation of the Ease of Use, Preference, and Safety of EutropinPen Inj. Somatropin - Short Stature, Idiopathic, Infant, Small for Gestational Age | Phase 4 | Completed | LG Life Sciences | 116 | 2016-08-11 | 2019-01-03 |
| Combining Lovastatin and a Parent-Implemented Language Intervention for Fragile X Syndrome Lovastatin, Placebo - Fragile X Syndrome, Genetic Diseases | Phase 4 | Completed | University of California, Davis | 30 | 2016-01-01 | 2019-09-11 |
| Body Composition in Infants With Klinefelter Syndrome and Effects of Testosterone Treatment testosterone cypionate 200mg/ml - Klinefelter Syndrome | Phase 4 | Completed | University of Colorado, Denver | 20 | 2015-05-08 | 2020-04-15 |
| First Year Growth Response Associated Genetic Markers Validation Phase IV Open-label Study in Growth Hormone Deficient and Turner Syndrome Pre-pubertal Children: the PREDICT Pharmacogenetics Validation Study Blood sampling - Idiopathic Growth Hormone Deficiency, Turner Syndrome | Phase 4 | Completed | Merck KGaA, Darmstadt, Germany | 458 | 2011-09-01 | 2014-01-16 |
| Norditropin NordiFlex® Device Compared to the Device Previously Used by Patients or Parents Norditropin NordiFlex® - Growth Hormone Disorder, Growth Hormone Deficiency in Children | Phase 4 | Completed | Novo Nordisk A/S | 103 | 2010-11-01 | 2017-02-27 |
| Riluzole in Fragile X Syndrome Riluzole - Fragile X Syndrome | Phase 4 | Completed | Indiana University | 6 | 2009-04-01 | 2017-04-18 |
| Is There a Sensibility Increased in the Growth Hormone at Child With Prader-Willi Syndrome? Growth hormone (Genotonorm® or Omnitrope®), DEXA, blood tests, H.G.P.O, osseous age., biopsy - Prader-Willi Syndrome, Growth Hormone Deficiency | Phase 4 | Completed | University Hospital, Toulouse | 111 | 2009-01-01 | 2021-09-24 |
| Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism 17 B estradiol orally, 17 B estradiol - Turner Syndrome, Hypogonadism | Phase 4 | Completed | Nemours Children's Clinic | 41 | 2009-01-01 | 2023-05-16 |
| Efficacy and Safety of Memantine Hydrochloride in Enhancing the Cognitive Abilities of Young Adults With Down Syndrome Memantine, Placebo - Down Syndrome | Phase 4 | Completed | University of Colorado, Denver | 42 | 2008-07-01 | 2013-02-01 |
| Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome Humatrope - Turner Syndrome | Phase 4 | Completed | Eli Lilly and Company | 69 | 2005-12-01 | 2017-03-31 |
| Defining the Optimal Hormonal Replacement Therapy in Turner Syndrome estradiol - Turner Syndrome | Phase 4 | Completed | Line Cleemann | 43 | 2005-06-01 | 2013-06-14 |
Showing 20 of 24. Sign in to see all of them.
Turner Syndrome (10) · Genetic Diseases, Inborn (5) · Dwarfism, Pituitary (4) · Prader-Willi Syndrome (4) · Down Syndrome (3) · Fragile X Syndrome (3) · Intellectual Disability (2) · Klinefelter Syndrome (2) · Neurobehavioral Manifestations (2) · Abnormalities, Multiple (1) · Afibrinogenemia (1) · Aggression (1) · Anxiety Disorders (1) · Attention Deficit Disorder with Hyperactivity (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (24) · Congenital Abnormalities (23) · Genetic Diseases, Inborn (19) · Sex Chromosome Disorders (15) · Nervous System Diseases (14) · Endocrine System Diseases (13) · Cardiovascular Diseases (12) · Disorders of Sex Development (12) · Female Urogenital Diseases (12) · Female Urogenital Diseases and Pregnancy Complications (12) · Gonadal Disorders (12) · Heart Diseases (12) · Male Urogenital Diseases (12) · Sex Chromosome Disorders of Sex Development (12)
Human Growth Hormone (7) · Growth Hormone (3) · Estradiol (2) · Absorptiometry, Photon (1) · Biopsy (1) · Blood Specimen Collection (1) · Buspirone (1) · Estrogens (1) · Fibrinogen (1) · Fluoxetine (1) · Guanfacine (1) · Hematologic Tests (1) · Lovastatin (1) · Memantine (1) · Metformin (1)
Merck KGaA, Darmstadt, Germany (3) · Novo Nordisk A/S (3) · University of Colorado, Denver (3) · Massachusetts General Hospital (2) · Children's Hospital Medical Center, Cincinnati (1) · Children's Hospital of Fudan University (1) · Corporacion Parc Tauli (1) · Eli Lilly and Company (1) · Indiana University (1) · LG Life Sciences (1) · Line Cleemann (1) · Maimonides Medical Center (1) · Nemours Children's Clinic (1) · Nicklaus Children's Hospital f/k/a Miami Children's Hospital (1) · The Hospital for Sick Children (1)
United States (12) · France (6) · Canada (3) · Spain (3) · Argentina (2) · Germany (2) · Italy (2) · Sweden (2) · United Kingdom (2) · Australia (1) · Austria (1) · Chile (1) · China (1) · Czechia (1) · Denmark (1)
Shanlee M Davis, MD (2) · Alberto Costa, MD, Ph.D (1) · Anna Esbensen, PhD (1) · Benjamin Handen, MD (1) · Christopher Tirotta, MD (1) · Craig A. Erickson, MD (1) · Deepan Singh, MD (1) · Edward Goldson, MD (1) · Gilles Della Corte (1) · Kathleen Angkustsiri, MD (1) · Line Cleemann, Doctor (1)
PMID 10518081, PMID 10599727, PMID 10599729, PMID 12466334, PMID 12629094, PMID 15900109, PMID 21059347, PMID 21398400, PMID 21880799, PMID 22806212, PMID 23567489, PMID 23678038, PMID 23737664, PMID 24406482, PMID 24916642, PMID 26340968, PMID 29618660, PMID 30571546, PMID 31613320, PMID 31908426, PMID 32316911, PMID 34040195, PMID 34045667, PMID 35305111, PMID 38561465, PMID 41291951, PMID 8923853
2009 (1), 2017 (1), K23HD092588 (1), UL1TR001082 (1)