15 completed, 6 unknown, 5 recruiting, 2 not yet recruiting. 23 Not applicable, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 23 | Completed 11, Unknown 5, Recruiting 2, Withdrawn 2, Active not recruiting 1, Not yet recruiting 1, Terminated 1 |
| Phase 3 | 3 | Recruiting 2, Not yet recruiting 1 |
Follow Venous Insufficiency of Leg: new trials by email Literature Review of Venous Insufficiency of Leg trials Research Report on Venous Insufficiency of Leg
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Randomized, Placebo-crontrolled Clinical Trial Evaluating the Efficacy and Safety of Heparan Sulfate 120 mg Prolonged-Release Tablets Compared With Placebo in Patients With Chronic Venous Disease CLR Tablets - Heparan Sulphate, CLR Placebo - Chronic Venous Disease, Vein Disease | Phase 3 | Not yet recruiting | Barbara Maglione | 174 | 2026-11-01 | 2026-07-06 |
| Therapeutic Efficacy of the Phlebology-oriented Thermal Cure at the Saint-Eloy Thermal Center in the Treatment of Symptoms of Severe Chronic Venous Insufficiency Phlebology oriented thermal cure - Venous Insufficiency of Leg | Not applicable | Recruiting | Société d'Exploitation des Thermes d'Amnéville | 84 | 2026-02-27 | 2026-07-20 |
| Effects of Different Compression Pressure Levels on Peripheral Circulation After Surgery Pressure-Controlled Compression Device - Postoperative Circulatory Changes, Peripheral Vascular Diseases | Not applicable | Completed | Agri Ibrahim Cecen University | 30 | 2026-02-15 | 2026-04-09 |
| Clinical Outcomes, Safety, and Cost-Effectiveness Analysis of Two Catheters (Xianrui Da and Medtronic) in Radiofrequency Ablation for Varicose Veins Compare the two brands of radiofrequency ablation catheters for the treatment of lower limb varicose veins. - Varicose Veins of Lower Limb, Venous Insufficiency of Leg | Not applicable | Not yet recruiting | Chengdu University of Traditional Chinese Medicine | 200 | 2025-08-01 | 2025-07-01 |
| The Feasibility, Efficacy and Safety of UZit®: Single-arm Clinical Trial in Patients With Symptomatic Chronic Venous Disease UZit® - Venous Insufficiency of Leg, Drainage | Not applicable | Completed | Universidade do Porto | 17 | 2025-04-01 | 2025-12-10 |
| Tissue Repair Gel in Venous Leg Ulcers in AU/US TR987 0.1% gel + Standard of Care, Standard of care - Venous Leg Ulcer, Venous Ulcer | Phase 3 | Recruiting | TR Therapeutics | 312 | 2025-04-01 | 2025-04-02 |
| Tissue Repair Gel in Venous Leg Ulcers (US) TR987 0.1% gel + Standard of Care, Standard of care - Venous Leg Ulcer, Venous Ulcer | Phase 3 | Recruiting | TR Therapeutics | 312 | 2025-01-28 | 2026-02-12 |
| Comparative Analysis of Radiofrequency Ablation and Microwave Ablation Procedures for the Treatment of Small Saphenous Varicose Veins Radiofrequency ablation and microwave ablation are used to treat small saphenous varicose veins, respectively - Varicose Veins of Lower Limb, Venous Insufficiency of Leg | Not applicable | Recruiting | Chengdu University of Traditional Chinese Medicine | 150 | 2024-12-01 | 2024-12-02 |
| Observation of Pain During the Treatment of Great Saphenous Vein Using Microwave Ablation， and Analysis of Related Factors VAS scores of the puncture - Vascular Disease，Peripheral, Venous Insufficiency of Leg | Recruiting | Chengdu University of Traditional Chinese Medicine | 155 | 2024-12-01 | 2024-11-18 | |
| Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee Arthroplasty Diosmin and Hesperidin Combination - Total Knee Arthroplasty, Venous Insufficiency of Leg | Completed | Ankara Etlik City Hospital | 190 | 2024-10-08 | 2025-07-15 | |
| Observation of Pain During Radiofrequency Ablation of Saphenous Vein，and Analysis of Related Factors VAS scores of the puncture - Vascular Diseases, Peripheral, Venous Insufficiency of Leg | Completed | Chengdu University of Traditional Chinese Medicine | 155 | 2024-07-01 | 2026-07-06 | |
| Evaluation of the Efficacy of Multilayer Compression & UrgoStart Plus Venous Leg Ulcer, Venous Ulcer | Completed | Gloucestershire Hospitals NHS Foundation Trust | 60 | 2023-10-20 | 2025-10-03 | |
| A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of Insight® Pro Device for Evaluating Lymphatic and Venous Disorders (VOLGA) Insight Pro Device for Diagnosis - Lymphedema, Chronic Venous Insufficiency | Completed | Koya Medical, Inc. | 67 | 2023-08-08 | 2025-12-12 | |
