4 completed, 1 active not recruiting, 1 recruiting, 1 terminated. 7 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 4, Active not recruiting 1, Recruiting 1, Terminated 1 |
| Phase 3 | 2 | Completed 1, Terminated 1 |
Follow Sclerosis: new trials by email Literature Review of Sclerosis trials Research Report on Sclerosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD) Vimseltinib - Chronic Graft-Versus-Host Disease (cGVHD) | Phase 2 | Recruiting | Deciphera Pharmaceuticals, LLC | 48 | 2024-11-21 | 2025-12-15 |
| Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegeneration Metformin Hydrochloride 850 mg Oral Tablet, Placebo - Multiple Sclerosis, Primary Progressive Multiple Sclerosis | Phase 2 | Active not recruiting | University Hospital, Antwerp | 120 | 2023-11-23 | 2025-06-24 |
| Simtuzumab (GS-6624) in the Prevention of Progression of Liver Fibrosis in Adults With Primary Sclerosing Cholangitis (PSC) Simtuzumab, Placebo - Primary Sclerosing Cholangitis (PSC) | Phase 2 | Completed | Gilead Sciences | 235 | 2013-03-04 | 2019-10-22 |
| Efficacy Study of Adrenocorticotropin Hormone to Treat Multiple Sclerosis (MS) Relapses After Sub-responding to an Initial 3 Day Course of Intravenous (IV) Methylprednisolone Methylprednisolone, ACTH, IV placebo - Multiple Sclerosis | Phase 2 / Phase 3 | Terminated | Neurologique Foundation, Inc. | 30 | 2009-10-01 | 2016-03-22 |
| A Study of Participants With Relapsing-Remitting Multiple Sclerosis (RRMS) LY2127399, Placebo - Relapsing-Remitting Multiple Sclerosis | Phase 2 | Completed | Eli Lilly and Company | 245 | 2009-04-01 | 2018-11-15 |
| Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease Levetiracetam - Motor Neuron Disease, Amyotrophic Lateral Sclerosis | Phase 2 | Completed | Duke University | 20 | 2006-05-01 | 2013-06-19 |
| Scleroderma: Cyclophosphamide or Transplantation mHSCT, cyclophosphamide - Scleroderma, Systemic, Sclerosis | Phase 2 / Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 75 | 2005-06-01 | 2023-04-12 |
Multiple Sclerosis (3) · Liver Diseases (2) · Recurrence (2) · Amyotrophic Lateral Sclerosis (1) · Autoimmune Diseases (1) · Autoimmune Diseases of the Nervous System (1) · Bronchial Diseases (1) · Bronchiolitis (1) · Bronchiolitis Obliterans (1) · Bronchiolitis Obliterans Syndrome (1) · Cholangitis, Sclerosing (1) · Demyelinating Autoimmune Diseases, CNS (1) · Fibrosis (1) · Graft vs Host Disease (1)
Pathological Conditions, Signs and Symptoms (7) · Pathologic Processes (6) · Immune System Diseases (4) · Nervous System Diseases (4) · Autoimmune Diseases (3) · Demyelinating Diseases (3) · Disease Attributes (3) · Autoimmune Diseases of the Nervous System (2) · Central Nervous System Diseases (2) · Demyelinating Autoimmune Diseases, CNS (2) · Digestive System Diseases (2) · Bile Duct Diseases (1) · Biliary Tract Diseases (1) · Brain Diseases (1) · Bronchitis (1)
Adrenocorticotropic Hormone (1) · BID protein, human (1) · Cyclophosphamide (1) · Levetiracetam (1) · Metformin (1) · Methylprednisolone (1) · Methylprednisolone Hemisuccinate (1) · Tablets (1) · simtuzumab (1) · tabalumab (1)
Deciphera Pharmaceuticals, LLC (1) · Duke University (1) · Eli Lilly and Company (1) · Gilead Sciences (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Neurologique Foundation, Inc. (1) · University Hospital, Antwerp (1)
United States (6) · Belgium (2) · Canada (2) · Germany (2) · Bulgaria (1) · Czechia (1) · Denmark (1) · France (1) · Hungary (1) · Israel (1) · Italy (1) · Netherlands (1) · Poland (1) · Romania (1) · Russia (1)
Barbara Willekens, MD, PhD (1) · Daniel E. Furst, MD (1) · Daniel Kantor, MD (1) · Keith M. Sullivan, MD (1) · Leslie J. Crofford, MD (1) · Maureen D. Mayes, MD, MPH (1) · Peter A. McSweeney, MD (1) · Richard A. Nash, MD (1) · Richard S Bedlack, MD, PhD (1)
PMID 20708086, PMID 20800376, PMID 23418384, PMID 28602891, PMID 29298160, PMID 30153359, PMID 33131208, PMID 34533286, PMID 35108379, PMID 35904231, PMID 38967589, PMID 39996122
2023 (1)