9 unknown, 6 completed, 5 recruiting, 3 terminated. 18 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 18 | Unknown 6, Completed 4, Recruiting 4, Terminated 3, Not yet recruiting 1 |
Follow Acute Hypercapnic Respiratory Failure: new trials by email Literature Review of Acute Hypercapnic Respiratory Failure trials Research Report on Acute Hypercapnic Respiratory Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Asymmetrical High Flow Oxygen Versus Noninvasive Ventilation in Acute Hypercapnic Respiratory Failure asymmetrical high-flow nasal cannula, non-invasive ventilation with standard mask, non-invasive ventilation with a new mask - Acute Hypercapnic Respiratory Failure | Not applicable | Not yet recruiting | Unity Health Toronto | 24 | 2025-08-25 | 2025-09-05 |
| Pilot Physiological Evaluation of an Investigational Mask with Expiratory Washout. Investigational full-face mask with expiratory washout, Conventional full-face mask - single-limb, Conventional full-face mask - dual-limb - Acute Hypercapnic Respiratory Failure, Acute Hypoxemic Respiratory Failure | Not applicable | Unknown | Fisher and Paykel Healthcare | 32 | 2024-05-06 | 2025-03-14 |
| Impact of Negative Pressure Ventilation in Patients Hospitalized With Acute Hypercapnic Respiratory Failure Intervention Arm (Biphasic cuirass ventilation) - Acute Hypercapnic Respiratory Failure | Not applicable | Terminated | University of Missouri-Columbia | 50 | 2024-04-03 | 2026-02-13 |
| Closed-Loop O2 Use During High Flow Oxygen Treatment of Critical Care Adult Patients (CLOUDHFOT) Closed-loop FiO2 controller, Conventional - Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure | Not applicable | Recruiting | Başakşehir Çam & Sakura City Hospital | 50 | 2024-03-21 | 2025-01-28 |
| Asymmetrical Versus Conventional High-flow Nasal Cannula in Acute Respiratory Failure Experimental: Asymmetrical high-flow nasal cannula, Active comparator: Conventional high-flow nasal cannula - Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure | Not applicable | Completed | Siriraj Hospital | 40 | 2024-01-20 | 2026-04-24 |
| Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prospective Observational Single Center Study Respiratory Insufficiency, Acute Hypercapnic Respiratory Failure | Unknown | Yonsei University | 100 | 2023-11-01 | 2023-10-03 | |
| HFNC vs. NIV in Acute COPD Exacerbations NIV, HFNC-30, HFNC-50 - COPD Exacerbations, Acute Hypercapnic Respiratory Failure | Not applicable | Completed | Haseki Training and Research Hospital | 137 | 2023-09-01 | 2024-07-10 |
| ReAcT CO2: A Study to Assess TcCO2 to Guide Acute NIV Trancutaneous CO2 monitoring (using TCM5 device), Arterial Blood Gas (ABG) sampling - Acute Hypercapnic Respiratory Failure | Not applicable | Unknown | Nottingham University Hospitals NHS Trust | 60 | 2023-02-10 | 2023-01-06 |
| The ROTAtional-USE of Interface STUDY Protocolized rotational use of interfaces, Standard of care - Pressure Ulcer, Noninvasive Positive Pressure Ventilation | Not applicable | Recruiting | Azienda Ospedaliero Universitaria Maggiore della Carita | 478 | 2022-12-08 | 2024-11-14 |
| High Flow Nasal Cannula Versus Non-Invasive (NIV)in Both Hypoxemic and Hypercapnic Respiratory Failure. High flow nasal cannula (HFNC), Non-Invasive Mechanical Ventilation (NIV) - Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure | Not applicable | Unknown | Assiut University | 80 | 2022-10-10 | 2022-09-01 |
| The Simplify Project High-flow nasal cannula therapy - Acute Hypercapnic Respiratory Failure | Recruiting | Unity Health Toronto | 50 | 2021-09-01 | 2025-05-20 | |
