16 completed, 5 terminated, 1 recruiting, 1 unknown. 23 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 23 | Completed 16, Terminated 5, Recruiting 1, Unknown 1 |
| Phase 2 | 4 | Completed 2, Recruiting 1, Terminated 1 |
Follow Lithium Carbonate: new trials by email Literature Review of Lithium Carbonate trials Research Report on Lithium Carbonate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment Lithium Carbonate Capsule - Cornelia De Lange Syndrome | Phase 2 / Phase 3 | Recruiting | University of Milan | 34 | 2024-05-01 | 2025-01-28 |
| Effect of Lithium in Patients With Autism Spectrum Disorder and Phelan-McDermid Syndrome (SHANK3 Haploinsufficiency) Lithium Carbonate, Placebo - Autism Spectrum Disorder | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 22 | 2022-02-21 | 2025-10-02 |
| A Lithium-Based Medication to Improve Neurological Outcomes After Surgical Carotid Reconstruction Lithium Carbonate, Placebo - Carotid Artery Diseases, Carotid Artery Stenosis | Phase 3 | Terminated | Negovsky Reanimatology Research Institute | 107 | 2021-11-20 | 2025-09-25 |
| Platform Trial to Assess the Efficacy of Multiple Drugs in Amyotrophic Lateral Sclerosis (ALS) Lithium Carbonate 400 MG - Amyotrophic Lateral Sclerosis | Phase 3 | Terminated | Stichting TRICALS Foundation | 88 | 2021-08-09 | 2026-05-13 |
| Efficacy of Lithium Against Chemotherapy Induced Neutropenia in Breast Cancer Patients Lithium Carbonate - Neutropenia | Phase 3 | Completed | Al-Azhar University | 50 | 2020-08-01 | 2022-10-21 |
| Safety and Efficacy of Lithium Carbonate in Patients With Spinocerebellar Ataxia Type 3 Lithium Carbonate, Placebo - Spinocerebellar Ataxia Type 3, Machado Joseph Disease | Phase 2 / Phase 3 | Completed | Hospital de Clinicas de Porto Alegre | 62 | 2011-05-01 | 2013-01-30 |
| Safety and Efficacy Study of Lithium for the Treatment of Pediatric Mania. Lithium Carbonate, Placebo - Bipolar Disorder | Phase 2 / Phase 3 | Completed | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 81 | 2010-06-01 | 2013-10-09 |
| The Neurotrophic Effects of Lithium Carbonate Following Stroke: A Feasibility Study Lithium Carbonate - Stroke | Phase 3 | Completed | Sunnybrook Health Sciences Centre | 12 | 2010-04-01 | 2024-01-31 |
| Efficacy and Safety of Quetiapine Versus Quetiapine Plus Lithium in Bipolar Depression Quetiapine fumarate XR, Lithium carbonate - Acute Bipolar Depression | Phase 3 | Completed | AstraZeneca | 421 | 2009-04-01 | 2012-07-11 |
| Study to Investigate the Safety and Efficacy of Lithium in Volunteers With Amyotrophic Lateral Sclerosis (ALS) Lithium Carbonate, Riluzole, placebo - Amyotrophic Lateral Sclerosis | Phase 2 / Phase 3 | Terminated | Massachusetts General Hospital | 84 | 2009-01-01 | 2011-04-19 |
| Comparing Quetiapine XR Monotherapy and Augmentation With Lithium Augmentation in TRD Patients Quetiapine XR, Lithium carbonate, SSRI/Venlafaxine - Major Depressive Disorder, Treatment Resistant Depression | Phase 3 | Completed | AstraZeneca | 688 | 2008-11-01 | 2012-05-23 |
| Lithium Versus Paroxetine in Patients With Major Depression Who Have a Family History of Bipolar Disorder or Suicide paroxetine, lithium - Major Depressive Disorder | Phase 3 | Terminated | Nova Scotia Health Authority | 2 | 2007-06-01 | 2021-01-29 |
| Safety and Efficacy Study of Lithium in Bipolar Disorder Lithium Carbonate Capsule - Bipolar Disorder, Mania | Phase 3 | Unknown | JDS Pharmaceuticals | 206 | 2007-01-01 | 2007-08-14 |
| Bipolar II Depression: Lithium, SSRI, or the Combination Sertraline, Lithium carbonate - Bipolar Disorder, Depression | Phase 3 | Completed | Lindner Center of HOPE | 139 | 2006-09-01 | 2013-05-10 |
