37 completed, 19 unknown, 11 recruiting, 6 terminated. 26 Not applicable, 10 Phase 2, 9 Phase 4, 4 Early Phase 1, 3 Phase 1.
Follow 46, XX Disorders of Sex Development: new trials by email Literature Review of 46, XX Disorders of Sex Development trials Research Report on 46, XX Disorders of Sex Development
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Biomarker Panel for PCOS-Associated Liver Steatosis in Adolescent Girls (COMPASS-pedPCOS) Extended Serum Biomarker and Hormonal Panel, Liver Elastography with Controlled Attenuation Parameter, Targeted Genotyping of PNPLA3 rs738409 and HSD17B13 rs72613567 - Polycystic Ovary Syndrome (PCOS), Metabolic Dysfunction-Associated Steatotic Liver Disease | Not yet recruiting | Kayseri City Hospital | 150 | 2026-09-01 | 2026-07-30 | |
| Lean Beef as Part of a Healthy Meal Plan in Adolescents With Polycystic Ovary Syndrome (PCOS)/Polyendocrine Metabolic Ovarian Syndrome (PMOS) Beef+ - PCOS (Polycystic Ovary Syndrome), Obese Adolescents | Not applicable | Recruiting | Texas A&M University | 36 | 2026-09-01 | 2026-08-21 |
| Evaluation of Circadian Hormonal Balance: LC-MS/MS Measurement of Salivary and Serum Steroids in Patients With Congenital Adrenal Hyperplasia Congenital Adrenal Hyperplasia, Adrenal Insufficiency | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 50 | 2026-09-01 | 2026-07-21 | |
| Evaluation of Serum Preptin Levels in Patients With Polycystic Ovary Syndrome Polycystic Ovary Syndrome (PCOS), Insulin Resistance | Not yet recruiting | GÜLDEN ANATACA | 60 | 2026-07-30 | 2026-07-30 | |
| Combination Osilodrostat and Cabergoline in Cushing's Disease osilodrostat, osilodrostat and cabergoline - Cushing Disease Due to Increased ACTH Secretion | Phase 4 | Enrolling by invitation | University of Basrah | 50 | 2026-05-11 | 2026-05-22 |
| Polycystic Ovary Syndrome in Type 1 Diabetes Type 1 diabetes mellitus, Elevated circulating androgen levels, Sex dimorphism - Type 1 Diabetes Mellitus, Polycystic Ovary Syndrome (PCOS) | Recruiting | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal | 60 | 2026-04-01 | 2026-09-03 | |
| Effect of Magnesium and Levocarnitine on Metabolic and Clinical Outcomes in Women With Polycystic Ovarian Syndrome (PCOS) Magnesium 500 mg, Levocarnitine 1000 mg, Placebo - Polycystic Ovary Syndrome (PCOS) | Not applicable | Recruiting | Behnood Abbasi | 84 | 2026-01-30 | 2025-12-23 |
| Combined Use of Machine Learning and Metabolomics to Improve the Diagnosis and Management of Hyperandrogenism data collection - Hyperandrogenism | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 800 | 2026-01-01 | 2025-12-04 | |
| This Study Aims to Evaluate Whether Milamend's Product Could Improve Hormone Balance in Women Who Suffer From Self-reported PCOS Symptoms. A dietary supplement powder for women, Placebo - Polycystic Ovarian Syndrome (PCOS) | Not applicable | Recruiting | Mila Mend Inc. | 225 | 2025-12-23 | 2026-08-13 |
| Myo-Inositol and D-Chiro-Inositol for Menstrual Irregularities and Hormone Changes in Women With Polycystic Ovarian Syndrome Myo-Inositol and D-Chiro-Inositol Combination Therapy, placebo (folic acid) - Polycystic Ovary Syndrome (PCOS), Myo-inositol | Phase 4 | Completed | Nishtar Medical University | 60 | 2025-06-01 | 2026-07-14 |
| Efficacy of Metformin With and Without Probiotics in Women With PCOS Metformin, Probiotics - Poly Cystic Ovary Syndrome | Not applicable | Completed | Dhivyaprasath Palaniappan | 60 | 2024-03-27 | 2026-10-15 |
| Cardiovascular and Endothelial Markers During OGTT Before and at Six and Twelve Months Post-treatment in Women With PCOS GLP-1 receptor agonist, Oral contraceptive, Metformin - PCOS, Hyperinsulinism | Recruiting | Attikon Hospital | 120 | 2024-02-01 | 2025-11-19 | |
| Phenotype and Epidemiology of the Polycystic Ovary Syndrome (PCOS) in Colombia (PEP - Colombia) Study. Diagnostic Ultrasound, Venous puncture - Polycystic Ovary Syndrome, Hyperandrogenism | Unknown | Instituto de fertilidad humana, InSer | 626 | 2023-03-04 | 2023-07-03 | |
| Mechanisms of Blood Pressure Dysfunction in Transmen Receiving Testosterone Trans men - Transgender Men, Blood Pressure | Not applicable | Withdrawn | Yale University | 2023-01-01 | 2022-11-03 | |
