16 completed, 2 active not recruiting, 1 recruiting, 1 terminated. 20 Phase 1, 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 20 | Completed 16, Active not recruiting 2, Recruiting 1, Terminated 1 |
| Phase 2 | 8 | Completed 5, Active not recruiting 2, Recruiting 1 |
Follow Sickle Cell Anemia: new trials by email Literature Review of Sickle Cell Anemia trials Research Report on Sickle Cell Anemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia TBI, Hydroxyurea, briquilimab - Sickle Cell Anemia, Beta Thalassemia | Phase 1 / Phase 2 | Active not recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 40 | 2022-05-12 | 2026-03-12 |
| Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Pociredir Pociredir oral capsule(s) - Sickle Cell Disease, Sickle Cell Anemia | Phase 1 | Completed | Fulcrum Therapeutics | 45 | 2021-12-13 | 2026-02-12 |
| Dose Escalation Study of PF-07209326 in Healthy Participants and Participants With Sickle Cell Disease Placebo, PF-07209326 - Healthy, Sickle Cell Anemia | Phase 1 | Completed | Pfizer | 52 | 2020-02-05 | 2026-06-15 |
| T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias CD3/CD19 depleted leukocytes, CD45RA depleted leukocytes, Hydroxyurea - Sickle Cell Anemia, Beta-thalassemia Major | Phase 1 / Phase 2 | Recruiting | Paul Szabolcs | 5 | 2018-08-02 | 2026-08-13 |
| Hematopoietic Stem Cell Transplant for Sickle Cell Disease Fludarabine, Hematopoietic Stem Cell Transplant (HSCT) - Sickle Cell Disease, Sickle Cell Anemia | Phase 1 | Completed | Case Comprehensive Cancer Center | 4 | 2015-10-19 | 2024-04-29 |
| The Role of Endothelin-1 in Sickle Cell Disease Ambrisentan, Placebo - Sickle Cell Anemia | Phase 1 | Completed | Augusta University | 26 | 2015-09-01 | 2020-04-02 |
| Gum Arabic as Fetal Hemoglobin Agent in Sickle Cell Anemia Gum Arabic - Sickle Cell Anemia | Phase 1 / Phase 2 | Completed | Al-Neelain University | 47 | 2014-04-01 | 2015-06-10 |
| Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell Disease Sodium Bicarbonate - Sickle Cell Anemia, Chronic Kidney Disease | Phase 1 | Terminated | University Hospitals Cleveland Medical Center | 7 | 2013-06-01 | 2019-03-20 |
| A Pilot Study of N-acetylcysteine in Patients With Sickle Cell Disease N-Acetylcysteine - Sickle Cell Disease, Sickle Cell Anemia | Phase 1 / Phase 2 | Completed | Bloodworks | 21 | 2013-03-01 | 2020-07-09 |
| Safety Study of MP4CO in Adult Sickle Cell Patients MP4CO, Sodium chloride solution - Anemia, Sickle Cell, Sickle Cell Anemia | Phase 1 | Completed | Sangart | 32 | 2012-01-01 | 2013-08-19 |
| The Efficacy of Jobelyn (Sorghum Bicolor Extract)in the Treatment of Sickle Cell Anemia Paludrine + Folic Acid, Paludrine + Folic Acid + Jobelyn - Sickle Cell Anemia | Phase 1 / Phase 2 | Completed | Lagos State University | 150 | 2012-01-01 | 2012-10-10 |
| Pharmacokinetics (PK) of Liquid Hydroxyurea in Pediatric Patients With Sickle Cell Anemia Hydroxyurea - Sickle Cell Anemia | Phase 1 | Completed | Children's Mercy Hospital Kansas City | 39 | 2011-12-01 | 2014-12-12 |
| Topical Sodium Nitrite for Chronic Leg Ulcers in Adult Patients With Blood Disorders Sodium Nitrite Cream - Sickle Cell Anemia, Sickle Cell Disease | Phase 1 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 28 | 2011-03-15 | 2018-10-22 |
| Haploidentical PBMC Transplant for Severe Congenital Anemias PBSC Transplant, Alemtuzumab, Sirolimus - Sickle Cell Anemia | Phase 1 / Phase 2 | Active not recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 23 | 2009-12-14 | 2026-04-23 |
| Therapeutic Application of Intravascular Nitrite for Sickle Cell Disease L-NMMA, Sodium Nitrite - Sickle Cell Anemia | Phase 1 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 18 | 2004-11-01 | 2019-11-05 |
