23 completed, 12 recruiting, 4 enrolling by invitation, 4 withdrawn. 51 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 51 | Completed 23, Recruiting 12, Enrolling by invitation 4, Withdrawn 4, Active not recruiting 3, Terminated 3, Unknown 2 |
Follow Aphasia, Primary Progressive: new trials by email Literature Review of Aphasia, Primary Progressive trials Research Report on Aphasia, Primary Progressive
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Stimulating the Aging Brain Using Brain and Sensory Stimulation tACS or multisensory stimulation - Primary Progressive Aphasia | Not applicable | Recruiting | Medical College of Wisconsin | 20 | 2026-06-01 | 2026-06-16 |
| Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive Aphasia Training with Speech Language Therapy, Standard rTMS, Targeted rTMS - Primary Progressive Aphasia(PPA) | Not applicable | Enrolling by invitation | IRCCS San Raffaele | 75 | 2026-05-13 | 2026-05-20 |
| Remotely-supervised Neuromodulation in PPA Lexical Retrieval Cascade Treatment, Remotely Supervised Transcranial Direct Current Stimulation- Active, Remotely Supervised Transcranial Direct Current Stimulation - Sham - Primary Progressive Aphasia(PPA), Progressive Aphasia | Not applicable | Recruiting | Maya Henry | 80 | 2026-04-15 | 2026-09-04 |
| Intervention for Communication Quality of Life in Primary Progressive Aphasia Multicomponent Lexical Retrieval Cascade Training, Multicomponent Video Implemented Script Training in Aphasia - Primary Progressive Aphasia(PPA), Semantic Dementia | Not applicable | Recruiting | Maya Henry | 30 | 2026-04-01 | 2026-04-21 |
| Long Term Effect of Brain Stimulation in PPA TMS, tDCS, Sham TMS - Primary Progressive Aphasia(PPA) | Not applicable | Recruiting | Hospital San Carlos, Madrid | 80 | 2025-09-15 | 2026-04-23 |
| STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care Partners STELLA-FTD Control, STELLA-FTD Test - Frontotemporal Dementia, Caregiver Burden | Not applicable | Recruiting | Oregon Health and Science University | 640 | 2025-06-23 | 2025-10-27 |
| Predict to Prevent PGRN Disease Clinical, behavioral and cognitive evaluation, blood sampling, brain MRI - Frontotemporal Dementia (FTD), GRN Related Frontotemporal Dementia | Not applicable | Withdrawn | Assistance Publique - Hôpitaux de Paris | 2025-01-01 | 2025-03-21 | |
| Effects of Transcranial Direct Current Stimulation (tDCS) on Inhibition and Brain Function in Primary Progressive Aphasia tDCS, SHAM - Aphasia, Primary Progressive | Not applicable | Recruiting | Centre Hospitalier Universitaire de Nice | 20 | 2024-11-04 | 2024-11-05 |
| Communication Bridge Pilot Study Communication Bridge - Primary Progressive Aphasia | Not applicable | Active not recruiting | University of Chicago | 12 | 2024-06-28 | 2025-08-07 |
| Transmagnetic Stimulation Pilot in Primary Progressive Aphasia Intermittent theta burst stimulation - Primary Progressive Aphasia | Not applicable | Completed | HealthPartners Institute | 3 | 2023-10-02 | 2025-06-03 |
| Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease Computerized Cognitive Training, Active tDCS (tDCS) on DLPFC - Mild Cognitive Impairment, Primary Progressive Aphasia | Not applicable | Terminated | Johns Hopkins University | 5 | 2023-08-10 | 2026-10-21 |
| Speech-Language Treatment With Remotely Supervised Transcranial Direct Current Stimulation in Primary Progressive Aphasia Remotely supervised Transcranial Direct Current Stimulation (RS-tDCS), Remotely supervised sham tDCS (RS-sham-tDCS), Lexical Retrieval Training (LRT) - Primary Progressive Aphasia | Not applicable | Enrolling by invitation | University of Texas at Austin | 10 | 2023-07-10 | 2025-10-08 |
| Primary Progressive Aphasia Multicomponent Language Treatment Study Multicomponent Lexical Retrieval Training (Multi-LRT), Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA), Multicomponent Communication Partner Training (Multi-CPT) - Primary Progressive Aphasia, Semantic Dementia | Not applicable | Enrolling by invitation | University of Texas at Austin | 21 | 2023-05-02 | 2025-10-08 |
| Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia Video-Implemented Script Training for Aphasia (VISTA), Lexical Retrieval Training (LRT) - Primary Progressive Aphasia, Dementia | Not applicable | Recruiting | Stephanie Grasso | 60 | 2023-05-01 | 2026-06-10 |
