Lichen Planus: Clinical Trials

110 completed, 36 unknown, 19 recruiting, 10 not yet recruiting. 51 Phase 2, 48 Not applicable, 19 Phase 4, 12 Phase 3, 11 Phase 1.

By phase and status

Phase	Trials	Status
Phase 2	51	Completed 31, Recruiting 6, Unknown 5, Terminated 3, Active not recruiting 2, Not yet recruiting 2, Enrolling by invitation 1, Withdrawn 1
Not applicable	48	Completed 27, Unknown 9, Recruiting 5, Not yet recruiting 3, Active not recruiting 1, Enrolling by invitation 1, Terminated 1, Withdrawn 1
Phase 4	19	Completed 13, Recruiting 2, Unknown 2, Active not recruiting 1, Not yet recruiting 1
Phase 3	12	Completed 5, Unknown 4, Active not recruiting 1, Recruiting 1, Terminated 1
Phase 1	11	Unknown 5, Completed 4, Enrolling by invitation 1, Recruiting 1
Early Phase 1	7	Unknown 4, Completed 2, Withdrawn 1

Follow Lichen Planus: new trials by email Literature Review of Lichen Planus trials Research Report on Lichen Planus

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
A Study to Assess the Efficacy and Safety of GIA632 Across a Range of Doses in Participants With Moderate to Severe Cutaneous Lichen Planus Placebo, GIA632 - Cutaneous Lichen Planus	Phase 2	Recruiting	Novartis Pharmaceuticals	259	2026-09-29	2026-10-13
Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions 5-Amino Levulinic Acid - Oral Cancer, Oral Cavity Cancer	Phase 2	Not yet recruiting	University of Massachusetts, Boston	65	2026-09-01	2026-03-19
Improving Prescribing Quality for Oral Mucosal Disorders Using a Pharmacist-Led Model Pharmacist-Led Prescribing Optimization and Patient Counselling - Oral Lichen Planus, Recurrent Aphthous Stomatitis	Not applicable	Not yet recruiting	University of Fujairah	336	2026-07-01	2026-07-22
Periodontal Status in Patients With Oral Lichen Planus Oral Lichen Planus, Periodontitis		Not yet recruiting	Catholic University of the Sacred Heart	176	2026-05-20	2026-05-22
Safety and Biomarker Responses of Delgocitinib (JAK1,2,3/TYK2 Inhibitor) in Central Centrifugal Cicatricial Alopecia and Lichen Planopilaris Delgocitinib - Central Centrifugal Cicatricial Alopecia, Lichen Planopilaris	Phase 2	Recruiting	Icahn School of Medicine at Mount Sinai	30	2026-05-19	2026-07-10
A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris Oral Brepocitinib, Placebo - Lichen Planopilaris	Phase 2 / Phase 3	Recruiting	Priovant Therapeutics, Inc.	342	2026-03-19	2026-07-08
Low Level Laser Therapy With Injectable Platelet Rich Fibrin in Management of Oral Lichen Planus Injectable Platelet Rich Fibrin, Low Level Laser Therapy, Triamcinolone acetonide (injection) - Oral Lichen Planus	Phase 4	Active not recruiting	Ain Shams University	39	2026-03-15	2026-09-29
Observational Study of OROSEDAL in Sore Throat and Minor Oral Lesions OROSEDAL - Sore Throat, Aphthous Ulcer		Recruiting	Laboratoires Elerte	124	2026-03-05	2026-06-02
Role of Subgingival Instrumentation in Oral Lichen Planus subgingival instrumentation - Oral Lichen Planus	Not applicable	Not yet recruiting	Postgraduate Institute of Dental Sciences Rohtak	30	2026-03-01	2026-02-06
Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus Topical Bromelain, 0.1% topical triamcinolone acetonide, Combination of Topical Bromelain and Triamcinolone Acetonide in Orabase - Oral Lichen Planus	Phase 2	Recruiting	Cairo University	42	2026-02-18	2026-06-09
