78 completed, 35 unknown, 28 recruiting, 12 terminated. 39 Phase 2, 34 Not applicable, 14 Phase 1, 13 Phase 3, 12 Phase 4.
Follow Adrenogenital Syndrome: new trials by email Literature Review of Adrenogenital Syndrome trials Research Report on Adrenogenital Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Development of Healthcare Transition for Patients With Congenital Adrenal Hyperplasia exposure to healthcare transition protocol - Congenital Adrenal Hyperplasia | Not yet recruiting | University of Alabama at Birmingham | 40 | 2027-01-01 | 2026-10-14 | |
| Efficacy, Safety, Tolerability, and Pharmacokinetics of NBIP-01435 in Adult Participants With Classic Congenital Adrenal Hyperplasia (CAH) NBIP-01435 - Congenital Adrenal Hyperplasia | Phase 2 | Not yet recruiting | Neurocrine Biosciences | 36 | 2026-12-01 | 2026-09-30 |
| An Extension Trial of Asedebart in Participants With Congenital Adrenal Hyperplasia Asedebart - Adrenal Hyperplasia, Congenital | Phase 2 | Not yet recruiting | H. Lundbeck A/S | 45 | 2026-10-01 | 2026-10-05 |
| Metyrapone Study for Patients Diagnosed With Mild Autonomous Cortisol Secretion - MACS Metyrapone 250 mg Oral Tablets, Placebo - Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS) | Phase 2 | Recruiting | Mayo Clinic | 90 | 2026-10-01 | 2026-09-25 |
| Biomarker Panel for PCOS-Associated Liver Steatosis in Adolescent Girls (COMPASS-pedPCOS) Extended Serum Biomarker and Hormonal Panel, Liver Elastography with Controlled Attenuation Parameter, Targeted Genotyping of PNPLA3 rs738409 and HSD17B13 rs72613567 - Polycystic Ovary Syndrome (PCOS), Metabolic Dysfunction-Associated Steatotic Liver Disease | Not yet recruiting | Kayseri City Hospital | 150 | 2026-09-01 | 2026-07-30 | |
| Lean Beef as Part of a Healthy Meal Plan in Adolescents With Polycystic Ovary Syndrome (PCOS)/Polyendocrine Metabolic Ovarian Syndrome (PMOS) Beef+ - PCOS (Polycystic Ovary Syndrome), Obese Adolescents | Not applicable | Recruiting | Texas A&M University | 36 | 2026-09-01 | 2026-08-21 |
| Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of OMS1620 OMS1620, Placebo - Congenital Adrenal Hyperplasia (CAH) | Phase 1 | Not yet recruiting | OMass Therapeutics Australia Proprietary Ltd | 84 | 2026-09-01 | 2026-09-09 |
| Evaluation of Circadian Hormonal Balance: LC-MS/MS Measurement of Salivary and Serum Steroids in Patients With Congenital Adrenal Hyperplasia Congenital Adrenal Hyperplasia, Adrenal Insufficiency | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 50 | 2026-09-01 | 2026-07-21 | |
| Hydrocortisone Modified-release in Adults: Real-world Monitoring of Longitudinal Outcomes in coNgenital Adrenal hYperplasia CAH - Congenital Adrenal Hyperplasia | Not yet recruiting | IRCCS San Raffaele | 100 | 2026-07-31 | 2026-06-08 | |
| Evaluation of Serum Preptin Levels in Patients With Polycystic Ovary Syndrome Polycystic Ovary Syndrome (PCOS), Insulin Resistance | Not yet recruiting | GÜLDEN ANATACA | 60 | 2026-07-30 | 2026-07-30 | |
| Pediatric Congenital Adrenal Hyperplasia Management: Regret and Long-term Outcomes questionnaire - Classic Congenital Adrenal Hyperplasia, 21-Hydroxylase Deficiency | Recruiting | University Hospital, Lille | 40 | 2026-07-08 | 2026-08-24 | |
| Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Crinecerfont in Participants With Classic Congenital Adrenal Hyperplasia (CAH) Who Are Less Than 4 Years Old Crinecerfont - Congenital Adrenal Hyperplasia | Phase 2 | Recruiting | Neurocrine Switzerland GmbH | 20 | 2026-07-01 | 2026-09-16 |
| Combination Osilodrostat and Cabergoline in Cushing's Disease osilodrostat, osilodrostat and cabergoline - Cushing Disease Due to Increased ACTH Secretion | Phase 4 | Enrolling by invitation | University of Basrah | 50 | 2026-05-11 | 2026-05-22 |
| Polycystic Ovary Syndrome in Type 1 Diabetes Type 1 diabetes mellitus, Elevated circulating androgen levels, Sex dimorphism - Type 1 Diabetes Mellitus, Polycystic Ovary Syndrome (PCOS) | Recruiting | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal | 60 | 2026-04-01 | 2026-09-03 | |
