66 completed. 66 Phase 3, 16 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 66 | Completed 66 |
| Phase 2 | 16 | Completed 16 |
Follow Child Development Disorders, Pervasive: new trials by email Literature Review of Child Development Disorders, Pervasive trials Research Report on Child Development Disorders, Pervasive
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Efficacy and Safety of AST-001 in ASD Children AST-001, Placebo of AST-001 - Autism Spectrum Disorder | Phase 3 | Completed | Astrogen, Inc. | 169 | 2023-08-29 | 2026-02-02 |
| Efficacy and Mechanism of Repetitive Transcranial Magnetic Stimulation in Children With Autism Spectrum Disorders repeated transcranial magnetic stimulation (continuous theta-burst stimulation), sham repeated transcranial magnetic stimulation - Autism Spectrum Disorder | Phase 2 / Phase 3 | Completed | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 200 | 2023-07-04 | 2026-05-19 |
| Evaluating the Efficacy of NTI164 in Young People With Autism Spectrum Disorder NTI164 - Autism Spectrum Disorder | Phase 2 / Phase 3 | Completed | Fenix Innovation Group | 54 | 2022-11-30 | 2026-09-10 |
| Study of Cariprazine Oral Capsules or Solution to Assess Adverse Events and Change in Irritability Due to Autism Spectrum Disorder (ASD) in Participants Aged 5-17 Years With ASD Cariprazine, Placebo - Autism Spectrum Disorder | Phase 3 | Completed | AbbVie | 161 | 2022-07-07 | 2025-04-04 |
| Effect of Lithium in Patients With Autism Spectrum Disorder and Phelan-McDermid Syndrome (SHANK3 Haploinsufficiency) Lithium Carbonate, Placebo - Autism Spectrum Disorder | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 22 | 2022-02-21 | 2025-10-02 |
| Open-Label, Flexible-dose Study to Evaluate the Long-Term Safety and Tolerability of Cariprazine in the Treatment of Pediatric Participants With Schizophrenia, Bipolar I Disorder, or Autism Spectrum Disorder Cariprazine Flexible Dose - Schizophrenia, Bipolar I Disorder | Phase 3 | Completed | AbbVie | 310 | 2021-02-01 | 2025-10-27 |
| Brexpiprazole in Treatment of Children and Adolescents With Irritability Associated With Autism Spectrum Disorder for Subjects That Have Completed Participation in 331-201-00148 Brexpiprazole - Irritability Associated With Autism Spectrum Disorder | Phase 3 | Completed | Otsuka Pharmaceutical Development & Commercialization, Inc. | 95 | 2020-01-23 | 2024-05-30 |
| The Effects of Medical Cannabis in Children With Autistic Spectrum Disorder Cannabis oil - Autism Spectrum Disorder | Phase 3 | Completed | Assaf-Harofeh Medical Center | 128 | 2019-11-14 | 2024-07-31 |
| Brexpiprazole in Treatment of Children and Adolescents With Irritability Associated With Autism Spectrum Disorder Brexpiprazole, Placebo - Irritability Associated With Autism Spectrum Disorder (ASD) | Phase 3 | Completed | Otsuka Pharmaceutical Development & Commercialization, Inc. | 119 | 2019-10-30 | 2025-08-28 |
| Modulating Socially Adaptive Mirror System Functioning in Autism by Oxytocin Oxytocin, Placebo - Autism Spectrum Disorder | Phase 3 | Completed | KU Leuven | 25 | 2018-07-26 | 2020-02-05 |
| Aripiprazole Oral Solution in the Treatment of Children and Adolescents With Autistic Disorder Aripiprazole Oral Solution, Placebo Oral Solution - Autistic Disorder | Phase 3 | Completed | Otsuka Beijing Research Institute | 111 | 2018-04-09 | 2020-12-29 |
| Intranasal Vasopressin Treatment in Children With Autism Vasopressin (USP) Injectable Solution [Vasostrict], Placebo - Autism, Autism Spectrum Disorder | Phase 2 / Phase 3 | Completed | Stanford University | 157 | 2018-02-20 | 2026-06-04 |
| Folinic Acid in Autism folinic acid - Autism Spectrum Disorder | Phase 2 / Phase 3 | Completed | University of California, San Francisco | 18 | 2018-02-15 | 2019-12-03 |
| Treatment of Encopresis in Children With Autism Spectrum Disorders MIE Treatment, Glycerin Suppository, Treatment as Usual (TAU) - Encopresis, Autism Spectrum Disorder | Phase 3 | Completed | Emory University | 117 | 2017-10-25 | 2024-01-31 |
