55 completed, 27 unknown, 6 terminated, 4 withdrawn. 55 Not applicable, 16 Phase 3, 7 Phase 4, 5 Phase 2, 3 Phase 1.
Follow Caries: new trials by email Literature Review of Caries trials Research Report on Caries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Enamel Lesion Detection With New DX Tool BlueCheck, Prevident 5000ppm Booster Plus Toothpaste - Enamel Lesions, Caries | Phase 4 | Not yet recruiting | Colgate Palmolive | 5 | 2026-09-15 | 2026-09-14 |
| New In Situ Model Design for Caries and Erosion 0 ppm fluoride toothpaste, 250 ppm fluoride toothpaste (dose-response control), 1150 ppm fluoride toothpaste - Caries, Erosive Tooth Wear | Phase 3 | Active not recruiting | Indiana University | 12 | 2026-08-03 | 2026-09-30 |
| Evaluate the Efficacy of an Oral Health Behavioral Intervention in People With Diabetes Diabetes Oral Health Program, Stannous Fluoride Dentifrice, Cetylpyridinium Chloride (CPC) and Zinc Lactate Mouthwash - Diabetes Type 2, Periodontal Disease | Phase 4 | Enrolling by invitation | Colgate Palmolive | 10000 | 2026-05-26 | 2026-09-03 |
| Construction of a Multidimensional Risk Prediction Model for Severe Early Childhood Caries questionnaire survey - Severe Early Childhood Caries, Caries | Not yet recruiting | The Children's Hospital of Zhejiang University School of Medicine | 1200 | 2026-03-01 | 2026-02-12 | |
| Intraoral Camera-Assisted Parent Training Intraoral Camera-Assisted Oral Hygiene Education, Standard Verbal Oral Hygiene Education, Intraoral Photography of Permanent First Molars - Oral Health Literacy, Oral Health Care | Not applicable | Recruiting | Aydin Adnan Menderes University | 40 | 2025-02-05 | 2026-01-09 |
| Prevalence of Dental Caries in Patients With Dental Crowding Caries | Unknown | Cairo University | 325 | 2024-09-01 | 2024-06-03 | |
| Modified Atraumatic Restorative Treatment Using CPP ACP MI varnish - Caries | Not applicable | Unknown | Cairo University | 40 | 2024-02-10 | 2024-02-13 |
| Clinical Performance and Acceptance of Bioflx Crowns Bioflex Crowns, Stainless steel crown - Caries | Not applicable | Recruiting | Hams Hamed Abdelrahman | 62 | 2024-02-01 | 2024-11-07 |
| Post-Debonding Finishing in Orthodontics Caries, Enamel Lesions | Recruiting | University of Roma La Sapienza | 100 | 2024-01-01 | 2026-04-20 | |
| Extraction of the Compromised First Permanent Molars Extraction - Caries, Caries,Dental | Not applicable | Active not recruiting | Ain Shams University | 37 | 2024-01-01 | 2025-02-19 |
| In Situ Comparison of the Remineralization Potential of Optimized Fluoride Dentifrice With Control Fluoride Dentifrice 0 ppm F (placebo, negative control), 1100 ppm F as sodium fluoride (positive control), 1100 ppm F as sodium fluoride Test Product - Caries | Phase 3 | Completed | Indiana University | 52 | 2023-10-02 | 2025-06-15 |
| Evaluation of the Anticaries Efficacy of Dentifrice Formulations Using an In-situ Model Oral-B 1450 ppm Fluoride (1.16% sodium monofluorophosphate) Dentifrice, Colgate 1450 ppm Fluoride (1.16% sodium monofluorophosphate)Dentifrice, Toms of Maine 0 ppm Fluoride Dentifrice - Caries | Not applicable | Completed | Procter and Gamble | 12 | 2023-07-31 | 2024-02-29 |
| Randomized Clinical Trial: Oral Health Package Law and Fluor Varnish Impact on Schoolchildren in Merida, Mexico Fluoride varnish, Fluoride toothpaste - Caries, Gum Disease | Phase 3 | Unknown | Anahuac Mayab University | 900 | 2023-06-22 | 2023-07-25 |
| Use Of Hall Technique In Deciduous Molars Affected By Extensive Caries Lesions Restoration with Resin, Hall Technique, Conventional Steel Crown - Caries | Phase 1 / Phase 2 | Unknown | University of Nove de Julho | 90 | 2023-06-20 | 2023-03-21 |
| Efficacy of an Antibacterial Toothpaste and Patients' Satisfaction Brushing - Caries, Gingivitis | Not applicable | Completed | University of Bologna | 100 | 2022-12-01 | 2025-04-29 |