| Parenting and CAH - 21-hydroxylase Deficiency phone questionnaire - CAH - 21-Hydroxylase Deficiency | Recruiting | Assistance Publique - Hôpitaux de Paris | 200 | 2026-03-16 | 2026-08-31 | |
| Isturisa Treatment in Mild Autonomous Cortisol Secretion( MACS) Osilodrostat (Isturisa) - Mild Autonomous Cortisol Secretion (MACS) | Phase 4 | Recruiting | Johns Hopkins University | 10 | 2026-02-02 | 2026-10-23 |
| Effect of Magnesium and Levocarnitine on Metabolic and Clinical Outcomes in Women With Polycystic Ovarian Syndrome (PCOS) Magnesium 500 mg, Levocarnitine 1000 mg, Placebo - Polycystic Ovary Syndrome (PCOS) | Not applicable | Recruiting | Behnood Abbasi | 84 | 2026-01-30 | 2025-12-23 |
| A Study in Pediatric Participants With Congenital Adrenal Hyperplasia (Balance-CAH) Atumelnant, Placebo - Congenital Adrenal Hyperplasia, Classic Congenital Adrenal Hyperplasia | Phase 2 / Phase 3 | Recruiting | Crinetics Pharmaceuticals Inc. | 153 | 2026-01-22 | 2026-10-16 |
| Impact of 1 mg Osilodrostat Therapy on Mild Autonomous Cortisol Secretion (MACS) Osilodrostat 1 MG - Mild Autonomous Cortisol Secretion, Autonomous Cortisol Secretion (ACS) | Phase 2 | Recruiting | Mayo Clinic | 15 | 2026-01-14 | 2026-02-11 |
| Combined Use of Machine Learning and Metabolomics to Improve the Diagnosis and Management of Hyperandrogenism data collection - Hyperandrogenism | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 800 | 2026-01-01 | 2025-12-04 |
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Adrenal Hyperplasia, Congenital (99) · Hyperandrogenism (81) · Polycystic Ovary Syndrome (57) · Insulin Resistance (21) · Adrenal Insufficiency (11) · Congenital adrenal hyperplasia due to 21 hydroxylase deficiency (11) · Anovulation (9) · Obesity (9) · Hirsutism (8) · Menstruation Disturbances (8) · Metabolic Syndrome (8) · Cushing Syndrome (7) · Disorders of Sex Development (7) · Adrenal Gland Diseases (6) · Endocrine System Diseases (6)
Female Urogenital Diseases (177) · Female Urogenital Diseases and Pregnancy Complications (177) · Male Urogenital Diseases (177) · Urogenital Diseases (177) · Congenital Abnormalities (176) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (176) · Gonadal Disorders (176) · Urogenital Abnormalities (175) · Endocrine System Diseases (171) · Disorders of Sex Development (170) · Nutritional and Metabolic Diseases (133) · Metabolic Diseases (125) · Genetic Diseases, Inborn (97) · Metabolism, Inborn Errors (97)
Hydrocortisone (13) · Metformin (11) · Dexamethasone (6) · Progesterone (6) · crinecerfont (6) · Inositol (4) · Prednisone (4) · Spironolactone (4) · Blood Specimen Collection (3) · Ethinyl Estradiol (3) · Flutamide (3) · Folic Acid (3) · Osilodrostat (3) · Prednisolone (3) · Surveys and Questionnaires (3)
University of Virginia (11) · Neurocrine UK Limited (8) · Assistance Publique - Hôpitaux de Paris (7) · Neurocrine Biosciences (6) · Spruce Biosciences (5) · Crinetics Pharmaceuticals Inc. (4) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (4) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (4) · Mayo Clinic (4) · Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal (3) · Haukeland University Hospital (3) · Hospices Civils de Lyon (3) · AGUNCO Obstetrics and Gynecology Centre (2) · Adrenas Therapeutics Inc (2) · Ain Shams University (2)
United States (78) · France (21) · Italy (19) · United Kingdom (15) · Germany (13) · Brazil (12) · Spain (12) · Poland (10) · Netherlands (9) · Sweden (9) · Canada (7) · Turkey (Türkiye) (7) · Belgium (6) · Argentina (5) · Australia (5)
Christine Burt Solorzano, MD (3) · Deborah P Merke, M.D. (3) · Christopher R McCartney, MD (2) · Christopher R. McCartney, MD (2) · Irina Bancos, MD (2) · Perrin C White, MD (2) · Abbas A Mansour (1)
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P50HD028934 (4), 2023 (3), U54HD028934 (2), 2015 (1), 2017 (1), 2018 (1), 2019 (1), K12HD001259 (1), M01RR001070 (1), P50HD012303 (1), R01AT009484 (1), R01DK107605 (1), R01HD057930 (1), R01HD102060 (1), U01HD083493 (1)