25 completed, 7 recruiting, 7 unknown, 4 enrolling by invitation. 10 Not applicable, 4 Phase 4, 3 Phase 2, 2 Phase 3, 1 Phase 1.
Follow Klinefelter Syndrome: new trials by email Literature Review of Klinefelter Syndrome trials Research Report on Klinefelter Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hematological Profile in Children With Numerical Chromosomal Disorders Down Syndrome, Turner Syndrome | Not yet recruiting | Assiut University | 158 | 2026-09-02 | 2026-09-10 | |
| A Multiple Baseline Feasibility Trial of Social Management Training for People With Sex Chromosome Aneuploidies Social Management Training - Sex Chromosome Disorders | Phase 1 | Recruiting | University of Oslo | 30 | 2026-06-01 | 2026-07-22 |
| Long-term Systematic Follow-up of Patients With Klinefelter Syndrome Followed at the Department of Growth and Reproduction, Rigshospitalet There is no intervention, only clinical description - Klinefelter Syndrome | Enrolling by invitation | Copenhagen University Hospital, Rigshospitalet | 300 | 2025-04-01 | 2025-09-10 | |
| Growing up With the Young Endocrine Support System (YESS!) YESS! game, Snake '97, Transition-toolkit - Congenital Adrenal Hyperplasia, Hypogonadotropic Hypogonadism | Not applicable | Not yet recruiting | dr. Laura C. G. de Graaff-Herder | 160 | 2024-12-01 | 2023-09-07 |
| Clinical and Genetic Aspects in Fetuses and Children With Sex Chromosome Disorders Sex Chromosome Disorders | Enrolling by invitation | University of Aarhus | 300 | 2024-09-01 | 2026-01-14 | |
| Klinefelter Syndrome and Testosterone Treatment in Puberty Testosterone gel, Placebo - Klinefelter Syndrome | Phase 4 | Recruiting | Lise Aksglæde | 32 | 2024-08-15 | 2025-02-19 |
| Clinical and Genetic Aspects of Fetuses With Sex-chromosome Disorders Sex Chromosome Disorders | Enrolling by invitation | University of Aarhus | 120 | 2024-01-01 | 2026-01-08 | |
| Retrospective Analysis of the Neonatal Management of Patients with an Antenatal Diagnosis of Genital Development Variation At the Hospital of Lyon Endocrinology, Disorders of Sexual Development | Completed | Hospices Civils de Lyon | 170 | 2023-10-01 | 2024-11-13 | |
| Sex Steroids Balance for Metabolic and Reproductive Health in Klinefelter Syndrome Anastrozole, Semaglutide, human chorionic gonadotropin - Klinefelter Syndrome | Phase 3 | Recruiting | Georgios Papadakis | 150 | 2023-03-21 | 2026-05-11 |
| Interrogating Fatty Acid Metabolism Impairment and Clinical Correlates in Males with Klinefelter Syndrome Fenofibrate 145 mg - Klinefelter Syndrome | Phase 4 | Unknown | University of Colorado, Denver | 44 | 2022-11-03 | 2024-10-16 |
| Endocrine, Metabolic, Cardiovascular and Immunological Aspects of Sex Chromosome Abnormalities in Relation to Genotype No intervention other than obtaining biopsies - Sex Chromosome Abnormality, Klinefelter Syndrome | Unknown | University of Aarhus | 320 | 2022-06-13 | 2023-11-29 | |
| Generating Advancements Through Longitudinal Analysis in X and Y Variations (GALAXY) no intervention - Sex Chromosome Aneuploidy | Recruiting | University of Colorado, Denver | 5000 | 2022-04-28 | 2024-04-18 | |
| Clinical, Biochemical, and Cytogenetic Heterogeneity in Mosaic 46,XX/47,XXY Sex Chromosome Aneuploidy Klinefelter Syndrome (47, XXY), Sex Chromosome Aneuploidy | Completed | Université Paris-Saclay | 257 | 2022-01-15 | 2026-10-21 | |
| Parent and Infant Inter(X)Action Intervention (PIXI) Parent-Infant Inter(X)action Intervention (PIXI) - Fragile X Syndrome, Angelman Syndrome | Not applicable | Enrolling by invitation | RTI International | 120 | 2018-11-30 | 2026-07-13 |
| GROWing Up With Rare GENEtic Syndromes Retrospective file studies - Prader-Willi Syndrome, PWS-like Syndrome | Recruiting | dr. Laura C. G. de Graaff-Herder | 600 | 2018-10-01 | 2023-09-06 | |
| Turner And Klinefelter Treatment Target Study Measurement of blood values, questionnaire scores and measurements of hormone levels in hair - Klinefelter Syndrome, Turner Syndrome | Unknown | dr. Laura C. G. de Graaff-Herder | 370 | 2018-07-01 | 2023-09-06 | |
| Unraveling the Klinefelter's Disease Physiopathology Testicular biopsy - Klinefelter Syndrome, Infertility, Male | Not applicable | Unknown | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 20 | 2018-06-12 | 2023-08-18 |
| TESTO: Testosterone Effects on Short-Term Outcomes in Infants With XXY Testosterone Cypionate 200 Milligram/Milliliter Injectable Solution, Placebo injectable saline - Klinefelter Syndrome | Phase 4 | Completed | University of Colorado, Denver | 72 | 2017-11-06 | 2022-05-06 |
| The eXtroardinarY Babies Study: Natural History of Health and Neurodevelopment in Infants and Young Children With Sex Chromosome Trisomy Assessments of Development and Growth - Klinefelter Syndrome, Trisomy X | Recruiting | University of Colorado, Denver | 300 | 2017-09-29 | 2024-05-09 | |
| Cardiometabolic Profiles of Boys With Klinefelter Syndrome No intervention - Klinefelter Syndrome, 47,XXY | Completed | University of Colorado, Denver | 31 | 2016-05-01 | 2022-03-08 |
Showing 20 of 47. Sign in to see all of them.
