18 completed, 5 recruiting, 4 not yet recruiting, 3 terminated. 17 Not applicable, 10 Phase 2, 4 Phase 3, 3 Phase 1, 1 Phase 4.
Follow Vulvar Lichen Sclerosus: new trials by email Literature Review of Vulvar Lichen Sclerosus trials Research Report on Vulvar Lichen Sclerosus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nemolizumab for LS Nemolizumab 30 mg - Lichen Sclerosus of Vulva | Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 25 | 2026-09-01 | 2026-07-15 |
| Efficacy of Collagendep in Reducing Vulvar Dryness in Patients With Lichen Sclerosus Treated With Fat Grafting Autologous Fat Grafting (Lipofilling), Collagendep Pink Beauty - Vulvar Lichen Sclerosus, Vulvar Atrophy | Not applicable | Not yet recruiting | San Gallicano Dermatological Institute IRCCS | 40 | 2026-02-20 | 2026-03-04 |
| Methotrexate for Severe Vulvar Lichen Sclerosus Methotrexate (MTX) - Vulvar Lichen Sclerosus | Phase 2 | Recruiting | Clinica Dermatologica Arbache ltda | 12 | 2026-01-21 | 2026-01-22 |
| Dynamic Quadripolar Radiofrequency VS Topical Corticosteroids in Women With Vulvar Lichen Sclerosus Dynamic Quadripolar Radiofrequency (DQRF), Topical high-potency corticosteroid - Vulvar Lichen Sclerosus | Not applicable | Recruiting | Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare | 68 | 2026-01-01 | 2026-01-23 |
| Treatment of Vulvar Lichen Sclerosus With Corticosteroid Ointment, Calcineurin Inhibitor Ointment, and Platelet-Rich Plasma (PRP) Therapy. Platelet-Rich Plasma (PRP) Treatment, Clobetasol Propionate 0.05% Cream (Dermovate), Pimecrolimus Cream (Elidel) - Vulvar Lichen Sclerosus | Not applicable | Not yet recruiting | Milosz Pietrus | 45 | 2025-12-01 | 2025-11-20 |
| Use of Topical Testosterone and Estrogen vs Estrogen Alone in Vulvodynia: a Randomized Controlled Trial Estradiol 0.01% Vag Cream, testosterone 0.1% and estradiol 0.01% vaginal cream - Vulvodynia, Dyspareunia | Phase 2 / Phase 3 | Not yet recruiting | TriHealth Inc. | 44 | 2025-12-01 | 2025-12-03 |
| StrataMGT in the Reduction of Vulvar Lichen Sclerosus (LS) Symptoms StrataMGT, Placebo - Vulvar Lichen Sclerosus | Phase 1 | Recruiting | Andrew T. Goldstein, MD | 100 | 2024-10-16 | 2024-11-08 |
| StrataMGT for the Treatment of Vulvar Lichen Sclerosus StrataMGT - Vulvar Lichen Sclerosus | Not applicable | Completed | Center for Vulvovaginal Disorders | 5 | 2024-04-16 | 2025-02-07 |
| VALOR: Vaginal Atrophy & Long-term Observation of Recovery 7-0940 - Atrophic Vaginitis, Vaginal Atrophy | Not applicable | Recruiting | Stratpharma AG | 2000 | 2023-10-30 | 2026-02-20 |
| Efficacy and Safety of MC2-25 Cream & Vehicle in Women With Vulvar Lichen Sclerosus (VLS) MC2-25 cream, MC2-25 vehicle - Vulvar Lichen Sclerosus | Phase 2 | Completed | MC2 Therapeutics | 33 | 2023-10-11 | 2025-10-15 |
| Use of Platelet Rich Plasma From Cord Blood vs Placebo in the Treatment of Vulvar Lichen Sclerosus Infiltrative treatment with CB-PRP - Vulvar Lichen Sclerosus | Phase 1 / Phase 2 | Completed | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 100 | 2023-01-24 | 2026-09-02 |
| A Comparative Study on the Efficacy of AI Temperature-controlled Radiofrequency Technology and Electrical Stimulation in the Treatment of Vulvar Leukoplakia Radiofrequency technology, Electrical stimulation - Vulvar Lichen Sclerosus | Not applicable | Unknown | Zhongnan Hospital | 120 | 2022-07-07 | 2024-02-05 |
| To Compare Inflammatory Biomarkers Before and After Treatment With Clobetasol or Fractional CO2 Laser, in Women With Histologically Confirmed Vulvar Lichen Sclerosus, Without Prior Corticosteroid Treatment. Fractional microablative CO2 Laser - Vulvar Lichen Sclerosus | Not applicable | Recruiting | Universidade Federal do Rio de Janeiro | 40 | 2022-06-22 | 2025-11-26 |
| Does Steroid Plus CO2 Laser Improve Lichen Sclerosus Symptoms Compared to Steroids Alone? MonaLisa Touch, Topical steroid - Vulvar Lichen Sclerosus | Phase 2 / Phase 3 | Terminated | University of South Alabama | 11 | 2022-04-13 | 2025-06-18 |
