15 completed, 13 unknown, 7 recruiting, 2 not yet recruiting. 12 Phase 3, 9 Not applicable, 9 Phase 4, 5 Phase 1, 4 Phase 2.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Study Comparing Diosmin vs Rebamipide as Adjuvant Therapies vs Conventional Therapy in Patients With Rheumatoid Arthritis Diosmin, Rebamipide 100mg, Convential medical treatment - Rheumatoid Arthritis (RA) | Phase 2 | Recruiting | Tanta University | 66 | 2026-08-01 | 2026-08-04 |
| Dimotec (Diosmin) 1000 mg Film Coated Tablet Fed Study Dimotec 1000 mg film-coated tablet, Detralex 1000 mg film-coated tablets - Healthy Volunteers | Phase 1 | Recruiting | Keri Pharma Hungary Kft | 72 | 2026-06-29 | 2026-09-09 |
| Study of Diosmin for the Treatment of Digital Ulcers in Systemic Sclerosis Diosmin, Placebo - Scleroderma, Systemic, Digital Ulcer | Not applicable | Recruiting | Primus Pharmaceuticals | 45 | 2025-05-02 | 2026-09-11 |
| Effect of Diosmin/Hesperidin Combination on Platinum Compounds-Induced Nephropathy in Cancer Patients diosmin/hesperdin - Cancer Patients | Phase 4 | Recruiting | Beni-Suef University | 100 | 2025-02-03 | 2026-05-20 |
| The Effect of Oral Administration of Hesperidin and Diosmin in Reducing Paclitaxel-induced Peripheral Neuropathy in Breast Cancer Patients Hespiridin and Diosmin - Breast Cancer | Phase 3 | Not yet recruiting | Alexandria University | 140 | 2025-01-27 | 2025-02-06 |
| Silymarin vs Hesperidin/Diosmin in Fibromyalgia Silymarin (LEGALON), Diosmin / Hesperidin (Daflon), no intervention (control group) - Fibromyalgia (FM) | Not applicable | Recruiting | Ain Shams University | 90 | 2024-11-16 | 2025-12-19 |
| Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee Arthroplasty Diosmin and Hesperidin Combination - Total Knee Arthroplasty, Venous Insufficiency of Leg | Completed | Ankara Etlik City Hospital | 190 | 2024-10-08 | 2025-07-15 | |
| Clinical Study to Evaluate the Possible Efficacy and Safety of Diosmin and Hesperidin Combined Therapy in Patients With Helicobacter Pylori Infection Placebo, Daflon - Helicobacter Pylori Infection | Phase 1 / Phase 2 | Unknown | Sadat City University | 46 | 2024-10-01 | 2024-08-12 |
| EFFECT OF DAFLON (DIOSMIN AND HESPERIDIN) ON POST-OPERATIVE SEROMA FORMATION IN BREAST CANCER SURGERY'' Daflon (Diosmin and Hesperidin) - Post-operative Seroma Formation, Breast Cancer Surgery | Phase 4 | Completed | Ittefaq Hospital trust | 190 | 2024-10-01 | 2026-05-15 |
| Glue Embolization vs Conservative Treatment for Pelvic Congestion Syndrome Micronized purified flavonoid fraction (Daflon ®), Glue embolization - Glue Embolization, Pelvic Congestion Syndrome | Not applicable | Recruiting | Tanta University | 40 | 2024-08-17 | 2025-08-19 |
| Outcomes of Different Treatment Options in Chronic Venous Disease Radiofrequency ablation using Closure fast, Aethoxysclerol, Daflon - Chronic Venous Disease | Not yet recruiting | Universitaire Ziekenhuizen KU Leuven | 2000 | 2024-07-01 | 2024-06-28 | |
| Diosmin for Treatment of Delayed-onset Muscle Soreness (DOMS) Diosmin750, Placebo - Myalgia | Phase 1 | Unknown | Sergio Marques Borghi | 20 | 2024-01-01 | 2023-11-09 |
| Randomized Control Trial of Micronized Purified Flavonoid Fraction for Post Operative Treatment in Anal Fistula Surgery Micronized purified flavonoid fraction(Daflon 1000mg), Placebo - Anal Fistula | Phase 4 | Completed | Taipei Medical University Shuang Ho Hospital | 106 | 2023-12-13 | 2025-05-16 |
