38 recruiting, 31 completed, 24 not yet recruiting, 8 unknown. 57 Not applicable, 29 Phase 2, 10 Phase 1, 3 Early Phase 1, 3 Phase 3.
Follow Alcohol Use Disorder (AUD): new trials by email Literature Review of Alcohol Use Disorder (AUD) trials Research Report on Alcohol Use Disorder (AUD)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Self-administered Neurostimulation Intervention for Firefighter Traumatic Stress to Reduce Alcohol Use: Pilot Study Transcutaneous auricular neurostimulation (tAN), Active Sham - Posttraumatic Stress Symptoms, Heavy Alcoholic Consumption | Not applicable | Not yet recruiting | University of Cincinnati | 20 | 2027-09-01 | 2026-10-09 |
| eTSF for Latinx Young Adults With Alcohol Use Disorder eTSF, Educational materials - Alcohol Use Disorder (AUD) | Not applicable | Not yet recruiting | Tulane University | 40 | 2027-08-01 | 2026-10-13 |
| Connecting Online Military Personnel to Alcohol Harm-reducing Smartphone Support Study VetChange (Explorer/Research version) Mobile App, Sober Time - Alcohol Use Disorder (AUD) | Not applicable | Not yet recruiting | University of New Mexico | 150 | 2027-04-01 | 2026-11-02 |
| Examining the Relationship Between Ongoing Alcohol Use, Suicidal Thoughts and Behaviors and Related Constructs, and Behavioral Economic Decision-Making. CBT4CBT - Alcohol Use Disorder (AUD), Suicidal Ideation | Not applicable | Not yet recruiting | Mark J Rzeszutek, PhD | 180 | 2027-03-01 | 2026-09-25 |
| Pregnenolone to Target Concurrent PTSD and Stress Induced Alcohol Use in Veterans: A Dose Finding Study Brexanolone - Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD) | Phase 2 | Not yet recruiting | Pharmacotherapies for Alcohol and Substance Use Disorders Alliance | 40 | 2027-01-15 | 2026-09-21 |
| Testing a Music Listening mHealth Intervention for Stress Reduction in Early Recovery (CalmiFy II) Stress Feedback, Music Listening - Alcohol Use Disorder (AUD) | Not applicable | Not yet recruiting | Washington State University | 30 | 2026-12-01 | 2026-05-05 |
| Disease Intervention Specialist (DIS) for SUD Substance Use Disorder (SUD), Opioid Use Disorder | Not yet recruiting | Ohio State University | 1200 | 2026-12-01 | 2026-10-15 | |
| Effectiveness of Nurse-Conducted Brief Intervention (NCBI) Supplemented With Mobile for Preventing Alcohol Use Disorders Nurse-Conducted Brief Intervention (NCBI). supplemented with mobile based application., Nurse-Conducted Brief Intervention (NCBI) - Alcohol Use Disorder (AUD) | Not applicable | Not yet recruiting | University of Pittsburgh | 74 | 2026-12-01 | 2026-06-05 |
| Alpha Down Electroencephalography (EEG) Neurofeedback for Alcohol Use Disorder: Feasibility Trial EEG Neurofeedback - Alcohol Use Disorder (AUD) | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 10 | 2026-12-01 | 2026-10-01 |
| Process-Based Psychological Processes in Alcohol Use Disorder: A Case-Control Study Using PBAT, PHQ-9, and GAD-7 Alcohol Use Disorder (AUD) | Not yet recruiting | George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures | 200 | 2026-12-01 | 2026-11-03 | |
| Investigation of the Gut-Brain Axis in Alcohol Use Disorder Fecal Microbiota Transplantation (FMT) Procedure and Cognitive Behavioral Therapy (CBT) Procedure - Alcohol Use Disorder (AUD), Alcohol Abstinence | Not applicable | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 78 | 2026-11-16 | 2026-10-29 |
| OEA for Young Adults With Alcohol Use Disorder oleoylethanolamide - Alcohol Use Disorder (AUD) | Phase 2 | Not yet recruiting | Medical University of South Carolina | 42 | 2026-11-01 | 2026-08-12 |
| Exercise Training Decreases Alcohol Consumption and Tissue Injury by an FGF21-dependent Mechanism Endurance Exercise - Alcohol Use Disorder (AUD), Alcohol Related Liver Disease | Not applicable | Recruiting | The Cleveland Clinic | 30 | 2026-10-25 | 2026-09-17 |
| Cannabidiol as an Adjunct Treatment for Alcohol Withdrawal and Craving Cannabidiol (CBD), Placebo - Alcohol Use Disorder (AUD), Withdrawal From Addictive Substance; Detoxification | Phase 2 / Phase 3 | Recruiting | Johns Hopkins University | 105 | 2026-10-21 | 2026-11-03 |
| High Intensity Alternating Current Stimulation as a Neuromodulation Therapy for Alcohol Use Disorder: A Pilot Study HI-tACS - Alcohol Use Disorder (AUD) | Not applicable | Recruiting | Shanghai Mental Health Center | 18 | 2026-10-11 | 2026-10-16 |
