19 completed. 19 Phase 2, 5 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 19 | Completed 19 |
| Phase 3 | 5 | Completed 5 |
Follow Adenomatous Polyps: new trials by email Literature Review of Adenomatous Polyps trials Research Report on Adenomatous Polyps
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The CHAMP-study: The CHemopreventive Effect of Lithium in Familial AdenoMatous Polyposis Lithium Carbonate - Familial Adenomatous Polyposis | Phase 2 | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 12 | 2022-06-02 | 2024-10-04 |
| Trial of eRapa to Prevent Progression in Familial Adenomatous Polyposis Patients Under Active Surveillance Encapsulated Rapamycin (eRapa) - Familial Adenomatous Polyposis | Phase 2 | Completed | Rapamycin Holdings Inc. | 30 | 2021-01-18 | 2026-10-22 |
| Erlotinib Hydrochloride in Reducing Duodenal Polyp Burden in Patients With Familial Adenomatous Polyposis at Risk of Developing Colon Cancer Erlotinib, Erlotinib Hydrochloride - Attenuated Familial Adenomatous Polyposis, Familial Adenomatous Polyposis | Phase 2 | Completed | National Cancer Institute (NCI) | 46 | 2017-10-27 | 2022-07-26 |
| Sirolimus and Familial Adenomatous Polyposis (FAP) Sirolimus - Adenomatous Polyposis Coli | Phase 2 | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 4 | 2017-10-03 | 2024-10-24 |
| The Chemopreventive Effect of Metformin in Patients With Familial Adenomatous Polyposis: Double Blinded Randomized Controlled Study Metformin, Placebo - Familial Adenomatous Polyposis | Phase 2 | Completed | Yonsei University | 34 | 2013-02-15 | 2021-09-20 |
| Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMI metformin hydrochloride - Adenomatous Polyp, Colorectal Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 45 | 2011-03-01 | 2019-03-05 |
| Curcumin in Treating Patients With Familial Adenomatous Polyposis Curcumin, Laboratory Biomarker Analysis, Placebo - Familial Adenomatous Polyposis | Phase 2 | Completed | National Cancer Institute (NCI) | 44 | 2010-10-01 | 2017-09-29 |
| A Clinical Trial of COX and EGFR Inhibition in Familial Polyposis Patients Erlotinib, Sulindac, Placebo A - Adenomatous Polyposis Coli | Phase 2 | Completed | University of Utah | 92 | 2010-04-01 | 2016-06-17 |
| Macrogol 3350-based Oral Osmotic Laxative in Preventing Cancer in Patients at Risk of Colorectal Cancer macrogol 3350-based oral osmotic laxative, Placebo, Laboratory Biomarker Analysis - Adenomatous Polyp, Colorectal Carcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 87 | 2009-10-01 | 2017-04-18 |
| Acetylsalicylic Acid and Eflornithine in Treating Patients at High Risk for Colorectal Cancer Aspirin, Eflornithine, Laboratory Biomarker Analysis - Adenomatous Polyp | Phase 2 | Completed | National Cancer Institute (NCI) | 107 | 2009-08-20 | 2019-09-04 |
| Prevention of Progression of Duodenal Adenomas in Patients With Familial Adenomatous Polyposis Celecoxib, Ursodeoxycholic acid, Placebo - Familial Adenomatous Polyposis, Duodenal Neoplasms | Phase 2 / Phase 3 | Completed | Radboud University Medical Center | 37 | 2009-05-01 | 2013-05-16 |
| Erlotinib Hydrochloride in Treating Patients With Stage I-III Colorectal Cancer or Adenoma erlotinib hydrochloride, placebo, laboratory biomarker analysis - Adenomatous Polyp, Recurrent Colon Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 45 | 2008-07-01 | 2015-01-06 |
| Chemoprevention Trial in Familial Adenomatous Polyposis (FAP) Coli Using EPA Eicosapentanoic Acid (EPA), Endoscopy, Biopsies taken - Familial Adenomatous Polyposis Coli, FAP | Phase 2 / Phase 3 | Completed | S.L.A. Pharma AG | 58 | 2006-11-01 | 2014-08-22 |
| Effect of 2 Doses of EPA on Apoptosis and Cell Proliferation on Colon Mucosa Eicosapentaenoic Acid (EPA), Endoscopy, Biopsies taken - Adenomatous Polyps | Phase 2 / Phase 3 | Completed | S.L.A. Pharma AG | 120 | 2006-10-01 | 2008-10-17 |
