26 recruiting, 12 not yet recruiting, 4 completed, 4 enrolling by invitation. 19 Not applicable, 7 Phase 1, 7 Phase 2, 1 Phase 3, 1 Phase 4.
Follow Alzheimer s Disease: new trials by email Literature Review of Alzheimer s Disease trials Research Report on Alzheimer s Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Terazosin And Metabolic Engagement in Alzheimer's Disease Terazosin (Hytrin), Placebo - Alzheimer s Disease | Phase 2 | Not yet recruiting | Qiang Zhang | 100 | 2027-08-01 | 2026-09-01 |
| Neuroprotective Effects of Oleanolic Acid and Erythrodiol in Prodromal Alzheimer's Disease Oleanolic acid-enriched olive oil, Pomace olive oil, Commercial olive oil 0.4 degrees - Alzheimer s Disease, Prodromal Alzheimer's Disease | Not applicable | Not yet recruiting | Spanish National Research Council | 120 | 2027-01-01 | 2026-09-29 |
| LiO-AD: Lithium Orotate in Alzheimers Disease Feasibility, Biomarker Engagement, and Clinical Response Lithium orotate, Matched Placebo (Capsules) - Alzheimer s Disease | Phase 1 / Phase 2 | Not yet recruiting | Johns Hopkins University | 40 | 2026-12-01 | 2026-10-07 |
| PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI) 18F-PF974, 18F-florbetaben - Alzheimer s Disease, Mild Cognitive Impairment | Phase 1 | Recruiting | National Institute of Mental Health (NIMH) | 90 | 2026-11-02 | 2026-10-28 |
| MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT) Antiphospholipid (aPL)-Positive, Rheumatic Arthritis | Not yet recruiting | Axiom Bioregistry | 5000 | 2026-10-18 | 2026-10-23 | |
| CommunityRx-Dementia + Peer Navigation (CRxDpeer) CommunityRx-Dpeer - Alzheimer s Disease, Dementia | Not applicable | Recruiting | University of Chicago | 330 | 2026-10-05 | 2026-10-13 |
| Precuneus Mapping With Sinaptistim® (an Investigational TMS-EEG System) in Mild to Moderate AD Patients TMS-EEG - Alzheimer s Disease | Not yet recruiting | Sinaptica Therapeutics, Inc. | 30 | 2026-10-01 | 2026-09-25 | |
| Deep Cervical Lymphovenous Anastomosis for Severe Alzheimer's Disease Deep Cervical Lymphovenous Anastomosis, Routine Treatment - Alzheimer s Disease | Not applicable | Not yet recruiting | Southwest Hospital, China | 59 | 2026-10-01 | 2026-06-25 |
| Ultrasonic Debris Clearance to Promote Brain Resilience Ultrasonic Debris Clearance, sham - Alzheimer s Disease, MCI With Increased Risk for Alzheimer Disease | Not applicable | Recruiting | Stanford University | 15 | 2026-10-01 | 2026-10-06 |
| Adaptation of the Mini-Mental State Examination (MMSE) for the Reunion Island Population MMSE-RUN and MMSE GRECO - Alzheimer s Disease, Vascular Cognitive Impairment | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de la Réunion | 400 | 2026-10-01 | 2026-09-11 |
| An Open Label Dose Escalation Study of VY1706 in Participants With Early Alzheimer's Disease VY1706 Low dose, VY1706 Mid dose, VY1706 High Dose - Alzheimer s Disease | Phase 1 | Recruiting | Voyager Therapeutics | 18 | 2026-09-03 | 2026-09-04 |
| A Study of the Metabolic Reconstruction Oral Biologics (Gut-X-001) Medication in People With Alzheimer's Disease (ESCAPE-AD) Gut-X-001 + Placebo capsule, Gut-X-001, Placebo - Alzheimer s Disease | Phase 1 / Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 120 | 2026-08-01 | 2026-06-11 |
| Validation of a Remediation Method for Memory Impairments Through Motor Encoding in Patients With Alzheimer's Disease Control condition, Motor mental imagery, Action execution - Alzheimer s Disease, Healhty | Not applicable | Recruiting | Centre Hospitalier Universitaire de Saint Etienne | 80 | 2026-07-15 | 2026-07-31 |
| Low-Dose Radiotherapy for Alzheimer's Disease Low Dose Radiation Therapy - Alzheimer Dementia, Dementia | Phase 1 / Phase 2 | Recruiting | Evan Thomas | 50 | 2026-07-15 | 2026-07-09 |
| Efficacy of Lymphatic-Venous Anastomosis Plus Donepezil Versus Donepezil Alone for Alzheimer's Disease Cervical lymph vessel/node-venous anastomosis surgery combined with oral donepezil, Oral treatment with donepezil - Alzheimer s Disease | Not applicable | Not yet recruiting | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | 216 | 2026-07-15 | 2026-07-22 |
