20 completed, 4 terminated, 3 recruiting, 2 unknown. 30 Phase 2, 7 Phase 1, 4 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 30 | Completed 20, Terminated 4, Recruiting 3, Unknown 2, Withdrawn 1 |
| Phase 1 | 7 | Completed 5, Recruiting 2 |
| Phase 3 | 4 | Completed 2, Recruiting 1, Terminated 1 |
Follow Lithium Carbonate: new trials by email Literature Review of Lithium Carbonate trials Research Report on Lithium Carbonate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Investigate Lithium Brain/Plasma Pharmacokinetics and Safety of an AL001 Oral Capsule Compared to a Marketed Immediate-release Lithium Carbonate Capsule in Subjects With Bipolar I Disorder AL001, Lithium carbonate - Bipolar I Disorder | Phase 1 / Phase 2 | Recruiting | Alzamend Neuro, Inc. | 20 | 2026-05-11 | 2026-07-28 |
| Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment Lithium Carbonate Capsule - Cornelia De Lange Syndrome | Phase 2 / Phase 3 | Recruiting | University of Milan | 34 | 2024-05-01 | 2025-01-28 |
| Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD) Fluoxetine, Sertraline, Vortioxetine - Depression, Sequestra | Phase 1 / Phase 2 | Recruiting | First Affiliated Hospital of Chongqing Medical University | 520 | 2023-02-20 | 2026-01-27 |
| The CHAMP-study: The CHemopreventive Effect of Lithium in Familial AdenoMatous Polyposis Lithium Carbonate - Familial Adenomatous Polyposis | Phase 2 | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 12 | 2022-06-02 | 2024-10-04 |
| Effect of Lithium Versus Placebo in Adults With Treatment-Resistant Depression Who Are Receiving Ketamine Lithium, Placebo, Ketamine - Treatment Resistant Depression | Phase 2 | Withdrawn | William V. Bobo, M.D. | 2017-11-30 | 2018-08-16 | |
| Lithium for Fracture Treatment: a Double Blind Randomized Controlled Trial (LiFT) Lithium Carbonate, Lactose Placebo - Fractures | Phase 2 | Unknown | Sunnybrook Health Sciences Centre | 160 | 2017-07-21 | 2024-01-26 |
| Low-Dose Lithium for the Treatment of Behavioral Symptoms in Frontotemporal Dementia Lithium Carbonate, Placebo - Frontotemporal Dementia (FTD) | Phase 2 | Completed | Columbia University | 17 | 2017-01-27 | 2025-02-03 |
| Treatment of Psychosis and Agitation in Alzheimer's Disease Lithium, Placebo - Alzheimer's Disease, Psychosis | Phase 2 | Completed | New York State Psychiatric Institute | 77 | 2014-06-01 | 2024-05-02 |
| Ketamine Plus Lithium in Treatment-Resistant Depression Lithium, Ketamine, Placebo - Depression | Phase 2 | Completed | Icahn School of Medicine at Mount Sinai | 34 | 2013-07-01 | 2018-07-31 |
| Study to Evaluate the Efficacy of Lithium Carbonate in Spinal Cord Injury Patients With Neuropathic Pain Lithium Carbonate, Placebo - Neuropathic Pain, Neuralgia | Phase 2 | Completed | China Spinal Cord Injury Network | 60 | 2013-05-01 | 2016-01-28 |
| Neuroprotective Effects of Lithium in Patients With Small Cell Lung Cancer Undergoing Radiation Therapy to the Brain Lithium Carbonate, Prophylactic cranial irradiation - Small Cell Lung Carcinoma | Phase 1 / Phase 2 | Completed | Washington University School of Medicine | 19 | 2012-04-26 | 2018-07-05 |
| Umbilical Cord Blood Mononuclear Cell Transplant to Treat Chronic Spinal Cord Injury Umbilical Cord Blood Mononuclear Cell, Methylprednisolone, Lithium Carbonate Tablet - Spinal Cord Injuries | Phase 1 / Phase 2 | Completed | China Spinal Cord Injury Network | 20 | 2011-09-01 | 2014-08-21 |
| Lithium, Cord Blood Cells and the Combination in the Treatment of Acute & Sub-acute Spinal Cord Injury Conventional Treatment, Lithium Carbonate Tablet, Cord Blood Cell - Spinal Cord Injury | Phase 1 / Phase 2 | Completed | China Spinal Cord Injury Network | 16 | 2011-09-01 | 2014-01-28 |