| Calcium and Vitamin D vs Markers of Adenomatous Polyps Calcium and vitamin D3 combined, Placebo, Calcium - Colorectal Adenomatous Polyps | Phase 2 | Completed | Emory University | 92 | 2005-05-01 | 2013-11-26 |
| Vitamin D/Calcium Polyp Prevention Study Calcium Carbonate, Vitamin D3, placebo - Colorectal Cancer, Polyps | Phase 2 / Phase 3 | Completed | Dartmouth-Hitchcock Medical Center | 2813 | 2004-07-01 | 2017-03-15 |
| Molecular Targeting of 15-Lipoxygenase-1 (15-LOX-1) for Apoptosis Induction in Human Colorectal Cancers Celecoxib, Colonoscopy Biopsy - Familial Adenomatous Polyposis | Phase 2 | Completed | M.D. Anderson Cancer Center | 51 | 2003-08-20 | 2023-02-13 |
| Celecoxib With or Without Eflornithine in Preventing Colorectal Cancer in Patients With Familial Adenomatous Polyposis Celecoxib, Placebo, eflornithine - Colorectal Cancer, Familial Adenomatous Polyposis | Phase 2 | Completed | National Cancer Institute (NCI) | 205 | 2001-12-13 | 2020-09-29 |
| Aspirin/Folate Prevention of Large Bowel Polyps Aspirin, Folate - Colorectal Cancer, Polyps | Phase 2 / Phase 3 | Completed | Dartmouth-Hitchcock Medical Center | 1121 | 1992-02-01 | 2020-03-13 |
Adenomatous Polyposis Coli (11) · Colorectal Neoplasms (6) · Polyps (5) · Adenoma (3) · Hyperplasia (2) · Attenuated familial adenomatous polyposis (1) · Colonic Neoplasms (1) · Colonic Polyps (1) · Digestive System Diseases (1) · Digestive System Neoplasms (1) · Duodenal Neoplasms (1) · Gastrointestinal Diseases (1) · Gastrointestinal Neoplasms (1) · Genetic Diseases, Inborn (1)
Neoplasms (19) · Neoplasms by Histologic Type (19) · Neoplasms, Glandular and Epithelial (19) · Adenoma (16) · Colonic Diseases (16) · Neoplasms by Site (16) · Digestive System Diseases (15) · Digestive System Neoplasms (15) · Gastrointestinal Diseases (15) · Gastrointestinal Neoplasms (15) · Intestinal Diseases (15) · Intestinal Neoplasms (15) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (11) · Intestinal Polyposis (11)
Celecoxib (3) · Erlotinib Hydrochloride (3) · Aspirin (2) · Cholecalciferol (2) · Eflornithine (2) · Eicosapentaenoic Acid (2) · Endoscopy (2) · Metformin (2) · Calcium (1) · Calcium Carbonate (1) · Clinical Chemistry Tests (1) · Colonoscopy (1) · Curcumin (1) · Folic Acid (1) · Lithium Carbonate (1)
National Cancer Institute (NCI) (7) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Dartmouth-Hitchcock Medical Center (2) · S.L.A. Pharma AG (2) · Emory University (1) · M.D. Anderson Cancer Center (1) · Radboud University Medical Center (1) · Rapamycin Holdings Inc. (1) · University of Utah (1) · Yonsei University (1)
United States (13) · Netherlands (3) · Puerto Rico (3) · Canada (2) · United Kingdom (2) · Italy (1) · South Korea (1)
Nicholas J West, MB BS FRCS (2) · Bjorn WH van Heumen, MD (1) · Ellen Kampman, Ph D (1) · Evelien Dekker, MD, PhD (1) · Fokko M Nagengast, MD, Ph D (1) · Francis Giardiello (1) · Frank A Sinicrope (1) · Gary Shangold, MD (1) · Imad Shureiqi, MD (1) · Jason Zell (1) · John A Baron, MD, MSc (1) · John A. Baron, MD (1) · Niloy J Samadder (1) · Niloy J Samadder, MD (1) · Patrick Lynch (1)
PMID 34289971, PMID 37119510, PMID 12621133, PMID 17551129, PMID 18541589, PMID 19258546, PMID 19861511, PMID 19923375, PMID 20056649, PMID 20332274, PMID 20348368, PMID 20516268, PMID 21084270, PMID 21724580, PMID 22149065, PMID 22964475, PMID 23170065, PMID 23919274, PMID 24014734, PMID 24166893, PMID 24245549, PMID 25070320, PMID 25329821, PMID 25792707, PMID 26465985, PMID 27002448, PMID 27094489, PMID 27474021, PMID 27683872, PMID 27978548, PMID 28218420, PMID 28767463, PMID 29423501, PMID 29496722, PMID 29617381, PMID 29802852, PMID 30012100, PMID 31263057, PMID 31401653, PMID 33022713, PMID 33376109, PMID 33509804, PMID 34762658, PMID 35636921, PMID 35962368, PMID 36701139
N01CN35160 (2), P30CA015083 (2), N01CN00042 (1), N01CN35157 (1), P01CA073992 (1), P30CA006973 (1), P30CA016672 (1), P30CA060553 (1), P30CA062203 (1), R01CA098286 (1), R01CA104637 (1), R01CA106577 (1), R01CA113681 (1), R01CA134620 (1)