6 completed, 2 active not recruiting, 1 unknown, 1 withdrawn. 10 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 10 | Completed 6, Active not recruiting 2, Unknown 1, Withdrawn 1 |
Follow Systemic Sclerosis: new trials by email Literature Review of Systemic Sclerosis trials Research Report on Systemic Sclerosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Safety and Efficacy of Telitacicept in the Treatment of Systemic Sclerosis Telitacicept - Systemic Sclerosis | Phase 4 | Unknown | Peking University Third Hospital | 20 | 2024-06-08 | 2024-08-09 |
| Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases Recombinant Herpes Zoster Vaccine (RZV), MTX Discontinuation, MMF Discontinuation - Rheumatoid Arthritis, Spondylitis, Ankylosing | Phase 4 | Active not recruiting | University of Sao Paulo General Hospital | 2005 | 2023-05-23 | 2026-05-04 |
| A Study Evaluating the Efficacy and Safety of Baricitinib in Systemic Sclerosis Baricitinib, Cyclophosphamide - Systemic Sclerosis | Phase 4 | Active not recruiting | Tongji Hospital | 60 | 2022-03-08 | 2026-01-27 |
| Upfront Autologous HSCT Versus Immunosuppression in Early Diffuse Cutaneous Systemic Sclerosis Upfront autologous HSCT - Systemic Sclerosis, Systemic Scleroses, Diffuse | Phase 4 | Completed | UMC Utrecht | 60 | 2020-09-17 | 2026-03-24 |
| Evaluation of Effectiveness of Acetylsalicylic Acid on Markers of Vascular Dysfunction in Scleroderma Patients Acetylsalicylic acid, Placebo oral capsule - Systemic Sclerosis | Phase 4 | Completed | Federal University of São Paulo | 70 | 2018-08-28 | 2021-12-01 |
| Intraoperative ICG for Systemic Sclerosis Order of two elements of surgical procedure, Indocyanine Green - Systemic Sclerosis | Phase 4 | Withdrawn | Duke University | 2017-06-01 | 2020-06-30 | |
| Effectiveness of Saccharomyces Boulardii for Gastrointestinal Bacterial-overgrowth in Systemic Sclerosis Saccharomyces Boulardii Oral Tablet, Metronidazole - Systemic Sclerosis, Small Intestinal Bacterial Overgrowth | Phase 4 | Completed | Coordinación de Investigación en Salud, Mexico | 39 | 2015-06-01 | 2019-07-30 |
| Bosentan in Systemic Sclerosis Bosentan - Systemic Sclerosis, Digital Ulcers | Phase 4 | Completed | Actelion | 18 | 2011-03-31 | 2026-06-03 |
| A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis tadalafil and ambrisentan upfront combination therapy - Pulmonary Arterial Hypertension, Systemic Sclerosis | Phase 4 | Completed | Johns Hopkins University | 25 | 2010-01-01 | 2017-09-12 |
| Exercise Induced Pulmonary Hypertension in Systemic Sclerosis and Treatment With Ambrisentan Ambrisentan - Systemic Sclerosis, Shortness of Breath | Phase 4 | Completed | University of California, Los Angeles | 12 | 2009-03-01 | 2020-11-02 |
Scleroderma, Systemic (10) · Connective Tissue Diseases (2) · Hypertension, Pulmonary (2) · Arthritis, Juvenile (1) · Arthritis, Rheumatoid (1) · Behcet Syndrome (1) · Dermatomyositis (1) · Dyspnea (1) · Herpes Zoster (1) · Lupus Erythematosus, Systemic (1) · Myositis (1) · Pulmonary Arterial Hypertension (1) · Scleroderma, Diffuse (1) · Sjogren's Syndrome (1) · Spondylarthritis (1)
Skin Diseases (10) · Skin and Connective Tissue Diseases (10) · Connective Tissue Diseases (8) · Cardiovascular Diseases (3) · Vascular Diseases (3) · Hypertension (2) · Lung Diseases (2) · Respiratory Tract Diseases (2) · Ankylosis (1) · Arthritis (1) · Autoimmune Diseases (1) · Axial Spondyloarthritis (1) · Bone Diseases (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · DNA Virus Infections (1)
ambrisentan (2) · Aspirin (1) · Bosentan (1) · Cyclophosphamide (1) · Indocyanine Green (1) · Metronidazole (1) · Tadalafil (1) · baricitinib (1) · telitacicept (1)
Actelion (1) · Coordinación de Investigación en Salud, Mexico (1) · Duke University (1) · Federal University of São Paulo (1) · Johns Hopkins University (1) · Peking University Third Hospital (1) · Tongji Hospital (1) · UMC Utrecht (1) · University of California, Los Angeles (1) · University of Sao Paulo General Hospital (1)
Brazil (2) · China (2) · Netherlands (2) · United States (2) · Italy (1) · Mexico (1) · United Kingdom (1)
Cristiane Kayser, PhD (1) · Dinesh Khanna, MD (1) · Jacob M van Laar, MD PhD (1) · Julia Spierings (1) · Paul Hassoun, MD (1) · Rajeev Saggar, MD (1) · Suhail Mithani, MD (1)
PMID 22777623, PMID 26360334, PMID 29251556, PMID 31549334, PMID 33737437, PMID 41679320, PMID 41932224, PMID 42261247, PMID 42294825, PMID 42843284
P50HL084946 (1)