190 completed, 22 active not recruiting, 22 unknown, 19 terminated. 282 Phase 3, 28 Phase 2.
Follow Spinal Diseases: new trials by email Literature Review of Spinal Diseases trials Research Report on Spinal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Zasocitinib in Adults With Psoriatic Arthritis (LATITUDE PsA NeXt) Placebo, Zasocitinib - Psoriatic Arthritis | Phase 3 | Not yet recruiting | Takeda | 644 | 2027-01-11 | 2026-10-27 |
| Continued Access to Deucravacitinib for Adult SLE/SjD and Pediatric PsO/PsA Study Completers Deucravacitinib - Systemic Lupus Erythematosus, Sjögren's Disease | Phase 3 | Not yet recruiting | Bristol-Myers Squibb | 2300 | 2026-12-31 | 2026-09-03 |
| Spinal Bracing in Adults With Painful Degenerative Scoliosis: a Randomized Controlled Open Trial Custom-molded lumbar-sacral orthosis, Usual Care - Degenerative Scoliosis, Scoliosis Idiopathic | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 130 | 2026-09-01 | 2026-05-01 |
| Efficacy and Safety of Novosis Putty in Transforaminal Lumbar Interbody Fusion for Patients With Lumbar Degenerative Disc Disease Novosis Putty, Standard of Care - Degenerative Disc Disease | Phase 3 | Recruiting | CGBio Inc. | 316 | 2026-06-11 | 2026-08-26 |
| MDT-0123 Japan Study MDT-0123, ICBG - Disc Degeneration, Spinal Deformity | Phase 3 | Recruiting | Medtronic Spinal and Biologics | 140 | 2026-04-24 | 2026-09-09 |
| Continuation Study of Zasocitinib in Adults With Psoriatic Arthritis Zasocitinib - Psoriatic Arthritis | Phase 3 | Recruiting | Takeda | 1182 | 2026-03-11 | 2026-11-12 |
| A Study to Evaluate the Efficacy and Safty of 608 in Patients With Non- Radiographic Axial Spondyloarthritis (Nr-axSpA) 608, Placebo - Axial Spondyloarthritis, Non-Radiographic | Phase 3 | Not yet recruiting | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 380 | 2026-03-09 | 2026-01-16 |
| Efficacy and Safety of Xeligekimab in the Treatment of Non-Radiographic Axial Spondyloarthritis Xeligekimab injection - Nr-axial Spondyloarthritis, Non-Radiographical Axial Spondyloarthritis | Phase 2 / Phase 3 | Not yet recruiting | Lingli Dong | 40 | 2026-01-31 | 2026-01-14 |
| A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease IDCT (rebonuputemcel), Sham (No Treatment) - Degenerative Disc Disease | Phase 3 | Recruiting | DiscGenics, Inc. | 162 | 2025-12-23 | 2026-10-15 |
| A Study of Picankibart in Patients With Active Psoriatic Arthritis Placebo, Picankibart - Psoriatic Arthritis | Phase 2 / Phase 3 | Recruiting | Innovent Biopharmaceutical Technology (Hangzhou) Co., LTD. | 222 | 2025-12-18 | 2026-03-20 |
| IntraVenous Iron in Kids With Iron Deficiency and Scoliosis Study Ferric carboxymaltose IV, Normal Saline (Placebo) - Scoliosis Correction, Iron Deficiency | Phase 2 / Phase 3 | Recruiting | Columbia University | 120 | 2025-11-21 | 2025-11-26 |
| A Study to Evaluate the Long-term Safety, Tolerability, and Efficacy of Subcutaneous Sonelokimab in Participants With Psoriatic Arthritis Sonelokimab - Arthritis, Psoriatic | Phase 3 | Enrolling by invitation | MoonLake Immunotherapeutics AG | 1560 | 2025-11-13 | 2026-11-12 |
| A Study to Evaluate the Efficacy and Safety of 608 in Adult Subjects With Active Ankylosing Spondylitis(AS) 608 dose, Placebo - Ankylosing Spondylitis | Phase 3 | Recruiting | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 500 | 2025-11-07 | 2025-12-10 |
| A Study to Evaluate Efficacy and Safety of LNK01001 in Adults With Ankylosing Spondylitis LNK01001, Placebo - Ankylosing Spondylitis | Phase 3 | Recruiting | Lynk Pharmaceuticals Co., Ltd | 352 | 2025-08-29 | 2026-11-12 |
| A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have or Have Not Been Treated With Biologic Medicines Zasocitinib, Placebo - Psoriatic Arthritis | Phase 3 | Active not recruiting | Takeda | 601 | 2025-03-10 | 2026-10-14 |
| A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines Zasocitinib, Active Comparator, Placebo - Psoriatic Arthritis | Phase 3 | Active not recruiting | Takeda | 1583 | 2025-03-03 | 2026-11-12 |
| A Study to Evaluate the Efficacy and Safety of JNJ-77242113 (Icotrokinra) in Biologic-naïve Participants With Active Psoriatic Arthritis Icotrokinra, Placebo, Active reference comparator - Arthritis, Psoriatic | Phase 3 | Active not recruiting | Janssen Research & Development, LLC | 552 | 2025-02-21 | 2026-11-03 |
| Home-based Cycling for People With Lumbar Spinal Stenosis Home-based cycling program, usual care - Symptomatic Lumbar Spinal Stenosis | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 302 | 2025-02-10 | 2025-11-20 |
| A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis Icotrokinra, Placebo - Arthritis, Psoriatic | Phase 3 | Active not recruiting | Janssen Research & Development, LLC | 813 | 2025-01-09 | 2026-11-03 |
| A Study of the Efficacy and Safety of SHR-1314 for Adult Active Psoriatic Arthritis SHR-1314 injection, Placebo - Psoriatic Arthritis | Phase 3 | Active not recruiting | Suzhou Suncadia Biopharmaceuticals Co., Ltd. | 208 | 2024-11-04 | 2026-08-06 |
Showing 20 of 282. Sign in to see all of them.
