6 not yet recruiting, 5 recruiting, 2 active not recruiting, 2 completed. 7 Not applicable, 2 Phase 4, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Not yet recruiting 4, Active not recruiting 1, Completed 1, Recruiting 1 |
| Phase 4 | 2 | Recruiting 2 |
| Phase 2 | 1 | Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Molecular Imaging to Identify Predictors of Aortic Valve Disease Activity AORTIC VALVE DISEASES, Calcification; Heart | Not yet recruiting | Massachusetts General Hospital | 100 | 2026-09-30 | 2026-09-16 | |
| Vericiguat for the Inhibition of Calcific Aortic Valve Stenosis Progression Vericiguat (BAY1021189), Placebo - Calcific Aortic Valve Disease, AORTIC VALVE DISEASES | Phase 2 | Recruiting | West China Hospital | 238 | 2026-09-24 | 2026-09-25 |
| Soft Foam Dressings for Pressure Injury Prevention of Cardiac Surgery CONVAFoam Hydrofiber Dressing, Standard Pressure Injury Prevention Care - CAD - Coronary Artery Disease, CABG | Not applicable | Not yet recruiting | Shih,Wen-Chi | 80 | 2026-05-31 | 2026-05-14 |
| A Prospective, Multicenter, Observational Study Evaluating Safety and Effectiveness of SAPIEN 3 Transcatheter Aortic Valve Replacement for Type-0 Bicuspid Aortic Valve Stenosis Patients in China Transcatheter Aortic Valve Replacement - Aortic Stenosis, AORTIC VALVE DISEASES | Not yet recruiting | Chinese Academy of Medical Sciences, Fuwai Hospital | 170 | 2026-04-15 | 2026-05-07 | |
| Self-Expanding Hydra Transcatheter Heart Valve (THV) Series Versus Balloon-Expandable Devices for Valve-In-Valve Transcatheter Aortic Valve Implantation (TAVI) for Patients With Failed Surgical Aortic Bioprosthesis. Hydra THV Series, Sapien THV Series and MyVal THV Series - AORTIC VALVE DISEASES, Valve-in-valve Procedures | Not applicable | Not yet recruiting | National University of Ireland, Galway, Ireland | 111 | 2026-04-01 | 2026-04-13 |
| Clinical Investigation for the PoliaValve Aortic Heart Valve- India PoliaValve (Aortic) - AORTIC VALVE DISEASES, Aortic Valve Stenosis | Not applicable | Not yet recruiting | Suzhou Hearthill Medical Technology Co.,LTD | 50 | 2025-11-15 | 2025-08-14 |
| Evaluation of Safety and Effectiveness of the EMBLOK EPS Compared With No Cerebral Embolic Protection During TAVR EMBLOK™ Embolic Protection System ("EMBLOK EPS") - AORTIC VALVE DISEASES, Aortic Valve Stenosis and/or Insufficiency | Not applicable | Not yet recruiting | Emblok, Inc. | 560 | 2025-10-21 | 2025-08-19 |
| Advanced Robotic Beds for the Early Rehabilitation of Cardiac Surgery Patients use of the robotic bed - AORTIC VALVE DISEASES, Mitral Valve Failure | Not applicable | Active not recruiting | University of Salerno | 20 | 2025-09-22 | 2025-12-09 |
| Early Feasibility Study of Surgical Implantation of a Polymer Prosthetic Mitral and Aortic Valve Polymer Prosthetic Heart Valve - AORTIC VALVE DISEASES, Mitral Valve Disease | Not applicable | Recruiting | Mitrassist Lifesciences Limited Co., Ltd. | 10 | 2025-06-27 | 2025-07-31 |
| TRanscAtheter TreatMent of PurE Aortic Regurgitation With VitaFlow Liberty System VitaFlow+GDMT, J-Valve+GDMT - AORTIC VALVE DISEASES, Aortic Regurgitation | Phase 4 | Recruiting | Ruijin Hospital | 120 | 2025-04-29 | 2026-01-30 |
| Sapien 3 Transcatheter Aortic Valve Replacement in Young Aortic Valve Stenosis Patients From China Transcatheter Aortic Valve Replacement (TAVR) - AORTIC VALVE DISEASES, Bicuspid Aortic Valve (BAV) | Recruiting | Xijing Hospital | 450 | 2025-04-24 | 2026-05-27 | |
