81 completed, 14 terminated, 11 recruiting, 11 unknown. 28 Not applicable, 27 Phase 4, 25 Phase 3, 19 Phase 2, 5 Phase 1.
Follow Hyperkalemia: new trials by email Literature Review of Hyperkalemia trials Research Report on Hyperkalemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Finerenone for AKI: a Multicenter, Randomized, Placebo-Controlled Feasibility Pilot Trial Finerenone (BAY94-8862 ) 10 mg, Placebo - Acute Kidney Injury, Renal Insufficiency,Chronic | Not applicable | Not yet recruiting | Jean-Maxime Côté | 72 | 2027-01-01 | 2026-08-20 |
| Effects of Minimally vs. Ultra-Processed Diets on Potassium (K) Handling in CKD Low-potassium, ultra-processed diet, Low-potassium, minimally processed diet, Normal potassium-rich, minimally processed diet - Chronic Kidney Disease | Not applicable | Not yet recruiting | University of Alberta | 48 | 2026-11-01 | 2026-10-26 |
| Safety of a Healthy Plant-based Diet With Higher Potassium Content, Compared to a Healthy Plant-based Diet With Limited Potassium Content in Patients With Chronic Kidney Disease: A Pilot Study Healthy plant-based diet (healthy-PBD), Potassium-restricted plant-based diet - Hyperkalemia, Chronic Kidney Disease (Stages 4 and 5) | Not applicable | Recruiting | Karolinska Institutet | 30 | 2026-09-29 | 2026-10-02 |
| A Phase 3 Study Evaluating the Efficacy and Safety of WS016 for the Treatment of Hyperkalemia WS016 - Hyperkalemia | Phase 3 | Recruiting | Waterstone Pharmaceutical (Wuhan) Co., LTD. | 300 | 2026-09-25 | 2026-10-26 |
| Liberalizing Potassium Restrictions in Patients Receiving Hemodialysis Liberalized Potassium Diet, Low Potassium Diet - End Stage Kidney Disease (ESKD), Hemodialysis | Not applicable | Not yet recruiting | University of Ontario Institute of Technology | 148 | 2026-08-01 | 2026-08-19 |
| Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD) Finerenone, Semaglutide, Lotensin - Chronic Kidney Disease, Type 2 Diabetes | Phase 4 | Enrolling by invitation | Baylor Research Institute | 64 | 2026-04-08 | 2026-10-13 |
| Spironolactone Alternate Dosing vs Finerenone in Elevated Potassium - K Safety Study Finerenone, Spironolactone (drug) - Heart Failure, Diabetic Kidney Disease | Phase 4 | Not yet recruiting | Hospital de Messejana Dr. Carlos Alberto Studart Gomes | 60 | 2026-04-01 | 2026-05-13 |
| Observational Study on the Prevalence and Risk Factors of Patients With Hyperkalaemia in Brazil Hyperkalemia | Completed | AstraZeneca | 6434 | 2026-03-31 | 2026-11-02 | |
| AI-Enabled ECG Stratification and Timing of Potassium-Lowering Therapy in Patients With Hyperkalemia: A Target Trial Emulation Study Timely treatment, Delayed treatment - Hyperkalaemia | Not applicable | Not yet recruiting | National Defense Medical Center, Taiwan | 5000 | 2026-01-01 | 2025-12-29 |
| AK+ Guard™ Pilot Study in Chronic Kidney Disease: Outpatient Diagnostic Accuracy and Remote Monitoring AK+ Guard™ ECG Application - Hyperkalemia, Chronic Kidney Disease (Stage 3-4) | Enrolling by invitation | AccurKardia, Inc. | 50 | 2025-10-14 | 2026-10-28 | |
| Adding Urea to the Final Dialysis Fluid Urea in the dialysate - Dysequilibrium Syndrome, ESRD | Phase 1 / Phase 2 | Recruiting | University of California, San Francisco | 20 | 2025-09-16 | 2026-02-12 |
