19 completed, 4 recruiting, 4 unknown, 1 not yet recruiting. 30 Phase 2, 6 Phase 3, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 30 | Completed 19, Recruiting 4, Unknown 4, Not yet recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 3 | 6 | Completed 5, Unknown 1 |
| Phase 1 | 3 | Recruiting 3 |
Follow Adenomatous Polyps: new trials by email Literature Review of Adenomatous Polyps trials Research Report on Adenomatous Polyps
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety Study for the Use of Rapamycin in Children With Familial Adenomatous Polyposis Rapamycin - Familial Adenomatous Polyposis | Phase 2 | Not yet recruiting | University Hospital, Toulouse | 25 | 2026-09-01 | 2026-05-08 |
| An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis Biopsy Procedure, Biospecimen Collection, EP2/EP4 Antagonist TPST-1495 - Colorectal Carcinoma, Familial Adenomatous Polyposis | Phase 2 | Recruiting | National Cancer Institute (NCI) | 38 | 2026-03-31 | 2026-09-14 |
| Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma Tegavivint - Metastatic Colorectal Carcinoma (mCRC), Colorectal Cancer (CRC) | Phase 1 / Phase 2 | Recruiting | HonorHealth Research Institute | 126 | 2026-02-17 | 2026-03-11 |
| Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP) REC-4881, Placebo - Familial Adenomatous Polyposis | Phase 1 / Phase 2 | Recruiting | Recursion Pharmaceuticals Inc. | 67 | 2023-07-10 | 2026-06-05 |
| FOG-001 in Locally Advanced or Metastatic Solid Tumors FOG-001, mFOLFOX-6, Nivolumab - Cancer, Colorectal Cancer | Phase 1 / Phase 2 | Recruiting | Parabilis Medicines, Inc. | 619 | 2023-05-23 | 2026-10-07 |
| Testing Obeticholic Acid for Familial Adenomatous Polyposis Biopsy Procedure, Biospecimen Collection, Gastrointestinal Endoscopy - Attenuated Familial Adenomatous Polyposis, Colorectal Carcinoma | Phase 2 | Terminated | National Cancer Institute (NCI) | 15 | 2023-01-19 | 2026-05-14 |
| The CHAMP-study: The CHemopreventive Effect of Lithium in Familial AdenoMatous Polyposis Lithium Carbonate - Familial Adenomatous Polyposis | Phase 2 | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 12 | 2022-06-02 | 2024-10-04 |
| Trial of eRapa to Prevent Progression in Familial Adenomatous Polyposis Patients Under Active Surveillance Encapsulated Rapamycin (eRapa) - Familial Adenomatous Polyposis | Phase 2 | Completed | Rapamycin Holdings Inc. | 30 | 2021-01-18 | 2026-10-22 |
| Niclosamide for Familial Adenomatous Polyposis Niclosamide, placebo - Familial Adenomatous Polyposis | Phase 2 | Unknown | Yonsei University | 72 | 2020-02-14 | 2020-03-05 |
| Erlotinib Hydrochloride in Reducing Duodenal Polyp Burden in Patients With Familial Adenomatous Polyposis at Risk of Developing Colon Cancer Erlotinib, Erlotinib Hydrochloride - Attenuated Familial Adenomatous Polyposis, Familial Adenomatous Polyposis | Phase 2 | Completed | National Cancer Institute (NCI) | 46 | 2017-10-27 | 2022-07-26 |
| Sirolimus and Familial Adenomatous Polyposis (FAP) Sirolimus - Adenomatous Polyposis Coli | Phase 2 | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 4 | 2017-10-03 | 2024-10-24 |
| Turmeric Supplementation on Polyp Number and Size in Patients With Familial Adenomatous Polyposis. Wholistic Turmeric capsules, Placebo - Familial Adenomatous Polyposis, FAP | Phase 2 | Unknown | Tel-Aviv Sourasky Medical Center | 40 | 2017-04-01 | 2017-02-23 |
| The Chemopreventive Effect of Metformin in Patients With Familial Adenomatous Polyposis: Double Blinded Randomized Controlled Study Metformin, Placebo - Familial Adenomatous Polyposis | Phase 2 | Completed | Yonsei University | 34 | 2013-02-15 | 2021-09-20 |
| Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMI metformin hydrochloride - Adenomatous Polyp, Colorectal Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 45 | 2011-03-01 | 2019-03-05 |
| Curcumin in Treating Patients With Familial Adenomatous Polyposis Curcumin, Laboratory Biomarker Analysis, Placebo - Familial Adenomatous Polyposis | Phase 2 | Completed | National Cancer Institute (NCI) | 44 | 2010-10-01 | 2017-09-29 |
| A Clinical Trial of COX and EGFR Inhibition in Familial Polyposis Patients Erlotinib, Sulindac, Placebo A - Adenomatous Polyposis Coli | Phase 2 | Completed | University of Utah | 92 | 2010-04-01 | 2016-06-17 |
| Macrogol 3350-based Oral Osmotic Laxative in Preventing Cancer in Patients at Risk of Colorectal Cancer macrogol 3350-based oral osmotic laxative, Placebo, Laboratory Biomarker Analysis - Adenomatous Polyp, Colorectal Carcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 87 | 2009-10-01 | 2017-04-18 |
| Acetylsalicylic Acid and Eflornithine in Treating Patients at High Risk for Colorectal Cancer Aspirin, Eflornithine, Laboratory Biomarker Analysis - Adenomatous Polyp | Phase 2 | Completed | National Cancer Institute (NCI) | 107 | 2009-08-20 | 2019-09-04 |
| Prevention of Progression of Duodenal Adenomas in Patients With Familial Adenomatous Polyposis Celecoxib, Ursodeoxycholic acid, Placebo - Familial Adenomatous Polyposis, Duodenal Neoplasms | Phase 2 / Phase 3 | Completed | Radboud University Medical Center | 37 | 2009-05-01 | 2013-05-16 |
| Erlotinib Hydrochloride in Treating Patients With Stage I-III Colorectal Cancer or Adenoma erlotinib hydrochloride, placebo, laboratory biomarker analysis - Adenomatous Polyp, Recurrent Colon Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 45 | 2008-07-01 | 2015-01-06 |
Showing 20 of 30. Sign in to see all of them.