| Evaluation of Hydroxyurea Plus L-arginine or Sildenafil to Treat Sickle Cell Anemia Hydroxyurea, L-Arginine, Sildenafil - Sickle Cell Anemia | Phase 1 | Completed | National Institutes of Health Clinical Center (CC) | 39 | 2003-03-10 | 2019-11-22 |
| Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension Nitric Oxide, INO Pulse - NO Delivery System - Sickle Cell Anemia, Pulmonary Hypertension | Phase 1 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 59 | 2001-07-27 | 2019-12-17 |
| A Phase I/II Trial of Recombinant-Methionyl Human Stem Cell Factor (SCF) in Adult Patients With Sickling Disorders Recombinant-methionyl human stem cell factor - Hemoglobin SC Disease, Sickle Cell Anemia | Phase 1 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 50 | 2000-03-01 | 2008-03-04 |
| Bone Marrow Transplantation in Treating Children With Sickle Cell Disease cyclosporine, fludarabine, mycophenolate mofetil - Sickle Cell Anemia | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 50 | 1999-12-01 | 2008-09-10 |
| Phase I/II Randomized Study of Hydroxyurea With or Without Clotrimazole in Patients With Sickle Cell Anemia clotrimazole, hydroxyurea - Sickle Cell Anemia | Phase 1 / Phase 2 | Completed | University of North Carolina | 20 | 1999-10-01 | 2015-03-25 |
Anemia, Sickle Cell (20) · Vaso-Occlusive Crises (3) · beta-Thalassemia (3) · Anemia (2) · Genetic Diseases, Inborn (2) · Hematologic Diseases (2) · Hemoglobin SC Disease (2) · Rare Diseases (2) · Thalassemia (2) · Acidosis (1) · Acute Chest Syndrome (1) · Anemia, Diamond-Blackfan (1) · Aneurysm (1) · Graft vs Host Disease (1) · Hemolysis (1)
Anemia, Hemolytic (20) · Anemia, Hemolytic, Congenital (20) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (20) · Hemic and Lymphatic Diseases (20) · Hemoglobinopathies (20) · Anemia (18) · Genetic Diseases, Inborn (18) · Hematologic Diseases (18) · Pathological Conditions, Signs and Symptoms (5) · Pathologic Processes (4) · Disease Attributes (3) · Thalassemia (3) · Cardiovascular Diseases (2) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2)
Hydroxyurea (5) · Alemtuzumab (3) · fludarabine (3) · Sirolimus (2) · fludarabine phosphate (2) · Acetylcysteine (1) · Arginine (1) · Bone Marrow Transplantation (1) · Clotrimazole (1) · Cyclophosphamide (1) · Cyclosporine (1) · Filgrastim (1) · Folic Acid (1) · Granulocyte Colony-Stimulating Factor (1) · Gum Arabic (1)
National Heart, Lung, and Blood Institute (NHLBI) (5) · Al-Neelain University (1) · Augusta University (1) · Bloodworks (1) · Case Comprehensive Cancer Center (1) · Children's Mercy Hospital Kansas City (1) · Fred Hutchinson Cancer Center (1) · Fulcrum Therapeutics (1) · Lagos State University (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · National Institutes of Health Clinical Center (CC) (1) · Paul Szabolcs (1) · Pfizer (1) · Sangart (1) · University Hospitals Cleveland Medical Center (1)
United States (17) · Nigeria (2) · France (1) · Jamaica (1) · Lebanon (1) · South Africa (1) · Sudan (1) · United Kingdom (1)
John F Tisdale, M.D. (4) · A O Dosunmu, M.D. (1) · Abdullah Kutlar, MD (1) · Adeyemi Adenola, MD (1) · Amal M Saeed, PhD (1) · Barbara A Konkle, M.D. (1) · Courtney D Fitzhugh, M.D. (1) · Eugene Paul Orringer (1) · Jane Little, MD (1) · Kathleen Neville, MD, MS (1) · Lamis AA Kaddam, MSc (1) · Mark Walters (1) · Matthew M Hsieh, M.D. (1) · Molly Gallogly, MD, PhD (1) · Paul Szabolcs, MD (1)
PMID 24916507, PMID 25938131, PMID 26589907, PMID 26719803, PMID 28331623, PMID 28884840, PMID 30956961, PMID 31316836, PMID 32188508, PMID 34917079, PMID 36240296, PMID 37254256, PMID 40569673, PMID 41871072, PMID 42133908
U01HL117684 (1)