57 completed, 12 unknown, 8 recruiting, 8 terminated. 97 Phase 3, 9 Phase 2.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Partner4Exercise Study Peer matching, Quailfied Exercise Professional (QEP) Support - Cancer | Phase 2 / Phase 3 | Recruiting | McMaster University | 183 | 2026-09-01 | 2026-10-29 |
| Tirzepatide in the Treatment of Cannabis Use Disorder Tirzepatide - Cannabis Use Disorder, Moderate, Cannabis Use Disorder, Severe | Phase 3 | Not yet recruiting | McMaster University | 15 | 2026-08-01 | 2026-07-01 |
| Evaluating a Shorter, Rifampicin-Based Treatment for People With Less Severe Tuberculosis Disease Extra 600mg of Rifampicin, Placebo - Pulmonary TB | Phase 3 | Not yet recruiting | Hamilton Health Sciences Corporation | 1000 | 2026-02-01 | 2025-08-12 |
| Hip Fracture Surgery Arterial and Venous Thrombotic Events Prevention rivaroxaban and ASA, Low-molecular weight heparin, Fondaparinux - Hip Fracture Surgery, Cardiovascular Prevention | Phase 3 | Not yet recruiting | McMaster University | 100 | 2025-12-01 | 2025-11-14 |
| Ketamine Sedation in the ICU (KANINE) RCT ketamine hydrochloride, Normal saline placebo - Mechanical Ventilation, Critically Ill Intensive Care Unit Patients | Phase 3 | Recruiting | McMaster University | 54 | 2025-11-20 | 2026-10-22 |
| Radiation Therapy Followed by Durvalumab (MEDI4736) and Tremelimumab And Surgery Versus Radiation Therapy Followed by Surgery for Resectable Hepatocellular Carcinoma. Chemotherapy/Radiation - Hepatocellular Carcinoma (HCC) | Phase 3 | Recruiting | Hamilton Health Sciences Corporation | 30 | 2025-11-07 | 2026-09-17 |
| ACB vs no Block for Pediatric ACL Reconstruction Ropivacaine 2-2.5mg/kg + dexmedetomidine 1 mcg/kg delivered via a single-shot adductor canal block under ultrasound guidance - Anterior Cruciate Ligament, Anterior Cruciate Ligament (ACL) Tear | Phase 3 | Recruiting | Isabella Jaramillo | 38 | 2025-07-01 | 2025-09-26 |
| Comparison of Medical RESCUE Strategies for Patients With Steroid-refractory Acute Severe Ulcerative Colitis Upadacitinib Oral Product - Colitis, Ulcerative | Phase 3 | Recruiting | McMaster University | 134 | 2025-04-16 | 2025-06-22 |
| Levetiracetam Prophylaxis in Brain Tumor Resection Pilot Levetiracetam, Placebo - Seizures, Brain Tumor | Phase 3 | Not yet recruiting | Hamilton Health Sciences Corporation | 70 | 2025-03-01 | 2024-10-23 |
| Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty Multiprofen-CC™ plus standard treatment, Placebo plus standard treatment - Postsurgical Pain | Phase 3 | Completed | KAZM Pharmaceuticals Inc. | 306 | 2024-09-09 | 2026-06-29 |
| Infection Prophylaxis in Total Joint Replacement Chlorhexidine Gluconate, Vancomycin Hydrochloride, Povidone-Iodine - Periprosthetic Joint Infection | Phase 3 | Recruiting | Hamilton Health Sciences Corporation | 21006 | 2024-05-07 | 2026-05-22 |
| Home-based Training and Supplementation in DM1 Patients Mult-ingredient supplement, Placebo, Concurrent exercise training - Myotonic Dystrophy 1 | Phase 3 | Unknown | McMaster University | 60 | 2024-01-01 | 2023-10-19 |
| Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy Antibiotic Cement Bead Pouch, Negative Pressure Wound Therapy - Open tíbia Fracture | Phase 3 | Recruiting | University of Maryland, Baltimore | 312 | 2023-11-05 | 2026-10-29 |
| Comparison of Ketorolac at Three Doses in Children With Acute Pain Ketorolac Tromethamine - Acute Pain, Abdominal Pain | Phase 3 | Completed | Hamilton Health Sciences Corporation | 171 | 2023-06-01 | 2025-07-09 |