| Brain Wave Informed Non-invasive Brain Stimulation: Improving Neural Networks of Working Memory in Dementia: a Proof-of-concept Study EEG-triggered TMS - Dementia, Alzheimer s Disease | Not applicable | Recruiting | McMaster University | 30 | 2026-07-07 | 2026-07-07 |
| SAD Study of CGB3002 in Healthy Participants CGB3002 0.08 mg/kg, CGB3002 0.4 mg/kg, CGB3002 1.2 mg/kg - Alzheimer s Disease | Phase 1 | Recruiting | ChainGen Biopharma Ltd | 46 | 2026-06-30 | 2026-07-08 |
| Effects of X Box Kinect 360 in Alzheimer's Disease 3D Kinect based game, Conventional therapy group - Alzheimer s Disease | Not applicable | Not yet recruiting | Ziauddin University | 38 | 2026-06-24 | 2026-06-29 |
| Usefulness of a Virtual Response Test as a Predictor of Functional and Cognitive Abilities in Older Adults With Different Degrees of Cognitive Impairment: a Pilot Study (ReactVR) Virtual reality reaction time test - Alzheimer s Disease, Dementia | Not applicable | Completed | University of Vigo | 20 | 2026-05-25 | 2026-06-02 |
| Crownlands Observing Progression With Neurons Study Alzheimer s Disease, Mild Cognitive Impairment (MCI) | Recruiting | Crownlands | 160 | 2026-05-19 | 2026-06-04 |
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Alzheimer Disease (17) · Dementia (15) · Cognitive Dysfunction (7) · Parkinson Disease (4) · Neurodegenerative Diseases (3) · Caregiver Burden (2) · Neurocognitive Disorders (2) · Amyotrophic Lateral Sclerosis (1) · Anemia, Sickle Cell (1) · Anxiety Disorders (1) · Behavior (1) · Brain Neoplasms (1) · Celiac Disease (1) · Constipation (1) · Crohn Disease (1)
Mental Disorders (27) · Nervous System Diseases (26) · Brain Diseases (25) · Central Nervous System Diseases (25) · Neurocognitive Disorders (25) · Neurodegenerative Diseases (18) · Tauopathies (16) · Dementia (8) · Cognition Disorders (7) · Pathological Conditions, Signs and Symptoms (6) · Nutritional and Metabolic Diseases (5) · Basal Ganglia Diseases (4) · Glucose Metabolism Disorders (4) · Metabolic Diseases (4) · Parkinsonian Disorders (4)
4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (1) · Biological Assay (1) · Capsules (1) · Donepezil (1) · Medication Review (1) · Methylphenidate (1) · N-benzyl-N-ethyl-2-(7,8-dihydro-7-methyl-8-oxo-2-phenyl-9H-purin-9-yl)acetamide (1) · Nutrition Assessment (1) · Occupational Therapy (1) · Radiotherapy (1) · Surveys and Questionnaires (1) · Terazosin (1) · Therapeutics (1) · Transcranial Direct Current Stimulation (1) · Transcranial Magnetic Stimulation (1)
Sunnybrook Health Sciences Centre (2) · AlFayhaa General Hospital (1) · Axiom Bioregistry (1) · Beijing Tiantan Hospital (1) · Bengt Nellgård (1) · Bitbrain (1) · Central Hospital, Nancy, France (1) · Centre Hospitalier Universitaire de Saint Etienne (1) · Centre Hospitalier Universitaire de la Réunion (1) · ChainGen Biopharma Ltd (1) · Chi-Ying (Roy) Lin (1) · Crownlands (1) · Danyang Huichuang Medical Equipment Co., Ltd. (1) · Evan Thomas (1) · First Affiliated Hospital of Wenzhou Medical University (1)
United States (10) · China (7) · France (4) · Spain (4) · Canada (3) · Italy (2) · United Kingdom (2) · Australia (1) · Belgium (1) · Germany (1) · Jordan (1) · Norway (1) · Pakistan (1) · Reunion (1) · Sweden (1)
Caroline Williams-Gray, Dr. (1) · Christopher Morrow, MD, MHS (1) · David Owen (1) · Evan Thomas, MD, PhD (1) · Gabriele Siciliano, Professor, MD, PhD (1) · Giacomo Koch, MD, PhD (1) · Ke-Yun Chao, PhD (1) · Krista Lanctot, PhD (1) · Marta Camacho, Dr. (1) · Mona Dixon Gundersen, MBChB, PhD (1) · Paul A Parcon, M.D. (1) · Qiang Zhang, MD (1) · Raag Airan, MD, PhD (1) · Rany Aburashed (1)
PMID 11317951, PMID 12919265, PMID 14511167, PMID 25621384, PMID 26992016, PMID 30155306, PMID 30239213, PMID 31719067, PMID 33292729, PMID 33586858, PMID 34511499, PMID 34526034, PMID 36817126, PMID 36918389
R01AG091308 (1)