14 completed, 11 unknown, 8 recruiting, 6 not yet recruiting. 25 Not applicable, 2 Phase 4, 1 Phase 2, 1 Phase 3.
Follow Varicose Veins of Lower Limb: new trials by email Literature Review of Varicose Veins of Lower Limb trials Research Report on Varicose Veins of Lower Limb
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mindfulness Intervention on Minimally Invasive Vascular Surgery VR-Based Mindfulness Intervention - Anxiety, Pain | Not applicable | Not yet recruiting | Tongji Hospital | 160 | 2026-10-01 | 2026-10-07 |
| Subfascial Endoscopic Perforator Surgery (SEPS) Versus Open Ligation for Lower Limb Varicose Veins Subfascial Endoscopic Perforator Surgery(SEPS), Open Perforator Ligation(Stab Avulsion) - Varicose Veins of Lower Limb | Not applicable | Recruiting | King Edward Medical University | 62 | 2026-07-10 | 2026-10-14 |
| Mechanochemical Ablation Versus Ultrasound-Guided Foam Sclerotherapy of the Great Saphenous Vein Flebogrif, Polidocanol foam sclerotherapy - Varicose Veins of Leg With Long Saphenous Vein Distribution, Varicose Veins of Lower Limb | Phase 4 | Recruiting | Antonio Eduardo Zerati | 50 | 2026-05-01 | 2026-05-01 |
| Comparison of Radiofrequency Ablation With Concomitant or Staged Treatment for Tributary Varicose Veins Staged surgery group, Concomitant surgery group - Varicose Veins of Lower Limb | Not applicable | Not yet recruiting | Sir Run Run Shaw Hospital | 206 | 2026-03-01 | 2026-03-03 |
| HEMOVAR Study on Hemorrhoids and Varicose Veins Varicose Veins of Lower Limb, Hemorrhoids | Recruiting | Aydin Adnan Menderes University | 400 | 2025-12-19 | 2026-04-29 | |
| Efficacy and Safety of Endovenous Ablation for Relief of Knee Pain in Elderly Patients With Lower Extremity Varicose Veins: A Prospective Observational Study Endovenous Ablation for Varicose Veins - Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI | Not yet recruiting | Chengdu University of Traditional Chinese Medicine | 50 | 2025-12-10 | 2025-11-20 | |
| Knee Pain Relief After Endovenous Treatment for Lower Limb Varicose Veins: A Prospective Observational Study Endovenous Ablation for Varicose Veins - Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI | Not yet recruiting | Chengdu University of Traditional Chinese Medicine | 50 | 2025-10-01 | 2025-09-09 | |
| Endovenous Laser Ablation With 1940 nm Versus 1470 nm EVLA for SFJ with laser 1470, EVLA for SFJ with laser 1940 - Varicose Veins of Lower Limb, Great Saphenous Vein (GSV) With Venous Reflux Disease | Phase 3 | Active not recruiting | Kafrelsheikh University | 220 | 2025-09-01 | 2026-05-22 |
| CLaCS Using 0.2% Aetoxysklerol Foam and 70% Glucose for the Treatment of Lower Limb Telangiectasias CLaCS - Varicose Veins of Lower Limb, Spider Veins | Phase 2 | Not yet recruiting | Charles University, Czech Republic | 240 | 2025-09-01 | 2025-07-18 |
| Clinical Outcomes, Safety, and Cost-Effectiveness Analysis of Two Catheters (Xianrui Da and Medtronic) in Radiofrequency Ablation for Varicose Veins Compare the two brands of radiofrequency ablation catheters for the treatment of lower limb varicose veins. - Varicose Veins of Lower Limb, Venous Insufficiency of Leg | Not applicable | Not yet recruiting | Chengdu University of Traditional Chinese Medicine | 200 | 2025-08-01 | 2025-07-01 |
| Varicose Veins in Petrol Pump Workers Varicose Veins of Lower Limb | Completed | Elite College of Management Sciences, Gujranwala, Pakistan | 323 | 2025-04-01 | 2025-07-17 | |
| Comparative Analysis of Radiofrequency Ablation and Microwave Ablation Procedures for the Treatment of Small Saphenous Varicose Veins Radiofrequency ablation and microwave ablation are used to treat small saphenous varicose veins, respectively - Varicose Veins of Lower Limb, Venous Insufficiency of Leg | Not applicable | Recruiting | Chengdu University of Traditional Chinese Medicine | 150 | 2024-12-01 | 2024-12-02 |
| Observation of Pain During the Treatment of Great Saphenous Vein Using Microwave Ablation， and Analysis of Related Factors VAS scores of the puncture - Vascular Disease，Peripheral, Venous Insufficiency of Leg | Recruiting | Chengdu University of Traditional Chinese Medicine | 155 | 2024-12-01 | 2024-11-18 | |
