30 completed, 9 unknown, 6 recruiting, 4 terminated. 54 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 54 | Completed 30, Unknown 9, Recruiting 6, Terminated 4, Active not recruiting 2, Enrolling by invitation 2, Withdrawn 1 |
Follow Brain Neoplasms: new trials by email Literature Review of Brain Neoplasms trials Research Report on Brain Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of the Efficacy of STRATAFIX for Neurosurgical Cranial and Spine Procedures STRATAFIX PDS and Monocryl suture - Wound Closure, Brain Tumor Adult | Phase 4 | Recruiting | University of Michigan | 160 | 2025-11-01 | 2025-11-05 |
| Comparison of Systemic Opioid (Morphine) and Pre-Incision Bilateral Scalp Nerve Block for Pain Management in Craniotomy Patients Scalp nerve block, Morphine, Lidocaine - Supratentorial Tumors | Phase 4 | Completed | Aga Khan University | 62 | 2025-01-01 | 2026-02-23 |
| Hydrocortisone in Hormone Replacement Therapy for Large Pituitary Neuroendocrine Tumors Hormone replacement therapy, Placebo - Pituitary Adenoma, Pituitary Neuroendocrine Tumor | Phase 4 | Recruiting | Beijing Tiantan Hospital | 882 | 2024-12-04 | 2025-01-14 |
| Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases Lorlatinib - Carcinoma, Non-Small-Cell Lung, Brain Metastases | Phase 4 | Active not recruiting | Guangdong Association of Clinical Trials | 41 | 2024-08-01 | 2026-04-09 |
| Cabergoline in the Management of Nonfunctioning Pituitary Adenoma Cabergoline 0.5 MG - Pituitary Adenoma, MRI | Phase 4 | Enrolling by invitation | National Taiwan University Hospital | 30 | 2024-05-20 | 2025-06-24 |
| Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer Brain Imaging with 18F-FES - Breast Cancer, Brain Metastases | Phase 4 | Recruiting | Weill Medical College of Cornell University | 20 | 2023-12-27 | 2026-10-29 |
| The Effects of Using Different Anesthetics on the Prognosis of Primary Tumors and Its Mechanism of Action Propofol, Sevoflurane - Lung Cancer, Brain Tumor | Phase 4 | Unknown | Kaohsiung Medical University Chung-Ho Memorial Hospital | 1316 | 2023-05-23 | 2023-09-28 |
| Comparison of Postoperative Recovery of Sevoflurane and Propofol After Transsphenoidal Surgery sevoflurane, propofol - Pituitary Adenoma | Phase 4 | Completed | Peking Union Medical College Hospital | 252 | 2023-05-03 | 2025-06-08 |
| An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis Copper Cu 64-DOTA-Trastuzumab, Magnetic Resonance Imaging, Positron Emission Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 4 | Recruiting | City of Hope Medical Center | 10 | 2022-12-21 | 2026-07-01 |
| Influences of Propofol and Sevoflurane Anesthesia in Brain Tumor Propofol, Sevoflurane - Brain Tumor | Phase 4 | Unknown | Kaohsiung Medical University Chung-Ho Memorial Hospital | 706 | 2022-02-18 | 2023-10-31 |
| Infraorbital Nerve Block for Endoscopic Transsphenoidal Approach to Remove Pituitary Tumor dexmedetomidine 5 mcg mixed with 0.5% plain bupivacaine - Intraoperative Pain Control | Phase 4 | Unknown | Chiang Mai University | 63 | 2021-07-01 | 2021-03-05 |
| Dexmedetomidine Infusion Effect on Hemodynamic Variables During Craniotomy Dexmedetomidine, normal saline - Hemodynamic Instability, Supratentorial Neoplasms | Phase 4 | Completed | Ain Shams University | 40 | 2020-11-21 | 2021-03-01 |
| Effect of Sugammadex for Reversal of Rocuronium-induced Neuromuscular Block on Perioperative Management of Awake Craniotomy sugammadex - Brain Tumors | Phase 4 | Unknown | Guangzhou General Hospital of Guangzhou Military Command | 40 | 2020-09-01 | 2022-03-09 |
| Effect of Dexmedetomidine on Brain Homeostasis and Neurocognitive Outcome Dexmedetomidine, Normal saline - Brain Tumor, Metabolic Disturbance | Phase 4 | Completed | Georgia Tsaousi | 56 | 2020-03-12 | 2026-03-25 |
| Pediatric Long-Term Follow-up and Rollover Study dabrafenib, trametinib - Diffuse Astrocytoma, Anaplastic Astrocytoma | Phase 4 | Active not recruiting | Novartis Pharmaceuticals | 163 | 2019-11-04 | 2026-08-27 |
| 68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors. Ga68-DOTATATE-PET/MRI - CNS Tumors, Meningioma | Phase 4 | Recruiting | Weill Medical College of Cornell University | 200 | 2019-09-04 | 2026-10-30 |
