8 unknown, 7 completed, 4 not yet recruiting, 3 recruiting. 18 Not applicable, 3 Phase 4, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 18 | Completed 4, Unknown 4, Not yet recruiting 3, Recruiting 3, Active not recruiting 2, Terminated 2 |
| Phase 4 | 3 | Completed 1, Terminated 1, Unknown 1 |
| Early Phase 1 | 1 | Unknown 1 |
Follow Acute Exacerbation of COPD: new trials by email Literature Review of Acute Exacerbation of COPD trials Research Report on Acute Exacerbation of COPD
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Remote Intervention Versus Routine Monitoring in COPD Patients With Chronic Hypercapnia Receiving Home Non-invasive Respiratory Support Remote Management, Remote Monitoring Only - COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD | Not applicable | Not yet recruiting | Sir Run Run Shaw Hospital | 236 | 2027-08-01 | 2026-08-06 |
| Evaluating Customized Antibiotic Duration (CDA) Strategy in Acute Exacerbations of COPD 7-day antibiotic course, 14-day antibiotic course - COPD, Acute Exacerbation of COPD | Not applicable | Not yet recruiting | Capital Development Authority (CDA) | 560 | 2026-10-26 | 2026-10-07 |
| The Impact of Indoor Environmental Quality on Symptoms in Patients With Chronic Obstructive Pulmonary Disease Wearable mobile device, Indoor environmental quality sensor, CAT Questionnaire - COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD | Not applicable | Not yet recruiting | Ziekenhuis Oost-Limburg | 15 | 2026-10-01 | 2026-09-02 |
| Controlled Versus Standard Oxygen Therapy in ICU Patients With Acute Exacerbation of COPD Controlled oxygen therapy, Standard oxygen therapy - Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of COPD | Not applicable | Recruiting | Hôpital Universitaire Taher Sfar | 240 | 2026-01-01 | 2026-09-25 |
| Inhaler Trainer Efficacy Study Inhaler Trainer System, Initial Inhaler Use Assessment, Inhaler Use Instruction - Asthma, Copd | Not applicable | Completed | Koronis Biomedical Technologies | 10 | 2025-10-09 | 2026-06-08 |
| Survey on NIV Settings in the Intensive Care Unit for Acute Exacerbation of COPD Non interventional study - COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD | Not yet recruiting | University Hospital, Caen | 976 | 2025-09-01 | 2025-03-26 | |
| Remote Monitoring of COPD Patients Experiencing an Acute Exacerbation Through Health Evaluations Using Wearable Mobile Technology Wearable mobile device, CAT Questionnaire, DHRQ Questionnaire - Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of COPD | Not applicable | Active not recruiting | David Ruttens | 50 | 2025-03-01 | 2026-09-18 |
| High Flow Nasal Oxygen for Exacerbation COPD HFNO, NIV - Acute Exacerbation of COPD | Not applicable | Recruiting | Franciscus Gasthuis | 40 | 2024-05-14 | 2025-08-21 |
| Randomized Controlled Study of Programmed Weaning From NIV for AECOPD Programmed Weaning From Noninvasive Mechanical Ventilation - Acute Exacerbation of COPD | Not applicable | Active not recruiting | Peking University Third Hospital | 80 | 2023-05-12 | 2026-06-11 |
| Treatment Efficacy of Systemic Corticosteroids in AECOPD Patients With Higher Blood Eosinophil Levels Prednisone, Placebo - Acute Exacerbation of COPD, Corticosteroid | Phase 4 | Terminated | Capital Medical University | 11 | 2023-03-05 | 2024-08-28 |
| Use of MULTIplex PCR, Procalcitonin, and Sputum Appearance to Reduce Duration of Antibiotic Therapy During Severe COPD EXAcerbation: A Controlled, Randomized, Open-label, Parallel-Group, Multicenter Trial Personalized antibiotic treatment, Usual antibiotic treatment - Acute Exacerbation of COPD | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 204 | 2022-12-08 | 2025-06-25 |
| Effect of NMES on Quadriceps Muscle Strength and Endurance in Patients With COPD Neuromuscular Electrical Nerve Stimulation, Usual Physiotherapy treatment (Chest Physiotherapy and mobility) - Chronic Obstructive Pulmonary Disease Moderate, Chronic Obstructive Pulmonary Disease Severe | Early Phase 1 | Unknown | Randall Debattista | 140 | 2022-10-01 | 2022-09-14 |
| Antibiotic Stewardship in AECOPD Through CRP-Guided Management The intervention (CRP-guided) group - Acute Exacerbation of COPD, Lung Diseases | Not applicable | Unknown | The University of Hong Kong | 1184 | 2022-09-01 | 2022-05-23 |
