28 terminated. 28 Phase 2, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 28 | Terminated 28 |
| Phase 3 | 3 | Terminated 3 |
Follow Brain Injuries: new trials by email Literature Review of Brain Injuries trials Research Report on Brain Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Insulin-sensitizing NE3107 in Improving Sleep and Fatigue in Subjects With Traumatic Brain Injury NE3107 - Traumatic Brain Injury | Phase 2 | Terminated | Neurological Associates of West Los Angeles | 4 | 2023-12-21 | 2025-07-25 |
| Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity Phase 2; Low Dose MYOBLOC (10,000 Units), Phase 2; High Dose MYOBLOC (20,000 Units), Phase 2; Placebo - Spasticity, Cerebrovascular Accident | Phase 2 / Phase 3 | Terminated | Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC | 32 | 2021-11-02 | 2026-05-27 |
| Sphenopalatine Ganglion Block for Headache After Concussion Lidocaine in SphenoCath device, Saline Solution in SphenoCath device - Concussion, Headache | Phase 2 | Terminated | University of Michigan | 2 | 2021-03-18 | 2022-09-14 |
| Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Lower Limb Spasticity Phase 2; Low Dose MYOBLOC (15,000 Units), Phase 2; High Dose MYOBLOC (20,000 Units), Phase 2; Placebo - Spasticity | Phase 2 / Phase 3 | Terminated | Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC | 40 | 2019-12-17 | 2026-05-22 |
| A Study to Evaluate the Efficacy and Safety of BIIB093 in Participants With Brain Contusion BIIB093, Placebo - Brain Contusion | Phase 2 | Terminated | Remedy Pharmaceuticals, Inc. | 92 | 2019-10-06 | 2024-11-27 |
| Cerebrovascular Reactivity Assessed With fNIRS as a Biomarker of TCVI After Acute Traumatic Brain Injury in Military Sildenafil Citrate 50Mg Tab, functional Near-infrared Spectroscopy (fNIRS), Carbon Dioxide (CO2) 5% - Traumatic Brain Injury | Phase 2 | Terminated | Uniformed Services University of the Health Sciences | 1 | 2019-08-09 | 2024-02-28 |
| Pilot rTMS for AUD+mTBI repetitive transcranial magnetic stimulation - Alcohol Use Disorder, Mild Traumatic Brain Injury | Phase 2 | Terminated | VA Office of Research and Development | 2 | 2019-03-21 | 2026-10-30 |
| Sildenafil Treatment for Mild TBI Sildenafil Citrate, Placebo oral capsule - Vascular System Injuries, Concussion, Brain | Phase 2 | Terminated | University of Texas Southwestern Medical Center | 22 | 2018-07-25 | 2020-11-19 |
| OPTIMA-TBI Pilot Study Omega-3 Polyunsaturated Fatty Acids (Fish Oil 1000 mg (contains 500 mg DHA & 100 mg EPA)) or placebo capsules., Placebo - Cap - Mild Traumatic Brain Injury | Phase 2 | Terminated | University of Michigan | 44 | 2017-09-12 | 2023-05-23 |
| fMRI-neuronavigated rTMS for the Treatment of Major Depression Associated With TBI Active, Sham - Major Depressive Disorder, Traumatic Brain Injury | Phase 2 | Terminated | Washington University School of Medicine | 15 | 2016-08-01 | 2018-03-29 |
| Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI methylphenidate, Placebo - Traumatic Brain Injury | Phase 2 | Terminated | Uniformed Services University of the Health Sciences | 11 | 2014-09-01 | 2018-10-04 |
| A Safety and Efficacy Study of NNZ-2566 in Patients With Mild Traumatic Brain Injury (mTBI) NNZ-2566, Placebo - Concussion | Phase 2 | Terminated | Neuren Pharmaceuticals Limited | 32 | 2014-09-01 | 2018-02-05 |
| Effects of Huperzine A in Treatment of Moderate to Severe TBI Huperzine A, Placebo - Traumatic Brain Injury | Phase 2 | Terminated | Spaulding Rehabilitation Hospital | 14 | 2013-12-01 | 2019-11-05 |
| Mild Hypothermia and Supplemental Magnesium Sulfate Infusion in Severe Traumatic Brain Injury (TBI) Subjects Arctic Sun, Magnesium Sulfate - Traumatic Brain Injury | Phase 2 | Terminated | United States Department of Defense | 6 | 2011-12-01 | 2015-10-28 |
| Sevoflurane Sedation on Intra Cranial Pressure in Traumatic Brain Injury Patients 1: Sevoflurane - Brain Injury | Phase 2 | Terminated | Assistance Publique - Hôpitaux de Paris | 10 | 2011-12-01 | 2015-03-27 |
