138 completed, 66 unknown, 27 recruiting, 20 terminated. 129 Not applicable, 19 Phase 2, 16 Phase 3, 8 Phase 4, 3 Phase 1.
Follow Acute Respiratory Failure: new trials by email Literature Review of Acute Respiratory Failure trials Research Report on Acute Respiratory Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport Advanced Respiratory Support During Patient Transport - Acute Respiratory Failure, Respiratory Insufficiency | Not yet recruiting | Medipol University | 565 | 2026-12-31 | 2026-09-04 | |
| Lactate/Albumin Ratio and Mortality in Respiratory Failure Assessment of Admission Serum Lactate-to-Albumin Ratio (LAR) - Acute Respiratory Failure, Critical Illness | Not yet recruiting | Kocaeli City Hospital | 1250 | 2026-11-01 | 2026-11-02 | |
| Mechanical Power During Pressure Controlled Versus Volume-Controlled Ventilation in Acute Respiratory Failure Mechanical Power, Acute Respiratory Failure | Not yet recruiting | Assiut University | 186 | 2026-10-30 | 2026-09-22 | |
| Diaphragm Response in Elderly for Acute Monitoring Acute Dyspnea, Acute Respiratory Failure | Not yet recruiting | Centre Hospitalier de Bethune | 145 | 2026-10-01 | 2026-10-26 | |
| INtubation With Sedation Only to Preserve Independent Respiratory Effort Trial Intubation with a sedative medication only, Intubation with a sedative medication and neuromuscular blockade agent - Acute Respiratory Failure | Not applicable | Enrolling by invitation | Vanderbilt University Medical Center | 228 | 2026-09-28 | 2026-09-30 |
| Research on Respiratory Support Decision-Making for Mechanically Ventilated ICU Patients Based on a Physiological World Model Acute Respiratory Failure | Not yet recruiting | Ruijin Hospital | 4232 | 2026-09-14 | 2026-09-22 | |
| ICU-SUCCEED for Survivors of Acute Respiratory Failure and Their Caregivers ICU-SUCCEED, Augmented Usual Care - Acute Respiratory Failure, Critical Illness | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 144 | 2026-09-01 | 2026-08-21 |
| Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and/or Acute Respiratory Failure Hydrocortisone Hemisuccinate: 200 mg per day., reduction of the level of immunosuppression - Sepsis and Septic Shock, Acute Respiratory Failure | Phase 4 | Recruiting | University Hospital, Strasbourg, France | 212 | 2026-08-11 | 2026-08-20 |
| Evaluation of Perfusion and Ventilation Distribution in Children: a Pilot Study. Evaluation of perfusion with Electrical impedance tomography using sodium chloride or sodium bicarbonate - Acute Respiratory Failure | Not applicable | Recruiting | Hospices Civils de Lyon | 20 | 2026-05-13 | 2026-05-19 |
| Examination of Personalized SpO2 Targets Personalized SpO2 Target, Usual Care - Acute Respiratory Failure | Not applicable | Enrolling by invitation | Vanderbilt University Medical Center | 3000 | 2026-05-12 | 2026-05-20 |
| Brain-lung Interaction During Acute Respiratory Failure EEG/NIRS/EMG - Acute Respiratory Failure | Recruiting | Assistance Publique - Hôpitaux de Paris | 25 | 2026-04-22 | 2026-10-14 | |
| Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients Proteomic analysis of exhaled breath condensate - Acute Respiratory Failure, Critical Illness | Recruiting | The Institute of Molecular and Translational Medicine, Czech Republic | 200 | 2026-03-01 | 2026-06-25 | |
| Early Inflammatory-Immune Stratification and Precision Glucocorticoid Intervention in Acute Respiratory Failure Induced by Community-Acquired Pneumonia Methylprednisolone - Acute Respiratory Failure, Community-Acquired Pneumonia | Phase 1 / Phase 2 | Not yet recruiting | Qingyuan Zhan | 500 | 2026-02-01 | 2026-01-22 |
| The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique Cardiogenic Shock, Malignant Arrhythmias | Not yet recruiting | University of Genova | 1200 | 2026-02-01 | 2026-01-20 | |
| ICU Admission Diagnoses and ICU Mortality Critical Illness, Sepsis | Completed | Ataturk University | 1248 | 2026-01-30 | 2026-02-04 | |
| Hyperangulated Versus Standard Geometry Laryngoscope Blade Trial Hyperangulated video laryngoscope blade, Standard geometry video laryngoscope blade - Acute Respiratory Failure | Not applicable | Enrolling by invitation | Vanderbilt University Medical Center | 2500 | 2025-12-30 | 2026-09-21 |
| Acute DYSPnea in the Emergency Department: Diagnostic Value of Point-of-care UltraSound Hydrostatic Pulmonary Edema, Acute Respiratory Failure | Recruiting | Università degli Studi del Piemonte Orientale Amedeo Avogadro | 200 | 2025-11-01 | 2026-01-08 | |
