144 completed, 59 unknown, 47 recruiting, 21 terminated. 83 Not applicable, 78 Phase 2, 51 Phase 1, 24 Phase 3, 12 Early Phase 1.
Follow Systemic Sclerosis: new trials by email Literature Review of Systemic Sclerosis trials Research Report on Systemic Sclerosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| C-CAR168, an Autologous Anti-CD20/BCMA Chimeric Antigen Receptor T-Cell Therapy, in Participants With Systemic Sclerosis (SSc) Refractory to Standard Therapy C-CAR168 - Systemic Sclerosis (SSc), Systemic Sclerosis | Phase 1 | Not yet recruiting | AbelZeta Inc. | 12 | 2027-03-01 | 2026-10-13 |
| A Study to Compare the Efficacy and Safety of BMS-986353 (Zolacabtagene- Autoleucel / Zola-cel), CD19-CAR T Cells, Versus Standard of Care in Participants With Active Systemic Sclerosis BMS-986353, Fludarabine, Cyclophosphamide - Systemic Sclerosis | Phase 3 | Not yet recruiting | Juno Therapeutics, Inc., a Bristol-Myers Squibb Company | 92 | 2027-02-03 | 2026-09-18 |
| Efficacy and Safety Study of L608 in Patients With Systemic Sclerosis-associated Digital Ulcers L608, Placebo - Systemic Sclerosis | Phase 2 | Not yet recruiting | Pharmosa Biopharm Inc. | 40 | 2027-02-01 | 2026-11-09 |
| A Study to Evaluate the Safety and Efficacy (How Well the Study Treatment Works) of ABBV-2294 in Adult Participants With Systemic Sclerosis That Are Currently Receiving Local Standard of Care Treatment, and to Determine the Best Dose of ABBV-2294 to be Evaluated Further. ABBV-722, Upadacitinib, Placebo for ABBV-722 - Systemic Sclerosis | Phase 2 / Phase 3 | Not yet recruiting | AbbVie | 580 | 2026-12-11 | 2026-11-12 |
| Hyaluronidase Injections for Sclerodactyly in Patients With Scleroderma hyaluronidase - Scleroderma, Sclerodactyly | Phase 2 | Not yet recruiting | Stanford University | 10 | 2026-12-01 | 2026-11-06 |
| A Study to Learn About a Medicine Called PF-08154225 in Participants With Autoimmune Diseases PF-08154225 - Systemic Lupus Erythematosus, Rheumatoid Arthritis | Phase 1 / Phase 2 | Not yet recruiting | Pfizer | 54 | 2026-11-19 | 2026-10-01 |
| Catestatin as a Novel Biomarker for Cardiovascular and Microvascular Involvement in Systemic Sclerosis Systemic Sclerosis | Not yet recruiting | Assiut University | 70 | 2026-11-01 | 2025-10-07 | |
| Hyaluronidase for Sclerodactyly in Systemic Sclerosis Trial Hyaluronidase (Hylenex) - Systemic Sclerosis, Sclerodactyly | Early Phase 1 | Not yet recruiting | Medical University of South Carolina | 10 | 2026-11-01 | 2026-10-16 |
| Hyperpolarized Xenon MRI in Adults With Pulmonary Hypertension in Interstitial Lung Disease and Systemic Sclerosis Hyperpolarized 129 Xenon Gas - Interstitial Lung Disease, Pulmonary Hypertension | Phase 2 | Not yet recruiting | Bastiaan Driehuys | 51 | 2026-11-01 | 2026-09-15 |
| A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases BMS-986553 - Systemic Lupus Erythematosus, Sjögren's Disease | Phase 1 | Not yet recruiting | Bristol-Myers Squibb | 60 | 2026-10-30 | 2026-10-14 |
| A Trial in Healthy Adult Participants and Adults With Autoimmune Diseases to Test How HBM7020 is Tolerated and How it Behaves in the Body HBM7020 - Rheumatoid Arthritis, Systemic Lupus Erythematosus | Phase 1 | Recruiting | Otsuka Pharmaceutical Development & Commercialization, Inc. | 63 | 2026-09-24 | 2026-11-05 |
| Inflammatory Disease Biobank for Immunophenotyping and Cardiovascular Research Pericarditis, Tako-TSUBO Cardiomyopathy | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 300 | 2026-09-01 | 2026-08-10 | |
| CD19/BCMA-Targeted Universal CAR-T Cell Injection for the Treatment of Autoimmune Diseases RD06-05 CAR-T Cell Injection - SLE - Systemic Lupus Erythematosus, Systemic Sclerosis | Early Phase 1 | Not yet recruiting | Nanjing Bioheng Biotech Co., Ltd. | 30 | 2026-09-01 | 2026-07-16 |
| Study to Evaluate the Safety, Tolerability, and Activity of CM-101 in Patients With Systemic Sclerosis 10 mg/kg CM-101, Placebo - Systemic Sclerosis | Phase 2 | Suspended | ChemomAb Ltd. | 45 | 2026-09-01 | 2026-04-15 |
| Extracellular Vesicle Dynamics Predicting Vascular Complications and Treatment Response in Systemic Sclerosis Blood sampling, nailfold capillaroscopy - Systemic Sclerosis, Pulmonary Arterial Hypertension | Not applicable | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 60 | 2026-09-01 | 2026-07-21 |