| Home-Based Exercise in Primary Progressive Aphasia (HEPPA) Home-based multicomponent exercise intervention program - Primary Progressive Aphasia, Neurodegenerative Diseases | Not applicable | Completed | Montreal Heart Institute | 13 | 2023-04-05 | 2025-02-06 |
| Investigating Speech Sequencing in Neurotypical Speakers and Persons With Disordered Speech Learning of non-native phoneme combinations: 6 training sessions, Learning of non-native phoneme combinations: 1 training session, Learning of novel multisyllabic nonwords - Stuttering, Developmental, Aphasia, Primary Progressive | Not applicable | Completed | Boston University Charles River Campus | 278 | 2023-04-03 | 2026-07-24 |
| A Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia, MAINSTREAM ID:3430931 Active tDCS, individualized language training, Placebo tDCS - Primary Progressive Aphasia | Not applicable | Unknown | IRCCS Centro San Giovanni di Dio Fatebenefratelli | 60 | 2023-02-01 | 2024-09-19 |
| Long-term Effect of TMS in Primary Progressive Aphasia Transcranial Magnetic Stimulation (active), Language therapy, Transcranial Magnetic Stimulation (sham) - Primary Progressive Aphasia, Frontotemporal Dementia | Not applicable | Completed | Hospital San Carlos, Madrid | 63 | 2023-02-01 | 2024-12-18 |
| Enhancing Language Function in Aphasia individualized speech-language training, standard language intervention - Aphasia, Acquired, Language Disorders | Not applicable | Recruiting | University of Arizona | 30 | 2022-10-30 | 2024-12-09 |
| Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA High-definition active tDCS (HD-tDCS) + "Repeat After Me" (RAM) Treatment, Sham + "Repeat After Me" (RAM) Treatment - Logopenic Progressive Aphasia, Primary Progressive Aphasia | Not applicable | Recruiting | Johns Hopkins University | 60 | 2022-10-15 | 2026-09-09 |
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Frontotemporal Dementia (20) · Aphasia (15) · Alzheimer Disease (13) · Primary Progressive Nonfluent Aphasia (9) · Dementia (7) · Neurodegenerative Diseases (7) · Apraxias (4) · Communication (4) · Communication Disorders (4) · Corticobasal Degeneration (4) · Frontotemporal Lobar Degeneration (4) · Nerve Degeneration (4) · Supranuclear Palsy, Progressive (4) · Amyotrophic Lateral Sclerosis (3)
Central Nervous System Diseases (51) · Mental Disorders (51) · Nervous System Diseases (51) · Neurobehavioral Manifestations (51) · Neurologic Manifestations (51) · Pathological Conditions, Signs and Symptoms (51) · Signs and Symptoms (51) · Brain Diseases (50) · Neurocognitive Disorders (49) · Speech Disorders (49) · Language Disorders (48) · Communication Disorders (47) · Dementia (44) · Aphasia (36) · Metabolic Diseases (22)
Transcranial Direct Current Stimulation (7) · Speech Therapy (5) · Language Therapy (4) · Transcranial Magnetic Stimulation (3) · Blood Specimen Collection (2) · Therapeutics (2) · Exercise (1) · Genetic Testing (1) · Palliative Care (1) · Spinal Puncture (1)
Johns Hopkins University (6) · University of Chicago (4) · Hospital San Carlos, Madrid (3) · University of Texas at Austin (3) · Baycrest (2) · IRCCS Centro San Giovanni di Dio Fatebenefratelli (2) · IRCCS San Raffaele (2) · Maya Henry (2) · Medical College of Wisconsin (2) · Peking Union Medical College Hospital (2) · University of Arizona (2) · University of British Columbia (2) · University of Pennsylvania (2) · Assistance Publique - Hôpitaux de Paris (1) · Boston University Charles River Campus (1)
United States (30) · Canada (6) · Italy (4) · Spain (4) · France (2) · China (1) · Sweden (1) · United Kingdom (1)
Kyrana Tsapkini, PhD (4) · Maya L Henry, PhD (4) · Aneta Kielar, PhD (2) · Aaron Meyer, PhD (1) · Aimee Mooney, MA, CCC-SLP (1) · Allison Lindauer, PhD, APRN (1) · Argye E Hillis, MD, MA (1) · Auriane Gros, Pr (1) · Benzi M Kluger, MD, MS (1) · Darby Morhardt, PhD (1) · Elias Granadillo (1) · Emily J Rogalski, PhD (1) · Emily Rogalski, Ph.D. (1) · Emily Roglaski, PhD (1) · Erik Stomrud, MD, Phd (1)
PMID 28713256, PMID 30258975, PMID 33031971, PMID 33441454, PMID 34006157, PMID 34487043, PMID 34489348, PMID 34875098, PMID 34937781, PMID 35698099, PMID 36662282, PMID 37287321, PMID 37508992, PMID 37821924, PMID 37838080, PMID 37955923, PMID 40070907, PMID 40788648, PMID 40857539, PMID 41041680, PMID 41812391, PMID 41864233, PMID 42161537, PMID 42818139
R01AG055425 (3), F31DC020352 (1), R01AG075404 (1), R01AG084523 (1), R01DC007683 (1), R01DC014475 (1), R01DC016291 (1), R01NR016037 (1), R56AG055425 (1), R56DC016291 (1), RF1AG085565 (1)