13 completed, 8 recruiting, 8 unknown, 5 active not recruiting. 25 Not applicable, 3 Phase 4.
Follow Aortic Regurgitation: new trials by email Literature Review of Aortic Regurgitation trials Research Report on Aortic Regurgitation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prospective Multicenter Study Evaluating Myval TAVR Safety and Effectiveness in High-risk Severe AR Myval THV series - Aortic Regurgitation, Aortic Disease | Not applicable | Not yet recruiting | Ceric Sàrl | 164 | 2026-10-30 | 2026-08-07 |
| Active Post-Market Surveillance of Innovative Devices for Valvular Heart Disease Transcatheter Aortic Valve Replacement, Transcatheter Edge-to-Edge Repair, Transcatheter Tricuspid Valve Annuloplasty - Aortic Stenosis, Aortic Regurgitation | Not yet recruiting | Beijing Anzhen Hospital | 5500 | 2026-05-10 | 2026-05-26 | |
| DELINEATE-Prospective Valve Disease, Aortic, Mitral Regurgitation (MR) | Recruiting | Columbia University | 50 | 2026-04-15 | 2026-04-16 | |
| TAVR for Aortic Regurgitation Under TTE Guidance TTE guided TAVR - Aortic Regurgitation, Transcatheter Aortic Valve Replacement (TAVR) | Not applicable | Not yet recruiting | Chinese Academy of Medical Sciences, Fuwai Hospital | 30 | 2026-03-10 | 2026-03-09 |
| ART Trial: Transcatheter J-VALVE Versus Surgery for Aortic Regurgitation Therapy J-VALVE Transfemoral Aortic Valve system, Commercially available surgical biological aortic valve replacement device - Aortic Regurgitation, Aortic Valve Insufficiency | Not applicable | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 1250 | 2026-03-05 | 2026-08-12 |
| TAVR for Aortic Regurgitation Under TEE Guidance TEE guided TAVR - Aortic Regurgitation, Transcatheter Aortic Valve Replacement | Not applicable | Not yet recruiting | Chinese Academy of Medical Sciences, Fuwai Hospital | 30 | 2026-03-01 | 2026-03-06 |
| Mild and Moderate Aortic Regurgitation: Risk Factors for Progress and Outcome Aortic Regurgitation | Not yet recruiting | Uppsala University | 35000 | 2025-08-01 | 2025-08-05 | |
| 3-Dimensional Simulation Guided Transcatheter Aortic Valve Replacement in Aortic Regurgitation(DIGITAL) 3D simulation technique - Aortic Regurgitation | Not applicable | Enrolling by invitation | Xijing Hospital | 354 | 2025-07-30 | 2026-02-10 |
| Early Feasibility Study of Surgical Implantation of a Polymer Prosthetic Mitral and Aortic Valve Polymer Prosthetic Heart Valve - AORTIC VALVE DISEASES, Mitral Valve Disease | Not applicable | Recruiting | Mitrassist Lifesciences Limited Co., Ltd. | 10 | 2025-06-27 | 2025-07-31 |
| ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™ Transcatheter Aortic Valve Replacement (TAVR) using Trilogy THV System, SAVR - Aortic Regurgitation, Aortic Valve Insufficiency | Not applicable | Recruiting | JenaValve Technology, Inc. | 1016 | 2025-06-18 | 2026-10-29 |
| TRanscAtheter TreatMent of PurE Aortic Regurgitation With VitaFlow Liberty System VitaFlow+GDMT, J-Valve+GDMT - AORTIC VALVE DISEASES, Aortic Regurgitation | Phase 4 | Recruiting | Ruijin Hospital | 120 | 2025-04-29 | 2026-01-30 |
| Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease CMR, Quality of Life Questionnaire - Aortic Regurgitation, Mitral Regurgitation | Recruiting | The Cleveland Clinic | 200 | 2024-12-10 | 2026-01-02 | |
| The JenaValve ALIGN-AR LVAD Registry JenaValve Trilogy Heart Valve System - Aortic Regurgitation, Aortic Valve Insufficiency | Not applicable | Active not recruiting | JenaValve Technology, Inc. | 50 | 2024-12-09 | 2026-10-29 |
| J-Valve TF Early Feasibility Study J-Valve TF System - Aortic Valve Disease, Aortic Valve Insufficiency | Not applicable | Active not recruiting | JC Medical, Inc., an affiliate of Edwards Lifesciences LLC | 25 | 2023-10-16 | 2025-07-11 |
| Safety and Effectiveness of TaurusTrio™ Heart Valve System in Patients With Severe Aortic Regurgitation (AR) TaurusTrio™ Heart Valve System - Aortic Regurgitation | Not applicable | Recruiting | Peijia Medical Technology (Suzhou) Co., Ltd. | 116 | 2023-08-01 | 2024-03-18 |
| CT-evaluation of Coronary Ostia Height After Surgical Aortic Valve Replacement. CT scan with contrast medium - Heart Valve Diseases, Aortic Valve Stenosis | Not applicable | Enrolling by invitation | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 90 | 2023-01-11 | 2025-08-15 |
