14 completed, 5 unknown, 2 recruiting, 1 active not recruiting. 7 Phase 4, 5 Not applicable, 5 Phase 3, 4 Phase 1, 3 Phase 2.
Follow Isosorbide Dinitrate: new trials by email Literature Review of Isosorbide Dinitrate trials Research Report on Isosorbide Dinitrate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| DECONGEST-AHF: Vasodilatation or Loop Diuretics in Acute Heart Failure Furosemide Injection, Isosorbide Dinitrate, Furosemide and isosorbide dinitrate - Pulmonary Edema, Congestive Heart Failure | Phase 4 | Recruiting | Copenhagen University Hospital, Rigshospitalet | 1041 | 2023-09-14 | 2026-10-23 |
| Hypertensive Heart Failure Treatment in SSA Isosorbide Dinitrate - A Feasibility Study on Hypertensive Heart Failure Treatment | Phase 4 | Completed | University of Abuja | 50 | 2022-03-25 | 2024-05-06 |
| Diuretics vs. Afterload Reduction for Treatment of HeartLogic Alerts Furosemide, Torsemide, Bumetanide - Heart Failure, Congestive | Phase 4 | Recruiting | Heart Center Research, LLC | 80 | 2021-07-08 | 2024-01-29 |
| Rectal Indomethacin Versus Rectal Indomethacin and Sublingual Nitrate for PEP Prevention Isosorbide Dinitrate 5 MG, Indomethacin 100 MG, Sublingual Placebo - Post-ERCP Acute Pancreatitis | Not applicable | Unknown | Air Force Military Medical University, China | 2700 | 2020-07-01 | 2020-10-22 |
| Nitrate Effect on Exercise Capacitance Isosorbide Dinitrate - Fontan | Phase 2 | Completed | Children's Hospital Medical Center, Cincinnati | 20 | 2019-12-12 | 2021-09-22 |
| Safety and Cardiovascular Efficacy of Hydralazine and Isosorbide Dinitrate in Dialysis-Dependent ESRD Hydralazine/Isorsorbide Dinitrate, Placebo - Chronic Hemodialysis (ESRD) | Phase 4 | Completed | Brigham and Women's Hospital | 17 | 2017-08-28 | 2021-04-27 |
| Short-term Efficacy of Furosemide, Isosorbide Dinitrate and Their Combination in ADHF Furosemide, Isosorbide Dinitrate - Heart Decompensation | Not applicable | Withdrawn | Chinese University of Hong Kong | 2017-01-01 | 2023-03-21 | |
| Adequate Hydration Therapy Combined With Intravenous Infusion of Isosorbide Dinitrate Prevention for CIN Hydration Combined With Intravenous Infusion of Isosorbide Dinitrate, Visipaque, 0.9% sodium chloride fluid administration - Cardio-Renal Syndrome | Not applicable | Unknown | Chinese PLA General Hospital | 400 | 2016-03-01 | 2016-03-24 |
| Pharmacodynamic and Pharmacokinetic Study of BiDil Extended-release Capsules and Commercial BiDil Tablets BiDil XR, BiDil Immediate Release (IR) - Heart Failure | Phase 1 | Completed | Arbor Pharmaceuticals, Inc. | 12 | 2015-09-01 | 2016-11-08 |
| Efficacy of the Combination of Isosorbide Dinitrate Spray and Chitosan in Diabetic Foot Ulcers Chitosan, Isosorbide dinitrate, Placebo - Diabetic Foot Ulcers | Phase 3 | Completed | University of Guadalajara | 68 | 2015-06-01 | 2021-01-12 |
| Non-inferiority of Pharmacological Prevention Alone Versus Pancreatic Stents to Prevent Post-ERCP Pancreatitis Pancreatic Stent, Indomethacin, Isosorbide Dinitrate - Pancreatitis | Not applicable | Unknown | Tehran University of Medical Sciences | 400 | 2015-02-01 | 2015-11-06 |
| Nitrates In Combination With Hydralazine in cardiorEnal Syndrome (NICHE) Study Hydralazine, Isosorbide Dinitrate - Cardio-Renal Syndrome | Phase 3 | Unknown | National University Hospital, Singapore | 100 | 2015-01-01 | 2015-01-22 |
| Intensive Arterial Pressure Control in Acute Coronary Syndrome Isosorbide Dinitrate - Acute Coronary Syndrome | Not applicable | Completed | University of Monastir | 1500 | 2014-03-01 | 2022-08-24 |
| Bi Treatment With Hydralazine/Nitrates Versus Placebo in Africans Admitted With Acute Heart Failure Hydralazine, Isosorbide Dinitrate - Acute Heart Failure, Left Ventricular Dysfunction | Phase 3 | Unknown | University of Cape Town | 500 | 2013-01-01 | 2015-08-14 |
