15 completed, 3 unknown, 1 active not recruiting, 1 not yet recruiting. 4 Not applicable, 3 Phase 2, 2 Phase 1, 2 Phase 4, 1 Early Phase 1.
Follow Ventricular Septal Defect: new trials by email Literature Review of Ventricular Septal Defect trials Research Report on Ventricular Septal Defect
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bypass Clear Priming VSD Cardiopulmonary Bypass Circuit Reduce Bypass Associated Inflammation? Clear priming of the bypass pump - Ventricular Septal Defect | Not applicable | Not yet recruiting | Seattle Children's Hospital | 60 | 2026-02-25 | 2026-02-06 |
| Mechanical Complications of Acute Myocardial Infarction: a Multicenter Prospective Study Surgical treatment, Percutaneous treatment - Ventricular Septal Defect, Papillary Muscle Rupture | Recruiting | Maastricht University Medical Center | 800 | 2025-01-01 | 2025-05-11 | |
| Clinical Evaluation Of Ventricular Septal Defect (VSD) In Children at Sohag Univesity Hospital ECHO - Ventricular Septal Defect | Unknown | Sohag University | 100 | 2024-06-24 | 2024-07-09 | |
| The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease Thiamine - Congenital Heart Disease, Thiamine Deficiency | Early Phase 1 | Completed | Universitas Sumatera Utara | 86 | 2024-05-01 | 2026-03-24 |
| Immune Heterogeneity Before and After Cardiopulmonary Bypass in Children Ventricular Septal Defect | Completed | The Children's Hospital of Zhejiang University School of Medicine | 3 | 2024-01-01 | 2025-03-11 | |
| Cera™ VSD Occluder Post Market Clinical Follow-up Cera™ VSD occluder implantation - Ventricular Septal Defect | Completed | Cardiac Children's Foundation Taiwan | 152 | 2023-10-13 | 2025-06-12 | |
| Regional Anesthesia Following Pediatric Cardiac Surgery Regional Anesthesia, Wound infiltration, Ropivacaine 0.2% Injectable Solution - Atrial Septal Defect, Ventricular Septal Defect | Phase 4 | Completed | Duke University | 52 | 2023-03-29 | 2025-08-28 |
| A Study Evaluating the Efficacy and Safety of IV L-Citrulline for the Prevention of Clinical Sequelae of Acute Lung Injury Induced by Cardiopulmonary Bypass in Pediatric Patients Undergoing Surgery for Congenital Heart Defects L-citrulline, Plasmalyte A - Ventricular Septal Defect, Atrioventricular Septal Defect | Phase 3 | Terminated | Asklepion Pharmaceuticals, LLC | 64 | 2022-06-29 | 2024-09-19 |
| Improving Care for Children With Congenital Heart Disease. Biomarker analysis at enrolment, Biomarker analyses throughout the study - Heart Disease Congenital, Ventricular Septal Defect | Not applicable | Completed | Lund University Hospital | 313 | 2020-02-17 | 2026-05-08 |
| Optical Tissue Identification for Myocardial Architecture Fluorescite, Cellvizio 100 Series System with Confocal Miniprobes - Ventricular Septal Defect, Complete Atrioventricular Canal | Phase 2 | Active not recruiting | Aditya Kaza | 70 | 2019-12-20 | 2023-06-15 |
| Lifetech KONAR MFO Post-Market Clinical Follow-Up Study KONAR-MF™ VSD Occluder - Ventricular Septal Defect | Completed | Lifetech Scientific (Shenzhen) Co., Ltd. | 40 | 2019-12-04 | 2024-04-15 | |
| A Trial to Evaluate the Safety and Efficacy of a Fully Degradable Ventricular Septal Defect (VSD) Closure Fully Absorbable VSD Occlusion System, VSD Occluder - Ventricular Septal Defect | Not applicable | Unknown | Chinese Academy of Medical Sciences, Fuwai Hospital | 108 | 2019-04-11 | 2019-05-08 |
| Cardiopulmonary Function in Adults Born With a Ventricular Septal Defect Cardiopulmonary function - Ventricular Septal Defect | Completed | University of Aarhus | 95 | 2018-09-24 | 2019-09-10 | |
| The Effect of Transcatheter VSD Closure on Children's Appetite, Hormones and Growth Ventricular Septal Defect, Appetite Loss | Completed | Kayseri City Hospital | 46 | 2018-07-16 | 2022-01-21 | |
