13 completed, 2 recruiting, 1 terminated, 1 withdrawn. 17 Phase 1, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 17 | Completed 13, Recruiting 2, Terminated 1, Withdrawn 1 |
| Phase 2 | 7 | Completed 5, Recruiting 2 |
Follow Lithium Carbonate: new trials by email Literature Review of Lithium Carbonate trials Research Report on Lithium Carbonate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Investigate Lithium Brain/Plasma Pharmacokinetics and Safety of an AL001 Oral Capsule Compared to a Marketed Immediate-release Lithium Carbonate Capsule in Subjects With Bipolar I Disorder AL001, Lithium carbonate - Bipolar I Disorder | Phase 1 / Phase 2 | Recruiting | Alzamend Neuro, Inc. | 20 | 2026-05-11 | 2026-07-28 |
| A Study to Investigate Lithium Brain/Plasma Pharmacokinetics and Safety of an AL001 Oral Capsule Compared to a Marketed Immediate-release Lithium Carbonate Capsule in Healthy Adult Subjects AL001, Lithium Carbonate Capsule - Pharmacokinetics, Neurology | Phase 1 | Completed | Alzamend Neuro, Inc. | 15 | 2025-05-09 | 2026-07-29 |
| A Study of Lithium and Enlicitide in Healthy Adult Participants (MK-0616-034) lithium carbonate, enlicitide - Healthy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 16 | 2025-01-02 | 2025-02-17 |
| Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD) Fluoxetine, Sertraline, Vortioxetine - Depression, Sequestra | Phase 1 / Phase 2 | Recruiting | First Affiliated Hospital of Chongqing Medical University | 520 | 2023-02-20 | 2026-01-27 |
| Evaluation of Lithium and It's Effect on Clinically Localized Prostate Cancer Lithium Carbonate - Prostate Cancer | Phase 1 | Completed | University of Kansas Medical Center | 11 | 2014-04-01 | 2017-01-09 |
| Lithium Carbonate and Tretinoin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia tretinoin, lithium carbonate, laboratory biomarker analysis - Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Monoblastic Leukemia (M5a) | Phase 1 | Completed | Paolo Caimi, MD | 12 | 2013-04-30 | 2017-04-27 |
| In Vivo Lithium Treatment Effects on Gene Expression Levels in Lymphoblastoid Cell Lines From Human Healthy Subjects Lithium Carbonate - Drug Mechanism | Phase 1 | Completed | Nova Scotia Health Authority | 2 | 2012-05-05 | 2024-08-21 |
| Neuroprotective Effects of Lithium in Patients With Small Cell Lung Cancer Undergoing Radiation Therapy to the Brain Lithium Carbonate, Prophylactic cranial irradiation - Small Cell Lung Carcinoma | Phase 1 / Phase 2 | Completed | Washington University School of Medicine | 19 | 2012-04-26 | 2018-07-05 |
| Umbilical Cord Blood Mononuclear Cell Transplant to Treat Chronic Spinal Cord Injury Umbilical Cord Blood Mononuclear Cell, Methylprednisolone, Lithium Carbonate Tablet - Spinal Cord Injuries | Phase 1 / Phase 2 | Completed | China Spinal Cord Injury Network | 20 | 2011-09-01 | 2014-08-21 |
| Lithium, Cord Blood Cells and the Combination in the Treatment of Acute & Sub-acute Spinal Cord Injury Conventional Treatment, Lithium Carbonate Tablet, Cord Blood Cell - Spinal Cord Injury | Phase 1 / Phase 2 | Completed | China Spinal Cord Injury Network | 16 | 2011-09-01 | 2014-01-28 |
| A Pilot Study of Lithium in Progressive Multiple Sclerosis Lithium Carbonate - Multiple Sclerosis | Phase 1 / Phase 2 | Completed | VA Office of Research and Development | 23 | 2011-05-01 | 2019-09-10 |
| Lithium Augmentation for Hyperarousal Symptoms of Post Traumatic Stress Disorder: Pilot Study Lithium Carbonate - Combat Posttraumatic Stess Disorder, Mild Traumatic Brain Injury | Phase 1 | Withdrawn | VA Eastern Colorado Health Care System | 2011-01-01 | 2016-01-07 | |
| Lithium Treatment for Patients With Spinocerebellar Ataxia Type I Lithium Carbonate - Spinocerebellar Ataxia Type I | Phase 1 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 13 | 2008-05-18 | 2019-12-17 |
| Continuation Ketamine in Major Depression Lithium, Ketamine - Major Depressive Disorder | Phase 1 | Completed | James Murrough | 36 | 2007-10-01 | 2014-05-23 |
| Safety and Pharmacokinetics Study of Oral Lithium in Patients With Chronic Spinal Cord Injury Lithium carbonate - Spinal Cord Injuries | Phase 1 | Completed | The University of Hong Kong | 20 | 2007-09-01 | 2012-01-16 |
| Valproate Efficacy in Cocaine-Bipolar Comorbidity Valproate, Placebo, Lithium Carbonate - Bipolar Disorder, Cocaine Dependence | Phase 1 / Phase 2 | Completed | University of Miami | 152 | 2006-03-01 | 2016-10-17 |
| Ph I Study of Lithium During Whole Brain Radiotherapy For Patients With Brain Metastases lithium carbonate, cognitive assessment, quality-of-life assessment - Brain and Central Nervous System Tumors, Cognitive/Functional Effects | Phase 1 | Terminated | Vanderbilt-Ingram Cancer Center | 9 | 2006-02-01 | 2012-02-28 |
Spinal Cord Injuries (3) · Bipolar Disorder (1) · Brain Concussion (1) · Brain Neoplasms (1) · Central Nervous System Neoplasms (1) · Cocaine-Related Disorders (1) · Congenital Abnormalities (1) · Depression (1) · Depressive Disorder, Major (1) · Leukemia, Erythroblastic, Acute (1) · Leukemia, Megakaryoblastic, Acute (1) · Leukemia, Monocytic, Acute (1) · Leukemia, Myeloid, Acute (1) · Leukemia, Myelomonocytic, Acute (1) · Multiple Sclerosis (1)
Alzamend Neuro, Inc. (2) · China Spinal Cord Injury Network (2) · First Affiliated Hospital of Chongqing Medical University (1) · James Murrough (1) · Merck Sharp & Dohme LLC (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Nova Scotia Health Authority (1) · Paolo Caimi, MD (1) · The University of Hong Kong (1) · University of Kansas Medical Center (1) · University of Miami (1) · VA Eastern Colorado Health Care System (1) · VA Office of Research and Development (1) · Vanderbilt-Ingram Cancer Center (1) · Washington University School of Medicine (1)
United States (12) · China (4) · Canada (1)
Hui Zhu, MD (2) · Bo Lu, MD, PhD (1) · Clifford Robinson, M.D. (1) · Grisel J Lopez, M.D. (1) · Ihsan M Salloum, MD, MPH (1) · James W Murrough, MD (1) · John R Rinker, MD (1) · Martin Alda, MD, FRCPC (1) · Moben Mirza, MD (1) · Paolo Caimi, MD (1) · Yat-wa Wong, MD (1)
PMID 19545857, PMID 19897179, PMID 21450159, PMID 25271445, PMID 32211336, PMID 32760832, PMID 37891522
R01DA019992 (1)