7 completed. 7 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 7 |
| Phase 3 | 2 | Completed 2 |
Follow Acidosis, Lactic: new trials by email Literature Review of Acidosis, Lactic trials Research Report on Acidosis, Lactic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 2b Study of Zagociguat in Patients With MELAS zagociguat 15mg, zagociguat 30mg, Placebo - Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome) | Phase 2 | Completed | Tisento Therapeutics | 43 | 2024-09-10 | 2026-10-23 |
| OMT-28 in Patients With Primary Mitochondrial Disease (PMD) (PMD-OPTION) OMT-28 - Primary Mitochondrial Disease | Phase 2 | Completed | Omeicos Therapeutics GmbH | 28 | 2023-05-22 | 2026-01-22 |
| Alcohol: Thiamine and or Magnesium 1 Magnesium Sulfate, Pabrinex - Alcohol Withdrawal, Lactic Acidosis | Phase 2 / Phase 3 | Completed | Glasgow Royal Infirmary | 127 | 2016-12-16 | 2019-07-31 |
| Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients MP4OX, Saline - Shock, Hemorrhagic, Shock, Traumatic | Phase 2 | Completed | Sangart | 348 | 2011-05-01 | 2013-08-22 |
| Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients MP4OX, Ringers Lactate solution - Shock, Hemorrhagic, Shock, Traumatic | Phase 2 | Completed | Sangart | 51 | 2009-12-01 | 2013-08-19 |
| D4T or Abacavir Plus Vitamin Enhancement in HIV-Infected Patients (DAVE) d4T, Abacavir, Riboflavin and Thiamine (Supplementation) - Acidosis, Lactic | Phase 2 / Phase 3 | Completed | University of British Columbia | 80 | 2001-08-01 | 2008-09-25 |
| Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia sodium dichloroacetate - Lactic Acidosis | Phase 2 | Completed | University of California, San Diego | 75 | 1998-09-01 | 2015-03-25 |
Hemorrhage (2) · MELAS Syndrome (2) · Mitochondrial encephalopathy (2) · Shock, Hemorrhagic (2) · Shock, Traumatic (2) · Wounds and Injuries (2) · Beriberi (1) · Cardiomyopathies (1) · Deafness (1) · MERRF Syndrome (1) · Magnesium Deficiency (1) · Metabolism, Inborn Errors (1) · Muscular Diseases (1) · Noninsulin-dependent diabetes mellitus with deafness (1)
Acid-Base Imbalance (7) · Acidosis (7) · Metabolic Diseases (7) · Nutritional and Metabolic Diseases (7) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Brain Diseases (3) · Brain Diseases, Metabolic (3) · Central Nervous System Diseases (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Genetic Diseases, Inborn (3) · Nervous System Diseases (3) · Brain Diseases, Metabolic, Inborn (2) · Cardiovascular Diseases (2) · Cerebral Small Vessel Diseases (2)
PEG-hemoglobin (2) · maleimide-polyethylene glycol-modified hemoglobin, MP4 (2) · Dichloroacetic Acid (1) · Dietary Supplements (1) · Magnesium Sulfate (1) · Riboflavin (1) · Ringer's Lactate (1) · Saline Solution (1) · Sodium Chloride (1) · Stavudine (1) · Thiamine (1) · abacavir (1) · polynitroxylated pegylated hemoglobin (1)
Sangart (2) · Glasgow Royal Infirmary (1) · Omeicos Therapeutics GmbH (1) · Tisento Therapeutics (1) · University of British Columbia (1) · University of California, San Diego (1)
Germany (4) · United Kingdom (4) · Australia (2) · Canada (2) · France (2) · Italy (2) · South Africa (2) · United States (2) · Austria (1) · Brazil (1) · Colombia (1) · Israel (1) · Netherlands (1) · New Zealand (1) · Norway (1)
Karim Brohi, MD (2) · Bruce Barshop (1) · Donogh Maguire, MB BCh (1) · Julio Montaner, MD (1) · Robert Fischer, MD (1)