| A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis Placebo matching nerandomilast formulation 1, Placebo matching nerandomilast formulation 2, Nerandomilast formulation 1 - Systemic Sclerosis | Phase 3 | Recruiting | Boehringer Ingelheim | 448 | 2026-07-27 | 2026-10-14 |
| A Study of C-CAR168 in the Treatment of Autoimmune Diseases Refractory to Standard Therapy CD20/BCMA-directed CAR-T cells Autologous 2nd generation - Multiple Sclerosis (MS), Myasthenia Gravis (MG) | Phase 1 | Not yet recruiting | The Affiliated Hospital of Qingdao University | 18 | 2026-07-01 | 2026-06-30 |
| Immun4Cure Cohort of Autoimmune Diseases Blood test and principal collection, Optional collection, Patient questionnaires - Rheumatoid Arthritis, Systemic Lupus Erythematosus | Recruiting | University Hospital, Montpellier | 500 | 2026-06-23 | 2026-06-30 | |
| Exploratory Clinical Study of Anti-CD19/BCMA Universal CAR-T Cell Injection for the Treatment of Refractory Autoimmune Diseases anti-CD19/BCMA-UCAR-T cells - Rheumatoid Arthritis, Dermatomyositis | Not applicable | Recruiting | The First Affiliated Hospital with Nanjing Medical University | 72 | 2026-05-10 | 2026-04-30 |
| Umbilical Cord Blood CD19-BCMA CART Cell Therapy for SLE-LN, SSc, andpSS PAH. umbilical cord blood CD19-BCMA CAR-T cells infusion - Refractory Lupus Nephritis, Systemic Sclerosis | Phase 1 / Phase 2 | Recruiting | Beijing GoBroad Hospital | 45 | 2026-03-18 | 2026-03-03 |
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Scleroderma, Systemic (317) · Scleroderma, Diffuse (72) · Lupus Erythematosus, Systemic (54) · Myositis (29) · Arthritis, Rheumatoid (26) · Sjogren's Syndrome (25) · Lung Diseases, Interstitial (22) · Hypertension, Pulmonary (21) · Autoimmune Diseases (20) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (17) · Dermatomyositis (14) · digital ulcers (14) · Raynaud Disease (11) · Connective Tissue Diseases (10) · Antiphospholipid Syndrome (9)
Skin Diseases (317) · Skin and Connective Tissue Diseases (317) · Connective Tissue Diseases (307) · Immune System Diseases (70) · Musculoskeletal Diseases (64) · Cardiovascular Diseases (61) · Respiratory Tract Diseases (57) · Vascular Diseases (57) · Lung Diseases (54) · Autoimmune Diseases (52) · Joint Diseases (52) · Nervous System Diseases (47) · Arthritis (44) · Neuromuscular Diseases (41) · Rheumatic Diseases (41)
Cyclophosphamide (16) · Blood Specimen Collection (12) · fludarabine (11) · Mycophenolic Acid (8) · Rituximab (5) · Hematologic Tests (4) · ambrisentan (4) · tocilizumab (4) · treprostinil (4) · Alemtuzumab (3) · Antilymphocyte Serum (3) · Bosentan (3) · Imatinib Mesylate (3) · Immunoglobulins, Intravenous (3) · Mesna (3)
Assistance Publique - Hôpitaux de Paris (14) · University Hospital, Lille (9) · Lady Davis Institute (7) · Actelion (5) · Central Hospital, Nancy, France (5) · University of Michigan (5) · Assiut University (4) · Duke University (4) · Echosense Ltd. (4) · Hospital for Special Surgery, New York (4) · Nanjing Bioheng Biotech Co., Ltd. (4) · University Hospital, Bordeaux (4) · University Hospital, Strasbourg, France (4) · Assistance Publique Hopitaux De Marseille (3) · Cukurova University (3)
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David Launay, MD,PhD (4) · Luc Mouthon, MD, PhD (4) · Robert Spiera, MD (4) · James Seibold, MD (3) · Brett Thombs, PhD (2) · Dinesh Khanna, MD (2) · Horst Olschewski, MD (2) · Julie A Konkle, BSN (2)
PMID 28298564, PMID 16960939, PMID 18634152, PMID 19158116, PMID 19420368, PMID 19950289, PMID 20634241, PMID 20805294, PMID 21148153, PMID 21398330, PMID 21476099, PMID 21769849, PMID 22127844, PMID 22542159, PMID 22733975, PMID 22777623, PMID 22859354, PMID 23070991, PMID 23139240, PMID 23588937, PMID 23597147, PMID 23942767, PMID 24067785, PMID 24507585, PMID 24515598, PMID 25007944, PMID 25114060, PMID 26283632, PMID 26360334, PMID 27163986, PMID 27179107, PMID 27370878, PMID 27429171, PMID 27586891, PMID 28229811, PMID 28270187, PMID 28399931, PMID 28705939, PMID 28724445, PMID 28977630, PMID 29073343, PMID 29073351, PMID 29251556, PMID 29732731, PMID 29871697, PMID 30092330, PMID 30127049, PMID 30134971, PMID 30277862, PMID 30463598
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