| Trial With Two New Tooth-colored Restorative Materials in Class I/II Cavities Alcasite restorative material, Bulk fill glass hybrid restorative material - Caries, Defective Restorations | Not applicable | Active not recruiting | Ivoclar Vivadent AG | 58 | 2022-11-22 | 2024-03-29 |
| Saliva Insulin as Biomarker of Risk Factors for Metabolic Dysregulation and Caries Drinking water, Apple juice - Caries, Metabolomic Profile | Not applicable | Completed | Jodi Stookey | 105 | 2022-10-12 | 2026-02-25 |
| Alveolar Ridge Preservation Following Tooth Extraction. Tooth extraction and ridge preservation using different barrier mermbranes - Tooth Fractures, Tooth Extraction Status Nos | Completed | University of Pennsylvania | 47 | 2022-08-15 | 2026-05-08 | |
| A Strategy to Prevent the Recurrence of Dental Disease in Children Receiving Dental Treatment With General Anesthesia verbal education, verbal education, visual aids, and motivational interviewing - Caries | Not applicable | Completed | Virginia Commonwealth University | 74 | 2022-06-10 | 2023-08-14 |
| Antimicrobial Photodynamic Therapy as an Adjunct for Management of Deep Caries Lesions Caries removal with a lowspeed drill, Partial removal of carious tissue with the administration of Papacarie™, Partial removal of carious tissue with the administration of Papacarie™ and application of Bixa Orellana extract (20%) - Caries | Phase 2 | Unknown | University of Nove de Julho | 160 | 2022-05-30 | 2022-05-17 |
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Dental Caries (12) · Periodontal Diseases (7) · Periodontitis (5) · Gingivitis (4) · Plaque, Amyloid (3) · Van der Woude syndrome (3) · Gingival Diseases (2) · Coitus (1) · Communicable Diseases (1) · Dental Plaque (1) · Dental Pulp Exposure (1) · Dentin Sensitivity (1) · Diabetes Mellitus, Type 2 (1) · Gingival Recession (1) · Head and Neck Neoplasms (1)
Stomatognathic Diseases (29) · Mouth Diseases (19) · Tooth Diseases (17) · Periodontal Diseases (12) · Tooth Demineralization (12) · Pathological Conditions, Signs and Symptoms (8) · Gingival Diseases (5) · Infections (5) · Pathologic Processes (4) · Disease Attributes (3) · Pathological Conditions, Anatomical (3) · Dental Pulp Diseases (2) · Nutritional and Metabolic Diseases (2) · Behavior (1) · Body Weight (1)
Chlorhexidine (4) · silver diamine fluoride (4) · Sodium Fluoride (3) · Fluorides (2) · Motivational Interviewing (2) · Mouthwashes (2) · chlorhexidine gluconate (2) · fluorophosphate (2) · Audiovisual Aids (1) · COVID-19 Serotherapy (1) · Calcium Hydroxide (1) · Cetylpyridinium (1) · Clinpro Sealant (1) · Control Groups (1) · Crowns (1)
Cairo University (11) · GlaxoSmithKline (4) · Hadassah Medical Organization (4) · Ivoclar Vivadent AG (4) · Procter and Gamble (4) · Istanbul Medipol University Hospital (3) · University of Nove de Julho (3) · Università degli Studi di Sassari (3) · Ain Shams University (2) · Colgate Palmolive (2) · DMG Dental Material Gesellschaft mbH (2) · Indiana University (2) · Jordan University of Science and Technology (2) · Kuwait University (2) · Malmö University (2)
United States (27) · Egypt (10) · Italy (6) · Turkey (Türkiye) (6) · Israel (4) · Australia (2) · Brazil (2) · Germany (2) · Jordan (2) · Poland (2) · Sweden (2) · United Kingdom (2) · Belgium (1) · Canada (1) · Chile (1)
Anderson Hara, DDS, PhD (3) · Frank Lippert, PhD (3) · Domenick Zero, DDS, MS (2) · Emir Yuzbasioglu, DDS,PhD (2) · Guglielmo Campus (2) · Nessrin Taha, PhD (2) · A.Ruya Yazici, DDS, PhD (1) · Anna Carolina R Horliana, phd (1) · Ari J Hollander, MSE (1) · Arzu Aykut- Yetkiner (1) · Christine Blue, BSDH, MS, DHSc (1) · Clark Stanford, PhD (1) · Claudia Brizuela (1) · Constantine Oulis, DDS,MS,PhD (1)
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R01DE029648 (1), R44DE019041 (1), R44DE019043 (1)