| Cannabinoids vs. Placebo on Persistent Post-surgical Pain Following TKA: A Pilot RCT MPL-001 (CBD: THC 25:1), Placebo oil for oral use - Knee Osteoarthritis | Phase 3 | Completed | McMaster University | 39 | 2023-05-03 | 2026-10-22 |
| Tezepelumab on Airway Structure and Function in Patients With Uncontrolled Moderate-to-severe Asthma Tezepelumab, Placebo - Asthma | Phase 3 | Completed | McMaster University | 27 | 2022-11-08 | 2026-01-07 |
| Retrograde Autologous Priming and Mannitol for Reducing Hemodilution in Cardiac Surgery Retrograde autologous priming, Mannitol, Conventional Priming - Hemodilution, Coronary Artery Disease | Phase 3 | Withdrawn | Hamilton Health Sciences Corporation | 2022-09-21 | 2023-02-28 | |
| Tranexamic Acid for Alloplastic Breast Reconstruction Tranexamic acid, Normal Saline - Hematoma Postoperative, Breast Cancer | Phase 3 | Unknown | McMaster University | 106 | 2022-08-01 | 2022-04-06 |
| Topical Tranexamic Acid for Bilateral Breast Reduction Surgery Tranexamic acid, Normal Saline - Hematoma Postoperative, Tranexamic Acid | Phase 3 | Unknown | McMaster University | 106 | 2022-08-01 | 2022-04-06 |
| Evaluation of Emerging New Treatments for Infection Prevention in Total Joint Replacement Povidone-Iodine Lavage Solution, Chlorhexidine Lavage Solution, Topical Antibiotic - Periprosthetic Joint Infection, Draining Wound | Phase 3 | Completed | McMaster University | 495 | 2022-03-11 | 2026-10-07 |
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Venous Thromboembolism (7) · Venous Thrombosis (6) · Asthma (5) · Depressive Disorder, Major (5) · Hemorrhage (5) · Pulmonary Embolism (4) · Atrial Fibrillation (3) · Chronic Pain (3) · Critical Illness (3) · Infections (3) · Inflammation (3) · Marijuana Abuse (3) · Osteoarthritis, Knee (3) · Sepsis (3) · Shock, Septic (3)
Saline Solution (6) · Heparin, Low-Molecular-Weight (3) · Pantoprazole (3) · Pregabalin (3) · Rifampin (3) · Rivaroxaban (3) · Tranexamic Acid (3) · Aspirin (2) · Dalteparin (2) · Dexetimide (2) · Escitalopram (2) · Sodium Chloride (2) · Vitamin K 2 (2) · brexpiprazole (2) · caffeine citrate (2)
Canada (89) · United States (16) · Australia (9) · Brazil (6) · United Kingdom (6) · Saudi Arabia (5) · Argentina (4) · India (4) · Italy (4) · Netherlands (4) · Austria (3) · Chile (3) · Germany (3) · Singapore (3) · Spain (3)
Parameswaran Nair, MD, PhD (4) · Joy C MacDermid, PhD (3) · Robin S Roberts, MTech (3) · Alfonso Solimano, MD (2) · Andre Lamy, MD (2) · Christine H Lee, MD (2) · Clive Kearon, MD (2) · Elizabeth Asztalos, MD (2) · Haresh Kirpalani, MD, MSc (2) · Jim Julian, MMath (2) · Mark A Crowther, MD (2) · Michael Van Ameringen, MD, FRCPC (2) · P.J. Devereaux, MD, PhD (2) · Sam Schulman, MD, PhD (2) · Aaron Chiu, MD (1)
PMID 16707748, PMID 16926353, PMID 16939737, PMID 17872784, PMID 17989382, PMID 18565256, PMID 19117884, PMID 19926098, PMID 20047905, PMID 20616670, PMID 21173002, PMID 21417952, PMID 21482348, PMID 22090469, PMID 22172429, PMID 22253394, PMID 22449296, PMID 22514244, PMID 23089679, PMID 23318311, PMID 23339639, PMID 23358966, PMID 23477676, PMID 23537968, PMID 23639498, PMID 23644995, PMID 23731019, PMID 23788287, PMID 23871290, PMID 23875181, PMID 23942857, PMID 23944299, PMID 24496539, PMID 24568963, PMID 24638843, PMID 24679061, PMID 24679062, PMID 24726205, PMID 24840756, PMID 24885201, PMID 24886787, PMID 24890528, PMID 24973289, PMID 25126039, PMID 25127655, PMID 25171195, PMID 25261272, PMID 25399007, PMID 25528663, PMID 25641237
2009 (1), R01HL098045 (1), U01HL088476 (1)