74 completed. 74 Phase 1, 24 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 74 | Completed 74 |
| Phase 2 | 24 | Completed 24 |
Follow Cardiovascular Abnormalities: new trials by email Literature Review of Cardiovascular Abnormalities trials Research Report on Cardiovascular Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Inhaled RCT1100 in Adults With PCD Caused by Pathogenic Mutations in the DNAI1 Gene to Measure Mucociliary Clearance RCT1100 - Primary Ciliary Dyskinesia (PCD) | Phase 1 | Completed | ReCode Therapeutics | 14 | 2024-10-22 | 2026-04-30 |
| PK/PD of Digoxin in Infants With SVHD PK/PD Model Based Dosing of Digoxin in Infants with Single Ventricle Heart Disease - Single-ventricle, Infant Conditions | Phase 1 / Phase 2 | Completed | Duke University | 24 | 2024-10-10 | 2026-08-14 |
| A Study to Assess the Safety, Tolerability, Ciliary Rescue, and Pharmacodynamics of RCT1100 in Adults With PCD RCT1100 - Primary Ciliary Dyskinesia | Phase 1 | Completed | ReCode Therapeutics | 7 | 2024-09-20 | 2025-10-08 |
| IC14 (Atibuclimab) in Arrhythmogenic Cardiomyopathy IC14 - Arrhythmogenic Right Ventricular Dysplasia, Arrhythmogenic Left Ventricular Cardiomyopathy | Phase 1 / Phase 2 | Completed | Implicit Bioscience | 1 | 2024-03-29 | 2026-04-22 |
| Study Evaluating the Safety and Tolerability of RCT1100 in Healthy and PCD Subjects RCT1100 - Primary Ciliary Dyskinesia | Phase 1 | Completed | ReCode Therapeutics | 9 | 2023-02-18 | 2025-04-29 |
| Phase 1 Study of LQT-1213 in Healthy Adults LQT-1213, Placebo - Long QT Syndrome | Phase 1 | Completed | Thryv Therapeutics, Inc. | 50 | 2022-09-14 | 2023-09-26 |
| Contrast Enhanced 3D Echocardiographic Quantification of Right Ventricular Volumes in Repaired CHD Sulfur Hexafluoride Lipid Type A Microspheres 25 MG Injection Powder for Suspension [LUMASON] - Tetralogy of Fallot, Pulmonary Insufficiency | Phase 1 / Phase 2 | Completed | Nemours Children's Clinic | 25 | 2022-08-23 | 2026-04-27 |
| A Study of Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Advanced NSCLC ERAS-007, ERAS-601, Osimertinib - Advanced Non-squamous Non-small-cell Lung Cancer | Phase 1 | Completed | Erasca, Inc. | 24 | 2021-09-02 | 2023-07-25 |
| Mirtazapine and Methamphetamine Drug-drug Interaction Study Mirtazapine, Methamphetamine - Methamphetamine Use Disorder, Drug Interaction | Phase 1 | Completed | San Francisco Department of Public Health | 15 | 2021-05-03 | 2024-09-27 |
| Fibrosis and the Fontan Spironolactone - Single-ventricle | Phase 1 / Phase 2 | Completed | Children's Hospital of Philadelphia | 98 | 2021-02-11 | 2026-07-01 |
| A Dose Escalation/Expansion Study of ERAS-601 in Patients With Advanced or Metastatic Solid Tumors ERAS-601, Cetuximab, Pembrolizumab - Advanced or Metastatic Solid Tumors | Phase 1 | Completed | Erasca, Inc. | 90 | 2020-12-15 | 2026-09-16 |
| A Study of JAB-3312 in Adult Patients With Advanced Solid Tumors in China JAB-3312 - Non-small Cell Lung Cancer, Colorectal Cancer | Phase 1 | Completed | Allist Pharmaceuticals, Inc. | 17 | 2020-07-14 | 2025-05-20 |
| RLY-1971 in Subjects With Advanced or Metastatic Solid Tumors RLY-1971 - Solid Tumor, Unspecified, Adult | Phase 1 | Completed | Hoffmann-La Roche | 56 | 2020-02-04 | 2023-01-31 |
| The CHILD Trial: Hypoplastic Left Heart Syndrome Study. c-kit+ cells - Hypoplastic Left Heart Syndrome | Phase 1 | Completed | Joshua M Hare | 25 | 2019-10-16 | 2026-01-23 |
| A First-in-Human, Phase 1 Study of JAB-3312 in Adult Patients With Advanced Solid Tumors JAB-3312 - Non-small Cell Lung Cancer, Colorectal Cancer | Phase 1 | Completed | Jacobio Pharmaceuticals Co., Ltd. | 40 | 2019-09-26 | 2025-12-29 |
| Dose-Esc/Exp RMC4630 & Cobi in Relapsed/Refractory Solid Tumors & RMC4630& Osi in EGFR+ Locally Adv/Meta NSCLC RMC-4630, Cobimetinib, Drug: Osimertinib - Solid Tumor | Phase 1 / Phase 2 | Completed | Revolution Medicines, Inc. | 113 | 2019-07-02 | 2023-06-26 |
| A First-in-Human Study of JAB-3068 (SHP2 Inhibitor) in Adult Patients With Advanced Solid Tumors in China JAB-3068 - Non-small Cell Lung Cancer, Head and Neck Cancer | Phase 1 / Phase 2 | Completed | Jacobio Pharmaceuticals Co., Ltd. | 126 | 2018-11-20 | 2024-09-25 |
| Extremely Low Gestatonal Age Infants' Paracetamol Study Paracetamol 10mg/mL infusion solution, Placebo - Prematurity; Extreme, Low Birthweight, Extremely (999 Grams or Less) | Phase 1 / Phase 2 | Completed | Outi Aikio | 40 | 2018-09-03 | 2024-03-15 |
| COmbiNing Cutting and Drug-Eluting Balloon for Resistant Arteriovenous Fistula sTenOsis (CONCERTO) Angioplasty - Arteriovenous Fistula Stenosis | Phase 1 | Completed | Singapore General Hospital | 19 | 2018-08-15 | 2023-07-27 |
| Atorvastatin Treatment of Cavernous Angiomas With Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial Atorvastatin, Placebo - Cerebral Cavernous Malformation | Phase 1 / Phase 2 | Completed | University of Chicago | 80 | 2018-07-17 | 2025-08-22 |
Showing 20 of 74. Sign in to see all of them.