Nemolizumab to Treat Lichen Planopilaris, a Noncontrolled, Prospective, Pilot Study. Nemolizumab - Lichen Plano-Pilaris	Phase 4	Recruiting	The Skin Center Dermatology Group	10	2026-02-01	2026-02-10
Effectiveness of a Sodium Hyaluronate 0.01% and Sh-Oligopeptide-85 SP Mouthwash for the Treatment of Symptomatic Oral Lichen Planus Sodium hyaluronate 0.01% and Sh-Oligopeptide-85 SP Mouthwash, Placebo - Oral Lichen Planus	Phase 4	Not yet recruiting	Universidad Complutense de Madrid	40	2026-01-08	2026-01-16
Cardiovascular and Prothrombotic Risk in Patients With Oral Lichen Planus. blood sample collection - Oral Lichen Planus		Not yet recruiting	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	55	2026-01-01	2026-01-12
Mucosal and Nasal Involvement and Their Correlation With Smell and Taste Functions in Lichen Planus Patients Grup 1 - Lichen Planus Patients Intervention Name: Taste and Smell Testing, Oral and Nasal Examination, Nasal Endoscopy Intervention Description: Participants undergo taste and smell testing to assess - Lichen Planus		Completed	Istanbul Training and Research Hospital	88	2026-01-01	2026-05-06
Evaluation of Artificial Intelligence in Diagnosis and Risk Assessment of Oral Potentially Malignant Disorders Toluidine blue staining of the lesion and cytological smears - Oral Lichen Planus, Oral Leukoplakia		Not yet recruiting	Ain Shams University	120	2025-12-16	2026-01-06
Photobiomodulation, Photodynamic Therapy, and Clobetasol in the Treatment of Oral Lichen Planus. Photobiomodulation using 635 nm diode laser, Photodynamic therapy - laser mucosal treatment, Clobetasol propionate 0.05 percent topical application - Oral Lichen Planus, Erosive Lichen Planus	Not applicable	Recruiting	Medical University of Silesia	60	2025-12-01	2026-04-30
Efficacy of Coconut Gel Compared to Corticosteroid Gel in the Management of Oral Lichen Planus Coconut oil, Triamcinolone Acetonide - Oral Lichen Planus	Phase 4	Completed	Ain Shams University	36	2025-11-11	2026-10-02
Identification of Cutaneous and Blood Biomarkers Predictive of Response to Systemic Treatments During Chronic Inflammatory Skin Diseases Sampling - Atopic Dermatitis, Psoriasis		Recruiting	Assistance Publique - Hôpitaux de Paris	830	2025-10-20	2026-06-12
Evaluation of Efficacy and Safety of add-on Tofacitinib in Patients With Oral Lichen Planus Tofacitinib 5 mg BID and Triamcinolone ointment, Placebo and Triamcinolone ointment - Oral Lichen Planus	Phase 4	Recruiting	All India Institute of Medical Sciences, Bhubaneswar	60	2025-10-10	2025-11-28
Koebner's Phenomenon in Psoriasis and Lichen Planus Tape stripping - Kobner Phenomenon, Psoriasis	Not applicable	Withdrawn	Marie-Charlotte Brüggen		2025-09-01	2026-03-17

Showing 20 of 194. Sign in to see all of them.

Narrower conditions

Lichen Planus, Oral (135)  ·  Leukoplakia, Oral (14)  ·  Mouth Neoplasms (14)  ·  Alopecia (6)  ·  Leukoplakia (5)  ·  Lichen Sclerosus et Atrophicus (5)  ·  Mouth Diseases (5)  ·  Psoriasis (5)  ·  Autoimmune Diseases (4)  ·  Erythroplasia (4)  ·  Squamous Cell Carcinoma of Head and Neck (4)  ·  Stomatitis, Aphthous (4)  ·  Dermatitis, Atopic (3)  ·  Graft vs Host Disease (3)