| High VS Low Flow Nasal O2 for Acute Hypercapnic Respiratory Failure High flow nasal therapy, Low flow oxygen - Acute Hypercapnic Respiratory Failure, Acute Exacerbation of COPD | Not applicable | Unknown | Belfast Health and Social Care Trust | 82 | 2021-06-13 | 2022-04-21 |
| High Pressure Non Invasive Ventilation in Hypercapnic Respiratory Failure High pressure non invasive ventilation in acute hypercapnic respiratory failure - Acute Hypercapnic Respiratory Failure | Unknown | Assiut University | 52 | 2020-08-01 | 2020-07-13 | |
| CO2 Clearance During Noninvasive Ventilation (NIV) DiMax Zero Total face mask "R",, traditional face mask - Acute Hypercapnic Respiratory Failure | Not applicable | Unknown | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 20 | 2019-01-01 | 2018-11-28 |
| The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU Toning, Ocean drum & SOK melody, SOK - Acute Respiratory Distress Syndrome, Acute Hypoxemic Respiratory Failure | Not applicable | Recruiting | Icahn School of Medicine at Mount Sinai | 178 | 2018-12-12 | 2025-04-09 |
| Under the Nose Face Mask to Prevent Facial Pressure Ulcers During NIV for Acute Hypercapnic Respiratory Failure (AHRF) Under-the-nose facemask, Over-the-nose facemask - Acute Hypercapnic Respiratory Failure | Not applicable | Completed | Centre Hospitalier Arras | 108 | 2018-11-21 | 2022-03-15 |
| High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease Non Invasive Ventilation, High Flow Oxygen Cannula 50, High Flow Oxygen Cannula 30 - Exacerbation Copd, Acute Respiratory Distress | Not applicable | Recruiting | Unity Health Toronto | 30 | 2018-09-02 | 2025-05-20 |
| HFNC and Acute Hypercapnic Respiratory Failure High Flow Oxygen Therapy, Acute Hypercapnic Respiratory Failure | Completed | Argentinian Intensive Care Society | 40 | 2018-08-01 | 2019-10-23 | |
| Integrated Care of Co-morbidities vs Standard Care After AHRF in the Intensive Care Unit Bundle of comorbidities care - Acute Hypercapnic Respiratory Failure | Not applicable | Terminated | CTU | 188 | 2018-05-28 | 2023-05-12 |
| Sedation During Noninvasive Ventilation (NIV) Remifentanil - Acute Hypercapnic Respiratory Failure | Not applicable | Unknown | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 15 | 2014-10-01 | 2016-10-11 |
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Respiratory Insufficiency (24) · Acute Lung Injury (1) · Heart Failure (1) · Pressure Ulcer (1) · Pulmonary Disease, Chronic Obstructive (1) · Respiratory Distress Syndrome (1) · Sleep Apnea, Obstructive (1) · Sleep Disorders, Intrinsic (1)
Respiration Disorders (24) · Respiratory Tract Diseases (24) · Lung Diseases (3) · Dyssomnias (2) · Nervous System Diseases (2) · Sleep Wake Disorders (2) · Apnea (1) · Cardiovascular Diseases (1) · Chronic Disease (1) · Disease Attributes (1) · Heart Diseases (1) · Lung Diseases, Obstructive (1) · Lung Injury (1) · Mental Disorders (1) · Pathologic Processes (1)
Noninvasive Ventilation (4) · Blood Gas Analysis (1) · Microscopy, Electron, Scanning Transmission (1) · Remifentanil (1) · Standard of Care (1)
Unity Health Toronto (3) · Assiut University (2) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (2) · Alung Technologies (1) · Argentinian Intensive Care Society (1) · Azienda Ospedaliero Universitaria Maggiore della Carita (1) · Başakşehir Çam & Sakura City Hospital (1) · Beijing Chao Yang Hospital (1) · Belfast Health and Social Care Trust (1) · CTU (1) · Centre Hospitalier Arras (1) · Fisher and Paykel Healthcare (1) · Haseki Training and Research Hospital (1) · Icahn School of Medicine at Mount Sinai (1) · Ligue Pulmonaire Genevoise (1)
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