19 completed, 5 withdrawn, 4 recruiting, 2 active not recruiting. 19 Not applicable, 4 Phase 2, 3 Phase 1, 2 Phase 4.
Follow Traumatic Brain Injury (TBI): new trials by email Literature Review of Traumatic Brain Injury (TBI) trials Research Report on Traumatic Brain Injury (TBI)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Allopregnanolone in Chronic Complex Traumatic Brain Injury Placebo, Allopregnanolone - Traumatic Brain Injury (TBI) | Phase 2 | Not yet recruiting | VA Office of Research and Development | 132 | 2026-12-01 | 2026-10-19 |
| Cognitive Rehabilitation for Treatment of Anger in Veterans With TBI and PTSD CALM (Cognitive Apps for Life Management), Psychoeducation - Traumatic Brain Injury (TBI), Posttraumatic Stress Disorder (PTSD) | Not applicable | Recruiting | Duke University | 100 | 2026-08-04 | 2026-08-06 |
| Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD) | Recruiting | Healing Hope International | 100 | 2026-03-01 | 2026-03-25 | |
| Low-Tech Treatments for Obstructive Sleep Apnea High-Resistance Breathing and Drinking Exercises, Low-Resistance Breathing and Drinking Exercises - Obstructive Sleep Apnea (OSA), Traumatic Brain Injury (TBI) | Phase 1 / Phase 2 | Recruiting | Uniformed Services University of the Health Sciences | 60 | 2026-01-29 | 2026-09-10 |
| Spinal Stimulation and Gait Training to Improve Mobility in TBI Transcutaneous Spinal Cord Stimulation, Sham - Traumatic Brain Injury, Traumatic Brain Injury (TBI) | Not applicable | Not yet recruiting | Kessler Foundation | 30 | 2025-09-01 | 2025-09-02 |
| Prognostic Model for Predicting Outcome After Moderate to Severe Paediatric Traumatic Brain Injury Traumatic Brain Injury (TBI) | Active not recruiting | Cambridge University Hospitals NHS Foundation Trust | 2000 | 2025-07-01 | 2026-09-17 | |
| Hemodynamic ABI Monitor Traumatic Brain Injury (TBI), Intracerebral Hemorrhage | Recruiting | University of Chicago | 50 | 2024-12-06 | 2026-03-04 | |
| Imaging Characterization of the Biomechanical Coupling of Brain and Skull Traumatic Brain Injury (Tbi), Traumatic Meningeal Enhancement (Tme) | Withdrawn | National Institutes of Health Clinical Center (CC) | 2024-09-12 | 2024-10-03 | ||
| A First in Human Study of the Safety, Tolerability and Pharmacokinetics of PRV-002 in Healthy Volunteers PRV-002, Placebo - Traumatic Brain Injury (TBI) | Phase 1 | Completed | Odyssey Group International, Inc. | 40 | 2022-02-09 | 2024-11-04 |
| Functional Recovery Effect of Bloodletting Puncture at Jing-well Points on Acute Brain Injury Patients acupuncture and bloodletting - Traumatic Brain Injury (TBI) | Not applicable | Unknown | Chang Gung Memorial Hospital | 72 | 2021-06-08 | 2021-06-21 |
| Locomotor Recovery Following Traumatic Brain Injury High Intensity Stepping Training, Conventional Therapy - Traumatic Brain Injury (TBI) | Not applicable | Completed | Indiana University | 17 | 2020-08-01 | 2024-05-02 |
| Prediction for Coma Recovery With Comaweb MRI sequence, MRI - Brain Injury, Coma, Cardiac Arrest (CA) | Not applicable | Unknown | Assistance Publique - Hôpitaux de Paris | 611 | 2020-01-15 | 2020-01-28 |
| The Effects of Fish Oil Supplementation on the Brain Health of Collegiate Football Athletes Fish Oil (DPA+EPA 2:1 ratio) Capsules, High Oleic Safflower Oil Capsules - Traumatic Brain Injury (TBI), Chronic Traumatic Encephalopathy (CTE) | Not applicable | Completed | University of Arizona | 38 | 2019-05-28 | 2025-05-09 |
| Managing Mild Traumatic Brain Injury Related Headaches With Repetitive Transcranial Magnetic Stimulation Transcranial Magnetic Stimulation, Sham Transcranial Magnetic Stimulation, Magnetic resonance imaging (MRI) - Traumatic Brain Injury (TBI) | Not applicable | Completed | VA Office of Research and Development | 179 | 2018-01-01 | 2025-08-07 |
| Effect of Exercise Training on Physical, Cognitive, and Behavioral Function in People With TBI Vigorous exercise, Light to moderate exercise - Traumatic Brain Injury (TBI) | Not applicable | Terminated | National Institutes of Health Clinical Center (CC) | 20 | 2016-12-15 | 2023-11-18 |