| Cognitive REmediation After Trauma Exposure Trial = CREATE Trial Methylphenidate Hydrochloride 20 mg, Placebo Capsule, Galantamine 12 mg - Posttraumatic Stress Disorder, Traumatic Brain Injury | Phase 2 | Terminated | INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium | 32 | 2011-08-01 | 2013-04-26 |
| Early Propranolol After Traumatic Brain Injury: Phase II Propranolol - Traumatic Brain Injury | Phase 2 | Terminated | Cedars-Sinai Medical Center | 10 | 2010-06-01 | 2016-05-13 |
| Mission Connect Mild Traumatic Brain Injury (TBI) Integrated Clinical Protocol Atorvastatin, Placebo - Traumatic Brain Injury, Post-traumatic Stress Disorder | Phase 2 | Terminated | Baylor College of Medicine | 52 | 2010-02-01 | 2017-01-09 |
| OSCAR - An Internet-based Supportive Coaching for Informal Caregivers of Adult Individuals With an Acquired Brain Injury Internet-based supportive coaching OSCAR, Waiting-list control group (TAU) - Caregivers, Brain Injury | Phase 2 | Terminated | University of Bern | 40 | 2010-01-01 | 2015-07-23 |
| Safety and Tolerability of Oxycyte in Patients With Traumatic Brain Injury (TBI) Oxycyte, Normal Saline - Traumatic Brain Injury | Phase 2 | Terminated | Tenax Therapeutics, Inc. | 18 | 2009-10-01 | 2014-11-13 |
Showing 20 of 28. Sign in to see all of them.
Brain Injuries, Traumatic (19) · Brain Concussion (6) · Stress Disorders, Post-Traumatic (3) · Depression (2) · Hemiplegia (2) · Muscle Spasticity (2) · Post-Concussion Syndrome (2) · Stroke (2) · Alcoholism (1) · Attention Deficit Disorder with Hyperactivity (1) · Autonomic Nervous System Diseases (1) · Brain Contusion (1) · Caregiver Burden (1) · Cerebral Palsy (1)
Brain Diseases (28) · Central Nervous System Diseases (28) · Craniocerebral Trauma (28) · Nervous System Diseases (28) · Trauma, Nervous System (28) · Wounds and Injuries (27) · Pathological Conditions, Signs and Symptoms (7) · Signs and Symptoms (7) · Wounds, Nonpenetrating (7) · Brain Injuries, Traumatic (6) · Head Injuries, Closed (6) · Neurologic Manifestations (6) · Mental Disorders (5) · Cardiovascular Diseases (4)
Clinical Trials, Phase II as Topic (2) · Clinical Trials, Phase III as Topic (2) · Methylphenidate (2) · Saline Solution (2) · Sildenafil Citrate (2) · perfluoro(t-butylcyclohexane) (2) · rimabotulinumtoxinB (2) · Atorvastatin (1) · Baclofen (1) · Carbon Dioxide (1) · Docosahexaenoic Acids (1) · Duloxetine Hydrochloride (1) · Erythropoietin (1) · Exercise (1) · Fish Oils (1)
Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC (2) · Tenax Therapeutics, Inc. (2) · Uniformed Services University of the Health Sciences (2) · University of Michigan (2) · Abbott Products (1) · Assistance Publique - Hôpitaux de Paris (1) · Atlantic Health System (1) · Baylor College of Medicine (1) · Cedars-Sinai Medical Center (1) · INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium (1) · Icahn School of Medicine at Mount Sinai (1) · Institut d'Anesthesiologie des Alpes Maritimes (1) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (1) · Neuren Pharmaceuticals Limited (1) · Neurological Associates of West Los Angeles (1)
United States (22) · France (5) · Israel (3) · Hungary (2) · Italy (2) · Poland (2) · Spain (2) · Switzerland (2) · Belgium (1) · Germany (1) · Japan (1)
Joseph T Hull, PhD (2) · Alex Hishaw, MD (1) · Amy A Herrold, PhD BA (1) · Brian O'Neil, MD (1) · Claudia S Robertson, MD (1) · Emmanuel Cuny, Professor (1) · Eric Wassermann, MD (1) · Eveline Frischknecht, lic. phil. (1) · Frederick Korley, M.D., Ph.D. (1) · Greg Zorman, MD (1) · Hansjoerg Znoj, Prof. Dr. phil. (1) · Helene Hofer, Dr. phil. (1)
PMID 12411660, PMID 17143244, PMID 17188664, PMID 18234750, PMID 18418368, PMID 20571524, PMID 21468088, PMID 26314998, PMID 28006970, PMID 29065769, PMID 33165153
2008 (1), 2018 (1), IK2RX000949 (1)