Examining the Relationship Between Ongoing Alcohol Use, Suicidal Thoughts and Behaviors and Related Constructs, and Behavioral Economic Decision-Making.

NCT07842588 — Not applicable, Not yet recruiting, 180 participants, Mark J Rzeszutek, PhD

ClinicalTrials Daily · Areas · Conditions · Drugs · Sponsors ·

Registry	NCT07842588
Status	Not yet recruiting
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: none, treatment
Enrollment	180 (Estimated)
Sponsor	Mark J Rzeszutek, PhD (Other)
Conditions	Alcohol Use Disorder (AUD), Suicidal Ideation
Interventions	CBT4CBT (Behavioral)
Dates	start 2027-03-01 (estimated), primary completion 2029-03-01 (estimated), completion 2029-08-01 (estimated), first posted 2026-09-25, last updated 2026-09-25

-Summary

This study will evaluate the relationship between alcohol use, suicidal thoughts and behaviors, and behavioral economic decision-making. Participants will complete surveys over approximately 12 weeks and will be randomly assigned to receive access to a self-guide computerized cognitive behavioral therapy (CBT4CBT) program either immediately or after a waiting period. The study will compare participants with and without recent suicidal thoughts and behaviors to better understand factors associated with alcohol use and engagement with treatment.

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+Detailed description

This randomized, 2x2 factorial study will enroll adults who drink alcohol regularly and are interested in reducing or stopping their alcohol use. Participants will complete four online assessments approximately four weeks apart over a 12 week study period. The assessments include questionnaires about alcohol use, suicidal thoughts and behaviors and behavioral economic decision-making.

Participants will be randomly assigned to receive access to Computer-Based Training for Cognitive Behavioral Therapy (CBT4CBT) program either immediately after the baseline assessment or after the second follow-up assessment. The study will compare participants with and without recent suicidal thoughts and behaviors to evaluate differences in decision-making, alcohol use, and engagement with the CBT4CBT program. The results may improve understanding of factors related to alcohol use and suicide risk and help inform future interventions for individuals with alcohol use concerns.

+Arms and interventions

Arm	Type	Interventions	Description
Recent Suicidal Thoughts/Behaviors + Immediate CBT4CBT	Experimental	Behavioral: CBT4CBT	Participants with recent suicidal thoughts or behaviors who receive immediate access to CBT4CBT.
Recent Suicidal Thoughts/Behaviors + Delayed CBT4CBT	Active comparator	Behavioral: CBT4CBT	Participants with recent suicidal thoughts or behaviors who receive delayed access to CBT4CBT after the second follow-up assessment.
No Recent Suicidal Thoughts/Behaviors + Immediate CBT4CBT	Experimental	Behavioral: CBT4CBT	Participants without recent suicidal thoughts or behaviors who receive immediate access to CBT4CBT.
No Recent Suicidal Thoughts/Behaviors + Delayed CBT4CBT	Active comparator	Behavioral: CBT4CBT	Participants without recent suicidal thoughts or behaviors who receive delayed access to CBT4CBT after the second follow-up assessment.

CBT4CBT (Behavioral): Computer-Based Training for Cognitive Behavioral Therapy (CBT4CBT), a self-guided computerized cognitive behavioral therapy program for alcohol use. Participants receive access either immediately following the baseline assessment or after the second follow-up assessment.

+Outcome measures

Primary outcomes

Change in Alcohol Use [Baseline, 4 Weeks, 8 Weeks, and 12 Weeks.]: Change in alcohol consumption measured using the 28-day Timeline Follow-Back (TLFB).
Change in Suicidal Thoughts and Behaviors [Baseline, 4 Weeks, 8 Weeks, and 12 Weeks.]: Change in suicidal thoughts and behaviors as measured by the Colombia Suicide Severity Rating Scale (C-SSRS)

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Consume alcohol at least weekly
* Score of 8 or greater on the Alcohol Use Disorder Identification Test (AUDIT)
* Some interest in cutting back on drinking or quitting
* Read and understand English
* Recent active/passion ideation

Exclusion Criteria:

* Score of 31 or greater on the AUDIT
* Having unmanaged psychiatric diagnoses
* Already being in treatment for alcohol use disorder at baseline
* Past month substance use other than cannabis or tobacco