Arthritis, Psoriatic (105) · Spondylitis, Ankylosing (82) · Axial Spondyloarthritis (26) · Intervertebral Disc Degeneration (23) · Psoriasis (23) · Intervertebral Disc Displacement (22) · Arthritis (18) · Spondylarthritis (16) · Spinal Stenosis (15) · Low Back Pain (12) · Scoliosis (12) · Spondylarthropathies (12) · Radiculopathy (11) · Non-Radiographic Axial Spondyloarthritis (10)
Bone Diseases (280) · Musculoskeletal Diseases (275) · Joint Diseases (204) · Spondylitis (202) · Spondylarthropathies (193) · Spondylarthritis (191) · Arthritis (190) · Skin and Connective Tissue Diseases (110) · Skin Diseases, Papulosquamous (105) · Skin Diseases (101) · Ankylosis (99) · Psoriasis (82) · Axial Spondyloarthritis (74) · Pathological Conditions, Signs and Symptoms (52)
secukinumab (29) · Adalimumab (26) · golimumab (14) · Etanercept (13) · Methotrexate (11) · bimekizumab (11) · ixekizumab (11) · Ustekinumab (10) · apremilast (10) · Infliximab (9) · tofacitinib (9) · guselkumab (7) · Certolizumab Pegol (5) · GLPG0634 (5) · risankizumab (5)
Novartis Pharmaceuticals (27) · Janssen Research & Development, LLC (14) · Amgen (11) · UCB Biopharma SRL (11) · Eli Lilly and Company (10) · Pfizer (9) · Abbott (8) · AbbVie (7) · Centocor, Inc. (6) · Biocad (4) · Bristol-Myers Squibb (4) · Gilead Sciences (4) · Medtronic Spinal and Biologics (4) · Merck Sharp & Dohme LLC (4) · Takeda (4)
United States (137) · Germany (90) · Poland (85) · Canada (78) · Czechia (78) · Spain (78) · United Kingdom (75) · Russia (69) · France (62) · Hungary (62) · Belgium (55) · Australia (54) · Italy (51) · Bulgaria (50) · China (50)
Beverly Paperiello (3) · Roman Ivanov, PhD (3)
PMID 31203228, PMID 38446397, PMID 37316690, PMID 40194794, PMID 41807031, PMID 41965705, PMID 42386286, PMID 34618347, PMID 35305260, PMID 38488975, PMID 39120849, PMID 33722947, PMID 34795065, PMID 36792107, PMID 39120848, PMID 40241921, PMID 30018799, PMID 30473179, PMID 31077258, PMID 31112005, PMID 31909868, PMID 31964419, PMID 32006348, PMID 32352653, PMID 32816215, PMID 33227175, PMID 33351179, PMID 34536218, PMID 34773130, PMID 34870800, PMID 35393269, PMID 35429281, PMID 36282526, PMID 36526796, PMID 36642439, PMID 36931693, PMID 36958766, PMID 36995469, PMID 37906417, PMID 37982966, PMID 38488976, PMID 38683479, PMID 38754125, PMID 39215949, PMID 39534481, PMID 39624020, PMID 40347389, PMID 40694276, PMID 40875187, PMID 41039829
2015 (12), 2023 (11), 2009 (10), 2016 (9), 2017 (7), 2014 (6), 2019 (6), 2018 (5), 2008 (1), 2025 (1), R01AR045622 (1), R21AR053646 (1)