16 completed, 5 unknown, 4 recruiting, 2 active not recruiting. 9 Not applicable, 7 Phase 2, 4 Phase 1, 2 Early Phase 1, 2 Phase 3.
Follow Sclerosis: new trials by email Literature Review of Sclerosis trials Research Report on Sclerosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases BMS-986515, Fludarabine, Cyclophosphamide - Refractory Autoimmune Diseases | Phase 1 | Recruiting | Juno Therapeutics, Inc., a Bristol-Myers Squibb Company | 125 | 2025-09-04 | 2026-07-14 |
| Study of Diosmin for the Treatment of Digital Ulcers in Systemic Sclerosis Diosmin, Placebo - Scleroderma, Systemic, Digital Ulcer | Not applicable | Recruiting | Primus Pharmaceuticals | 45 | 2025-05-02 | 2026-11-10 |
| A Study of CNTY-101 in Participants With Refractory B Cell-mediated Autoimmune Diseases CNTY-101, IL-2, Lymphodepleting Chemotherapy - Systemic Lupus Erythematosus, Lupus Nephritis | Phase 1 | Active not recruiting | Century Therapeutics, Inc. | 6 | 2025-02-06 | 2026-01-08 |
| PET Study of PIPE-791 in Healthy Volunteers and Volunteers With PrMS and IPF PIPE-791 - Idiopathic Pulmonary Fibrosis (IPF), Idiopathic Pulmonary Fibrosis | Phase 1 | Completed | Contineum Therapeutics | 16 | 2024-12-09 | 2025-08-06 |
| A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD) Vimseltinib - Chronic Graft-Versus-Host Disease (cGVHD) | Phase 2 | Recruiting | Deciphera Pharmaceuticals, LLC | 48 | 2024-11-21 | 2025-12-15 |
| Finding Patterns In Clinical Study Experiences of Multiple Sclerosis Patients Multiple Sclerosis | Unknown | Power Life Sciences Inc. | 500 | 2024-09-01 | 2024-01-02 | |
| A Study of RD06-04 in Patients With Active Autoimmune Diseases RD06-04 cell infusion - SLE, Sclerosis | Early Phase 1 | Withdrawn | Nanjing Bioheng Biotech Co., Ltd. | 2024-08-31 | 2026-02-03 | |
| Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegeneration Metformin Hydrochloride 850 mg Oral Tablet, Placebo - Multiple Sclerosis, Primary Progressive Multiple Sclerosis | Phase 2 | Active not recruiting | University Hospital, Antwerp | 120 | 2023-11-23 | 2025-06-24 |
| Effects of Individualized Training to Reduce Fatigue in Patients With Newly and Advanced Diagnosed Multiple Sclerosis Traditional exercise, Individualized exercise - Sclerosis, Fatigue | Not applicable | Recruiting | Centre Hospitalier Universitaire de Saint Etienne | 96 | 2023-09-12 | 2024-10-23 |
| Acceptability of Exoskeleton Assisted Walking for Persons With Mobility Issues Due to Multiple Sclerosis Standard Exercise Training, Phoenix Exoskeleton suit - Multiple Sclerosis, Pathologic Processes | Not applicable | Completed | Sheffield Teaching Hospitals NHS Foundation Trust | 24 | 2022-06-23 | 2026-05-19 |
| Magnetic Imaging for Diagnostic of Amyotrophic Lateral Sclerosis Whole Body MRI and ENMG - Amyotrophic Lateral Sclerosis With Dementia | Not applicable | Unknown | University Hospital, Toulouse | 50 | 2021-06-01 | 2024-08-02 |
| Aerobic Exercise for Remyelination in Multiple Sclerosis Aerobic exercise, Education Group Control - Multiple Sclerosis, Sclerosis | Not applicable | Completed | Oregon Health and Science University | 60 | 2021-04-29 | 2026-09-23 |
| Power Training in Older Multiple Sclerosis Patients Power training - Multiple Sclerosis, Sclerosis | Not applicable | Unknown | University of Aarhus | 60 | 2020-12-07 | 2023-06-23 |
| Endovascular Versus Medical Treatment for the Pelvic Congestion Syndrome Medtronic® Concerto® detachable coil system, sclerosis, Diosmin / Hesperidin - Pelvic Congestive Syndrome, Pelvic Varices | Phase 4 | Unknown | Hospital de Clínicas Dr. Manuel Quintela | 120 | 2020-10-01 | 2020-04-24 |
| Assessment of Language Disorders in Multiple Sclerosis Patients Case, Withness - Sclerosis, Language Disorders | Not applicable | Completed | Fondation Ophtalmologique Adolphe de Rothschild | 142 | 2020-08-17 | 2023-02-15 |
| Allogeneic Mesenchymal Stem Cell-Derived Exosome Therapy for Progressive Multiple Sclerosis MSC-Derived Exosomes, Placebo (Normal Saline) - Multiple Sclerosis | Early Phase 1 | Suspended | Biocells Medical | 20 | 2020-07-01 | 2025-08-28 |
| Behavior and Activity Monitoring in MS Step Tracking, Water Tracking - Relapsing-Remitting Multiple Sclerosis | Not applicable | Completed | Ohio State University | 87 | 2017-11-02 | 2023-03-24 |
| Physiological Effects of N-Acetyl Cysteine in Patients With Multiple Sclerosis N-acetyl Cysteine - Multiple Sclerosis | Not applicable | Enrolling by invitation | Thomas Jefferson University | 55 | 2017-01-05 | 2025-09-17 |
| A Non-Interventional Pilot Study Assessing Whether Lysyl Oxidase-like 2 (LOXL2) is Present in Subjects With Scleroderma Limited Scleroderma, Diffuse Scleroderma | Completed | Gilead Sciences | 29 | 2013-04-01 | 2014-04-17 | |
| Simtuzumab (GS-6624) in the Prevention of Progression of Liver Fibrosis in Adults With Primary Sclerosing Cholangitis (PSC) Simtuzumab, Placebo - Primary Sclerosing Cholangitis (PSC) | Phase 2 | Completed | Gilead Sciences | 235 | 2013-03-04 | 2019-10-22 |
Showing 20 of 33. Sign in to see all of them.