| The Cardiopulmonary Effect of Inhaled Beta-2-agonists on Adult Patients Born With Ventricular Septum Defects. Salbutamol, Norflouran (Placebo Evohaler(R) ) - Ventricular Septal Defect | Phase 4 | Completed | University of Aarhus | 96 | 2016-10-15 | 2018-07-05 |
| The Effect of Transcatheter Ventricular Septal Defect Closure on Heart Rate Variability Parameters 24 hours ambulatory Holter monitoring - Ventricular Septal Defect, Closure; Interventricular Septum | Completed | Kayseri City Hospital | 37 | 2016-04-01 | 2021-04-26 | |
| Cardiac Function After Transcatheter VSD Closure Ventricular Septal Defect | Unknown | National Taiwan University Hospital | 50 | 2015-07-01 | 2017-04-25 | |
| A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and Pharmacokinetics Dexmedetomidine - Transposition of the Great Arteries, Tetralogy of Fallot | Phase 1 | Completed | Carelon Research | 119 | 2014-04-02 | 2018-03-23 |
| Longterm Outcome After Ventricular Septal Defect Closure MRI exercise test, Gas-exchange exercise test - Ventricular Septal Defect | Completed | University of Aarhus | 40 | 2014-03-01 | 2016-09-13 | |
| The Effect of Remote Ischemic Preconditioning on the Ischemic Reperfusion Injury in Infants With Ventricular Septal Defect and Pulmonary Hypertension remote ischemic preconditioning (RIPC) - Ventricular Septal Defect, Pulmonary Hypertension | Not applicable | Completed | Seoul National University Hospital | 60 | 2010-12-01 | 2012-02-02 |
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Heart Septal Defects, Ventricular (22) · Heart Defects, Congenital (4) · Heart Septal Defects, Atrial (4) · Atrioventricular Septal Defect (2) · Ductus Arteriosus, Patent (2) · Aneurysm, False (1) · Anorexia (1) · Aortopulmonary Septal Defect (1) · Cardiovascular Diseases (1) · Complete atrioventricular septal defect (1) · Heart Rupture (1) · Hypertension, Pulmonary (1) · Inflammation (1) · Pain, Procedural (1) · Partial atrioventricular canal (1)
Cardiovascular Abnormalities (22) · Congenital Abnormalities (22) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (22) · Heart Diseases (22) · Heart Septal Defects (22) · Cardiovascular Diseases (21) · Heart Defects, Congenital (18) · Pathological Conditions, Signs and Symptoms (3) · Signs and Symptoms (2) · Vascular Diseases (2) · Avitaminosis (1) · Deficiency Diseases (1) · Hypertension (1) · Lung Diseases (1) · Malnutrition (1)
Albuterol (1) · Anesthesia, Conduction (1) · Citrulline (1) · Dexmedetomidine (1) · Fluorescein (1) · Ketamine (1) · Plasmalyte A (1) · Ropivacaine (1) · Sodium Chloride (1) · Surgical Procedures, Operative (1) · Thiamine (1)
University of Aarhus (3) · Asklepion Pharmaceuticals, LLC (2) · Kayseri City Hospital (2) · Aditya Kaza (1) · Arkansas Children's Hospital Research Institute (1) · Cardiac Children's Foundation Taiwan (1) · Carelon Research (1) · Chinese Academy of Medical Sciences, Fuwai Hospital (1) · Duke University (1) · Lifetech Scientific (Shenzhen) Co., Ltd. (1) · Lund University Hospital (1) · Maastricht University Medical Center (1) · National Taiwan University Hospital (1) · Seattle Children's Hospital (1) · Seoul National University Hospital (1)
United States (7) · Denmark (3) · China (2) · Italy (2) · Taiwan (2) · Turkey (Türkiye) (2) · Egypt (1) · Germany (1) · Indonesia (1) · South Korea (1) · Sweden (1)
Aditya K Kaza, MD (1) · Adnan T Bhutta, MD (1) · Allan Doctor, MD (1) · Catherine Krawczeski, MD (1) · Christopher Mastropietro, MD, FCCM (1) · Chun-An Chen, MD, PhD (1) · Frederick E Barr, MD (1) · Gurdyal Kalsi, MD, MFPM (1) · Henning Clausen, MD (1) · Jou-Kou Wang (1) · Lisa M Einhorn, MD (1) · Onur Tasci (1) · Pan Xiangbin, MD, Ph.D (1) · Putri Amelia (1)
PMID 21926656, PMID 22157844, PMID 30233808, PMID 31623840, PMID 32291090, PMID 32519889, PMID 37548158, PMID 41032451
2019 (1), R56HL128813 (1)