| Evaluation of the Effects of Diosmin/Hespiridin Combination on the Clinical Outcomes in Patients With Polycystic Ovary Syndrome Daflon, Combined oral contraceptive, Metformin - Poly Cystic Ovary Syndrome | Phase 4 | Unknown | Ain Shams University | 120 | 2023-11-01 | 2023-10-16 |
| Effect of Diosmin and Hesperidin in Treatment of Patients With Rheumatoid Arthritis Diosmin and Hesperidin Combination - Rheumatoid Arthritis | Phase 3 | Recruiting | Alexandria University | 80 | 2023-07-18 | 2025-04-25 |
| the Efficacy and Safety of Diosmin on Non-diabetic Patients With Non-alcoholic Steatohepatitis. Diosmin, Placebo - Non Alcoholic Steatohepatitis | Phase 3 | Unknown | Tanta University | 48 | 2023-07-10 | 2023-07-12 |
| Effects of Bioflavanoids on Vascular Wall Remodeling in Patients With Varicose Veins "Venarus®" (diosmin and hesperidin), Endovenous laser ablation (EVLA) with miniphlebectomy, Elastic compression - Varicose Veins of Lower Limb, Varix | Not applicable | Active not recruiting | Ryazan State Medical University | 100 | 2023-04-01 | 2025-07-23 |
| Randomised, Double-blind, Placebo-controlled to Assess the Efficacy and Safety of the Food Supplement Microsmin® Plus diosmin and micronized flavonoids, Placebo - Haemorrhoids | Not applicable | Unknown | Giellepi S.p.A | 80 | 2023-02-28 | 2023-03-01 |
| the Efficacy and Safety of Diosmin in Patients With Ulcerative Colitis Placebo, Diosmin - Ulcerative Colitis | Phase 3 | Unknown | Tanta University | 60 | 2022-12-15 | 2023-04-12 |
| Comparative Study Between Calcium Gluconate With Diosmin, Cabergoline and Cabergoline With Diosmin Calcium Gluconate - Ovarian Hyperstimulation Syndrome | Not applicable | Completed | Minia University | 180 | 2022-10-01 | 2025-01-07 |
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Hemorrhoids (3) · Varicose Veins (3) · Venous Insufficiency (3) · Arthritis, Rheumatoid (2) · Infertility (2) · Inflammation (2) · Sclerosis (2) · Agnosia (1) · Breast Neoplasms (1) · Colitis, Ulcerative (1) · Diabetes Mellitus, Type 2 (1) · Disease (1) · Fibromyalgia (1) · Menorrhagia (1) · Motor Activity (1)
Tanta University (5) · Ain Shams University (4) · Alexandria University (2) · Benha University (2) · Pirogov Russian National Research Medical University (2) · Primus Pharmaceuticals (2) · Ankara Etlik City Hospital (1) · Azidus Brasil (1) · Beni-Suef University (1) · Fundação Educacional Serra dos Órgãos (1) · Giellepi S.p.A (1) · Hanoi Medical University (1) · Hospital de Clínicas Dr. Manuel Quintela (1) · Interregional Clinical Diagnostic Center, Russia (1) · Ittefaq Hospital trust (1)
Egypt (13) · Brazil (4) · Russia (4) · India (2) · Pakistan (2) · Canada (1) · Croatia (1) · France (1) · Romania (1) · Taiwan (1) · Turkey (Türkiye) (1) · United States (1) · Vietnam (1)
Alexandre Frederico, Doctor (1) · Dr. Waris Farooka, MBBS, FCPS, FRCS, FACS (1) · Fabio Terruzzi, CSO (1) · Hatem Sarhan, Professor (1) · Igor Suchkov (1) · Igor Zolotukhin, PhD (1) · Ilya Schastlivtsev, PhD (1) · Jacques Waisberg, Investigator (1)
PMID 33141449, PMID 21274547, PMID 31970659, PMID 33201130, PMID 33851429, PMID 37701088, PMID 38109425, PMID 40818103, PMID 41221041, PMID 41776089