Multiple Sclerosis (13) · Autoimmune Diseases of the Nervous System (6) · Demyelinating Autoimmune Diseases, CNS (6) · Scleroderma, Diffuse (6) · Amyotrophic Lateral Sclerosis (5) · Autoimmune Diseases (5) · Scleroderma, Systemic (5) · Demyelinating Diseases (4) · Nervous System Diseases (4) · Immune System Diseases (3) · Motor Activity (3) · Motor Neuron Disease (3) · Pathologic Processes (3) · Dermatomyositis (2)
Pathological Conditions, Signs and Symptoms (33) · Pathologic Processes (30) · Nervous System Diseases (19) · Immune System Diseases (15) · Autoimmune Diseases (12) · Central Nervous System Diseases (10) · Demyelinating Diseases (10) · Skin and Connective Tissue Diseases (10) · Skin Diseases (9) · Autoimmune Diseases of the Nervous System (8) · Demyelinating Autoimmune Diseases, CNS (8) · Connective Tissue Diseases (7) · Neuromuscular Diseases (7) · Brain Diseases (6) · Leukoencephalopathies (6)
Cyclophosphamide (2) · Diosmin (2) · Acetylcysteine (1) · Adrenocorticotropic Hormone (1) · Anti-Inflammatory Agents, Non-Steroidal (1) · BID protein, human (1) · Bosentan (1) · Exercise (1) · Hesperidin (1) · Ibuprofen (1) · Interleukin-2 (1) · Levetiracetam (1) · Metformin (1) · Methylprednisolone (1) · Methylprednisolone Hemisuccinate (1)
Gilead Sciences (2) · Hope Biosciences Research Foundation (2) · Merck KGaA, Darmstadt, Germany (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Actelion (1) · Biocells Medical (1) · Centre Hospitalier Universitaire de Saint Etienne (1) · Century Therapeutics, Inc. (1) · Contineum Therapeutics (1) · Deciphera Pharmaceuticals, LLC (1) · Duke University (1) · Eli Lilly and Company (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Hospital de Clínicas Dr. Manuel Quintela (1) · Juno Therapeutics, Inc., a Bristol-Myers Squibb Company (1)
United States (15) · France (6) · Australia (3) · Canada (3) · Germany (3) · Poland (3) · United Kingdom (3) · Belgium (2) · Czechia (2) · Denmark (2) · Israel (2) · Romania (2) · Spain (2) · Argentina (1) · Brazil (1)
Leslie J. Crofford, MD (2) · Anouska Carter (1) · Barbara Willekens, MD, PhD (1) · Bittoo Kanwar, MD (1) · CC Mok, MD FRCP (1) · Christine Smith (1) · Daniel A Monti, MD, MBA (1) · Daniel E. Furst, MD (1) · Daniel Furst, MD (1) · Daniel Kantor, MD (1) · David Celermajer, Professor (1)
PMID 11050032, PMID 15084121, PMID 17978354, PMID 20708086, PMID 20800376, PMID 23300829, PMID 23418384, PMID 28602891, PMID 29298160, PMID 30153359, PMID 33131208, PMID 34309408, PMID 34377857, PMID 34533286, PMID 35108379, PMID 35904231, PMID 37690438, PMID 38444875, PMID 38967589, PMID 39207422, PMID 39996122, PMID 40966534
2023 (1), K23HD101667 (1), UL1TR002369 (1)