8 completed, 3 recruiting, 2 terminated, 2 unknown. 19 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 19 | Completed 8, Recruiting 3, Terminated 2, Unknown 2, Withdrawn 2, Active not recruiting 1, Not yet recruiting 1 |
| Phase 2 | 1 | Withdrawn 1 |
Follow Varicose Ulcer: new trials by email Literature Review of Varicose Ulcer trials Research Report on Varicose Ulcer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nimsai Herbal for Grade 2-3 Hemorrhoids: A Quadruple-Blind Placebo-Controlled Mechanistic Trial Nimsai Herbal, Placebo - Hemorrhoid, Hemorrhoidal Disease | Phase 3 | Not yet recruiting | Nimsai Academia | 50 | 2026-06-22 | 2026-06-25 |
| A Double Blind Study Performed to Evaluate the Efficacy and the Safety of EscharEx in Debridement of VLU (VALUE) EscharEx (EX-03), Placebo (Gel vehicle) - Venous Leg Ulcer (VLU) | Phase 3 | Recruiting | MediWound Ltd | 216 | 2025-06-01 | 2026-10-09 |
| Tissue Repair Gel in Venous Leg Ulcers in AU/US TR987 0.1% gel + Standard of Care, Standard of care - Venous Leg Ulcer, Venous Ulcer | Phase 3 | Recruiting | TR Therapeutics | 312 | 2025-04-01 | 2025-04-02 |
| Tissue Repair Gel in Venous Leg Ulcers (US) TR987 0.1% gel + Standard of Care, Standard of care - Venous Leg Ulcer, Venous Ulcer | Phase 3 | Recruiting | TR Therapeutics | 312 | 2025-01-28 | 2026-02-12 |
| Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Therapy-resistant CVU (Phase III) allo-APZ2-CVU, Placebo - Venous Leg Ulcer | Phase 3 | Active not recruiting | RHEACELL GmbH & Co. KG | 250 | 2024-12-26 | 2025-10-01 |
| Effects of Local Insulin on Varicose Ulcers for Wound Healing Insulin Glargine, Saline - Chronic Venous Disease, Varicose Ulcer | Phase 3 | Completed | Hospital Central "Dr. Ignacio Morones Prieto" | 13 | 2019-06-01 | 2020-03-17 |
| Study of Combined Topical Growth Factor and Protease Inhibitor in Chronic Wound Healing Becaplermin, Promagran Dressing, Placebo Dressing - Venous Ulcer, Foot Ulcer, Diabetic | Phase 3 | Unknown | McMaster University | 80 | 2018-08-01 | 2018-04-09 |
| A Prospective Randomized, Double-Blind, Placebo-Controlled Trial Comparing VitroGro® ECM to Placebo in Patients With Venous Leg Ulcers VitroGro® ECM, Dulbecco's Phosphate Buffered Saline - Venous Leg Ulcer | Phase 2 / Phase 3 | Withdrawn | Tissue Therapies Ltd. | 2017-01-01 | 2017-05-30 | |
| Safety And Efficacy Of Topical Platelet Rich Plasma And Thrombin Coagulum PRP/thrombin mixture - Stasis Ulcer | Phase 3 | Terminated | University of Witwatersrand, South Africa | 15 | 2016-05-01 | 2017-10-26 |
| Low Dose Aspirin for Venous Leg Ulcers Aspirin, Placebo - Venous Leg Ulcer | Phase 3 | Completed | University of Auckland, New Zealand | 251 | 2015-03-01 | 2019-01-04 |
| Evaluation of CureXcell® in Treating Chronic Venous Leg Ulcers CureXcell®, Placebo injection - Chronic Venous Leg Ulcers | Phase 3 | Unknown | Macrocure Ltd. | 252 | 2014-05-01 | 2015-09-23 |
| Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers HP802-247, HP802-247 Vehicle - Venous Ulcer, Venous Stasis Ulcer | Phase 3 | Terminated | Healthpoint | 252 | 2013-11-01 | 2016-10-03 |
| Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2 HP802-247, Vehicle - Venous Leg Ulcers | Phase 3 | Completed | Healthpoint | 155 | 2012-11-01 | 2017-07-26 |
| Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers HP-802-247, Vehicle - Venous Leg Ulcers | Phase 3 | Completed | Healthpoint | 447 | 2012-08-01 | 2016-03-14 |
| Long-Term Follow-Up to the DEVO Pivotal Trial of Dermagraft(R) to Treat Venous Leg Ulcers Dermagraft, Profore - Venous Leg Ulcer | Phase 3 | Completed | Shire Regenerative Medicine, Inc. | 225 | 2010-05-01 | 2013-08-21 |
| Pivotal Trial of Dermagraft(R) to Treat Venous Leg Ulcers Dermagraft(R), Profore - Venous Leg Ulcer | Phase 3 | Completed | Organogenesis | 537 | 2009-06-01 | 2018-06-18 |
| THERMES ET VEINES: Spa for Prevention of Leg Ulcers Immediate spa treatment, Late spa treatment - Venous Insufficiency, Leg Ulcer | Phase 3 | Completed | Association Francaise pour la Recherche Thermale | 425 | 2008-05-01 | 2012-10-01 |
| Trial of Zesteem (Estradiol) in Healing of Split Thickness Skin Graft Donor Sites estradiol (Zesteem) - Burn, Trauma | Phase 3 | Completed | Renovo | 148 | 2007-01-01 | 2009-08-28 |
| Clinical Effectiveness of Topical Autologous Platelet Gel for the Treatment of Venous Ulcers Autologous Platelet Gel (APG) - Venous Ulcer | Phase 3 | Withdrawn | National Healing Corporation | 70 | 2006-01-01 | 2007-03-06 |
Wounds and Injuries (5) · Ulcer (4) · Venous Insufficiency (3) · Leg Ulcer (2) · Varicose Veins (2) · Venous Thrombosis (2) · Burns (1) · Diabetic Foot (1) · Hemorrhoids (1) · Insulin Resistance (1) · Skin Ulcer (1)
Cardiovascular Diseases (19) · Skin Diseases (19) · Skin and Connective Tissue Diseases (19) · Vascular Diseases (19) · Skin Ulcer (18) · Leg Ulcer (17) · Varicose Veins (17) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Embolism and Thrombosis (2) · Thrombosis (2) · Diabetes Complications (1) · Diabetes Mellitus (1) · Diabetic Angiopathies (1) · Diabetic Neuropathies (1)
Gels (3) · Standard of Care (2) · Aspirin (1) · Becaplermin (1) · Estradiol (1) · Insulin Glargine (1) · Sodium Chloride (1)
Healthpoint (3) · TR Therapeutics (2) · Association Francaise pour la Recherche Thermale (1) · Hospital Central "Dr. Ignacio Morones Prieto" (1) · Macrocure Ltd. (1) · McMaster University (1) · MediWound Ltd (1) · National Healing Corporation (1) · Nimsai Academia (1) · Organogenesis (1) · RHEACELL GmbH & Co. KG (1) · Renovo (1) · Shire Regenerative Medicine, Inc. (1) · Tissue Therapies Ltd. (1) · University of Auckland, New Zealand (1)
United States (10) · Germany (6) · Poland (5) · Canada (4) · United Kingdom (4) · Austria (3) · South Africa (3) · Czechia (2) · Estonia (2) · France (2) · Hungary (2) · Italy (2) · Sweden (2) · Australia (1) · Belgium (1)
Tommy Lee, MSHS (3) · William Marston, MD (3) · Herbert B Slade, MD (2) · Robert Kirsner, MD (2) · Andrew Jull, RN PhD (1) · Anna Moessmer (1) · Bob Bartlett, MD (1) · David Bergqvist, MD (1) · Herbert B. Slade, MD (1) · John Lantis, MD (1) · Johnny Mahlangu, MBBCH, MMed (1) · Jose L Ramirez-GarciaLuna, MD, PhD (1) · Keith Harding, MD (1) · Ken Dunn, MD (1) · Michael Stacey, MBBS, Doctor of Surgery (1)
PMID 29037354, PMID 2396195, PMID 24135621, PMID 24281606, PMID 29175902, PMID 29703712, PMID 29845043, PMID 35932720