| Observation of Pain During Radiofrequency Ablation of Saphenous Vein，and Analysis of Related Factors VAS scores of the puncture - Vascular Diseases, Peripheral, Venous Insufficiency of Leg | Completed | Chengdu University of Traditional Chinese Medicine | 155 | 2024-07-01 | 2026-07-06 | |
| Effect of Cold Immersion on Patients With Varicose Vein Cold water immersion - Varicose Veins of Lower Limb | Not applicable | Unknown | Gazi University | 60 | 2023-09-25 | 2023-09-25 |
| Efficiency of Determining the Clinical Class of Chronic Venous Disorders by Artificial Intelligence Determining of the clinical class of chronic venous disorders by artificial intelligence - Varicose Veins of Lower Limb, Telangiectasia | Not applicable | Completed | Clinic of Phlebology and Laser Surgery, Chelyabinsk, Russia | 1622 | 2023-08-25 | 2026-03-06 |
| Comparative Clinical Efficacy Between Multi-layer Bandage Pressure Therapy and Gradient Pressure Elastic Stocking Treatment After Endovenous Radiofrequency Ablation Questionnaires - Vascular Diseases, Peripheral, Venous Insufficiency of Leg | Not applicable | Unknown | Chengdu University of Traditional Chinese Medicine | 210 | 2023-08-01 | 2024-04-16 |
| Effect of Vitis Vinifera Seed Extract on Venous Reflux Time in Varicose Vein Vitis Vinifera seed extract medication plus therapeutic lifestyle change, Therapeutic lifestyle change only - Varicose Veins of Lower Limb | Phase 4 | Completed | Yonsei University | 200 | 2023-07-20 | 2025-03-04 |
| Study of Venous Outflow From the Lower Limbs in Patients With Pelvic Varicosities Radionuclide venography, single-photon emission computed tomography - Pelvic Varices, Varicose Veins of Lower Limb | Recruiting | Pirogov Russian National Research Medical University | 90 | 2023-05-12 | 2024-12-27 | |
| Feasibility Study of Ultrasound-guided Functional Remodeling of Lower Extremity Superficial Venous Valve Ultrasound guided functional remodeling of lower extremity superficial vein valve - Varicose Veins of Lower Limb | Not applicable | Unknown | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 10 | 2023-04-19 | 2023-06-22 |
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Varicose Veins (14) · Peripheral Vascular Diseases (7) · Telangiectasis (3) · Venous Insufficiency (3) · Blindness, Cortical (2) · Osteoarthritis, Knee (2) · Pain (2) · Anxiety Disorders (1) · Edema (1) · Hemorrhoids (1) · Varicocele (1) · Varicose Ulcer (1) · Vascular Diseases (1) · Venous Thrombosis (1)
Cardiovascular Diseases (23) · Vascular Diseases (22) · Neurologic Manifestations (4) · Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4) · Arthritis (2) · Blindness (2) · Eye Diseases (2) · Joint Diseases (2) · Musculoskeletal Diseases (2) · Nervous System Diseases (2) · Osteoarthritis (2) · Rheumatic Diseases (2) · Sensation Disorders (2) · Vision Disorders (2)
Radiofrequency Ablation (5) · Surveys and Questionnaires (2) · Athletic Tape (1) · Catheters (1) · Diosmin (1) · Fibronectins (1) · Flavonoids (1) · Hesperidin (1) · Laser Therapy (1) · Photoplethysmography (1) · Plasminogen Activator Inhibitor 1 (1) · Platelet Endothelial Cell Adhesion Molecule-1 (1) · Resistance Training (1) · Sclerotherapy (1) · Stockings, Compression (1)
Chengdu University of Traditional Chinese Medicine (9) · Pirogov Russian National Research Medical University (3) · Imperial College London (2) · Russian Phlebological Association (2) · Acotec Scientific Co., Ltd (1) · Antonio Eduardo Zerati (1) · Aydin Adnan Menderes University (1) · Beijing Tsinghua Chang Gung Hospital (1) · Charles University, Czech Republic (1) · Clinic of Phlebology and Laser Surgery, Chelyabinsk, Russia (1) · Elite College of Management Sciences, Gujranwala, Pakistan (1) · Gazi University (1) · Helsinki University Central Hospital (1) · Hospital Israelita Albert Einstein (1) · I-VASC S.r.l (1)
China (14) · Russia (8) · Brazil (3) · Turkey (Türkiye) (3) · United Kingdom (3) · Pakistan (2) · Egypt (1) · Finland (1) · Italy (1) · South Korea (1)
Akay Edizsoy, Assist Prof. (1) · Baha Naci, PT, MSc (1) · Claudine Hamel-Desnos (1) · Denis Borsuk (1) · Dr Mohammed Aslam, PhD (1) · Hailei Li, M.D, Ph.D (1) · Hongkun Zhang, MD (1) · Igor R Sincos, PhD (1) · Igor Suchkov (1) · In Hyun Jung, MD, PhD (1) · Isaac Nyamekye, FRCS, MD (1) · Juliana Puggina, MD (1) · Mario MS Salerno (1) · Matthieu Josnin (1) · Mohammed Aslam, PhD (1)
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