| Fractionated CO2 Laser With and Without Clobetasol for Treatment of Vulvar Lichen Sclerosus Fractionated CO2-laser, Clobetasol Propionate 0.05% Ointment - Vulvar Lichen Sclerosus | Phase 4 | Completed | Medstar Health Research Institute | 212 | 2022-03-01 | 2025-06-05 |
| A Study to Evaluate Platelet Rich Plasma to Treat Vulvar Lichen Sclerosus Autologous Platelet-Rich Plasma (PRP), Sham Procedure - Vulvar Lichen Sclerosus | Phase 1 / Phase 2 | Completed | Jennifer R. Arthurs | 30 | 2022-01-19 | 2026-07-22 |
| Plasma Rich in Growth Factors (PRGF) for the Treatment of Lichen Sclerosus Atrophicus of the Vulva PRGF, Clobetasol Propionate - Lichen Sclerosus of Vulva | Phase 3 | Withdrawn | Fundación Eduardo Anitua | 2021-12-23 | 2025-02-27 | |
| Carbon Dioxide（CO2）Fractional Laser Plus Photodynamic Therapy in Female Patients With Vulvar Lichen Sclerosus CO2 fractional laser, 5-aminolevulinic acid (5-ALA) with red light illumination, Mometasone furoate (MMF) 0.1% ointment - Vulva Lichen Sclerosus | Not applicable | Unknown | Xijing Hospital | 134 | 2021-11-23 | 2022-02-08 |
| Early Detection of Vulval CAncer Through Self-Examination (EDuCATE): Intervention Study Training in Vulval Self-Examination - Self-Examination, Vulvar Cancer | Not applicable | Completed | University of Manchester | 25 | 2021-11-04 | 2023-06-22 |
| Characterizing the Microbiome in Postmenopausal Women With Vulvar Lichen Sclerosus Vulvar Lichen Sclerosus | Completed | University of Texas Southwestern Medical Center | 17 | 2021-09-16 | 2022-08-31 |
Showing 20 of 33. Sign in to see all of them.
Lichen Sclerosus et Atrophicus (6) · Vulvodynia (3) · Lichen Planus (2) · Atrophic Vaginitis (1) · Dyspareunia (1) · Female Urogenital Diseases (1) · Keratoderma, Palmoplantar, Epidermolytic (1) · Leukoplakia (1) · Neurodermatitis (1) · Self-Examination (1) · Skin Diseases (1) · Vulvar Diseases (1) · Vulvar Neoplasms (1) · Vulvar Vestibulitis (1)
Female Urogenital Diseases and Pregnancy Complications (33) · Genital Diseases (33) · Genital Diseases, Female (33) · Urogenital Diseases (33) · Female Urogenital Diseases (32) · Vulvar Diseases (32) · Skin and Connective Tissue Diseases (9) · Skin Diseases (8) · Lichenoid Eruptions (7) · Skin Diseases, Papulosquamous (7) · Neoplasms (2) · Behavior (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Dermatitis (1) · Genetic Diseases, Inborn (1)
Clobetasol (8) · Ointments (4) · Adrenal Cortex Hormones (2) · 1-phenyl-3,3-dimethyltriazene (1) · Aminolevulinic Acid (1) · Cortisone (1) · Electric Stimulation (1) · Estradiol (1) · Laser Therapy (1) · Lasers (1) · Low-Level Light Therapy (1) · Methotrexate (1) · Mometasone Furoate (1) · Photochemotherapy (1) · Steroids (1)
Center for Vulvovaginal Disorders (2) · Medstar Health Research Institute (2) · University of Texas Southwestern Medical Center (2) · 1st Federal Budgetary Healthcare Institution Volga District Medical Center (1) · Andrew T. Goldstein, MD (1) · Beth Israel Deaconess Medical Center (1) · Candela Corporation (1) · Clinica Dermatologica Arbache ltda (1) · Daniela de Fátima Teixeira da Silva (1) · Deana Funaro (1) · Dermtreat (1) · Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare (1) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (1) · Fundación Eduardo Anitua (1) · Ginekološka Poliklinika Dr. Vesna Harni (1)
United States (13) · Brazil (3) · China (2) · Denmark (2) · Russia (2) · Switzerland (2) · Canada (1) · Croatia (1) · Germany (1) · Italy (1) · Poland (1) · Spain (1) · United Kingdom (1)
Alexander Kreuter, MD, Prof. (1) · Andrea Cytryn, Master of Science in Health (1) · Andreas Guenthert, Prof. Dr. med. (1) · Andrew T Goldstein, MD (1) · Chailee Moss, MD (1) · Charles Hanes, MD (1) · Cheryl Iglesia, MD (1) · Daniela FT Silva, PhD (1) · Deana Funaro, Doctor (1) · Gregor B.E. Jemec, MD (1) · Guannan Zhu (1) · Jill Krapf, MD (1) · Katherine Bodiford, MD (1) · Khava Balashova, MD, Obstetrics and Gynecology (1) · Konika P Schallen, MD (1)
PMID 33957642, PMID 17034521, PMID 24696010, PMID 28793884, PMID 30742321, PMID 32021489, PMID 32373174, PMID 34541702, PMID 34878932, PMID 35290878, PMID 35663131, PMID 37145134, PMID 37352640, PMID 39998969, PMID 42384057