Adenomatous Polyposis Coli (22) · Colorectal Neoplasms (10) · Polyps (5) · Adenoma (4) · Attenuated familial adenomatous polyposis (2) · Duodenal Neoplasms (2) · Hyperplasia (2) · Carcinoma, Hepatocellular (1) · Colonic Neoplasms (1) · Colonic Polyps (1) · Craniopharyngioma (1) · Desmoid Tumors (1) · Digestive System Diseases (1) · Digestive System Neoplasms (1)
Neoplasms by Histologic Type (30) · Neoplasms, Glandular and Epithelial (30) · Neoplasms (29) · Colonic Diseases (27) · Neoplasms by Site (27) · Adenoma (26) · Digestive System Diseases (26) · Digestive System Neoplasms (26) · Gastrointestinal Diseases (26) · Gastrointestinal Neoplasms (26) · Intestinal Diseases (26) · Intestinal Neoplasms (26) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (22) · Intestinal Polyposis (22)
Celecoxib (3) · Erlotinib Hydrochloride (3) · Aspirin (2) · Biopsy (2) · Cholecalciferol (2) · Curcumin (2) · Eflornithine (2) · Eicosapentaenoic Acid (2) · Endoscopy (2) · Endoscopy, Gastrointestinal (2) · Metformin (2) · Sirolimus (2) · Specimen Handling (2) · Sulindac (2) · Ursodeoxycholic Acid (2)
National Cancer Institute (NCI) (9) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Dartmouth-Hitchcock Medical Center (2) · Radboud University Medical Center (2) · S.L.A. Pharma AG (2) · Yonsei University (2) · Assistance Publique - Hôpitaux de Paris (1) · Emory University (1) · HonorHealth Research Institute (1) · Johns Hopkins University (1) · M.D. Anderson Cancer Center (1) · Parabilis Medicines, Inc. (1) · Rapamycin Holdings Inc. (1) · Recursion Pharmaceuticals Inc. (1) · Tel-Aviv Sourasky Medical Center (1)
United States (18) · Netherlands (4) · Puerto Rico (4) · Canada (2) · France (2) · South Korea (2) · United Kingdom (2) · Australia (1) · Italy (1)
Nicholas J West, MB BS FRCS (2) · Niloy J Samadder (2) · Benjamin Oshrine (1) · Bjorn WH van Heumen, MD (1) · Eduardo Vilar-Sanchez (1) · Ellen Kampman, Ph D (1) · Emmanuel Mas, Pr (1) · Evelien Dekker, MD, PhD (1) · Fokko M Nagengast, MD, Ph D (1) · Fokko M Nagengast, PhD (1) · Francis Giardiello (1) · Francis M Giardiello, M.D. (1) · Frank A Sinicrope (1) · Gary Shangold, MD (1) · Imad Shureiqi, MD (1)
PMID 34289971, PMID 37119510, PMID 12621133, PMID 17551129, PMID 18541589, PMID 19258546, PMID 19861511, PMID 19923375, PMID 20056649, PMID 20332274, PMID 20348368, PMID 20516268, PMID 21084270, PMID 21724580, PMID 21899713, PMID 22149065, PMID 22964475, PMID 23170065, PMID 23919274, PMID 24014734, PMID 24166893, PMID 24245549, PMID 25070320, PMID 25329821, PMID 25792707, PMID 26465985, PMID 27002448, PMID 27094489, PMID 27474021, PMID 27683872, PMID 27978548, PMID 28218420, PMID 28767463, PMID 29423501, PMID 29496722, PMID 29617381, PMID 29802852, PMID 30012100, PMID 31263057, PMID 31401653, PMID 33022713, PMID 33376109, PMID 33509804, PMID 34762658, PMID 35636921, PMID 35962368, PMID 36701139, PMID 39956770
N01CN35160 (2), P30CA015083 (2), P30CA016672 (2), N01CN00042 (1), N01CN35157 (1), P01CA073992 (1), P30CA006973 (1), P30CA014520 (1), P30CA060553 (1), P30CA062203 (1), R01CA098286 (1), R01CA104637 (1), R01CA106577 (1), R01CA113681 (1), R01CA134620 (1)