| Safety and Efficacy of Lithium Carbonate in Patients With Spinocerebellar Ataxia Type 3 Lithium Carbonate, Placebo - Spinocerebellar Ataxia Type 3, Machado Joseph Disease | Phase 2 / Phase 3 | Completed | Hospital de Clinicas de Porto Alegre | 62 | 2011-05-01 | 2013-01-30 |
| A Pilot Study of Lithium in Progressive Multiple Sclerosis Lithium Carbonate - Multiple Sclerosis | Phase 1 / Phase 2 | Completed | VA Office of Research and Development | 23 | 2011-05-01 | 2019-09-10 |
| Safety and Efficacy Study of Lithium for the Treatment of Pediatric Mania. Lithium Carbonate, Placebo - Bipolar Disorder | Phase 2 / Phase 3 | Completed | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 81 | 2010-06-01 | 2013-10-09 |
| Temodar (Temozolomide), Bevacizumab, Lithium and Radiation for High Grade Glioma Temozolomide, Bevacizumab, Lithium Carbonate - Brain Cancer | Phase 2 | Terminated | NYU Langone Health | 28 | 2010-05-01 | 2016-08-04 |
| Safety and Efficacy Study of Citalopram and Lithium for the Treatment of Depressive Mood Disorder Symptoms Lithium Carbonate, Placebo, Citalopram - Major Depressive Disorder, Dysthymia | Phase 2 | Completed | Columbia Northwest Pharmaceuticals | 80 | 2010-03-01 | 2011-08-24 |
| Lithium in Multiple System Atrophy Lithium Carbonate, Placebo - Multiple System Atrophy | Phase 2 | Terminated | Federico II University | 10 | 2009-10-01 | 2014-02-03 |
| Safety and Tolerability of Lithium in Spinocerebellar Ataxia 2 (SCA2) LITHIUM CARBONATE - SPINOCEREBELLAR ATAXIA 2 | Phase 2 | Completed | Federico II University | 20 | 2009-10-01 | 2013-01-08 |
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Depression (4) · Spinal Cord Injuries (4) · Bipolar Disorder (3) · Alzheimer Disease (2) · Amyotrophic Lateral Sclerosis (2) · Depressive Disorder, Major (2) · Spinocerebellar Ataxias (2) · Adenomatous Polyposis Coli (1) · Aggression (1) · Borderline Personality Disorder (1) · Brain Neoplasms (1) · Callosities (1) · Carcinoma, Medullary (1) · Cocaine-Related Disorders (1) · Cognitive Dysfunction (1)
China Spinal Cord Injury Network (4) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · Federico II University (2) · University of Wisconsin, Madison (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Alzamend Neuro, Inc. (1) · Columbia Northwest Pharmaceuticals (1) · Columbia University (1) · First Affiliated Hospital of Chongqing Medical University (1) · Forbes Norris MDA/ALS Research Center (1) · Hospital de Clinicas de Porto Alegre (1) · Icahn School of Medicine at Mount Sinai (1) · Massachusetts General Hospital (1) · NYU Langone Health (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1)
United States (17) · China (5) · Italy (3) · Brazil (2) · Canada (2) · Australia (1) · Netherlands (1) · Taiwan (1)
Alessandro Filla, MD (2) · Herbert Chen, MD (2) · Hui Zhu, MD (2) · Adam R Winstock, MBBS BSc MSc MRCP(UK) MRCP (1) · Aglaia Vignoli, Professor, MD (1) · Arifulla Khan, MD (1) · Clifford Robinson, M.D. (1) · DP Devanand, MD (1) · Deborah Gruber, MD (1) · Diane Nam, MSc,MD,FRCSC (1) · Edward Huey, MD (1) · Ihsan M Salloum, MD, MPH (1) · James W Murrough, MD (1) · Jianjun Li, M.D. (1) · Jinsy Andrews, MD (1)
PMID 30738555, PMID 18700004, PMID 20363190, PMID 21393344, PMID 21525519, PMID 22105463, PMID 24399647, PMID 25093483, PMID 26297649, PMID 26459650, PMID 29859917, PMID 30947755, PMID 31915160, PMID 32760832, PMID 34059401, PMID 35962368, PMID 37732619, PMID 37794802, PMID 37891522
R01AG047146 (1), R01DA019992 (1), R21CA117117 (1), U01NS049640 (1)