96 completed, 15 terminated, 10 recruiting, 7 unknown. 38 Phase 2, 30 Not applicable, 20 Phase 1, 15 Phase 3, 4 Phase 4.
Follow Sickle Cell Anemia: new trials by email Literature Review of Sickle Cell Anemia trials Research Report on Sickle Cell Anemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of SIL-8301 for Control of Hemolysis in a Uniform Sickle Cell Disease Endotype Senicapoc, Placebo - Sickle Cell Disease, Sickle Cell Anaemia | Phase 2 | Recruiting | Biossil Inc. | 105 | 2026-08-13 | 2026-08-17 |
| Alendronate for Osteonecrosis in Adults With Sickle Cell Disease Alendronate Sodium - Sickle Cell Disease, Sickle Cell Anemia | Phase 2 | Recruiting | University of California, Davis | 30 | 2026-03-09 | 2026-07-16 |
| Awake Prone Positioning for Severe Acute Chest Syndrome Awake prone positioning (APP) - Acute Chest Syndrome, Sickle Cell Anemia | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 15 | 2026-01-01 | 2025-09-02 |
| Verifying Antibodies After Live Immunization Delivery (VALID): A Study of Measles Vaccine Immunogenicity in Children With Sickle Cell Disease Sickle Cell Disease, Measles Vaccination | Recruiting | Children's Hospital Medical Center, Cincinnati | 130 | 2025-03-13 | 2026-01-21 | |
| Investigating the Mechanistic Effects of Mitapivat in Subjects With Sickle Cell Disease Sickle Cell Anemia, Sickle Cell Thalassemia | Active not recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 6 | 2024-05-09 | 2026-09-22 | |
| Feasibility and Preliminary Efficacy of Acceptance and Commitment Therapy (ACT) for Sleep Disturbances in Adults With Sickle Cell Disease (SCD) ACT Intervention, Waitlist - Sickle Cell Disease, Sickle Cell Anemia | Not applicable | Suspended | National Cancer Institute (NCI) | 3 | 2024-05-03 | 2025-11-20 |
| Pressure Pain Tolerance in Relation to Balance and Strength in Children Pressure pain tolerance measurement using Digital Pressure Algometer, Balance assessment using HUMAC balance system, Lower limb muscular strength using Lafayette hand held dynamometer - Sickle Cell Anemia | Not applicable | Recruiting | Adly A Adam | 80 | 2024-02-01 | 2025-04-01 |
| Full Assessment of Clinical Transfusion Support Sickle Cell Anemia, Blood Transfusion | Completed | Children's Hospital Medical Center, Cincinnati | 250 | 2023-09-21 | 2025-07-30 | |
| Serial Assessment of Fertility Experiences Sickle Cell Anemia | Recruiting | Children's Hospital Medical Center, Cincinnati | 250 | 2023-07-10 | 2026-02-04 | |
| Sickle Cell Disease (SCD) Bone Pain Study Dual-energy X-ray absorptiometry, Vertebral fracture analysis, Adult Sickle Cell Quality of Life Measurement System pain impact questionnaire - Sickle Cell Disease, Sickle Cell Anemia | Not applicable | Active not recruiting | University of California, Davis | 53 | 2022-11-03 | 2026-09-23 |
| The Montreal Cognitive Assessment.Test in Adults With Sickle Cell Disease Montreal cognitive assessment - Sickle Cell Anemia | Not applicable | Completed | Assistance Publique - Hôpitaux de Paris | 65 | 2022-10-20 | 2026-02-10 |
| Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease CTX001 - Beta-Thalassemia, Thalassemia | Phase 3 | Recruiting | Vertex Pharmaceuticals Incorporated | 26 | 2022-08-02 | 2026-03-23 |
| Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia TBI, Hydroxyurea, briquilimab - Sickle Cell Anemia, Beta Thalassemia | Phase 1 / Phase 2 | Active not recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 40 | 2022-05-12 | 2026-03-12 |
| A Low-Interventional Study of an Electronic Sickle Cell Disease Patient Reported Outcomes in Sickle Cell Participants Sickle Cell Disease, Sickle Cell Anemia | Terminated | Sanguine Biosciences | 52 | 2022-01-19 | 2024-07-16 | |
| Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Pociredir Pociredir oral capsule(s) - Sickle Cell Disease, Sickle Cell Anemia | Phase 1 | Completed | Fulcrum Therapeutics | 45 | 2021-12-13 | 2026-02-12 |
| Management of Severe Acute Malnutrition in SCD, in Northern Nigeria hydroxyurea (20mg/kg/day), Ready-to-use therapeutic food - Sickle Cell Anemia, Severe Acute Malnutrition | Phase 2 | Completed | Vanderbilt University Medical Center | 132 | 2021-08-18 | 2024-03-27 |
| A Trial to Assess Haploidentical T-depleted Stem Cell Transplantation in Patients With SCD TCRα/β+ and CD19+ depleted haploidentical stem cell transplantation, Matched sibling donor transplantation - HbS Disease, Hemoglobin S Disease | Phase 2 | Recruiting | University of Regensburg | 212 | 2021-06-30 | 2024-05-13 |
| Stroke Prevention in Young Adults With Sickle Cell Anemia Hydroxyurea therapy per standard care - Sickle Cell Disease, Sickle Cell Anemia | Active not recruiting | Vanderbilt University Medical Center | 250 | 2021-05-17 | 2026-09-09 | |
| Red Cell Half Life Determination in Patients With and Without Sickle Cell Disease Biotin label - Sickle Cell Disease, Sickle Cell Anemia | Early Phase 1 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 22 | 2021-04-19 | 2024-02-13 |
| A Long-term Follow-up Study in Participants Who Received CTX001 CTX001 - Beta-Thalassemia, Thalassemia | Phase 3 | Enrolling by invitation | Vertex Pharmaceuticals Incorporated | 160 | 2021-01-20 | 2026-08-11 |
Showing 20 of 142. Sign in to see all of them.