Broader conditions

Skin Diseases, Papulosquamous (194)  ·  Skin and Connective Tissue Diseases (194)  ·  Lichenoid Eruptions (193)  ·  Skin Diseases (193)  ·  Stomatognathic Diseases (141)  ·  Mouth Diseases (136)  ·  Pathological Conditions, Signs and Symptoms (34)  ·  Neoplasms (27)  ·  Pathological Conditions, Anatomical (25)  ·  Neoplasms by Site (23)  ·  Head and Neck Neoplasms (21)  ·  Precancerous Conditions (17)  ·  Immune System Diseases (12)  ·  Leukoplakia (12)

Interventions

Triamcinolone Acetonide (19)  ·  Adrenal Cortex Hormones (13)  ·  Triamcinolone (8)  ·  Clobetasol (7)  ·  Orabase (7)  ·  Dexamethasone (5)  ·  Biopsy (4)  ·  Methotrexate (4)  ·  Curcumin (3)  ·  Hydroxychloroquine (3)  ·  Low-Level Light Therapy (3)  ·  Photochemotherapy (3)  ·  Solutions (3)  ·  apremilast (3)  ·  pimecrolimus (3)

Sponsors

Cairo University (19)  ·  Ain Shams University (10)  ·  Catholic University of the Sacred Heart (4)  ·  Fayoum University (4)  ·  Mashhad University of Medical Sciences (4)  ·  National Institute of Dental and Craniofacial Research (NIDCR) (4)  ·  Hams Hamed Abdelrahman (3)  ·  Mayo Clinic (3)  ·  University of Catania (3)  ·  University of Zagreb (3)  ·  Wroclaw Medical University (3)  ·  Aaron R. Mangold (2)  ·  Al-Azhar University (2)  ·  All India Institute of Medical Sciences, Bhubaneswar (2)  ·  Assistance Publique - Hôpitaux de Paris (2)

Countries

United States (41)  ·  Egypt (38)  ·  France (10)  ·  Italy (10)  ·  India (8)  ·  United Kingdom (7)  ·  Canada (6)  ·  Germany (6)  ·  Iran (6)  ·  Spain (6)  ·  China (5)  ·  Poland (5)  ·  Croatia (4)  ·  Turkey (Türkiye) (4)  ·  Australia (3)

Top investigators

Gaetano Isola (3)  ·  DirkJan Hijnen, MD, PhD (2)  ·  Zhihui Zhang (2)  ·  Aaron Mangold, MD (1)  ·  Aaron R Mangold (1)  ·  Aaron R Mangold, MD (1)  ·  Ahmed Amr (1)  ·  Ahmed F. Assistant Professor, PhD (1)  ·  Alessandro Villa, DDS, PhD, MPH (1)  ·  Alexandra B. Kimball, MD, MPH (1)  ·  Amy McMichael, MD (1)

Results publications

PMID 10761562, PMID 10865927, PMID 10921388, PMID 10965678, PMID 11059069, PMID 11059125, PMID 11331037, PMID 12076323, PMID 12419687, PMID 12543777, PMID 12969224, PMID 14662419, PMID 15972624, PMID 16122679, PMID 16128740, PMID 16225582, PMID 16386358, PMID 17410291, PMID 17552026, PMID 17604143, PMID 17822813, PMID 18024283, PMID 18155609, PMID 19037107, PMID 19540661, PMID 20232393, PMID 20491973, PMID 21175873, PMID 21743296, PMID 21827739, PMID 21907450, PMID 22242640, PMID 22322481, PMID 22582895, PMID 22739938, PMID 22910104, PMID 23445815, PMID 23668304, PMID 23675060, PMID 26507685, PMID 27349424, PMID 30004820, PMID 30297352, PMID 3144585, PMID 33123228, PMID 33374791, PMID 33605440, PMID 33760691, PMID 33831097, PMID 34251533

NIH funding

2019 (1), 2023 (1), 2025 (1), P30CA016672 (1), U01CA279862 (1)