12 completed, 2 not yet recruiting, 2 recruiting, 1 terminated. 19 Phase 2, 6 Phase 3, 2 Phase 1.
Follow Acute Respiratory Failure: new trials by email Literature Review of Acute Respiratory Failure trials Research Report on Acute Respiratory Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early Inflammatory-Immune Stratification and Precision Glucocorticoid Intervention in Acute Respiratory Failure Induced by Community-Acquired Pneumonia Methylprednisolone - Acute Respiratory Failure, Community-Acquired Pneumonia | Phase 1 / Phase 2 | Not yet recruiting | Qingyuan Zhan | 500 | 2026-02-01 | 2026-01-22 |
| Physiological Effects of Nebulized Salbutamol in Acute Respiratory Failure Patients on HFNC salbutamol 2.5 mg via vibrating mesh nebulizer (VMN) - Acute Respiratory Failure, Pneumonia | Phase 2 / Phase 3 | Not yet recruiting | Università degli Studi di Ferrara | 20 | 2025-03-01 | 2025-02-07 |
| Infusion of Prostacyclin vs Placebo for 72-hours in Mechanically Ventilated Patients With Acute Respiratory Failure Iloprost, Isotonic saline - Acute Respiratory Failure, Endothelial Dysfunction | Phase 2 | Recruiting | Pär Johansson | 450 | 2024-04-15 | 2025-08-22 |
| Viscoelastic Testing Guided Tissue Plasminogen Activator Treatment in Acute Respiratory Failure Alteplase - Acute Respiratory Failure, Hypercoagulability | Phase 2 | Recruiting | South West Sydney Local Health District | 70 | 2022-05-18 | 2024-04-17 |
| Propofol Versus Ketamine for Rapid Sequence Intubation in Critically Ill Patients Esketamine, Propofol - Acute Respiratory Failure | Phase 2 | Completed | Federal University of São Paulo | 207 | 2021-10-23 | 2026-04-17 |
| Low Dose Morphine to Relieve Dyspnea in Acute Respiratory Failure (OPIDYS) Chlorhydrate de morphine, NaCl 0,9%, - Acute Respiratory Failure | Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 23 | 2020-12-16 | 2022-10-25 |
| REmimazolam Infusion in the Context of Hypnotic Shortage in the Critical Care Unit During the Pandemic of COVID-19: REHSCU Study Remimazolam - Acute Respiratory Failure, COVID-19 | Phase 2 | Completed | Nantes University Hospital | 30 | 2020-11-30 | 2021-11-04 |
| Revefenacin in Acute Respiratory Insufficiency in COPD Revefenacin Inhalation Solution [Yupelri], Ipratropium Bromide - COPD, Acute Respiratory Failure | Phase 2 | Completed | University of California, Los Angeles | 21 | 2020-11-01 | 2026-10-14 |
| Treatment of Lung Injury From COVID-19 Infection With Intravenous Sodium Nitrite Sodium Nitrite, Normal Saline - COVID-19, Acute Respiratory Distress Syndrome | Phase 2 | Withdrawn | Hope Pharmaceuticals | 2020-07-22 | 2020-09-16 | |
| Safety and Efficacy of Hyperbaric Oxygen for ARDS in Patients With COVID-19 Hyperbaric oxygen - SARS (Severe Acute Respiratory Syndrome), Cytokine Storm | Phase 2 / Phase 3 | Terminated | Karolinska Institutet | 34 | 2020-06-03 | 2023-01-09 |
| Mavrilimumab in Severe COVID-19 Pneumonia and Hyper-inflammation (COMBAT-19) Mavrilimumab, Placebo - Covid-19, Acute Respiratory Failure | Phase 2 | Unknown | Ospedale San Raffaele | 50 | 2020-05-22 | 2020-05-26 |
| Nutrition and Exercise in Critical Illness IV amino acids, In-bed cycle ergometry exercise - Acute Respiratory Failure | Phase 2 | Completed | Clinical Evaluation Research Unit at Kingston General Hospital | 115 | 2017-09-28 | 2025-08-27 |
| Enteral Feeding Composition and Acute Respiratory Failure high-protein low-carbohydrate diet with high olive oil, high-protein low-carbohydrate diet with high sunflower oil - Acute Respiratory Failure | Phase 2 / Phase 3 | Completed | Zahra Vahdat Shariatpanahi | 48 | 2013-08-01 | 2016-03-22 |
| Testing the Feasibility of Patient Controlled Sedation for Ventilated ICU Patients Dexmedetomidine - Acute Respiratory Failure, Anxiety | Phase 1 / Phase 2 | Completed | University of Minnesota | 15 | 2013-03-01 | 2018-03-13 |