Heart Defects, Congenital (11) · Long QT Syndrome (11) · Hypoplastic Left Heart Syndrome (9) · Noonan Syndrome (8) · Carcinoma, Non-Small-Cell Lung (6) · Colorectal Neoplasms (6) · Telangiectasia, Hereditary Hemorrhagic (6) · Squamous Cell Carcinoma of Head and Neck (5) · DiGeorge Syndrome (4) · Tetralogy of Fallot (4) · Univentricular Heart (4) · Vascular Malformations (4) · Arteriovenous Fistula (3) · Arteriovenous Malformations (3) · Ciliary Motility Disorders (3)
Congenital Abnormalities (74) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (74) · Cardiovascular Diseases (72) · Heart Diseases (52) · Heart Defects, Congenital (46) · Pathological Conditions, Signs and Symptoms (24) · Pathologic Processes (22) · Vascular Diseases (15) · Hemic and Lymphatic Diseases (14) · Craniofacial Abnormalities (12) · Musculoskeletal Abnormalities (12) · Musculoskeletal Diseases (12) · Respiratory Tract Diseases (12) · Arrhythmias, Cardiac (11)
eleclazine (4) · Dexmedetomidine (3) · Moxifloxacin (3) · Acetaminophen (2) · Doxycycline (2) · Saline Solution (2) · Sildenafil Citrate (2) · Thymus Extracts (2) · osimertinib (2) · 1-(1-(imidazo(1,2-a)pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-(1,2,3)triazolo(4,5-b)pyrazine (1) · Adenosine (1) · Angioplasty (1) · Antilymphocyte Serum (1) · Atorvastatin (1) · Bevacizumab (1)
Gilead Sciences (4) · Jacobio Pharmaceuticals Co., Ltd. (3) · ReCode Therapeutics (3) · Sumitomo Pharma Switzerland GmbH (3) · Albireo (2) · Athena Zuppa (2) · Duke University (2) · Erasca, Inc. (2) · Timothy J Nelson, MD, PhD (2) · University of California, San Francisco (2) · University of Utah (2) · Aditya Kaza (1) · Aevi Genomic Medicine, LLC, a Cerecor company (1) · Allist Pharmaceuticals, Inc. (1) · Asklepion Pharmaceuticals, LLC (1)
United States (53) · Australia (3) · China (3) · United Kingdom (3) · Canada (2) · France (2) · Germany (2) · New Zealand (2) · Romania (2) · Spain (2) · Brazil (1) · Denmark (1) · Egypt (1) · Finland (1) · Japan (1)
John Matthews, MBBS, MCRP, PhD (3) · M. Louise Markert, MD, PhD (3) · Muhammad Y Qureshi, MBBS (3) · Timothy J Nelson, M.D., Ph.D. (2) · Yuankai Shi, MD (2) · Adelina Pellicer, PhD (1) · Aditya K Kaza (1) · Alfred T Lane, MD (1) · Allan Doctor, MD (1) · Ana Paula CP Carlotti, 1 (1) · Athena Zuppa, MD, MSCE (1) · Beny Charbit, MD (1)
PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 20236866, PMID 15100156, PMID 17284531, PMID 23607606, PMID 15100681, PMID 17662768, PMID 18155964, PMID 18212521, PMID 18333898, PMID 20978268, PMID 22590644, PMID 23102686, PMID 23172172, PMID 23228403, PMID 23823195, PMID 24201857, PMID 24481211, PMID 24656411, PMID 24666686, PMID 25403163, PMID 26232942, PMID 28750642, PMID 28800628, PMID 29367212, PMID 30501611, PMID 31623840, PMID 32083653, PMID 33400845, PMID 33733338, PMID 34217109, PMID 34479739, PMID 35394149, PMID 35690720, PMID 37120522, PMID 37527726, PMID 38629477, PMID 39510938, PMID 39526355, PMID 40120614, PMID 41117517, PMID 41258851, PMID 41608890
K12HD043494 (3), R01AI047040 (3), R01AI054843 (3), 2014 (2), R56AI047040 (2), 2016 (1), R01HD106588 (1), R01HL073317 (1), R01HL149139 (1), R21HD055501 (1), R56HL128813 (1), U10HD045986 (1), U54NS065705 (1), UL1TR000093 (1)