33 completed, 1 unknown. 17 Not applicable, 15 Phase 3, 2 Phase 4, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 17 | Completed 16, Unknown 1 |
| Phase 3 | 15 | Completed 15 |
| Phase 4 | 2 | Completed 2 |
| Phase 2 | 1 | Completed 1 |
Follow this drug Literature Review of fluorophosphate trials Research Report on fluorophosphate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Investigate Toothpaste on Antibacterial Effects in the Different Regions of the Mouth stannous fluoride toothpaste, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste - Plaque, Gingivitis | Phase 3 | Completed | Colgate Palmolive | 95 | 2026-05-18 | 2026-09-24 |
| Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis. 0.454%Stannous fluoride toothpaste, 0.075% Cetylpyridinium Chloride (CPC) and 0.28% zinc lactatmouthwashe, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste - Plaque | Phase 3 | Completed | Colgate Palmolive | 134 | 2026-01-26 | 2026-05-22 |
| Evaluation of the Anticaries Efficacy of Dentifrice Formulations Using an In-situ Model Oral-B 1450 ppm Fluoride (1.16% sodium monofluorophosphate) Dentifrice, Colgate 1450 ppm Fluoride (1.16% sodium monofluorophosphate)Dentifrice, Toms of Maine 0 ppm Fluoride Dentifrice - Caries | Not applicable | Completed | Procter and Gamble | 12 | 2023-07-31 | 2024-02-29 |
| Assessment of the Cytotoxic and Genotoxic Effect of Toothpastes With Different Forms of Fluoride on the Buccal Mucosa Toothpaste without fluoride, Toothpaste with sodium fluoride, Toothpaste with sodium monofluorophosphate - DNA Damage | Not applicable | Unknown | University of Zagreb | 80 | 2022-11-01 | 2022-10-27 |
| Comparision of the Clinical Efficacy of Different Desensitizing Toothpastes Sodium Monofluorophosphate, Stannous Fluoride, Nano-Hydroxyapatite - Dentine Hypersensitivity | Not applicable | Completed | Altinbas University | 48 | 2022-05-01 | 2024-01-09 |
| A Three Month Bleeding-Model Clinical Study 0.454% stannous fluoride, 0.76% sodium monofluorophosphate, 0.454% stannous fluoride AM and 0.76% sodium monofluorophosphate PM - Gingivitis | Not applicable | Completed | Procter and Gamble | 90 | 2021-11-15 | 2023-06-23 |
| A Bleeding-Model Clinical Study 0.454% stannous fluoride, 0.76% sodium monofluorophosphate, 0.454% stannous fluoride AM and 0.76% sodium monofluorophosphate PM - Gingivitis | Not applicable | Completed | Procter and Gamble | 90 | 2020-10-19 | 2023-06-23 |
| Salivary SARS-CoV-2 Load of Covid-19 Patients After Oral Antimicrobial Solutions and Dentifrices Colgate Periogard® mouthwash, Colgate Peroxyl® mouthwash, Colgate Total® Mouthwash - Corona Virus Infection | Not applicable | Completed | Hospital Israelita Albert Einstein | 202 | 2020-07-14 | 2022-02-25 |
| Dentin Hypersensitivity Reduction Efficacy Clinical 0.454% stannous fluoride toothpaste, 5% potassium nitrate, 0.76% sodium monofluorophosphate - Dental Hypersensitivity | Phase 3 | Completed | Colgate Palmolive | 116 | 2018-11-26 | 2026-07-31 |
| A Clinical Study Conducted in the Bangkok, Thailand Area, to Investigate the Clinical Efficacy of a New Toothpaste 0.454% stannous fluoride, 0.76% sodium monofluorophosphate - Oral Malodor | Phase 3 | Completed | Colgate Palmolive | 80 | 2017-12-21 | 2025-10-31 |
| A Clinical Study to Evaluate a Stannous Fluoride Toothpaste for the Relief of Dentinal Hypersensitivity 0.454% Stannous fluoride (SnF2) and 0.072% sodium fluoride (NaF): 1450 ppm fluoride in total, 1400 ppm fluoride as sodium monofluorophosphate (SMFP), Stannous Chloride (SnCl2) and 0.15% NaF: 1450 ppm fluoride in total - Dentin Sensitivity | Not applicable | Completed | GlaxoSmithKline | 185 | 2017-11-18 | 2020-11-27 |