| Treatment of Mania Symptoms With Drug Therapy Divalproex-extended release (DVP-ER), Lithium, Quetiapine - Bipolar Disorder, Schizophrenia | Phase 3 | Completed | Palo Alto Veterans Institute for Research | 75 | 2005-02-01 | 2018-07-17 |
| Olanzapine Versus Comparator in the Treatment of Bipolar Disorder Olanzapine Hydrochloride, Lithium Carbonate - Bipolar Disorder | Phase 3 | Completed | Eli Lilly and Company | 140 | 2003-12-01 | 2007-06-13 |
| Study of Outcome and Safety of Lithium, Divalproex and Risperidone for Mania in Children and Adolescents Lithium carbonate, Valproate, Risperidone - Bipolar Disorder | Phase 3 | Completed | Washington University School of Medicine | 379 | 2003-02-01 | 2013-04-04 |
| Atypical Antipsychotics for Continuation and Maintenance Treatment After an Acute Manic Episode Valproate, Lithium, Risperidone - Bipolar I Disorder | Phase 3 | Completed | University of British Columbia | 159 | 2003-01-01 | 2015-11-20 |
| Combination Therapy in Dual Diagnosis Bipolar Rapid Cycling Divalproex, Lamotrigine, Lithium - Bipolar Disorder | Phase 3 | Completed | University Hospitals Cleveland Medical Center | 98 | 2002-07-01 | 2014-12-03 |
| Combination Therapy for the Treatment of Bipolar Disorders Lithium, Lamotrigine, Divalproex - Bipolar Disorder | Phase 3 | Terminated | University Hospitals Cleveland Medical Center | 49 | 2002-02-01 | 2016-11-07 |
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Bipolar Disorder (12) · Depression (4) · Mania (3) · Amyotrophic Lateral Sclerosis (2) · Depressive Disorder, Major (2) · Stroke (2) · Autism Spectrum Disorder (1) · Autistic Disorder (1) · Carotid Artery Diseases (1) · Carotid Stenosis (1) · De Lange Syndrome (1) · Depressive Disorder, Treatment-Resistant (1) · Emergence Delirium (1) · Machado-Joseph Disease (1) · Nerve Degeneration (1)
University Hospitals Cleveland Medical Center (3) · AstraZeneca (2) · Al-Azhar University (1) · Assistance Publique - Hôpitaux de Paris (1) · Children's Hospital Medical Center, Cincinnati (1) · Eli Lilly and Company (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Hospital de Clinicas de Porto Alegre (1) · JDS Pharmaceuticals (1) · Lindner Center of HOPE (1) · Massachusetts General Hospital (1) · Negovsky Reanimatology Research Institute (1) · Nova Scotia Health Authority (1) · Palo Alto Veterans Institute for Research (1) · Stichting TRICALS Foundation (1)
United States (9) · Canada (4) · Australia (2) · Belgium (2) · Brazil (2) · Italy (2) · Spain (2) · United Kingdom (2) · Argentina (1) · Austria (1) · Bulgaria (1) · Chile (1) · China (1) · Colombia (1) · Denmark (1)
Keming Gao, MD, PhD (2) · Aglaia Vignoli, Professor, MD (1) · Andree Daigneault, Dr. (1) · Ayal Schaffer, Dr. (1) · Barbara Geller, MD (1) · Benny Lafer, Dr. (1) · Birgit Ekholm, PhD (1) · Claire O'Donovan M O'Donovan, MB FRCPC (1) · Claire O'Donovan, Dr. (1) · Delorme Richard, PHD (1) · Ellen Frank, PhD (1) · Flavio Kapczinski, Dr. (1) · Hubert Wong, Dr. (1)
PMID 18588360, PMID 10609422, PMID 10831476, PMID 10941997, PMID 11018230, PMID 11196004, PMID 11256459, PMID 11522262, PMID 11593071, PMID 11748774, PMID 11772699, PMID 11874212, PMID 12027038, PMID 16143731, PMID 17335331, PMID 19192457, PMID 20363190, PMID 22213771, PMID 22917200, PMID 23810357, PMID 24399647, PMID 26297649, PMID 26459650, PMID 26598475, PMID 26598476, PMID 26975266, PMID 30566418, PMID 30738555, PMID 35235061, PMID 37794802, PMID 8993082, PMID 9171907, PMID 9262937, PMID 9707380
R01MH050165 (1), R01MH063632 (1), R01MH069801 (1), R01MH074707 (1), R21MH062650 (1), U01MH064846 (1), U01MH064850 (1), U01MH064868 (1), U01MH064869 (1), U01MH064887 (1), U01MH064911 (1), U01NS049640 (1)