Turner Syndrome (14) · Down Syndrome (6) · Triple X syndrome (5) · Trisomy 18 Syndrome (5) · 47, XYY syndrome (4) · DiGeorge Syndrome (4) · Hypogonadism (4) · Infertility (4) · Sex Chromosome Disorders (4) · Trisomy 13 Syndrome (4) · Azoospermia (3) · Cardiovascular Diseases (3) · Disorders of Sex Development (3) · Sex Chromosome Aberrations (3)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (47) · Endocrine System Diseases (47) · Female Urogenital Diseases (47) · Female Urogenital Diseases and Pregnancy Complications (47) · Genetic Diseases, Inborn (47) · Gonadal Disorders (47) · Male Urogenital Diseases (47) · Sex Chromosome Disorders of Sex Development (47) · Urogenital Abnormalities (47) · Urogenital Diseases (47) · Chromosome Disorders (46) · Congenital Abnormalities (46) · Disorders of Sex Development (44) · Hypogonadism (43) · Sex Chromosome Disorders (43)
Chorionic Gonadotropin (2) · Absorptiometry, Photon (1) · Anastrozole (1) · Blood Specimen Collection (1) · Calcitriol (1) · Castor Oil (1) · Counseling (1) · Fenofibrate (1) · Growth (1) · Isotretinoin (1) · Orchiectomy (1) · Telbivudine (1) · Testosterone (1) · semaglutide (1) · testosterone 17 beta-cypionate (1)
University of Aarhus (8) · University of Colorado, Denver (7) · dr. Laura C. G. de Graaff-Herder (3) · Hospices Civils de Lyon (2) · Odense University Hospital (2) · Progenity, Inc. (2) · University of Roma La Sapienza (2) · Assiut University (1) · Azienda USL Modena (1) · Boston Children's Hospital (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Copenhagen University Hospital, Rigshospitalet (1) · Georgios Papadakis (1) · Gulhane School of Medicine (1) · Lenetix Medical Screening Laboratory (1)
United States (18) · Denmark (12) · France (3) · Italy (3) · Netherlands (3) · Belgium (2) · Egypt (1) · Norway (1) · Spain (1) · Switzerland (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Shanlee M Davis, MD (3) · Shanlee M Davis, MD, PhD (2) · Abdullah Demirtas, MD (1) · Alper Sonmez, Prof. (1) · Anders B Bojesen, MD, PhD (1) · Andrea Isidori, MD, PhD (1) · Andrea Lenzi, MD (1) · Andrea M Isidori, MD, PhD (1) · Anne S Jensen, MD (1) · Anne Wheeler, PhD (1) · Barbara B Biesecker (1) · Christian Trolle, MD (1) · Christine Wyns, MD, PhD (1)
PMID 36978128, PMID 32542985, PMID 11531930, PMID 16801584, PMID 17535868, PMID 24659579, PMID 24865607, PMID 25423570, PMID 25514102, PMID 25532039, PMID 26254174, PMID 26746120, PMID 27355107, PMID 27637014, PMID 28285751, PMID 29931143, PMID 30642344, PMID 31532522, PMID 32613319, PMID 34001264, PMID 36112034, PMID 39237101, PMID 40090688, PMID 41891299, PMID 8555850
UL1TR001082 (2), 2023 (1), K23HD092588 (1), K23NS070337 (1)