| Effect of Pioglitazone on Insulin Resistance, Atherosclerosis Progression and Clinical Course of Coronary Heart Disease Pioglitazone 15 mg Tablet, Isosorbide Dinitrate 10Mg Tablet, Acetylsalicylic Acid 75Mg Tablet - Adverse Effect, Atherosclerosis, Coronary | Phase 4 | Completed | Ukrainian Medical Stomatological Academy | 43 | 2012-11-01 | 2022-03-10 |
| A Clinical Trials of Quick-Acting Heart Reliever for Moderate Coronary Stenosis Quick-Acting Heart Reliever, Isosorbide Dinitrate, Placebo of Isosorbide Dinitrate - Coronary Artery Stenosis, Coronary Heart Disease | Phase 4 | Completed | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | 120 | 2012-04-01 | 2014-08-05 |
| A Comparison of Various Combinations of BiDil Capsules and BiDil Tablets in Healthy Human Volunteers Isosorbide dinitrate / hydralazine capsules - Healthy | Phase 1 | Completed | Arbor Pharmaceuticals, Inc. | 36 | 2012-04-01 | 2015-08-06 |
| Vasodilator Therapy for Heart Failure and Preserved Ejection Fraction Isosorbide Dinitrate, Isosorbide Dinitrate + Hydralazine, Placebo - Heart Failure, Congestive Heart Failure | Phase 2 | Completed | Corporal Michael J. Crescenz VA Medical Center | 44 | 2012-01-01 | 2022-06-21 |
| To Compare the Pharmacokinetics Profiles of ISO 20, IBU 200 and IBU Plus ISO Combinations 200 + 20 Isosorbide Dinitrate, Ibuprofen, Ibuprofen and Isosorbide Dinitrate combination - Duchenne Muscular Dystrophy (DMD) | Phase 1 | Completed | Parent Project, Italy | 12 | 2011-10-01 | 2018-08-31 |
| Clevidipine in the Treatment of Blood Pressure in Patients With Acute Heart Failure (PRONTO) Clevidipine, Standard of Care IV antihypertensive - Hypertension, Heart Failure | Phase 3 | Completed | The Medicines Company | 117 | 2008-12-01 | 2014-08-29 |
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Heart Failure (6) · Coronary Disease (3) · Cardio-Renal Syndrome (2) · Cardiovascular Diseases (2) · Acute Coronary Syndrome (1) · Angina Pectoris (1) · Atherosclerosis (1) · Coronary Artery Disease (1) · Coronary Stenosis (1) · Diabetic Foot (1) · Heart Diseases (1) · Hypertension (1) · Insulin Resistance (1) · Kidney Failure, Chronic (1) · Metabolic Syndrome (1)
Arbor Pharmaceuticals, Inc. (2) · Air Force Military Medical University, China (1) · Brigham and Women's Hospital (1) · Children's Hospital Medical Center, Cincinnati (1) · Chinese PLA General Hospital (1) · Chinese University of Hong Kong (1) · Copenhagen University Hospital, Rigshospitalet (1) · Corporal Michael J. Crescenz VA Medical Center (1) · Guang'anmen Hospital of China Academy of Chinese Medical Sciences (1) · Heart Center Research, LLC (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · National Institute of Perinatology (1) · National University Hospital, Singapore (1) · Parent Project, Italy (1) · Satish R. Raj (1)
United States (8) · China (3) · Denmark (1) · France (1) · Germany (1) · Hong Kong (1) · Iran (1) · Italy (1) · Nigeria (1) · Singapore (1) · South Africa (1) · Tunisia (1) · Ukraine (1)
Andrew Selwyn (1) · Carl Pepine (1) · Colin A Graham, MD (1) · Craig Pratt (1) · David Charytan, MD (1) · Emilio Clementi (1) · Gabriel Arteaga-Troncoso, PhD. (1) · Gad Cotter, MD (1) · Genell Knatterud (1) · Gregory J Tracey, MD (1) · Hiltrud Mueller (1) · Jay Dinerman, MD (1) · Jerome Cohen (1) · Jie Wang, MD (1) · Johannes Grand, PhD (1)
PMID 10863541, PMID 10960643, PMID 11146149, PMID 11194687, PMID 11284645, PMID 11303205, PMID 11336776, PMID 12013166, PMID 12648175, PMID 14749647, PMID 15121558, PMID 15911704, PMID 16305563, PMID 1656970, PMID 17961568, PMID 19687359, PMID 20661052, PMID 20927722, PMID 2110975, PMID 2201190, PMID 2266162, PMID 23784865, PMID 24002370, PMID 24227635, PMID 24495468, PMID 24606242, PMID 24721800, PMID 2564216, PMID 27206810, PMID 28219917, PMID 30054906, PMID 30764699, PMID 3144030, PMID 31454851, PMID 31751343, PMID 32673517, PMID 33000470, PMID 33247624, PMID 35460884, PMID 37084132, PMID 42044762, PMID 6115052, PMID 6149646, PMID 7688574, PMID 7690516, PMID 7913616, PMID 8646141
R21AG043802 (1), UL1TR000445 (1)