13 completed, 1 terminated, 1 unknown. 7 Phase 1, 6 Not applicable, 4 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 6, Unknown 1 |
| Not applicable | 6 | Completed 5, Terminated 1 |
| Phase 2 | 4 | Completed 3, Unknown 1 |
| Phase 4 | 1 | Completed 1 |
Follow Proguanil: new trials by email Literature Review of Proguanil trials Research Report on Proguanil
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Evaluate the Influence of Tegoprazan on the Pharmacokinetics of Proguanil in Healthy Volunteers Atovaquone / Proguanil 250/100 mg, Tegoprazan 50 mg, Esomeprazole 40 mg - Gastroesophageal Reflux Disease | Phase 1 | Completed | Seoul National University Hospital | 19 | 2020-11-25 | 2021-09-27 |
| Safety and Efficacy of NF135 CPS Immunization CPS-immunization, malaria challenge infection, P. falciparum NF135.C10, malaria challenge infection, P. falciparum NF54 - Malaria,Falciparum, Controlled Human Malaria Infection | Not applicable | Terminated | Radboud University Medical Center | 43 | 2019-04-01 | 2023-05-26 |
| Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE) Proguanil Oral Tablet, Sulfadoxine/Pyrimethanine-Amodiaquine (SP-AQ), Dihydroartemisinin-Piperaquine (DP) - Malaria,Falciparum | Phase 4 | Completed | Duke University | 246 | 2018-01-23 | 2024-04-23 |
| Safety and Protective Efficacy of IV Immunization With Cryopreserved PfSPZ Under A/P Chemoprophylaxis atovaquone/proguanil 250mg/100mg (A/P), PfSPZ Challenge (NF54), NaCl 0,9% - Malaria | Phase 1 | Completed | University Hospital Tuebingen | 30 | 2016-11-28 | 2019-07-15 |
| Zinc Supplementation in Children With Sickle Cell Disease in Western Kenya Zinc Sulfate Tablets, Standard of Care - Sickle Cell Disease, Zinc Deficiency | Not applicable | Completed | Lucas Otieno Tina, MD MSc | 40 | 2016-05-20 | 2017-09-26 |
| Quality of Life Study for Sickle Cell Patients Treated With Jobelyn (Sorghum Bicolor Extract) Folic Acid + Paludrine + Jobelyn (500mg), Folic Acid + Paludrine + Jobelyn (250mg), Folic Acid + Paludrine + Jobelyn (2mg) - Other Sickle-cell Disorders With Crisis, Unspecified | Phase 1 / Phase 2 | Unknown | Lagos State University | 96 | 2013-04-01 | 2013-04-04 |
| Re-exposure of Human Volunteers to a Heterologous Strain of P. Falciparum Sporozoites Heterologous challenge, Malarone treatment - Malaria, Falciparum | Not applicable | Completed | Radboud University Medical Center | 21 | 2012-07-01 | 2013-02-13 |
| Single Oral Dose Study of Atovaquone/Proguanil Hydrochloride Combination Tablets and Atovaquone Suspension Atovaquone/proguanil HCL, Atovaquone - Malaria | Phase 1 | Completed | GlaxoSmithKline | 30 | 2012-04-01 | 2017-03-22 |
| Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine Versus Mefloquine Prophylaxis Chloroquine prophylaxis, Mefloquine prophylaxis, Immunization - Malaria, Plasmodium Falciparum | Not applicable | Completed | Radboud University Medical Center | 20 | 2012-01-01 | 2013-04-29 |
| The Efficacy of Jobelyn (Sorghum Bicolor Extract)in the Treatment of Sickle Cell Anemia Paludrine + Folic Acid, Paludrine + Folic Acid + Jobelyn - Sickle Cell Anemia | Phase 1 / Phase 2 | Completed | Lagos State University | 150 | 2012-01-01 | 2012-10-10 |
| Impact of CYP2C19*17 on the Pharmacokinetics of Proguanil and Clopidogrel Proguanil, Clopidogrel - CYP2C19 Genotypes | Phase 1 | Completed | University of Southern Denmark | 31 | 2011-10-01 | 2013-07-03 |
| Intermittent Preventive Treatment for Malaria in Patient With Sickle Cell Disease Proguanil, mefloquine plus artesunate, Sulfadoxine-pyrimethamine plus amodiaquine - Malaria, Sickle Cell Crisis | Phase 1 / Phase 2 | Completed | London School of Hygiene and Tropical Medicine | 270 | 2011-09-01 | 2014-03-21 |
| Experimental Human Malaria Infection After Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine Prophylaxis Chloroquine prophylaxis, Immunization, Plasmodium falciparum Bloodstage challenge - Plasmodium Falciparum Malaria | Not applicable | Completed | Radboud University Medical Center | 25 | 2011-04-01 | 2014-01-22 |
| Immunization With Different Doses of Plasmodium Falciparum Sporozoites Under Chloroquine Prophylaxis Chloroquine prophylaxis, Immunization, Plasmodium falciparum challenge - Plasmodium Falciparum Malaria | Not applicable | Completed | Radboud University Medical Center | 30 | 2011-04-01 | 2012-04-02 |
| Safety and Efficacy Study of IV Artesunate to Treat Malaria Artesunate, Malarone - Malaria | Phase 2 | Completed | U.S. Army Medical Research and Development Command | 30 | 2006-03-01 | 2019-10-01 |
Malaria (8) · Malaria, Falciparum (6) · Anemia, Sickle Cell (4) · Infections (2) · Gastroesophageal Reflux (1) · Vaso-Occlusive Crises (1)
Radboud University Medical Center (5) · Lagos State University (2) · Duke University (1) · GlaxoSmithKline (1) · London School of Hygiene and Tropical Medicine (1) · Lucas Otieno Tina, MD MSc (1) · Seoul National University Hospital (1) · U.S. Army Medical Research and Development Command (1) · University Hospital Tuebingen (1) · University of Southern Denmark (1)
Netherlands (5) · Nigeria (3) · Kenya (2) · Denmark (1) · Japan (1) · South Korea (1)
A O Dosunmu, M.D. (2) · Leo G Visser, MD, PhD (2) · Kalifa Bojang, PhD (1) · Lucas O Tina, MD MSc (1) · Matthew BB McCall, MD PhD DTMH (1) · Paul J Milligan, PhD (1) · Peter G Kremsner, Prof (1) · RW Sauerwein, PhD (1) · Rasaq Olaosebikan, MD (1) · Robert W Sauerwein, MD, PhD (1) · SeungHwan Lee, MD, PhD (1) · Shon A Remich, MD (1)
PMID 24970846, PMID 23599283, PMID 24872326, PMID 25396417, PMID 25701866, PMID 25933168, PMID 28081133, PMID 36215323, PMID 36897544, PMID 37024868
R01HL134211 (1)