Alcohol Use Disorder: Clinical Trials

318 completed, 137 recruiting, 51 unknown, 37 active not recruiting. 341 Not applicable, 155 Phase 2, 52 Phase 1, 26 Phase 3, 21 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	341	Completed 176, Recruiting 70, Unknown 33, Active not recruiting 19, Not yet recruiting 18, Terminated 10, Withdrawn 8, Enrolling by invitation 5, Suspended 2
Phase 2	155	Completed 80, Recruiting 30, Not yet recruiting 10, Terminated 9, Withdrawn 9, Active not recruiting 8, Unknown 6, Enrolling by invitation 2, Suspended 1
Phase 1	52	Completed 26, Recruiting 11, Active not recruiting 5, Withdrawn 4, Terminated 3, Unknown 2, Not yet recruiting 1
Phase 3	26	Recruiting 11, Completed 10, Not yet recruiting 2, Enrolling by invitation 1, Suspended 1, Terminated 1
Phase 4	21	Completed 10, Terminated 5, Recruiting 3, Unknown 2, Withdrawn 1
Early Phase 1	16	Completed 7, Recruiting 5, Active not recruiting 3, Terminated 1

Follow Alcohol Use Disorder: new trials by email Literature Review of Alcohol Use Disorder trials Research Report on Alcohol Use Disorder