| Sensory and Physical Reactions to Beverage Cues Alcohol Cue Reactivity Paradigm - Alcohol Use Disorder (AUD) | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 20 | 2026-10-01 | 2026-08-26 |
| Semaglutide Dose Effects on Metabolic and Stress Hormone, Craving and Alcohol Use Outcomes Placebo, Semaglutide 1.0 mg, Semaglutide 2.0 mg - Alcohol Use Disorder (AUD), Obesity (BMI Equal to or >30) | Phase 1 | Not yet recruiting | Yale University | 90 | 2026-10-01 | 2026-08-19 |
| Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder Pregnenolone, Placebo - Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD) | Phase 2 | Not yet recruiting | Sherwood Brown, MD, PhD | 100 | 2026-10-01 | 2026-08-24 |
| Imaging Mitochondrial Complex-I in Alcohol Use Disorder [F-18]BCPP-EF, [F-18]FDG - Alcohol Use Disorder (AUD), Healthy Controls Group - Age and Sex-matched | Early Phase 1 | Recruiting | Rajesh Narendran | 100 | 2026-09-30 | 2026-11-03 |
| Deaf CBT-TS to Reduce Suicide Risk Deaf CBT-TS - Depression - Major Depressive Disorder, Anxiety | Not applicable | Not yet recruiting | University of Rochester | 110 | 2026-09-01 | 2026-06-22 |
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Alcoholism (115) · Substance-Related Disorders (21) · Alcohol Drinking (13) · Stress Disorders, Post-Traumatic (9) · Alcohol-Related Disorders (7) · Behavior, Addictive (6) · Depressive Disorder, Major (6) · Anxiety Disorders (5) · Mental Disorders (4) · Tobacco Use Disorder (4) · Alcohol Abstinence (3) · Combat Disorders (3) · Obesity (3) · Psychological Well-Being (3) · Alcoholic Intoxication (2)
Chemically-Induced Disorders (114) · Mental Disorders (111) · Alcohol-Related Disorders (108) · Substance-Related Disorders (94) · Behavior (35) · Drinking Behavior (16) · Stress Disorders, Traumatic (11) · Trauma and Stressor Related Disorders (11) · Pathological Conditions, Signs and Symptoms (9) · Behavioral Symptoms (6) · Compulsive Behavior (6) · Depressive Disorder (6) · Mood Disorders (6) · Impulsive Behavior (5) · Nervous System Diseases (5)
Ethanol (7) · Cognitive Behavioral Therapy (4) · Psilocybin (3) · Tirzepatide (3) · suvorexant (3) · Acetylcysteine (2) · Cannabidiol (2) · Dexmedetomidine (2) · Ketamine (2) · Methods (2) · Organization and Administration (2) · Practice Management, Medical (2) · Surveys and Questionnaires (2) · Therapeutics (2) · semaglutide (2)
Yale University (6) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (4) · Pharmacotherapies for Alcohol and Substance Use Disorders Alliance (4) · Washington State University (4) · Medical University of South Carolina (3) · Shanghai Mental Health Center (3) · South West Sydney Local Health District (3) · Technische Universität Dresden (3) · University of Pennsylvania (3) · Brigham and Women's Hospital (2) · Brown University (2) · Kaiser Permanente (2) · Massachusetts General Hospital (2) · Stanford University (2) · Universitair Ziekenhuis Brussel (2)
United States (60) · Germany (6) · Australia (5) · China (4) · Romania (3) · Switzerland (3) · Belgium (2) · Denmark (2) · France (2) · United Kingdom (2) · Austria (1) · Brazil (1) · Canada (1) · Hong Kong (1) · Italy (1)
Ismene Petrakis, MD (2) · Nora D Volkow Adler, M.D. (2) · Albert R Powers, MD, PhD (1) · Alexander C Tsai, MD (1) · Alexandra M Gaina, MD (1) · Amandine Luquiens (1) · Anahita Bassir Nia, MD (1) · Anders Fink-Jensen, Professor (1) · Andreea S Szalontay, Clinical Professor (1) · Andrzej Jakubczyk, MD, PhD (1) · Barbara J. Mason, Ph.D. (1) · Brendan J Clark, MD (1) · Carolina Haass-Koffler, PharmD, PhD (1) · Carolina L Haass-Koffler, PHARMD, PHD (1)
PMID 24283802, PMID 26037245, PMID 27736135, PMID 28551590, PMID 29654477, PMID 29749279, PMID 30043457, PMID 32024421, PMID 32500211, PMID 32546139, PMID 32858777, PMID 33130158, PMID 34049101, PMID 34075542, PMID 34899419, PMID 35229945, PMID 35796481, PMID 36190537, PMID 36379437, PMID 36380640, PMID 36813084, PMID 38627843, PMID 38693570, PMID 38751764, PMID 39252861, PMID 39910606, PMID 40018886, PMID 40445294, PMID 40548528, PMID 40555227, PMID 40905156, PMID 40921646, PMID 41620760, PMID 41630040, PMID 41853081, PMID 42035882, PMID 42099725, PMID 42280319, PMID 42404370
R61AA031474 (2), D43TW009114 (1), I01HX003742 (1), K01AA031323 (1), K23MH137406 (1), K99AA031716 (1), P01AA029545 (1), P50AA010761 (1), P50AA012870 (1), P60AA006420 (1), R01AA023192 (1), R01AA028211 (1), R01AA031453 (1), R01AA031552 (1), R01AA031762 (1)