| Patiromer and Diet/hrQoL in Chronic Dialysis Patiromer 8400 MG [Veltassa], Placebo - Hyperkalaemia, Chronic Kidney Disease Stage 3 and 4 | Phase 3 | Recruiting | Mario Negri Institute for Pharmacological Research | 40 | 2025-07-08 | 2025-09-04 |
| Hyperkalemia Quality Improvement Program (HK-QIP) Study standard hyperkalemia management implementation - Hyperkalemia | Not applicable | Active not recruiting | AstraZeneca | 1000 | 2025-06-25 | 2026-08-20 |
| Prediction of Hyperkalemia in Dialysis Patients Through Waveform Analysis Using Wearable ECG HiCardi wearable ECG - Hyperkalemia, Chronic Kidney Disease | Completed | Kyungho Park | 32 | 2025-06-23 | 2026-03-20 | |
| Evidence for Potassium Restriction in Hemodialysis Novel dietary approach focused on restricting the intake of highly bioavailable potassium, Traditional approach - Hyperkalemia, Diminished Renal Excretion | Not applicable | Completed | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 50 | 2025-06-17 | 2026-11-09 |
| Prevalence and Risk Factors of Hyperkalemia in Non-Dialysis Chronic Kidney Disease Patients in Community No Intervention - Hyperkalemia, Chronic Kidney Disease(CKD) | Recruiting | Xiujuan Zang | 1890 | 2025-04-28 | 2025-07-11 | |
| Lower vs. Standard Insulin-Dextrose Doses for Treating Mild to Moderate Hyperkalemia in the Emergency Department Lower Dose Therapy, Conventional Dose Therapy - Hyperkalemia | Not applicable | Enrolling by invitation | University of Malaya | 50 | 2025-04-20 | 2026-05-05 |
| Effect of Patiromer in Children Under 12 Years of Age With High Blood Potassium Levels Patiromer - Hyperkalemia | Phase 2 | Recruiting | Vifor Pharma, Inc. | 36 | 2025-04-06 | 2026-09-25 |
| Monitoring Hyperkalemia Using Point-of-care AI-enabled ECG Device Among Patients With Chronic Kidney Disease Stages 3b-5 A mobile artificial intelligence-enhanced electrocardiogram device estimating plasma potassium categories (<5 mmol/L, 5 - <5.5 mmol/L, 5.5 - <6.0 mmol/L and ≥ 6.0 mmol/L) - Chronic Kidney Disease (Stages 3b-5) | Not applicable | Recruiting | Peking University First Hospital | 1066 | 2025-04-02 | 2025-09-17 |
| the Cardioprotective Effects of Improving Potassium Variability in Maintenance Hemodialysis Patients Sodium Zirconium Cyclosilicate (SZC) - Chronic Kidney Disease on Hemodialysis, Hypokalemia | Phase 4 | Not yet recruiting | Qianfoshan Hospital | 100 | 2025-03-01 | 2024-12-16 |
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Renal Insufficiency, Chronic (40) · Heart Failure (11) · Hypertension (7) · Hypokalemia (6) · Kidney Failure, Chronic (6) · Acute Kidney Injury (4) · Diabetic Nephropathies (4) · Acidosis (3) · Albuminuria (3) · Atrial Fibrillation (3) · Diabetes Mellitus, Type 2 (3) · Emergencies (3) · Kidney Diseases (3) · Arrhythmias, Cardiac (2)
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sodium zirconium cyclosilicate (29) · patiromer (18) · Suspensions (10) · Spironolactone (9) · Albuterol (4) · polystyrene sulfonic acid (4) · Insulin (3) · Lisinopril (3) · Losartan (3) · finerenone (3) · zircon (3) · Dietary Fiber (2) · Irbesartan (2) · Streptozocin (2) · Telmisartan (2)
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