| The RolE oF Androgen Excess in MUscle Energy MetaboLism in Women With PolyCystic Ovary Syndrome (REFUEL PCOS) Study 2 Bicalutamide 50 mg - Polycystic Ovary Syndrome, Androgen Excess | Not applicable | Unknown | Royal College of Surgeons, Ireland | 16 | 2023-01-01 | 2022-12-12 |
| Effect of Hyperandrogenism on IVF Outcomes in PCOS Patients Ferriman-Gallwey Score - PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries | Terminated | Clinique Ovo | 32 | 2022-01-21 | 2025-12-09 | |
| Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism? Spironolactone, Placebo - Hyperandrogenism, Polycystic Ovary Syndrome | Early Phase 1 | Recruiting | University of Virginia | 32 | 2021-11-12 | 2025-08-05 |
| Metabolic Profile and Adipokine Levels in Young Hyperandrogenemic Females Hyperandrogenism, Obesity | Unknown | Medical University of Gdansk | 40 | 2021-09-22 | 2021-11-08 | |
| FEmale Metabolic Risk and Androgens: an Irish Longitudinal (FEMAIL) Study Longitudinal follow up - Hyperandrogenism, Metabolic Disease | Recruiting | Royal College of Surgeons, Ireland | 500 | 2021-04-01 | 2024-05-02 | |
| Ketogenic Diet in PCOS With Obesity and Insulin Resistance Very low calorie ketogenic diet, Low calorie standard diet - PCOS, Obesity | Not applicable | Completed | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 30 | 2021-03-02 | 2022-01-27 |
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Hyperandrogenism (81) · Polycystic Ovary Syndrome (57) · Insulin Resistance (21) · Anovulation (9) · Obesity (9) · Hirsutism (8) · Menstruation Disturbances (8) · Metabolic Syndrome (8) · Oligomenorrhea (6) · Endocrine System Diseases (4) · Inflammation (4) · Adrenal Hyperplasia, Congenital (3) · Adrenal Insufficiency (3) · Amenorrhea (3) · Infertility (3)
Adrenogenital Syndrome (81) · Congenital Abnormalities (81) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (81) · Disorders of Sex Development (81) · Female Urogenital Diseases (81) · Female Urogenital Diseases and Pregnancy Complications (81) · Gonadal Disorders (81) · Male Urogenital Diseases (81) · Urogenital Abnormalities (81) · Urogenital Diseases (81) · Endocrine System Diseases (77) · Neoplasms (58) · Adnexal Diseases (57) · Cysts (57)
Metformin (11) · Progesterone (6) · Inositol (4) · Spironolactone (4) · Ethinyl Estradiol (3) · Folic Acid (3) · drospirenone and ethinyl estradiol combination (3) · Blood Specimen Collection (2) · Clomiphene (2) · Cyproterone Acetate (2) · Cyproterone acetate, ethinyl estradiol drug combination (2) · Estradiol (2) · Flutamide (2) · Sugars (2) · salicylsalicylic acid (2)
University of Virginia (11) · Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal (3) · AGUNCO Obstetrics and Gynecology Centre (2) · Assistance Publique - Hôpitaux de Paris (2) · National Institute of Environmental Health Sciences (NIEHS) (2) · Royal College of Surgeons, Ireland (2) · 59th Medical Wing (1) · Aarhus University Hospital Skejby (1) · Attikon Hospital (1) · Behnood Abbasi (1) · Catholic University of the Sacred Heart (1) · Charite University, Berlin, Germany (1) · Clinique Ovo (1) · Dhivyaprasath Palaniappan (1) · Diana Speelman, Ph.D. (1)
United States (30) · Spain (6) · Italy (4) · Brazil (3) · Germany (3) · Israel (3) · Poland (3) · Turkey (Türkiye) (3) · Canada (2) · China (2) · France (2) · India (2) · Ireland (2) · Pakistan (2) · Russia (2)
Christine Burt Solorzano, MD (3) · Christopher R McCartney, MD (2) · Christopher R. McCartney, MD (2) · Abbas A Mansour (1) · Alexandre Rossi (1) · Azam Azargoon, MD (1) · Bader F Zuberi, FCPS (1) · Beata Banaszewska (1) · Birute Zilaitiene, Ass. Proff. (1)
PMID 11476780, PMID 17536071, PMID 18064739, PMID 18375410, PMID 18820647, PMID 18852641, PMID 18997670, PMID 19910321, PMID 20730705, PMID 22168920, PMID 22693172, PMID 23845740, PMID 26511519, PMID 27336356, PMID 27680873, PMID 27901631, PMID 28321694, PMID 29095983, PMID 29300925, PMID 29562163, PMID 30003563, PMID 30590569, PMID 30612112, PMID 30615047, PMID 31381969, PMID 32140727, PMID 32285088, PMID 32325487, PMID 32337566, PMID 33462622, PMID 34764381, PMID 35807149, PMID 36373234, PMID 36400597, PMID 36611327, PMID 37364790, PMID 37580861, PMID 38611586, PMID 40069730, PMID 42359269, PMID 8970487
P50HD028934 (4), U54HD028934 (2), 2015 (1), 2017 (1), 2018 (1), K12HD001259 (1), P50HD012303 (1), R01AT009484 (1), R01DK107605 (1), R01HD102060 (1)