13 terminated. 13 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 13 | Terminated 13 |
Follow Sleep Initiation and Maintenance Disorders: new trials by email Literature Review of Sleep Initiation and Maintenance Disorders trials Research Report on Sleep Initiation and Maintenance Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Double-blind Randomized Controlled Trial Comparing Suvorexant 20 mg to Placebo for Treatment of Insomnia in Cancer Survivors Suvorexant Tablets, Placebo Control - Breast Cancer, Insomnia | Phase 4 | Terminated | Medical University of South Carolina | 6 | 2024-09-20 | 2026-08-12 |
| CBT-I Augmentation of Medication for Drinking in AUD Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene Education - Alcohol Use Disorder With Insomnia | Phase 4 | Terminated | VA Office of Research and Development | 82 | 2022-06-15 | 2025-02-28 |
| Insomnia Prevalence and Treatment Impact on Systemic Hypertension Ramelteon (RozeremR), sleep hygiene - Insomnia, Hypertension | Phase 4 | Terminated | University of Sao Paulo | 5 | 2022-05-01 | 2022-12-29 |
| A Six Week, Randomized, Double-Blind Placebo-Controlled, Suvorexant Augmentation Study of Antidepressant Treatment of Major Depressive Disorder With Residual Insomnia suvorexant, Placebo - Depression, Major Depressive Disorder | Phase 4 | Terminated | Institute for Advanced Medical Research, Alpharetta, GA | 32 | 2017-03-01 | 2026-11-04 |
| Suvorexant in Insomnia Co-morbid With Fibromyalgia suvorexant, placebo - Insomnia, Fibromyalgia | Phase 4 | Terminated | Henry Ford Health System | 10 | 2016-02-01 | 2021-06-16 |
| Magnesium Oxide Monohydrate for Nocturnal Leg Cramps MAGNOX 520®, placebo - Nocturnal Leg Cramps, Quality of Life | Phase 4 | Terminated | Uzi Milman | 94 | 2013-02-01 | 2017-07-21 |
| Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans Quetiapine, Trazodone - Insomnia, Mental Health Disorder | Phase 4 | Terminated | VA Connecticut Healthcare System | 1 | 2012-07-01 | 2018-10-16 |
| An Intervention Study to Reduce the Use and Impact of Potentially Inappropriate Medications Among Older Adults knowledge transfer tool - Polypharmacy, Incontinence | Phase 4 | Terminated | Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal | 300 | 2010-06-01 | 2013-05-15 |
| Effect of Guanfacine Extended-Release on Attention Deficit Hyperactivity Disorder (ADHD)-Associated Insomnia Guanfacine extended-release tablets, Placebo comparator - Attention-Deficit/Hyperactivity Disorder, Attention Deficit Disorder | Phase 4 | Terminated | Children's Specialized Hospital | 29 | 2010-06-01 | 2014-08-11 |
| Modafinil Treatment for Sleep/Wake Disturbances in Older Adults modafinil - Insomnia, Sleep Initiation and Maintenance Disorders | Phase 4 | Terminated | VA Palo Alto Health Care System | 2 | 2008-02-01 | 2019-10-28 |
| Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban Eszopiclone, Bupropion - Insomnia, Nicotine Dependence | Phase 4 | Terminated | Yale University | 4 | 2007-04-01 | 2022-05-09 |
| How do Sleeping Pills Affect Pain in the Brain? Eszopiclone, Placebo - Primary Insomnia | Phase 4 | Terminated | University of California, San Diego | 40 | 2006-12-01 | 2015-10-26 |
| Treating Chronic Insomnia in Breast Cancer Patients Placebo, Ramelteon - Chronic Insomnia | Phase 4 | Terminated | Accelerated Community Oncology Research Network | 16 | 2006-08-01 | 2011-08-22 |
Agnosia (1) · Alcoholism (1) · Alzheimer Disease (1) · Anxiety Disorders (1) · Attention Deficit Disorder with Hyperactivity (1) · Breast Neoplasms (1) · Cognitive Dysfunction (1) · Depression (1) · Depressive Disorder, Major (1) · Fatigue (1) · Fibromyalgia (1) · Hypertension (1) · Mental Disorders (1) · Pain (1)
Dyssomnias (13) · Nervous System Diseases (13) · Sleep Disorders, Intrinsic (13) · Mental Disorders (12) · Sleep Wake Disorders (12) · Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4) · Behavior (3) · Chemically-Induced Disorders (3) · Neurologic Manifestations (3) · Health Behavior (2) · Substance-Related Disorders (2) · Alcohol-Related Disorders (1) · Attention Deficit and Disruptive Behavior Disorders (1) · Behavioral Symptoms (1)
suvorexant (3) · Eszopiclone (2) · ramelteon (2) · Bupropion (1) · Cognitive Behavioral Therapy (1) · Guanfacine (1) · Modafinil (1) · Quetiapine Fumarate (1) · Sugars (1) · Trazodone (1)
Accelerated Community Oncology Research Network (1) · Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal (1) · Children's Specialized Hospital (1) · Henry Ford Health System (1) · Institute for Advanced Medical Research, Alpharetta, GA (1) · Medical University of South Carolina (1) · University of California, San Diego (1) · University of Sao Paulo (1) · Uzi Milman (1) · VA Connecticut Healthcare System (1) · VA Office of Research and Development (1) · VA Palo Alto Health Care System (1) · Yale University (1)
United States (10) · Brazil (1) · Canada (1) · Israel (1)
Albert J Arias, MD, MS (1) · Andrea H. Weinberger, Ph.D. (1) · Angelo Sambunaris, MD (1) · Cara Tannenbaum, MD (1) · Edward J. Stepanski, Ph.D. (1) · Elizabeth Ralevski, Ph.D. (1) · Jamie M Zeitzer, PhD (1) · Martin P Paulus, M.D. (1) · Noga Maor Rougin, MD (1) · Sarah Marrison, MD PhD (1) · Subhajit Chakravorty, MD (1) · Thomas A Rugino, MD (1) · Thomas Roth, PhD (1) · Timothy Roehrs, PhD (1) · Uzi Milman, MD (1)
PMID 15683149, PMID 23514019, PMID 24733354, PMID 28143413, PMID 28241153, PMID 28473524, PMID 31992394, PMID 33189083, PMID 33275278
I01CX001957 (1)