| A Study of Oxytocin for the Treatment of Social Impairment in Individuals With High Functioning Autism Spectrum Disorder Intranasal Oxytocin - Autism Spectrum Disorder, Pervasive Developmental Disorder | Phase 3 | Completed | Massachusetts General Hospital | 7 | 2017-10-09 | 2024-07-01 |
| Verification of the Efficacy of NPC-15 for Sleep Disorders of Children With Autism Spectrum Disorders NPC-15 Granules Lower Dose, NPC-15 Granules Higher Dose, NPC-15 Placebo Granule - Sleep Disorders, Autism Spectrum Disorder | Phase 2 / Phase 3 | Completed | Nobelpharma | 196 | 2016-06-16 | 2019-04-16 |
| Open Label of Clinical Trial of Sulforaphane in Children With Autism Sulforaphane - Autism | Phase 3 | Completed | University of California, San Francisco | 21 | 2016-01-01 | 2019-03-06 |
| A Trial of CM-AT in Children With Autism With All Levels of FCT (The Blum Study) CM-AT, PLACEBO - Autism | Phase 3 | Completed | Curemark | 190 | 2015-05-13 | 2023-05-24 |
| Behavioral and Neural Response to Memantine in Adolescents With Autism Spectrum Disorder Memantine, Placebo - Autism Spectrum Disorder | Phase 3 | Completed | Massachusetts General Hospital | 84 | 2015-02-17 | 2024-07-01 |
| Testing a Novel Speech Intervention in Minimally Verbal Children With Autism Spectrum Disorder (ASD) Auditory-Motor Mapping Training, Speech-Repetition Therapy - Autism | Phase 2 / Phase 3 | Completed | Beth Israel Deaconess Medical Center | 14 | 2014-11-01 | 2020-05-19 |
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Autistic Disorder (50) · Autism Spectrum Disorder (27) · Asperger Syndrome (4) · Attention Deficit Disorder with Hyperactivity (3) · Behavioral Symptoms (2) · Bipolar Disorder (2) · Problem Behavior (2) · Schizophrenia (2) · Sleep Wake Disorders (2) · Adjustment Disorders (1) · Aggression (1) · Angelman Syndrome (1) · Anxiety Disorders (1) · Anxiety, Separation (1)
Mental Disorders (66) · Neurodevelopmental Disorders (66) · Autism Spectrum Disorder (37) · Behavior (7) · Nervous System Diseases (4) · Neurologic Manifestations (4) · Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4) · Attention Deficit and Disruptive Behavior Disorders (3) · Behavioral Symptoms (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Genetic Diseases, Inborn (3) · Heredodegenerative Disorders, Nervous System (3) · Bipolar and Related Disorders (2)
Aripiprazole (8) · Risperidone (5) · Cycloserine (3) · Sugars (3) · Lurasidone Hydrochloride (2) · Melatonin (2) · Methylphenidate (2) · Oxytocin (2) · Secretin (2) · Therapeutics (2) · Vitamin B 12 (2) · brexpiprazole (2) · mecobalamin (2) · Acupuncture Therapy (1) · Arginine Vasopressin (1)
University of California, San Francisco (7) · Indiana University (5) · Otsuka Pharmaceutical Development & Commercialization, Inc. (5) · Massachusetts General Hospital (4) · The University of Hong Kong (4) · Curemark (3) · AbbVie (2) · Otsuka Pharmaceutical Co., Ltd. (2) · Sumitomo Pharma America, Inc. (2) · Assaf-Harofeh Medical Center (1) · Assistance Publique - Hôpitaux de Paris (1) · Astrogen, Inc. (1) · Beth Israel Deaconess Medical Center (1) · Chugani, Diane C. (1) · Drexel University (1)
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Wong Virginia (4) · Christopher J. McDougle, MD (3) · Robert Hendren, DO (3) · Robert L Hendren, DO (3) · Gagan Joshi, MD (2) · Alan Unis, MD (1) · Antonio Y. Hardan, M.D. (1) · Benedetto Vitiello, NIMH Coordinator (1) · Benjamin Handen, Ph.D. (1) · Christopher J McDougle (1) · Christopher J. McDougle, M.D. (1) · Craig A. Erickson, M.D. (1)
PMID 37811711, PMID 21731831, PMID 24138011, PMID 33583058, PMID 15492353, PMID 20973712, PMID 21663425, PMID 21813076, PMID 21818676, PMID 23233021, PMID 23357440, PMID 25878901, PMID 26746121, PMID 26770664, PMID 26802979, PMID 26889605, PMID 27556593, PMID 28138381, PMID 28941259, PMID 28942807, PMID 29096777, PMID 29854372, PMID 31267292, PMID 31982581, PMID 32912180, PMID 34324397, PMID 35241779, PMID 36006807, PMID 37267443, PMID 38032645, PMID 41032298, PMID 42055586
2018 (1), K23MH068627 (1), P01HD035465 (1), P01HD035468 (1), R01HD091972 (1), R01MH072263 (1), R01MH072961 (1), R01MH073524 (1), R01MH077600 (1), R21MH080026 (1), U01NS061264 (1)