| To Investigate the Gingivitis Efficacy of a Stannous Fluoride Dentifrice in a Chinese Population Stannous fluoride, Sodium monofluorophosphate - Gingivitis | Not applicable | Completed | GlaxoSmithKline | 128 | 2017-09-19 | 2019-06-14 |
| Study to Investigate the Stain Control of Two Stannous Fluoride Dentifrices Stannous fluoride (SnF2, 0.454%), Sodium tripolyphosphate (STP, 5%), 2.0% abrasive silica, Stannous fluoride (SnF2, 0.454%), Sodium tripolyphosphate (STP, 5%), abrasive silica (3.5%), Sodium Monofluorophosphate (1000 ppm fluoride ), RDA~80 - Extrinsic Dental Stain, Oral Hygiene | Not applicable | Completed | GlaxoSmithKline | 220 | 2017-07-10 | 2019-06-04 |
| Efficacy of Toothpaste Containing 0.454% Stannous Fluoride as Compared to a Regular Fluoride Toothpaste Containing 0.76% Sodium Monofluorophosphate in Controlling Supragingival Calculus Formation Over a 12-week Period. 0.454% stannous fluoride, 0.76% sodium monofluorophosphate - Calculus, Dental | Phase 2 / Phase 3 | Completed | Colgate Palmolive | 100 | 2017-05-17 | 2025-12-11 |
| The Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity (DH) Stannous fluoride, Sodium monofluorophosphate - Dentin Sensitivity | Not applicable | Completed | GlaxoSmithKline | 205 | 2016-11-07 | 2018-08-20 |
| To Investigate the Efficacy of an Occluding Dentifrice in Dentinal Hypersensitivity (DH) Stannous fluoride, Sodium monofluorophosphate - Dentin Sensitivity | Phase 4 | Completed | GlaxoSmithKline | 197 | 2016-10-11 | 2018-10-29 |
| Assessment of the Efficacy of an Experimental Occlusion Technology Dentifrice in Dentinal Hypersensitivity Stannous fluoride (SnF2), Sodium monofluorophosphate (SMFP) - Dentin Sensitivity | Not applicable | Completed | GlaxoSmithKline | 135 | 2016-09-21 | 2018-08-10 |
| Dentine Tubule Occlusion Assessment in a Modified in Situ Model Stannous fluoride, Sodium monofluorophosphate, Mineral water - Dentin Sensitivity | Not applicable | Completed | GlaxoSmithKline | 26 | 2016-07-06 | 2018-06-25 |
| Assessing the Effects of Three Oral Care Regimens Toothbrushing, Fluoridated Dentifrice (.15% sodium monofluorophosphate), Fluoridated Dentifrice Whitening System (.454% stannous fluoride with 2% hydrogen peroxide) - Dental Plaque, Gingivitis | Not applicable | Completed | Pearl Network | 142 | 2016-05-30 | 2017-11-14 |
| Short Term Clinical Study Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity stannous fluoride, sodium monofluorophosphate - Dentin Sensitivity | Phase 4 | Completed | GlaxoSmithKline | 229 | 2016-04-01 | 2017-05-17 |
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Dentin Sensitivity (14) · Gingivitis (9) · Dental Plaque (4) · Plaque, Amyloid (2) · Coronavirus Infections (1) · Dental Calculus (1) · Gingival Diseases (1)
GlaxoSmithKline (18) · Colgate Palmolive (8) · Procter and Gamble (3) · Altinbas University (1) · Hospital Israelita Albert Einstein (1) · Pearl Network (1) · Technische Universität Dresden (1) · University of Zagreb (1)
United States (14) · United Kingdom (4) · Canada (3) · China (3) · Thailand (3) · Australia (1) · Brazil (1) · Croatia (1) · Germany (1) · Ireland (1) · Turkey (Türkiye) (1)
Patricia Corby, DDS (2) · Ashley C Grill, MPH, RDH (1) · Debora H Douek, PhD (1) · Dutmanee Seriwatanachai (1) · Farid Ayad (1) · Frederick A Curro, DMD, PhD (1) · Luciana Correa, PhD (1) · Maha Hetata (1) · Terdphong Triratana, DDS (1) · Thomas Van Dyke, DDS (1)
PMID 31164116, PMID 27093773, PMID 39118360, PMID 26437498, PMID 29981778, PMID 32216778, PMID 32391584, PMID 34059275, PMID 35570015, PMID 38130922