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
A Digital Pill System to Measure and Support Acamprosate Adherence in Individuals With Alcohol Associated Liver Disease AcamproSync - Alcohol Use Disorder, Alcohol Associated Liver Disease	Not applicable	Not yet recruiting	Yale University	50	2027-10-01	2026-04-28
Adapting a Telehealth Intervention for Suicide Prevention Among Patients With Alcohol Use Disorder in Tanzania IDEAS-AUD - Alcohol Use Disorder, Suicide Prevention	Not applicable	Not yet recruiting	Duke University	30	2027-08-01	2026-03-17
A Feasibility and Acceptability Study of a Large Language Model-based Chatbot for Brief Alcohol Intervention Among Emerging Adults Large language model-based chatbot brief alcohol intervention session - Alcohol Use Disorder	Not applicable	Not yet recruiting	Massachusetts General Hospital	20	2027-06-01	2025-10-22
TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD) TMS Low-Dose, TMS High-Dose - Alcohol Use Disorder, Opioid Use Disorder	Not applicable	Recruiting	Washington State University	60	2027-06-01	2026-05-29
Preventing Harmful Alcohol Use Among Trauma Patients in Cameroon Cameroon-Adapted SBIRT, Usual Care - Alcohol Use Disorder, Alcohol-Related Injury	Not applicable	Not yet recruiting	University of Buea	690	2027-03-01	2026-06-30
Daridorexant for Alcohol Use Disorder Daridorexant 50 mg, Placebo - Alcohol Use Disorder	Phase 2	Not yet recruiting	Johns Hopkins University	150	2027-01-01	2026-04-20
Pomegranate Dietary Supplements in AUD and ALD Pomegranate Dietary Ssupplement - Alcohol Use Disorder, Alcohol-associated Liver Disease		Not yet recruiting	University of Louisville	144	2027-01-01	2026-07-24
Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder Kenetik, magnetic resonance imaging scan, Alcohol bar lab - Alcohol Use Disorder, Ketosis	Phase 2 / Phase 3	Recruiting	University of Pennsylvania	60	2026-12-01	2026-10-21
Psilocybin-Assisted Psychotherapy for the Treatment of Severe Alcohol Use Disorder Psilocybin - Alcohol Use Disorder	Phase 2	Not yet recruiting	Brigham and Women's Hospital	36	2026-11-15	2026-10-09
Effects of Olfactory Stimuli in Virtual Reality Cue Exposure on Craving and Attentional Bias in Alcohol Use Disorder VR-CE - Alcohol Use Disorder	Not applicable	Not yet recruiting	Charite University, Berlin, Germany	60	2026-11-15	2026-10-22
Environment and Alcohol: A Pilot Study Evaluate the effects of Environmental Enrichment (EE) on alcohol consumption - Alcohol Use Disorder	Phase 1	Recruiting	National Institute on Drug Abuse (NIDA)	44	2026-11-05	2026-11-02
Recovery Management Checkup Scalability and Sustainability Hybrid Experiment Recovery Management Checkups (RMC) delivered by community-based agencies (RMC adopters), Recovery Management Checkups (RMC) delivered by staff under the research team (RMC by research staff) - Substance Use Disorder (SUD), Opioid Use Disorders	Phase 3	Not yet recruiting	Chestnut Health Systems	600	2026-11-02	2026-10-14
Combination Therapy for Alcohol Use Disorder Placebo, Glucagon-Like Peptide-1 Agonist (GLP-1), Naltrexone (oral tablets) - Alcohol Use Disorder	Phase 2	Not yet recruiting	Johns Hopkins University	45	2026-11-01	2026-10-01
GLP-1 RA on Alcohol Consumption, Metabolism and Liver Parameters in Patients With Obesity and Fatty Liver Disease Semaglutide, Weight reduction recommendations (nutritional and exercise) - Adiposity, Fatty Liver	Not applicable	Not yet recruiting	Insel Gruppe AG, University Hospital Bern	64	2026-11-01	2026-08-19
Intravenous Acetate as an Adjunctive Treatment for Alcohol Withdrawal in Hospitalized Patients Sodium Acetate, Placebo - Alcohol Withdrawal, Alcohol Abstinence	Phase 1 / Phase 2	Not yet recruiting	University of Colorado, Denver	75	2026-11-01	2026-10-30
Peer Support for Liver Transplant Recipients With History of ALD Peer Support - Alcohol Use Disorder, Alcohol Related Liver Disease	Not applicable	Recruiting	Johns Hopkins University	95	2026-10-27	2026-10-28
Study on Thiamine Supplementation to REduce braiN Injury Associated With Chronic Alcohol Use in Outpatients With Alcohol Use Disorder Thiamine - Alcohol Use Disorder	Phase 2	Not yet recruiting	Institut National de la Santé Et de la Recherche Médicale, France	60	2026-10-23	2026-09-28
Peer Support in Alcohol Dependence Quality life questionnaire AQoLS, Quality life questionnaire Euroqol EQ-5D-5L, Peer support consultations - Alcohol Use Disorder	Not applicable	Recruiting	Hospices Civils de Lyon	626	2026-10-19	2026-10-21
Hepatic Lipid Metabolism-Alcohol Use Disorder Liver biopsy - Alcohol Use Disorder		Recruiting	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	25	2026-10-05	2026-10-08
Methylphenidate and Response to Alcohol Cues Methylphenidate Pill, Placebo Pill - Alcohol Use Disorder	Phase 2	Not yet recruiting	University of Florida	50	2026-10-01	2026-08-20

Showing 20 of 640. Sign in to see all of them.

Narrower conditions

Alcoholism (640)  ·  Alcohol Drinking (64)  ·  Substance-Related Disorders (52)  ·  Stress Disorders, Post-Traumatic (39)  ·  Behavior, Addictive (29)  ·  Depression (27)  ·  Anxiety Disorders (25)  ·  Opioid-Related Disorders (21)  ·  Alcohol-Related Disorders (18)  ·  Recurrence (11)  ·  Sleep Initiation and Maintenance Disorders (10)  ·  Acquired Immunodeficiency Syndrome (9)  ·  Alcoholic Intoxication (9)  ·  Bipolar Disorder (9)  ·  Mental Disorders (9)

Broader conditions

Chemically-Induced Disorders (637)  ·  Mental Disorders (631)  ·  Alcohol-Related Disorders (622)  ·  Substance-Related Disorders (588)  ·  Behavior (157)  ·  Drinking Behavior (67)  ·  Pathological Conditions, Signs and Symptoms (56)  ·  Trauma and Stressor Related Disorders (42)  ·  Pathologic Processes (41)  ·  Stress Disorders, Traumatic (41)  ·  Behavioral Symptoms (34)  ·  Compulsive Behavior (29)  ·  Impulsive Behavior (28)  ·  Nervous System Diseases (24)  ·  Disease Attributes (23)