| Clinical Effect of the Association of Noninvasive Ventilation and High Flow Nasal Oxygen Therapy in Resuscitation of Patients With Acute Lung Injury (FLORALI Study) O2 conventional, O2-HFN : high flow nasal oxygen therapy, O2-HFN/NPPV : association of high flow nasal oxygen therapy and non invasive positive pressure ventilation - Acute Lung Injury, Acute Respiratory Failure | Phase 2 / Phase 3 | Completed | Poitiers University Hospital | 313 | 2011-03-01 | 2016-10-11 |
| Efficacy and Safety of Dexmedetomidine During Non-Invasive Positive Pressure Ventilation Dexmedetomidine, Placebo - Acute Respiratory Failure | Phase 2 | Completed | Tufts Medical Center | 36 | 2009-03-01 | 2017-12-18 |
| Early Mechanical Ventilation for Guillain Barré Syndrome mechanical ventilation, physiotherapy and oxygen if needed - Guillain Barré Syndrome, Acute Respiratory Failure | Phase 2 | Completed | University of Versailles | 50 | 2005-04-01 | 2016-07-20 |
| Timing of Target Enteral Feeding in the Mechanically Ventilated Patient trophic enteral feeds - Acute Respiratory Failure | Phase 2 / Phase 3 | Completed | Vanderbilt University | 200 | 2003-09-01 | 2013-12-17 |
| Heparin Binding Protein in Patients With Acute Respiratory Failure Treated With GCSF (Filgrastim) Filgrastim - Acute Respiratory Failure, Critically Ill | Phase 2 / Phase 3 | Completed | Helsinki University Central Hospital | 59 | 1996-01-01 | 2012-10-29 |
COVID-19 (4) · Respiratory Distress Syndrome (3) · Pneumonia (2) · Respiratory Insufficiency (2) · Acute Lung Injury (1) · Anxiety Disorders (1) · Community-Acquired Pneumonia (1) · Critical Illness (1) · Cytokine Release Syndrome (1) · Dyspnea (1) · Guillain-Barre Syndrome (1) · Pneumonia, Viral (1) · Pulmonary Disease, Chronic Obstructive (1) · Sepsis (1) · Severe Acute Respiratory Syndrome (1)
Respiratory Tract Diseases (11) · Lung Diseases (8) · Infections (7) · Respiratory Tract Infections (7) · Pathological Conditions, Signs and Symptoms (6) · Pathologic Processes (5) · Pneumonia (5) · Respiration Disorders (5) · Coronaviridae Infections (4) · Coronavirus Infections (4) · Nidovirales Infections (4) · RNA Virus Infections (4) · Virus Diseases (4) · Disease Attributes (3) · Pneumonia, Viral (3)
Dexmedetomidine (2) · Albuterol (1) · Amino Acids (1) · Diet, High-Protein Low-Carbohydrate (1) · Esketamine (1) · Filgrastim (1) · Hyperbaric Oxygenation (1) · Iloprost (1) · Injections (1) · Ipratropium (1) · Methylprednisolone (1) · Methylprednisolone Hemisuccinate (1) · Physical Therapy Modalities (1) · Propofol (1) · Respiration, Artificial (1)
Assistance Publique - Hôpitaux de Paris (1) · Clinical Evaluation Research Unit at Kingston General Hospital (1) · Federal University of São Paulo (1) · Helsinki University Central Hospital (1) · Hope Pharmaceuticals (1) · Karolinska Institutet (1) · Nantes University Hospital (1) · Ospedale San Raffaele (1) · Poitiers University Hospital (1) · Pär Johansson (1) · Qingyuan Zhan (1) · South West Sydney Local Health District (1) · Tufts Medical Center (1) · University of California, Los Angeles (1) · University of Minnesota (1)
United States (6) · France (4) · Italy (2) · Australia (1) · Brazil (1) · Denmark (1) · Finland (1) · Germany (1) · Iran (1) · Sweden (1)
Anders Aneman (1) · Anders Kjellberg, MD (1) · Carlo Alberto Volta, Professor (1) · Craig Weinert, MD (1) · Dale M Needham, MD, PhD (1) · Daren K Heyland, MD, MSc (1) · Donald Tashkin, MD (1) · Flavia R Machado, MD, PhD (1) · Igor Z Barjaktarevic, MD, PhD (1) · Kenny Rodriguez-Wallberg, MD, PhD (1) · Kirsi-Maija Kaukonen, MD, PhD (1) · Lorenzo Dagna, MD (1)
PMID 11098963, PMID 15883741, PMID 21242788, PMID 23363492, PMID 25981908, PMID 31371287, PMID 32997260, PMID 34226219, PMID 34930871, PMID 36175968, PMID 36743674, PMID 36765421, PMID 37510965, PMID 37607815, PMID 38675226, PMID 38783367, PMID 39014448, PMID 39393522, PMID 40174701, PMID 41259542, PMID 41870554, PMID 42438140
2019 (1), R21NR012795 (1)