Anemia, Sickle Cell (142) · Thalassemia (17) · Genetic Diseases, Inborn (13) · Hematologic Diseases (12) · beta-Thalassemia (11) · Hemoglobinopathies (9) · Anemia (8) · Hypertension, Pulmonary (8) · Rare Diseases (8) · Hemoglobin SC Disease (7) · Vaso-Occlusive Crises (7) · Pain (6) · Stroke (6) · Anemia, Diamond-Blackfan (4) · Acute Chest Syndrome (3)
Anemia, Hemolytic (141) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (141) · Hemic and Lymphatic Diseases (141) · Anemia, Hemolytic, Congenital (140) · Anemia (134) · Hemoglobinopathies (133) · Hematologic Diseases (130) · Genetic Diseases, Inborn (129) · Pathological Conditions, Signs and Symptoms (25) · Cardiovascular Diseases (20) · Pathologic Processes (18) · Vascular Diseases (17) · Lung Diseases (14) · Respiratory Tract Diseases (14) · Disease Attributes (12)
Hydroxyurea (23) · Alemtuzumab (5) · Cyclophosphamide (5) · fludarabine (5) · Busulfan (3) · Glutamine (3) · Saline Solution (3) · Watchful Waiting (3) · fludarabine phosphate (3) · maltodextrin (3) · senicapoc (3) · 2,2-dimethylbutyric acid (2) · Bone Marrow Transplantation (2) · Clotrimazole (2) · Granulocyte Colony-Stimulating Factor (2)
National Heart, Lung, and Blood Institute (NHLBI) (12) · Children's Hospital Medical Center, Cincinnati (11) · HaEmek Medical Center, Israel (10) · Assistance Publique - Hôpitaux de Paris (5) · Vanderbilt University Medical Center (5) · National Institutes of Health Clinical Center (CC) (4) · Baylor College of Medicine (3) · St. Jude Children's Research Hospital (3) · Albert Einstein College of Medicine (2) · Ann & Robert H Lurie Children's Hospital of Chicago (2) · Dana-Farber Cancer Institute (2) · Duke University (2) · Emmaus Medical, Inc. (2) · HemaQuest Pharmaceuticals Inc. (2) · Icagen (2)
United States (94) · Israel (12) · Canada (8) · Nigeria (8) · France (7) · Jamaica (6) · Germany (4) · Lebanon (4) · Uganda (4) · United Kingdom (4) · Brazil (3) · Egypt (3) · Belgium (2) · Dominican Republic (2) · Italy (2)
Ariel Koren, MD (6) · John F Tisdale, M.D. (6) · Michael R. DeBaun, MD, MPH (3) · Russell Ware, MD, PhD (3) · Ashutosh Lal, MD (2) · Carina Levin, MD (2) · Kenneth I Ataga, MBBS (2) · Michael R DeBaun, MD, MPH (2) · Oyebimpe O Adesina, MD, MS (2) · Richard Ghalie, MD, MBA (2) · Russell E Ware, MD, PhD (2) · Russell E. Ware, MD, PhD (2) · Swee Lay Thein, M.D. (2) · Tania Small, MD (2)
PMID 26589907, PMID 34000072, PMID 38775255, PMID 41026975, PMID 15877730, PMID 18192510, PMID 19344390, PMID 1944426, PMID 20175775, PMID 20335221, PMID 20955402, PMID 21179892, PMID 21228717, PMID 21523806, PMID 21630312, PMID 21890147, PMID 21993671, PMID 23065513, PMID 23103089, PMID 23828223, PMID 24224021, PMID 24529619, PMID 24675916, PMID 24677033, PMID 24916507, PMID 25047658, PMID 25140956, PMID 25471989, PMID 25662725, PMID 25773175, PMID 25938131, PMID 26414435, PMID 26547630, PMID 26576059, PMID 26670617, PMID 26719803, PMID 26969771, PMID 27030156, PMID 27339303, PMID 27582423, PMID 27619954, PMID 28110136, PMID 28174191, PMID 28331623, PMID 28576754, PMID 28589652, PMID 28821470, PMID 28884840, PMID 29051184, PMID 29296811
K23HL094376 (2), K23HL148310 (2), 1RC2HL101496 (1), 2009 (1), P01HL053749 (1), P50HL110790 (1), R01HL095647 (1), R01HL098239 (1), R01NS094041 (1), R21NS080639 (1), R34HL127162 (1), R37HL058091 (1), U01HL117659 (1), U01HL117684 (1), U01NS042804 (1)