Interventions

Ethanol (65)  ·  Naltrexone (16)  ·  Psilocybin (13)  ·  Sugars (12)  ·  Cognitive Behavioral Therapy (11)  ·  Methods (8)  ·  Sodium Chloride (8)  ·  semaglutide (8)  ·  Cannabidiol (7)  ·  Crisis Intervention (7)  ·  Ketamine (7)  ·  Motivational Interviewing (7)  ·  Oxytocin (7)  ·  Therapeutics (7)  ·  vivitrol (7)

Sponsors

Yale University (32)  ·  VA Office of Research and Development (22)  ·  Medical University of South Carolina (19)  ·  University of California, Los Angeles (15)  ·  National Institute on Alcohol Abuse and Alcoholism (NIAAA) (13)  ·  University of Colorado, Denver (11)  ·  New York State Psychiatric Institute (10)  ·  Brown University (9)  ·  Central Institute of Mental Health, Mannheim (9)  ·  Centre for Addiction and Mental Health (9)  ·  University of California, San Francisco (9)  ·  Johns Hopkins University (8)  ·  Shanghai Mental Health Center (8)  ·  University of Minnesota (8)  ·  Indiana University (7)

Countries

United States (426)  ·  France (34)  ·  Canada (22)  ·  Germany (19)  ·  China (13)  ·  Denmark (12)  ·  Sweden (12)  ·  United Kingdom (12)  ·  Belgium (6)  ·  Spain (6)  ·  Switzerland (6)  ·  Turkey (Türkiye) (6)  ·  Finland (4)  ·  India (4)  ·  Uganda (4)

Top investigators

Lara Ray, PhD (7)  ·  Lorenzo Leggio, M.D. (5)  ·  Barbara J. Mason, Ph.D. (4)  ·  Jessica Weafer, PhD (4)  ·  Joseph P Schacht, PhD (4)  ·  Min Zhao (4)  ·  Corinde Wiers, Ph.D. (3)  ·  Elizabeth Lippard, PhD (3)  ·  Eric Devine, PhD (3)  ·  Gihyun Yoon, MD (3)  ·  Matthew Sloan, MD (3)  ·  Nancy Diazgranados, M.D. (3)  ·  Robert Miranda, PhD (3)  ·  Sherry McKee, PhD (3)

Results publications

PMID 35858989, PMID 37146499, PMID 37897693, PMID 10553740, PMID 10628520, PMID 10891633, PMID 11707638, PMID 1334156, PMID 1345133, PMID 1444726, PMID 15811981, PMID 15850502, PMID 16624967, PMID 16943402, PMID 17045423, PMID 18472999, PMID 19032530, PMID 19345510, PMID 20921122, PMID 21700411, PMID 22439295, PMID 22642856, PMID 22829885, PMID 23227826, PMID 23253201, PMID 23502815, PMID 23627868, PMID 24650044, PMID 24825644, PMID 25092008, PMID 25941185, PMID 26039070, PMID 26284824, PMID 26475403, PMID 26629534, PMID 26668589, PMID 27080865, PMID 27920321, PMID 28061017, PMID 28158504, PMID 28207680, PMID 28679676, PMID 28716049, PMID 28801393, PMID 28851459, PMID 28855962, PMID 29255898, PMID 29336496, PMID 29379114, PMID 29461920

NIH funding

2025 (5), 2023 (4), U54AA027989 (4), P50AA010761 (3), 2015 (2), K24AA026326 (2), P01AA029545 (2), P50AA012870 (2), P50AA027054 (2), P60AA007611 (2), R01AA025247 (2), R01AA026605 (2), R01AA027381 (2), 1IK2RX001492-01A1 (1), 2016 (1)