| TAVR in Adults With Pure Severe Aortic Regurgitation Transcatheter Aortic Valve Replacement, Aortic Regurgitation | Unknown | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 76 | 2022-12-01 | 2023-05-30 | |
| HLT® Meridian® TAVR Valve System Early Feasibility Study for Aortic Regurgitation The HLT® Meridian® TAVR Valve (Meridian® with TriVentTM Anticalcification Treatment Valve and Pathfinder® Delivery System) - Aortic Regurgitation | Not applicable | Withdrawn | HLT Inc. | 2022-07-08 | 2023-05-31 | |
| Performance of Currently Available traNscaTHEter Aortic Valve Platforms in Inoperable Patients With Pure Aortic regurgitatiON of a Native Valve. The PANTHEON International Project. TAVR - Aortic Regurgitation | Unknown | IRCCS Policlinico S. Donato | 100 | 2022-05-01 | 2022-04-08 | |
| Fate of Moderate Secondary Mitral Regurgitation in Patients Undergoing Aortic Valve Surgery for Severe Aortic Regurgitation Aortic valve replacement, Mitral valve annuloplasty - Aortic Regurgitation, Functional Mitral Regurgitation | Completed | Michele De Bonis | 154 | 2022-02-02 | 2023-03-20 |
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Aortic Valve Insufficiency (44) · Aortic Valve Stenosis (15) · Aortic Valve Disease (8) · Mitral Valve Insufficiency (7) · Heart Valve Diseases (6) · Bicuspid Aortic Valve Disease (2) · Cardiovascular Diseases (2) · Hypertrophy, Left Ventricular (2) · Tricuspid Valve Insufficiency (2) · Aortic Diseases (1) · Aortic Root Aneurysm (1) · Aortic Stenosis, Subvalvular (1) · Aortic Valve, Calcification of (1) · Bites and Stings (1) · Cardiovascular Abnormalities (1)
Heart Diseases (43) · Cardiovascular Diseases (42) · Heart Valve Diseases (38) · Aortic Valve Disease (36) · Ventricular Outflow Obstruction (16) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Vascular Diseases (4) · Cardiovascular Abnormalities (3) · Congenital Abnormalities (3) · Pathological Conditions, Signs and Symptoms (3) · Cardiomegaly (2) · Heart Defects, Congenital (2) · Hypertrophy (2) · Pathological Conditions, Anatomical (2) · Aneurysm (1)
Transcatheter Aortic Valve Replacement (6) · Echocardiography (2) · Amlodipine (1) · Aspirin (1) · Cardiopulmonary Bypass (1) · Contrast Media (1) · Extracorporeal Membrane Oxygenation (1) · Losartan (1) · Magnetic Resonance Imaging (1) · Meridians (1) · Mitral Valve Annuloplasty (1) · Rivaroxaban (1) · Tablets (1) · Ventilation (1) · amlodipine-losartan drug combination (1)
JenaValve Technology, Inc. (5) · Chinese Academy of Medical Sciences, Fuwai Hospital (3) · Edwards Lifesciences (2) · Michele De Bonis (2) · The Cleveland Clinic (2) · Xijing Hospital (2) · Atlantic Health System (1) · Beijing Anzhen Hospital (1) · Biostable Science & Engineering (1) · Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec (1) · Ceric Sàrl (1) · Christian Torp-Pedersen (1) · Columbia University (1) · Florence Nightingale Hospital, Istanbul (1) · Fondation Hôpital Saint-Joseph (1)
China (12) · United States (11) · Italy (6) · Germany (3) · France (2) · Netherlands (2) · South Korea (2) · Switzerland (2) · Belgium (1) · Canada (1) · Czechia (1) · Denmark (1) · Sweden (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Martin B. Leon, MD (2) · Torsten P. Vahl, MD (2) · Vinod H. Thourani, MD (2) · Attilio Maseri, MD (1) · Charles Davidson, MD (1) · Christof Stamm, M.D. (1) · Dean J Kereiakes, MD (1) · Deborah Kwon, M. D. (1) · Deborah Kwon, MD (1) · Duk-Hyun Kang (1) · Elena Bignami, MD (1) · Gabriel Sayer, MD (1) · Hendrik Treede, MD (1) · Hendrik Treede, Prof (1)
PMID 29171730, PMID 34556282, PMID 37648345, PMID 41260228, PMID 11081028, PMID 12091180, PMID 19933939, PMID 23959743, PMID 24113022, PMID 25468084, PMID 26156945, PMID 27242354, PMID 28521923, PMID 29191323, PMID 30072124, PMID 30269437, PMID 30477541, PMID 32408828, PMID 32725310, PMID 32905623, PMID 33871579, PMID 34915984, PMID 35188539, PMID 35324429, PMID 36211543, PMID 36218214, PMID 36398903, PMID 37028710, PMID 37565470, PMID 37883682, PMID 38006908, PMID 38552656, PMID 39198100, PMID 40392571, PMID 41739727, PMID 41928824, PMID 42087322
2016 (1), 2025 (1)