| Effectiveness of a Driving Intervention on Safe Community Mobility for Returning Combat Veterans Driving Behavior Interview, Clinical Driving Assessment, Propensity for Angry Driving Scale - Traumatic Brain Injury (TBI), Post Traumatic Stress Disorder (PTSD) | Not applicable | Completed | University of Florida | 58 | 2016-12-01 | 2024-01-19 |
| Monitoring the Alterations That Occur in the Brain Following Traumatic Brain Injury fMRI - Traumatic Brain Injury (TBI) | Completed | ElMindA Ltd | 68 | 2016-09-21 | 2019-01-04 | |
| LearningRx Cognitive Training for Brain Injury LearningRx cognitive training - Traumatic Brain Injury (TBI), Acquired Brain Injury | Not applicable | Active not recruiting | Gibson Institute of Cognitive Research | 30 | 2016-09-01 | 2026-02-13 |
| N-acetylcysteine Treatment of Alcohol Use Disorder In Veterans With TBI Medical Management Counseling, N-acetylcysteine, Placebo - Traumatic Brain Injury (TBI), Hazardous and Harmful Alcohol Use | Phase 2 | Completed | University of California, San Francisco | 30 | 2016-08-01 | 2021-05-11 |
| LED Light Therapy to Improve Cognitive & Psychosocial Function in TBI-PTSD Veterans Photomedex Sham Helmet with Red/Near-Infrared Light-Emitting Diodes (LEDs) that are not turned on - Traumatic Brain Injury (TBI), Post-traumatic Stress Disorder (PTSD) | Not applicable | Withdrawn | VA Office of Research and Development | 2016-03-01 | 2022-03-09 |
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Brain Injuries, Traumatic (35) · Brain Injuries (5) · Stress Disorders, Post-Traumatic (5) · Brain Concussion (2) · Chronic Traumatic Encephalopathy (2) · Craniocerebral Trauma (2) · Dementia (2) · Subarachnoid Hemorrhage (2) · Alcoholism (1) · Attention Deficit Disorder with Hyperactivity (1) · Autism Spectrum Disorder (1) · Brain Contusion (1) · Brain Edema (1) · Brain Hemorrhage, Traumatic (1) · Cerebral Hemorrhage (1)
Brain Diseases (35) · Central Nervous System Diseases (35) · Nervous System Diseases (35) · Trauma, Nervous System (34) · Wounds and Injuries (34) · Craniocerebral Trauma (33) · Brain Injuries (30) · Pathological Conditions, Signs and Symptoms (13) · Mental Disorders (10) · Pathologic Processes (8) · Neurologic Manifestations (7) · Signs and Symptoms (7) · Cardiovascular Diseases (6) · Cerebrovascular Disorders (6) · Vascular Diseases (6)
Magnetic Resonance Spectroscopy (3) · Magnetic Resonance Imaging (2) · (methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine (1) · Acetylcysteine (1) · Acupuncture Therapy (1) · Bloodletting (1) · Capsules (1) · Drugs, Investigational (1) · Electroencephalography (1) · Fish Oils (1) · Magnetoencephalography (1) · Neuropsychological Tests (1) · Pregnanolone (1) · Standard of Care (1) · Sugars (1)
VA Office of Research and Development (3) · National Institutes of Health Clinical Center (CC) (2) · Uniformed Services University of the Health Sciences (2) · University of California, San Francisco (2) · University of Florida (2) · Advanced Brain Monitoring, Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Avanir Pharmaceuticals (1) · Cambridge University Hospitals NHS Foundation Trust (1) · Chang Gung Memorial Hospital (1) · Children's Hospital Medical Center, Cincinnati (1) · Duke University (1) · ElMindA Ltd (1) · Gibson Institute of Cognitive Research (1) · Healing Hope International (1)
United States (25) · France (2) · Australia (1) · Denmark (1) · Finland (1) · Israel (1) · Switzerland (1) · Taiwan (1) · United Kingdom (1)
Steven L. Batki, MD (2) · Albert Yick Leung, MD (1) · Amy L Moore, PhD (1) · Andrew Hartwick, OD, PhD (1) · Anne Vehmas, MD (1) · Christina Ledbetter, PhD (1) · Christine E. Marx, MD MA (1) · Christos Lazaridis, MD (1) · Diane L Damiano, Ph.D. (1) · Djordje Popovic, MD (1) · Dr. Tina Casoglos-Adamopoulos, OT, OTD, BCP (1) · Eric Elbogen (1) · Floyd Chilton, Ph.D. (1) · George Hornby, PhD (1) · Javier Fandino, M.D. (1)
PMID 26471212, PMID 27276999, PMID 27464575, PMID 27830643, PMID 29477412, PMID 29749279, PMID 32670040, PMID 32712569, PMID 35456277, PMID 36188406, PMID 38204184, PMID 41109991, PMID 42744153
I01RX002798 (1), I21RX001768 (1)