11 completed, 4 terminated, 3 unknown, 1 recruiting. 11 Not applicable, 3 Phase 2, 2 Phase 1, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 7, Terminated 2, Recruiting 1, Unknown 1 |
| Phase 2 | 3 | Terminated 2, Completed 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 1 | Unknown 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Vulvar Vestibulitis: new trials by email Literature Review of Vulvar Vestibulitis trials Research Report on Vulvar Vestibulitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Does a Virtual Program for Pelvic Pain Improve Pain and Sexual Outcomes in Individuals With Provoked Vestibulodynia? Virtual online pelvic health program - Vulvodynia (Chronic Vulvar Pain), Vulvar Vestibulitis | Not applicable | Recruiting | Queen's University | 250 | 2025-12-17 | 2026-02-12 |
| Effects of Flourish HEC on Localized Provoked Vulvodynia BioNourish, a component of the Flourish HEC kit, Control - no intervention - Vulvodynia, Vestibulodynia | Not applicable | Completed | Vaginal Biome Science | 7 | 2022-09-26 | 2024-02-06 |
| Acupuncture for Vulvodynia: A Pre-pilot Study Active Acupuncture, Placebo Acupuncture - Vulvodynia, Vulvar Vestibulitis | Not applicable | Completed | University of Illinois at Chicago | 6 | 2018-02-23 | 2024-02-21 |
| Effect of Acupuncture on Patient Vulvodynia Outcomes Active Acupuncture, Placebo Acupuncture - Vulvodynia, Vulvodynia, Generalized | Not applicable | Completed | University of Illinois at Chicago | 89 | 2018-02-23 | 2025-05-30 |
| Effect of Two Acupuncture Protocols on Vulvodynia Acupuncture, Standard care - Vulvodynia, Vulvodynia, Generalized | Not applicable | Unknown | McLean Center for Complementary and Alternative Medicine, PLC | 51 | 2018-01-01 | 2020-09-03 |
| Dysbiosis in Localized Provoked Vulvodynia (LPV) Low Oxalate Diet - Vulvodynia, Vulvar Vestibulitis | Phase 3 | Unknown | Western Galilee Hospital-Nahariya | 70 | 2015-03-01 | 2015-03-20 |
| Cold Laser: A Modality to Promote Vulvar Healing and Pain Relief Cold laser - Vulvar Vestibulitis, Vestibulodynia | Not applicable | Terminated | ProHealth Care, Inc | 10 | 2014-03-01 | 2017-07-02 |
| Provoked, Localized Vulvodynia Treatment With Acupuncture and Lidocaine Pilot Study Classical Acupuncture, Non-classical acupuncture, Lidocaine - Provoked, Localized Vulvodynia, Provoked Vestibulodynia | Phase 1 | Completed | Oregon College of Oriental Medicine | 19 | 2013-11-01 | 2017-10-06 |
| Acupuncture for the Treatment of Vulvodynia Acupuncture - Vulvodynia, Vulvar Vestibulitis | Not applicable | Completed | Schlaeger, Judith M., CNM, LAc, PhD | 36 | 2012-02-01 | 2014-07-22 |
| Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis "Three Rings Vulvoscopy" (TRIV), Histopathology - Lichen Sclerosus, Lichen Planus | Not applicable | Completed | Ginekološka Poliklinika Dr. Vesna Harni | 328 | 2011-12-01 | 2019-10-30 |
| Study of Emu Oil vs. Placebo for Vulvar Pain in Women. Emu Oil, Inert oil - Vulvodynia, Vestibulodynia | Not applicable | Terminated | Corewell Health East | 1 | 2011-02-01 | 2017-01-25 |
| Effectiveness of Cognitive Behavioural Therapy and Physical Therapy for Provoked Vestibulodynia cognitive-behavioural therapy, physical therapy - Vulvar Vestibulitis | Not applicable | Completed | Queen's University | 20 | 2009-09-01 | 2015-09-01 |
| Pregabalin for the Treatment of Vulvodynia pregabalin - Vulvodynia, Vulvar Vestibulitis | Phase 2 | Terminated | The Cleveland Clinic | 16 | 2009-02-01 | 2021-07-19 |