| Comparative Clinical Efficacy Between Multi-layer Bandage Pressure Therapy and Gradient Pressure Elastic Stocking Treatment After Endovenous Radiofrequency Ablation Questionnaires - Vascular Diseases, Peripheral, Venous Insufficiency of Leg | Not applicable | Unknown | Chengdu University of Traditional Chinese Medicine | 210 | 2023-08-01 | 2024-04-16 |
| Cook Venous Valve System for Treatment of Chronic Venous Insufficiency Cook® Venous Valve System - Venous Insufficiency of Leg | Not applicable | Active not recruiting | MED Institute Inc. | 4 | 2023-04-24 | 2026-05-19 |
| Preliminary Investigation of a Smart Compression Therapy Prototype Compression Therapy System Prototype, Standard Compression - Venous Leg Ulcer, Venous Insufficiency of Leg | Not applicable | Completed | DeRoyal Industries, Inc. | 11 | 2023-03-04 | 2023-09-07 |
| The Study of Reducing Adverse Effects After Radiofrequency Ablation Combined With Sclerotherapy Sulodexide - Vascular Diseases, Peripheral, Venous Insufficiency of Leg | Not applicable | Unknown | Chengdu University of Traditional Chinese Medicine | 120 | 2023-02-01 | 2023-01-03 |
| Game-Based Foot & Ankle Exercise for Those With Lower Extremity Edema Game-based exercise - Lower Extremity Swelling, Lower Extremity Edema | Not applicable | Completed | Baylor College of Medicine | 19 | 2022-11-03 | 2023-11-18 |
| Utilization of Compreflex Wraps in Patients With Chronic Venous Insuffciency Compreflex - Varicose Ulcer, Venous Insufficiency of Leg | Not applicable | Unknown | Kuala Lumpur General Hospital | 100 | 2021-09-01 | 2022-10-25 |
| Impact of Endovenous Water Vapor Treatment on Quality of Life in Superficial Venous Insufficiency of the Lower Limbs VBox Hybrid - Venous Insufficiency of Leg | Not applicable | Withdrawn | Centre Hospitalier Universitaire de Besancon | 2021-06-01 | 2024-09-19 |
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Peripheral Vascular Diseases (8) · Varicose Ulcer (7) · Varicose Veins (4) · Venous Insufficiency (3) · Edema (2) · Nocturia (2) · Wounds and Injuries (2) · Agnosia (1) · Contusions (1) · Ecchymosis (1) · Familial cyclic vomiting syndrome (1) · Gastroesophageal Reflux (1) · Hematoma (1) · Inflammation (1) · Leg Ulcer (1)
Cardiovascular Diseases (18) · Vascular Diseases (18) · Skin Diseases (7) · Skin Ulcer (7) · Skin and Connective Tissue Diseases (7) · Varicose Veins (7) · Leg Ulcer (6) · Pathological Conditions, Signs and Symptoms (6) · Signs and Symptoms (5) · Pathologic Processes (3) · Hemic and Lymphatic Diseases (2) · Lower Urinary Tract Symptoms (2) · Urological Manifestations (2) · Blood Coagulation Disorders (1) · Deglutition Disorders (1)
Surveys and Questionnaires (3) · Gels (2) · Standard of Care (2) · Blood Specimen Collection (1) · Diagnosis (1) · Diosmin (1) · Drug Therapy (1) · Epinephrine (1) · Heparitin Sulfate (1) · Radiofrequency Ablation (1) · Saline Solution (1) · glucuronyl glucosamine glycan sulfate (1)
Chengdu University of Traditional Chinese Medicine (7) · Medtronic Endovascular (2) · TR Therapeutics (2) · University Hospital, Ghent (2) · University of Zurich (2) · Agri Ibrahim Cecen University (1) · Ankara Etlik City Hospital (1) · Barbara Maglione (1) · Baylor College of Medicine (1) · Centre Hospitalier Universitaire de Besancon (1) · Chang Gung Memorial Hospital (1) · Corewell Health West (1) · DeRoyal Industries, Inc. (1) · Gloucestershire Hospitals NHS Foundation Trust (1) · Junior Doctors Network-Hellas (1)
China (7) · United States (6) · Belgium (2) · Switzerland (2) · Turkey (Türkiye) (2) · United Kingdom (2) · Australia (1) · Colombia (1) · Denmark (1) · Dominican Republic (1) · France (1) · Germany (1) · Greece (1) · Ireland (1) · Malaysia (1)
Bijan Najafi, PhD (1) · Claudia Bautista, MD (1) · Colin E Davies, MSc (1) · Declan Patton, PhD (1) · Dimitrios Mavros, MD, MSc, PhD (1) · Harikrishna R Nair (1) · Jennifer J. Watson, MD (1) · Juerg Hafner, M.D. Prof. (1) · Juerg Hafner, Prof. (1) · Karel Everaert, MD PhD (1) · Konstantinos Roditis, MD, MSc (1) · Thomas Proebstle, MD (1) · Thomas Serena, MD (1)
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