| Dual Time Point FDG PET/MRI Scan in Improving the Imaging Cancer Patients With Brain Metastases Fludeoxyglucose F-18, Magnetic Resonance Imaging, Positron Emission Tomography - Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm | Phase 4 | Completed | M.D. Anderson Cancer Center | 12 | 2018-08-03 | 2024-05-01 |
| The Effect of Local Anesthesia on Postopanalgesia in Patients Using Head Holder lidocaine was administered subcutaneously at 0.5% concentration., lidocaine was administered subcutaneously at 1% concentration. - Postoperative Pain, Acute | Phase 4 | Completed | Kocaeli University | 75 | 2018-01-10 | 2026-06-05 |
| Prophylactic Oral Antibiotics on Sinonasal Outcomes Following Endoscopic Transsphenoidal Surgery for Pituitary Lesions Placebo, Oral Antibiotics cefdinir or trimethoprim/sulfamethoxazole - Antibiotics, Pituitary Adenoma | Phase 4 | Recruiting | St. Joseph's Hospital and Medical Center, Phoenix | 116 | 2017-07-01 | 2018-08-15 |
| Comparison of Efficacy and Safety of the Postoperative Analgesia Methods Morphine, Dexketoprofen, Placebo - Supratentorial Neoplasms | Phase 4 | Unknown | Istanbul University | 90 | 2016-11-01 | 2016-10-11 |
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Pituitary Neoplasms (16) · Acromegaly (4) · Supratentorial Neoplasms (4) · Breast Neoplasms (3) · Epilepsy (3) · Melanoma (3) · Neoplasm Metastasis (3) · Glioblastoma (2) · Lung Neoplasms (2) · Neuroblastoma (2) · Ovarian Neoplasms (2) · Seizures (2) · Astrocytoma (1) · Brain Concussion (1)
Brain Diseases (54) · Central Nervous System Diseases (54) · Neoplasms by Site (54) · Nervous System Diseases (54) · Nervous System Neoplasms (54) · Central Nervous System Neoplasms (53) · Neoplasms (53) · Endocrine Gland Neoplasms (18) · Endocrine System Diseases (18) · Hypothalamic Diseases (16) · Hypothalamic Neoplasms (16) · Supratentorial Neoplasms (16) · Pituitary Diseases (15) · Pathological Conditions, Signs and Symptoms (10)
Saline Solution (7) · Dexmedetomidine (6) · Propofol (4) · Cabergoline (3) · Morphine (3) · Sevoflurane (3) · Sodium Chloride (3) · Anesthesia, Inhalation (2) · Fluorescein (2) · Levetiracetam (2) · Magnetic Resonance Spectroscopy (2) · Sugammadex (2) · dexketoprofen trometamol (2) · 64Cu-DOTA-trastuzumab (1) · Acetaminophen (1)
Aga Khan University (2) · Chiang Mai University (2) · Istanbul University (2) · Kaohsiung Medical University Chung-Ho Memorial Hospital (2) · M.D. Anderson Cancer Center (2) · Mahidol University (2) · NYU Langone Health (2) · Novartis Pharmaceuticals (2) · St. Joseph's Hospital and Medical Center, Phoenix (2) · Weill Medical College of Cornell University (2) · AdventHealth (1) · Ain Shams University (1) · Baskent University (1) · Beijing Tiantan Hospital (1) · Bracco Diagnostics, Inc (1)
United States (25) · China (6) · Turkey (Türkiye) (5) · Germany (4) · Taiwan (4) · Thailand (4) · Argentina (3) · Italy (3) · South Korea (3) · Belgium (2) · Brazil (2) · Canada (2) · Denmark (2) · France (2) · Greece (2)
Zhi-Fu Wu (2) · Aaron A Cohen, MD, MSc (1) · Alejandro D Muggeri, Physician (1) · Alex Bekker, MD, PhD (1) · Andrew Little, MD (1) · Andrew S Little, MD (1) · Anita Mahajan, MD (1) · Annamaria AL Colao, Prof. (1) · Asma A Salam, MCPS, FCPS (1) · Bing Xing, MD (1) · Daniel F Kelly, MD (1) · David M Kleinberg, MD (1) · Dawid Schellingerhout (1) · Dileep Kumar, MBBS, FCPS (1)
PMID 10469005, PMID 10690849, PMID 10999798, PMID 11397887, PMID 12843148, PMID 14764779, PMID 15070920, PMID 15613435, PMID 15827109, PMID 15886238, PMID 15886256, PMID 16373932, PMID 16449332, PMID 16487447, PMID 16537687, PMID 17984237, PMID 19306364, PMID 19564304, PMID 21319349, PMID 21909835, PMID 25293480, PMID 25493927, PMID 26229757, PMID 26329913, PMID 28298041, PMID 28756607, PMID 29151054, PMID 30010438, PMID 35275019, PMID 35661809, PMID 36239858, PMID 37013278, PMID 38553990, PMID 3899825, PMID 40760415, PMID 42046793, PMID 5427331, PMID 8050136, PMID 8327647, PMID 8514973, PMID 9709939, PMID 9768640, PMID 9768641, PMID 9808008
2023 (1), P30CA021765 (1), P30CA033572 (1), R01CA078957 (1), U01CA081445 (1)