| 5% Lidocaine Ointment in the Treatment of Vulvar Vestibulitis 5% topical lidocaine ointment, Placebo cream - Vulvar Vestibulitis | Phase 2 | Terminated | University of North Carolina, Chapel Hill | 14 | 2006-12-01 | 2012-07-16 |
| "Vestibulitis Educational Seminar Trial" Study Educational - Vulvar Vestibulitis | Completed | University of British Columbia | 500 | 2006-01-01 | 2015-06-15 | |
| Botox on Vulvar Vestibulitis Botulinum toxin - Vulvar Vestibulitis, Vulvar Diseases | Phase 4 | Unknown | Copenhagen University Hospital, Rigshospitalet | 64 | 2005-04-01 | 2007-04-19 |
| A Search for Helicobacter Pylori in Localized Vulvodynia Vulvodynia, Vulvar Vestibulitis | Completed | Western Galilee Hospital-Nahariya | 27 | 2004-05-01 | 2007-07-16 | |
| Vulvar Vestibulitis Clinical Trial: Desipramine-Lidocaine topical lidocaine + oral desipramine, and/or placebo - Vulvar Disease | Not applicable | Completed | University of Rochester | 128 | 2002-08-01 | 2007-11-14 |
| Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis capsaicin, Placebo - Interstitial Cystitis, Vulvar Diseases | Phase 1 / Phase 2 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 139 | 1995-06-01 | 2025-05-04 |
Vulvodynia (14) · Vulvar Diseases (5) · Dyspareunia (3) · Pain (3) · Chronic Pain (1) · Cystitis, Interstitial (1) · Lichen Planus (1) · Lichen Sclerosus et Atrophicus (1) · Neurodermatitis (1) · Rare Diseases (1) · Urogenital Diseases (1) · Vulvar Lichen Sclerosus (1)
Female Urogenital Diseases (19) · Female Urogenital Diseases and Pregnancy Complications (19) · Genital Diseases (19) · Genital Diseases, Female (19) · Vulvitis (19) · Urogenital Diseases (18) · Vulvar Diseases (14) · Pathological Conditions, Signs and Symptoms (5) · Male Urogenital Diseases (4) · Neurologic Manifestations (4) · Signs and Symptoms (4) · Genital Diseases, Male (3) · Mental Disorders (3) · Sexual Dysfunction, Physiological (3) · Sexual Dysfunctions, Psychological (3)
Acupuncture Therapy (2) · Lidocaine (2) · Botulinum Toxins (1) · Capsaicin (1) · Cognitive Behavioral Therapy (1) · Desipramine (1) · Physical Therapy Modalities (1) · Pregabalin (1) · Standard of Care (1) · emu Oil (1)
Queen's University (2) · University of Illinois at Chicago (2) · Western Galilee Hospital-Nahariya (2) · Copenhagen University Hospital, Rigshospitalet (1) · Corewell Health East (1) · Ginekološka Poliklinika Dr. Vesna Harni (1) · McLean Center for Complementary and Alternative Medicine, PLC (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · Oregon College of Oriental Medicine (1) · ProHealth Care, Inc (1) · Schlaeger, Judith M., CNM, LAc, PhD (1) · The Cleveland Clinic (1) · University of British Columbia (1) · University of North Carolina, Chapel Hill (1) · University of Rochester (1)
United States (11) · Canada (2) · Croatia (1) · Denmark (1) · Israel (1)
Caroline Pukall, PhD (2) · Jacob Bornstein, MD (2) · Judith M. Schlaeger, PhD (2) · Arthur Y Fan, MD(CHN),PhD (1) · Beri M Ridgeway, MD (1) · Christina Damsted Petersen, MD (1) · David C Foster, MD, MPH (1) · Denniz Zolnoun, MD MPH (1) · Donna J Carrico, WHNP, MS (1) · Hugh Flood (1) · Jacqueline Rohl, MD (1) · John Steege, MD (1) · Lee E Hullender Rubin, DAOM (1) · Linda A LaBorde, BS PT (1) · Lori A Brotto, PhD (1)
PMID 15162347, PMID 19305326, PMID 20733439, PMID 29686883, PMID 30341023, PMID 31592976, PMID 35943448, PMID 36130137, PMID 36387991
R01DK049524 (1), R01HD040123 (1)