| Invasive Versus Echocardiography-derived Transvalvular Gradients After TAVI Usign Balloon-expandable Transcatheter Heart Valves. AORTIC VALVE DISEASES, Aortic Stenosis | Enrolling by invitation | Deutsches Herzzentrum Muenchen | 250 | 2024-05-28 | 2024-12-31 | |
| Expanded Studies on the SCAPIS Stockholm Reexamination Cohort Coronary computer tomography (CCTA), Echocardiograhy and aortic ultrasound, Liver elastography - Coronary Artery Disease, Arterial Stiffness, Blood Pressure | Active not recruiting | Danderyd Hospital | 1400 | 2024-04-08 | 2026-10-21 | |
| Post-market Safety and Performance Outcomes of the VIVERE® Bovine Pericardial Bioprosthetic Valve VIVERE Bovine Pericardial Bioprosthetic Valve - AORTIC VALVE DISEASES, Aortic Valve Stenosis and Insufficiency | Completed | Braile Biomedica Ind. Com. e Repr. Ltda. | 150 | 2024-03-18 | 2025-05-07 | |
| Clinical Validation of a Novel Handsfree Doppler Ultrasound Device, RescueDoppler, in Adult Cardiac Surgery Patients RescueDoppler - Cardio-pulmonary Bypass, AORTIC VALVE DISEASES | Not applicable | Completed | St. Olavs Hospital | 42 | 2024-01-28 | 2024-11-04 |
| Long-term Anticoagulation With Oral Factor Xa Inhibitor Versus Vitamin K Antagonist After Mechanical Aortic Valve Replacement Rivaroxaban Oral Tablet, Vitamin K antagonist(warfarin) - AORTIC VALVE DISEASES, Thromboembolism | Phase 4 | Recruiting | Joon Bum Kim | 1300 | 2022-02-21 | 2026-07-06 |
Aortic Valve Disease (16) · Aortic Valve Stenosis (8) · Aortic Valve Insufficiency (4) · Aortic Aneurysm (2) · Coronary Artery Disease (2) · Heart Valve Diseases (2) · Mitral Valve Insufficiency (2) · Aortic Diseases (1) · Aortic Dissection (1) · Bicuspid Aortic Valve Disease (1) · Calcinosis (1) · Disease (1) · Dyslipidemias (1) · Fatty Liver (1) · Heart Failure (1)
Cardiovascular Diseases (16) · Heart Diseases (16) · Heart Valve Diseases (14) · Ventricular Outflow Obstruction (8) · Vascular Diseases (3) · Aneurysm (2) · Arterial Occlusive Diseases (2) · Arteriosclerosis (2) · Coronary Disease (2) · Metabolic Diseases (2) · Myocardial Ischemia (2) · Nutritional and Metabolic Diseases (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Acute Aortic Syndrome (1)
Transcatheter Aortic Valve Replacement (2) · Rivaroxaban (1) · Vascular Stiffness (1) · vericiguat (1)
Braile Biomedica Ind. Com. e Repr. Ltda. (1) · Chinese Academy of Medical Sciences, Fuwai Hospital (1) · Danderyd Hospital (1) · Deutsches Herzzentrum Muenchen (1) · Emblok, Inc. (1) · Joon Bum Kim (1) · Massachusetts General Hospital (1) · Mitrassist Lifesciences Limited Co., Ltd. (1) · National University of Ireland, Galway, Ireland (1) · Ruijin Hospital (1) · Shih,Wen-Chi (1) · St. Olavs Hospital (1) · Suzhou Hearthill Medical Technology Co.,LTD (1) · University of Salerno (1) · West China Hospital (1)
China (5) · Brazil (1) · Germany (1) · Ireland (1) · Italy (1) · Norway (1) · South Korea (1) · Sweden (1)
Apostolos Bossios (1) · Bahira Shahim (1) · Daniel Andersson (1) · Georgios Belibasakis (1) · Jian Yang, MD, PhD (1) · Jung-min Ahn, MD (1) · Karin Leander (1) · Matteo Pedrelli (1) · Michael Joner, Professor Dr. med. (1) · Paolo Parini (1) · Rebecka Hultgren (1) · Tomas Jernberg (1) · Xiangbin Pan (1)