13 completed. 13 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 13 | Completed 13 |
| Phase 2 | 2 | Completed 2 |
Follow Acidosis: new trials by email Literature Review of Acidosis trials Research Report on Acidosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of Exogenous Ketones on Sleep and Breathing in Healthy Volunteers (K-SLEEP) KETONE-IQ 20 grams (g), KETONE-IQ 40 grams (g) - Healthy Participants, Sleep | Phase 1 | Completed | Johns Hopkins University | 20 | 2025-12-18 | 2026-09-28 |
| the Effect of Interdialytic Serum Bicarbonate Correction on Vascular Calcification in Hemodialysis Patients Oral sodium bicarbonate - End Stage Renal Disease (ESRD), Metabolic Acidosis | Phase 1 | Completed | Ain Shams University | 40 | 2023-09-01 | 2026-08-14 |
| Ketone Pharmacokinetic Study in HFrEF DeltaG (250 mg/kg), DeltaG (500 mg/kg) - Heart Failure With Reduced Ejection Fraction | Phase 1 | Completed | Duke University | 20 | 2023-06-02 | 2024-12-27 |
| Sodium-glucose Co Transporter 2 (sGLT2) Inhibitor and Endogenous Ketone Production empagliflozin (Jardiance) 25 mg - Empaglifozin, Physiological Effects of Drugs | Phase 1 | Completed | National Institute on Aging (NIA) | 21 | 2019-03-28 | 2022-08-02 |
| Effects of Ketone Bodies on Cognition in Type 2 Diabetes Ketone infusion, Saline infusion - Type2 Diabetes, Ketonemia | Phase 1 | Completed | Bispebjerg Hospital | 18 | 2018-09-17 | 2019-02-20 |
| Exogenous Ketones and Glucose Tolerance Ketone monoester, Placebo - Ketones, Dietary Supplements | Phase 1 | Completed | University of British Columbia | 15 | 2018-03-26 | 2019-04-18 |
| Evaluation of TRC101 in Subjects With Chronic Kidney Disease and Metabolic Acidosis Placebo, TRC101 - Acidosis | Phase 1 / Phase 2 | Completed | Tricida, Inc. | 135 | 2016-03-01 | 2020-01-14 |
| Effects of a Ketogenic Diet on Acute Stroke Ketocal 4:1 (Nutricia), Control diet: Regular diet offered at the hospitals, Ketogenic meals - Acute Stroke | Phase 1 | Completed | University of Copenhagen | 64 | 2013-05-01 | 2014-07-18 |
| Comparison of Standard Versus Low Bicarbonate Hemodialysis Low bicarbonate dialysis - Chronic Kidney Disease, Metabolic Acidosis | Phase 1 | Completed | Albert Einstein College of Medicine | 10 | 2013-01-01 | 2019-04-30 |
| Effects of Triglycerides on Age-Related Cognitive Function Decline in Older Subjects GSK2981710, Placebo - Alzheimer's Disease | Phase 1 | Completed | GlaxoSmithKline | 116 | 2012-11-05 | 2017-05-09 |
| Dietary Intervention With the Modified Atkins Diet in Stroke Rehabilitation Modified Atkins Diet, Control diet - Stroke, Ischemic Stroke | Phase 1 / Phase 2 | Completed | Burke Rehabilitation Hospital | 20 | 2012-03-01 | 2016-02-24 |
| Atkins Diet for Difficult-to-Control Headaches in Teenagers Modified Atkins diet - Chronic Daily Headache | Phase 1 | Completed | Johns Hopkins University | 10 | 2005-09-01 | 2009-07-02 |
| Use of the Atkins Diet for Children With Intractable Epilepsy: A Comparison of Daily Carbohydrate Limits Modified Atkins diet - Epilepsy | Phase 1 | Completed | Johns Hopkins University | 30 | 2005-02-01 | 2009-03-27 |
Ketosis (10) · Alzheimer Disease (2) · Stroke (2) · Epilepsy (1) · Headache (1) · Headache Disorders (1) · Hyperglycemia (1) · Ischemia (1) · Ischemic Stroke (1) · Kidney Diseases (1) · Kidney Failure, Chronic (1) · Renal Insufficiency, Chronic (1) · Seizures (1)
Acid-Base Imbalance (13) · Metabolic Diseases (13) · Nutritional and Metabolic Diseases (13) · Brain Diseases (6) · Central Nervous System Diseases (6) · Nervous System Diseases (6) · Pathological Conditions, Signs and Symptoms (5) · Female Urogenital Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Male Urogenital Diseases (3) · Pathologic Processes (3) · Urogenital Diseases (3) · Urologic Diseases (3) · Cardiovascular Diseases (2)
Diet (1) · Diet, Diabetic (1) · Diet, Sodium-Restricted (1) · GSK2981710 (1) · Sodium Bicarbonate (1) · empagliflozin (1) · veverimer (1)
Johns Hopkins University (3) · Ain Shams University (1) · Albert Einstein College of Medicine (1) · Bispebjerg Hospital (1) · Burke Rehabilitation Hospital (1) · Duke University (1) · GlaxoSmithKline (1) · National Institute on Aging (NIA) (1) · Tricida, Inc. (1) · University of British Columbia (1) · University of Copenhagen (1)
United States (7) · Denmark (2) · Bulgaria (1) · Canada (1) · Egypt (1) · Georgia (1) · United Kingdom (1)
Eric H Kossoff, MD (2) · Carolin I Dohle, MD (1) · Jens Rikardt Andersen, MD (1) · Jonathan Jun, MD (1) · Josephine M Egan, M.D. (1) · Matthew K Abramowitz, MD, MS (1) · Senthil Selvaraj, MD, MSTR, MA (1) · Yuri Stasiv, PhD (1)
PMID 29102959, PMID 31599919, PMID 40139871
2015 (1), K23HL161348 (1)