16 completed. 16 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 16 | Completed 16 |
| Phase 2 | 5 | Completed 5 |
Follow Sickle Cell Anemia: new trials by email Literature Review of Sickle Cell Anemia trials Research Report on Sickle Cell Anemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Pociredir Pociredir oral capsule(s) - Sickle Cell Disease, Sickle Cell Anemia | Phase 1 | Completed | Fulcrum Therapeutics | 45 | 2021-12-13 | 2026-02-12 |
| Dose Escalation Study of PF-07209326 in Healthy Participants and Participants With Sickle Cell Disease Placebo, PF-07209326 - Healthy, Sickle Cell Anemia | Phase 1 | Completed | Pfizer | 52 | 2020-02-05 | 2026-06-15 |
| Hematopoietic Stem Cell Transplant for Sickle Cell Disease Fludarabine, Hematopoietic Stem Cell Transplant (HSCT) - Sickle Cell Disease, Sickle Cell Anemia | Phase 1 | Completed | Case Comprehensive Cancer Center | 4 | 2015-10-19 | 2024-04-29 |
| The Role of Endothelin-1 in Sickle Cell Disease Ambrisentan, Placebo - Sickle Cell Anemia | Phase 1 | Completed | Augusta University | 26 | 2015-09-01 | 2020-04-02 |
| Gum Arabic as Fetal Hemoglobin Agent in Sickle Cell Anemia Gum Arabic - Sickle Cell Anemia | Phase 1 / Phase 2 | Completed | Al-Neelain University | 47 | 2014-04-01 | 2015-06-10 |
| A Pilot Study of N-acetylcysteine in Patients With Sickle Cell Disease N-Acetylcysteine - Sickle Cell Disease, Sickle Cell Anemia | Phase 1 / Phase 2 | Completed | Bloodworks | 21 | 2013-03-01 | 2020-07-09 |
| Safety Study of MP4CO in Adult Sickle Cell Patients MP4CO, Sodium chloride solution - Anemia, Sickle Cell, Sickle Cell Anemia | Phase 1 | Completed | Sangart | 32 | 2012-01-01 | 2013-08-19 |
| The Efficacy of Jobelyn (Sorghum Bicolor Extract)in the Treatment of Sickle Cell Anemia Paludrine + Folic Acid, Paludrine + Folic Acid + Jobelyn - Sickle Cell Anemia | Phase 1 / Phase 2 | Completed | Lagos State University | 150 | 2012-01-01 | 2012-10-10 |
| Pharmacokinetics (PK) of Liquid Hydroxyurea in Pediatric Patients With Sickle Cell Anemia Hydroxyurea - Sickle Cell Anemia | Phase 1 | Completed | Children's Mercy Hospital Kansas City | 39 | 2011-12-01 | 2014-12-12 |
| Topical Sodium Nitrite for Chronic Leg Ulcers in Adult Patients With Blood Disorders Sodium Nitrite Cream - Sickle Cell Anemia, Sickle Cell Disease | Phase 1 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 28 | 2011-03-15 | 2018-10-22 |
| Therapeutic Application of Intravascular Nitrite for Sickle Cell Disease L-NMMA, Sodium Nitrite - Sickle Cell Anemia | Phase 1 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 18 | 2004-11-01 | 2019-11-05 |
| Evaluation of Hydroxyurea Plus L-arginine or Sildenafil to Treat Sickle Cell Anemia Hydroxyurea, L-Arginine, Sildenafil - Sickle Cell Anemia | Phase 1 | Completed | National Institutes of Health Clinical Center (CC) | 39 | 2003-03-10 | 2019-11-22 |
| Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension Nitric Oxide, INO Pulse - NO Delivery System - Sickle Cell Anemia, Pulmonary Hypertension | Phase 1 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 59 | 2001-07-27 | 2019-12-17 |
| A Phase I/II Trial of Recombinant-Methionyl Human Stem Cell Factor (SCF) in Adult Patients With Sickling Disorders Recombinant-methionyl human stem cell factor - Hemoglobin SC Disease, Sickle Cell Anemia | Phase 1 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 50 | 2000-03-01 | 2008-03-04 |
| Bone Marrow Transplantation in Treating Children With Sickle Cell Disease cyclosporine, fludarabine, mycophenolate mofetil - Sickle Cell Anemia | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 50 | 1999-12-01 | 2008-09-10 |
| Phase I/II Randomized Study of Hydroxyurea With or Without Clotrimazole in Patients With Sickle Cell Anemia clotrimazole, hydroxyurea - Sickle Cell Anemia | Phase 1 / Phase 2 | Completed | University of North Carolina | 20 | 1999-10-01 | 2015-03-25 |
Anemia, Sickle Cell (16) · Vaso-Occlusive Crises (3) · Genetic Diseases, Inborn (2) · Hematologic Diseases (2) · Hemoglobin SC Disease (2) · Rare Diseases (2) · Acute Chest Syndrome (1) · Anemia (1) · Aneurysm (1) · Hemolysis (1) · Hypertension, Pulmonary (1) · Leg Ulcer (1) · Proteinuria (1) · Thalassemia (1) · beta-Thalassemia (1)
Anemia, Hemolytic (16) · Anemia, Hemolytic, Congenital (16) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (16) · Hemic and Lymphatic Diseases (16) · Hemoglobinopathies (16) · Anemia (15) · Genetic Diseases, Inborn (14) · Hematologic Diseases (14) · Pathological Conditions, Signs and Symptoms (4) · Pathologic Processes (3) · Cardiovascular Diseases (2) · Disease Attributes (2) · Vascular Diseases (2) · Female Urogenital Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1)
Hydroxyurea (3) · fludarabine (2) · Acetylcysteine (1) · Arginine (1) · Bone Marrow Transplantation (1) · Clotrimazole (1) · Cyclosporine (1) · Folic Acid (1) · Gum Arabic (1) · Mycophenolic Acid (1) · Nitric Oxide (1) · PEGylated carboxyhemoglobin bovine (1) · Proguanil (1) · Saline Solution (1) · Sildenafil Citrate (1)
National Heart, Lung, and Blood Institute (NHLBI) (3) · Al-Neelain University (1) · Augusta University (1) · Bloodworks (1) · Case Comprehensive Cancer Center (1) · Children's Mercy Hospital Kansas City (1) · Fred Hutchinson Cancer Center (1) · Fulcrum Therapeutics (1) · Lagos State University (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · National Institutes of Health Clinical Center (CC) (1) · Pfizer (1) · Sangart (1) · University of North Carolina (1)
United States (13) · Nigeria (2) · France (1) · Jamaica (1) · Lebanon (1) · South Africa (1) · Sudan (1) · United Kingdom (1)
John F Tisdale, M.D. (3) · A O Dosunmu, M.D. (1) · Abdullah Kutlar, MD (1) · Adeyemi Adenola, MD (1) · Amal M Saeed, PhD (1) · Barbara A Konkle, M.D. (1) · Eugene Paul Orringer (1) · Kathleen Neville, MD, MS (1) · Lamis AA Kaddam, MSc (1) · Mark Walters (1) · Matthew M Hsieh, M.D. (1) · Molly Gallogly, MD, PhD (1) · Tania Small, MD (1)
PMID 24916507, PMID 25938131, PMID 26589907, PMID 26719803, PMID 28331623, PMID 28884840, PMID 30956961, PMID 31316836, PMID 32188508, PMID 37254256, PMID 40569673
U01HL117684 (1)