| Comparison of Two SpO2 Targets With Two Different Oximeters - Impact on FiO2 During Nasal High Flow Oxygen Therapy Manual FiO2 titration with Philips oximeter (SpO2 target 90%), Manual FiO2 titration with Nonin oximeter (SpO2 target 90%), Manual FiO2 titration with Philips oximeter (SpO2 target 94%) - Oxygen Delivery, Acute Respiratory Failure | Not applicable | Recruiting | Laval University | 30 | 2025-10-21 | 2026-03-09 |
| Evaluating the Safety and Performance of the MiniLung Petite Kit in Neonatal and Pediatric Patients With Acute Respiratory and Cardiac Failure MiniLung petite kit combined with the Xenios console - Extracorporeal Membrane Oxygenation Complication, Neonatal Aspiration Pneumonia | Recruiting | Xenios AG | 20 | 2025-10-12 | 2025-12-24 | |
| Simulation Trial of Telemedical Support for Paramedics Video teleconsultation, Audio support - Emergencies, Cardiopulmonary Arrest | Not applicable | Recruiting | Boston Medical Center | 420 | 2025-07-10 | 2026-06-30 |
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Respiratory Distress Syndrome (31) · Critical Illness (28) · COVID-19 (22) · Respiratory Insufficiency (22) · Pneumonia (13) · Dyspnea (10) · Hypoxia (9) · Sepsis (9) · Shock (9) · Pulmonary Disease, Chronic Obstructive (8) · Acute Lung Injury (7) · Emergencies (6) · Heart Arrest (6) · Heart Failure (6) · Hypercapnia (6)
Respiratory Tract Diseases (106) · Pathological Conditions, Signs and Symptoms (84) · Lung Diseases (79) · Pathologic Processes (66) · Respiration Disorders (64) · Infections (49) · Disease Attributes (46) · Respiratory Tract Infections (35) · Signs and Symptoms (32) · Coronaviridae Infections (24) · Nidovirales Infections (24) · RNA Virus Infections (24) · Signs and Symptoms, Respiratory (24) · Virus Diseases (24) · Pneumonia (22)
Noninvasive Ventilation (12) · Continuous Positive Airway Pressure (5) · Dexmedetomidine (3) · Enteral Nutrition (3) · Ketamine (3) · Oxygen (3) · Parenteral Nutrition (3) · Respiration, Artificial (3) · Amino Acids (2) · Blood Gas Analysis (2) · Etomidate (2) · Extracorporeal Membrane Oxygenation (2) · Interactive Ventilatory Support (2) · Masks (2) · Prone Position (2)
Assistance Publique - Hôpitaux de Paris (13) · Vanderbilt University Medical Center (11) · University Magna Graecia (9) · Poitiers University Hospital (7) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (5) · Hospital Universitari Vall d'Hebron Research Institute (5) · Nantes University Hospital (4) · Southeast University, China (4) · University Hospital, Montpellier (4) · University of Vermont (4) · Università degli Studi di Ferrara (4) · Centre Hospitalier Departemental Vendee (3) · Dr. Behcet Uz Children's Hospital (3) · Hennepin Healthcare Research Institute (3) · Ruijin Hospital (3)
United States (71) · France (55) · Italy (49) · China (15) · Spain (15) · Turkey (Türkiye) (15) · Brazil (6) · Canada (6) · Egypt (6) · Greece (5) · South Korea (5) · Germany (4) · Sweden (4) · Taiwan (4) · Australia (3)
Federico Longhini, MD (9) · Giovanna Chidini, MD (4) · Matthew W Semler, MD, MSc (4) · Jonathan D Casey, MD, MSc (3) · Nicholas S Hill, MD (3) · Todd W Rice, MD, MSc (3) · Adit A Ginde, MD, MPH (2) · Brian E Driver, MD (2) · Elie Azoulay, MD,PhD (2) · Hasan Agin, Professor (2) · Hongping Qu (2) · Jesus Villar, MD, PhD (2) · Jorge IF Salluh, MD, PhD (2) · Paolo Pelosi, Professor (2)
PMID 20660548, PMID 26464393, PMID 26493592, PMID 37326325, PMID 38341938, PMID 39073580, PMID 10752330, PMID 10768086, PMID 11066187, PMID 11098963, PMID 11810114, PMID 12706763, PMID 15190137, PMID 15537123, PMID 15791098, PMID 15883741, PMID 16215375, PMID 16267363, PMID 16354864, PMID 17573487, PMID 17585106, PMID 18048893, PMID 18242994, PMID 19001507, PMID 19029434, PMID 19183949, PMID 19242333, PMID 19293693, PMID 19561556, PMID 19789456, PMID 19794328, PMID 19800091, PMID 19880908, PMID 20207275, PMID 20429929, PMID 20581167, PMID 21242788, PMID 21906390, PMID 21907451, PMID 22202709, PMID 22417884, PMID 22610179, PMID 22661448, PMID 22721944, PMID 22885649, PMID 23154957, PMID 23184037, PMID 23184866, PMID 23335231, PMID 23363492
1UG3HL141722-01A1 (1), 1UG3HL147011-01A1 (1), 2019 (1), K01HL141637 (1), K23HL141704 (1), K23HL153584 (1), K23HL171951 (1), K23HL181100 (1), R01HD115574 (1), R01HL141608 (1), R01HL158626 (1), R01HL163660 (1), R01HL168474 (1), R21NR012795 (1), R43AT013038 (1)