| Effects of Chair-Based Exercise Training on Exercise Capacity in Patients With Acute Exacerbation of COPD Treatment group, Chair-Based Exercise Training, Control group, Breathing exercise - Acute Exacerbation of COPD | Not applicable | Completed | Necmettin Erbakan University | 30 | 2022-08-20 | 2024-02-07 |
| Functional Strength Training and Neuromuscular Electrical Stimulation in Severe Acute Exacerbations of COPD Functional strength training, NMES, Daily medical treatment (e.g., oxygen, medrol, duovent, azitromycine) - Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Acute Exacerbation of COPD | Not applicable | Terminated | Hasselt University | 35 | 2022-06-01 | 2025-09-15 |
| Social Media-based Bundle Care of AECOPD Patients. Mobile Medical and bundle management, Mobile Medical and standard of care - Acute Exacerbation of COPD, Pulmonary Disease, Chronic Obstructive | Phase 4 | Unknown | Beijing Chao Yang Hospital | 648 | 2022-02-01 | 2022-01-26 |
| Prediction of Exacerbations and Management of COPD Patients With SAH Based on Millimeter Wave Radar Monitoring Polysomnography, Millimeter wave radar equipment - COPD, Sleep Apnea Hypopnea Syndrome | Unknown | Peking University Third Hospital | 922 | 2021-10-01 | 2021-08-25 | |
| High VS Low Flow Nasal O2 for Acute Hypercapnic Respiratory Failure High flow nasal therapy, Low flow oxygen - Acute Hypercapnic Respiratory Failure, Acute Exacerbation of COPD | Not applicable | Unknown | Belfast Health and Social Care Trust | 82 | 2021-06-13 | 2022-04-21 |
| Negative Pressure Ventilation-rehabilitation on Acute Exacerbation of Chronic Obstructive Pulmonary Disease cuirass ventilator (cuirass diameter 21 cm or 34 cm, Dima Italia Srl.,Bologna, Italy), breathing training, and an educational program (relaxation techniques and a home pacing walking exercise) - Chronic Obstructive Pulmonary Disease, Acute Exacerbation of COPD | Not applicable | Unknown | Chang Gung Memorial Hospital | 150 | 2021-04-08 | 2021-04-13 |
| ecco2R to facilitatE earLy libEration From mechanicAl Ventilation inpatientS With Copd Acute Exacerbation Low flow ECCO2R, Invasive mechanical ventilation - Acute Exacerbation of COPD | Not applicable | Unknown | Hospital Quiron Sagrado Corazon | 90 | 2021-02-01 | 2020-08-20 |
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Pulmonary Disease, Chronic Obstructive (17) · Lung Diseases, Obstructive (3) · Respiratory Insufficiency (2) · Asthma (1) · Disease (1) · Emergencies (1) · Hypercapnia (1) · Lung Diseases (1) · Lung Diseases, Interstitial (1) · Neuromuscular Diseases (1) · Obesity Hypoventilation Syndrome (1) · Respiratory Tract Diseases (1) · Sleep Apnea, Obstructive (1)
Pathologic Processes (18) · Pathological Conditions, Signs and Symptoms (18) · Respiratory Tract Diseases (18) · Chronic Disease (17) · Disease Attributes (17) · Lung Diseases (17) · Lung Diseases, Obstructive (14) · Respiration Disorders (4) · Apnea (2) · Dyssomnias (2) · Nervous System Diseases (2) · Sleep Apnea Syndromes (2) · Sleep Disorders, Intrinsic (2) · Sleep Wake Disorders (2) · Bronchial Diseases (1)
Breathing Exercises (1) · Control Groups (1) · Dosage Forms (1) · Methylprednisolone (1) · Noninvasive Ventilation (1) · Oxygen (1) · Polysomnography (1) · Population Groups (1) · Prednisone (1) · Range of Motion, Articular (1) · Relaxation Therapy (1) · Sildenafil Citrate (1) · Standard of Care (1) · fenoterol, ipratropium drug combination (1)
Peking University Third Hospital (2) · Alung Technologies (1) · Ankara University (1) · Assistance Publique - Hôpitaux de Paris (1) · Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil (1) · Beijing Chao Yang Hospital (1) · Belfast Health and Social Care Trust (1) · Capital Development Authority (CDA) (1) · Capital Medical University (1) · Chang Gung Memorial Hospital (1) · Chronic Obstructive Pulmonary Disease Trial Network, Denmark (1) · David Ruttens (1) · Franciscus Gasthuis (1) · Hasselt University (1) · Hospital Authority, Hong Kong (1)
China (4) · Belgium (3) · Turkey (Türkiye) (3) · France (2) · Hong Kong (2) · United States (2) · Denmark (1) · India (1) · Netherlands (1) · Pakistan (1) · Taiwan (1) · Tunisia (1) · United Kingdom (1)
Alexandre Demoule, MD, PHD (1) · Antonio Artigas, MD (1) · Chris Burtin, PhD (1) · David Ruttens, MD, PhD (1) · Dorien Kiers, MD, PhD (1) · Dr. Tonio Agius, Physiotherapist (1) · Fazal Rabbi, MD (1) · Inderpaul Singh Sehgal, MD DM (1) · Nicholas Hill, MD (1)
PMID 31291514, PMID 33419742, PMID 33854019, PMID 36680884, PMID 37247957, PMID 37976375, PMID 38261630
R44AG071430 (1)